CN103819564A - 用于将gdnf和bdnf递送至中枢神经系统的融合蛋白 - Google Patents
用于将gdnf和bdnf递送至中枢神经系统的融合蛋白 Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/48—Nerve growth factor [NGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18624609P | 2009-06-11 | 2009-06-11 | |
| US61/186,246 | 2009-06-11 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010800317596A Division CN102459348A (zh) | 2009-06-11 | 2010-06-11 | 用于将gdnf和bdnf递送至中枢神经系统的融合蛋白 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103819564A true CN103819564A (zh) | 2014-05-28 |
Family
ID=43308346
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410030902.XA Pending CN103819564A (zh) | 2009-06-11 | 2010-06-11 | 用于将gdnf和bdnf递送至中枢神经系统的融合蛋白 |
| CN2010800317596A Pending CN102459348A (zh) | 2009-06-11 | 2010-06-11 | 用于将gdnf和bdnf递送至中枢神经系统的融合蛋白 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010800317596A Pending CN102459348A (zh) | 2009-06-11 | 2010-06-11 | 用于将gdnf和bdnf递送至中枢神经系统的融合蛋白 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20120196803A1 (https=) |
| EP (1) | EP2440581A4 (https=) |
| JP (1) | JP2012529272A (https=) |
| CN (2) | CN103819564A (https=) |
| AU (1) | AU2010258052A1 (https=) |
| BR (1) | BRPI1012971A2 (https=) |
| CA (1) | CA2764777A1 (https=) |
| MX (1) | MX2011013258A (https=) |
| WO (1) | WO2010142035A1 (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107141354A (zh) * | 2017-05-05 | 2017-09-08 | 李斯文 | 一种融合蛋白及光敏剂复合物及其制备方法和应用 |
| CN114729324A (zh) * | 2019-07-24 | 2022-07-08 | 斯比根公司 | 永生化干细胞株的制备方法及其用途 |
| WO2025067354A1 (zh) * | 2023-09-28 | 2025-04-03 | 广州必贝特医药股份有限公司 | 抑制淀粉样前体蛋白(APP)基因表达的siRNA、药物及其应用 |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004060403A2 (en) | 2003-01-06 | 2004-07-22 | Angiochem Inc. | Aprotinin and anglos as carriers across the blood-brain barrier |
| ES2744225T3 (es) | 2005-07-15 | 2020-02-24 | Angiochem Inc | Uso de polipéptidos de aprotinina como portadores en conjugados farmacéuticos |
| JP2010506860A (ja) | 2006-10-19 | 2010-03-04 | アンジオケム，インコーポレーテッド | Ｐ−糖タンパク質機能を刺激するための化合物およびその使用 |
| US9365634B2 (en) | 2007-05-29 | 2016-06-14 | Angiochem Inc. | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
| CA2740316A1 (en) | 2008-10-15 | 2010-04-22 | Angiochem Inc. | Conjugates of glp-1 agonists and uses thereof |
| CA2745524C (en) | 2008-12-05 | 2020-06-09 | Angiochem Inc. | Conjugates of neurotensin or neurotensin analogs and uses thereof |
| US8853353B2 (en) | 2008-12-17 | 2014-10-07 | Angiochem, Inc. | Membrane type-1 matrix metalloprotein inhibitors and uses thereof |
| MX2011011023A (es) | 2009-04-20 | 2012-01-20 | Angiochem Inc | Tratamiento de cancer de ovarios usando un agente anti-cancer conjugado con un analogo de angiopep-2. |
| RU2012103240A (ru) | 2009-07-02 | 2013-08-10 | Ангиокем Инк. | Мультимерные пептидные конъюгаты и их применение |
| WO2011153642A1 (en) * | 2010-06-10 | 2011-12-15 | Angiochem Inc. | Leptin and leptin analog conjugates and fusion proteins and uses thereof |
| JP2013530993A (ja) * | 2010-07-02 | 2013-08-01 | アンジオケム インコーポレーテッド | 治療用コンジュゲートのための短く且つｄ−アミノ酸を含有するポリペプチドおよびその使用 |
| JP2015526434A (ja) | 2012-08-14 | 2015-09-10 | アンジオケム インコーポレーテッド | ペプチド−デンドリマーコンジュゲート及びその使用 |
| JP6234331B2 (ja) * | 2014-06-13 | 2017-11-22 | 森永乳業株式会社 | 統合失調症治療剤 |
| EP3307326B9 (en) | 2015-06-15 | 2021-02-24 | Angiochem Inc. | Methods for the treatment of leptomeningeal carcinomatosis |
| EP3454886A1 (en) | 2016-05-13 | 2019-03-20 | Instituto de Medicina Molecular | Methods of treating diseases associated with ilc3 cells |
| WO2018089702A1 (en) * | 2016-11-10 | 2018-05-17 | Keros Therapeutics, Inc. | Gdnf fusion polypeptides and methods of use thereof |
| EP4347645A1 (en) | 2021-06-03 | 2024-04-10 | Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud Foundation | Neuro-mesenchyme units control ilc2 and obesity via a brain-adipose circuit |
| CN116270429B (zh) * | 2023-02-17 | 2025-06-10 | 山东省药学科学院 | 一种鼻黏膜给药的抗抑郁制剂及其制备方法和应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008144919A1 (en) * | 2007-05-29 | 2008-12-04 | Angiochem, Inc. | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
| WO2009039188A1 (en) * | 2007-09-17 | 2009-03-26 | Ludwig Institute For Cancer Research Ltd | Peptides and methods for the treatment of gliomas and other cancers |
| WO2009070597A2 (en) * | 2007-11-26 | 2009-06-04 | Armagen Technologies, Inc. | Fusion proteins for delivery of gdnf to the cns |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2408605C2 (ru) * | 2005-02-18 | 2011-01-10 | Анджиокем Инк. | Полипептид, способный преодолевать гематоэнцефалический барьер, и его конъюгат |
| US20090016959A1 (en) * | 2005-02-18 | 2009-01-15 | Richard Beliveau | Delivery of antibodies to the central nervous system |
| US8053569B2 (en) * | 2005-10-07 | 2011-11-08 | Armagen Technologies, Inc. | Nucleic acids encoding and methods of producing fusion proteins |
-
2010
- 2010-06-11 CN CN201410030902.XA patent/CN103819564A/zh active Pending
- 2010-06-11 JP JP2012514307A patent/JP2012529272A/ja active Pending
- 2010-06-11 MX MX2011013258A patent/MX2011013258A/es not_active Application Discontinuation
- 2010-06-11 WO PCT/CA2010/000889 patent/WO2010142035A1/en not_active Ceased
- 2010-06-11 CA CA2764777A patent/CA2764777A1/en not_active Abandoned
- 2010-06-11 AU AU2010258052A patent/AU2010258052A1/en not_active Abandoned
- 2010-06-11 BR BRPI1012971A patent/BRPI1012971A2/pt not_active IP Right Cessation
- 2010-06-11 EP EP10785633A patent/EP2440581A4/en not_active Withdrawn
- 2010-06-11 CN CN2010800317596A patent/CN102459348A/zh active Pending
- 2010-06-11 US US13/377,480 patent/US20120196803A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008144919A1 (en) * | 2007-05-29 | 2008-12-04 | Angiochem, Inc. | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
| WO2009039188A1 (en) * | 2007-09-17 | 2009-03-26 | Ludwig Institute For Cancer Research Ltd | Peptides and methods for the treatment of gliomas and other cancers |
| WO2009070597A2 (en) * | 2007-11-26 | 2009-06-04 | Armagen Technologies, Inc. | Fusion proteins for delivery of gdnf to the cns |
Non-Patent Citations (1)
| Title |
|---|
| ULKAN KILIC等: "Intravenous TAT-GDNF Is Protective After Focal Cerebral Ischemia in Mice", 《STROCK》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107141354A (zh) * | 2017-05-05 | 2017-09-08 | 李斯文 | 一种融合蛋白及光敏剂复合物及其制备方法和应用 |
| CN114729324A (zh) * | 2019-07-24 | 2022-07-08 | 斯比根公司 | 永生化干细胞株的制备方法及其用途 |
| WO2025067354A1 (zh) * | 2023-09-28 | 2025-04-03 | 广州必贝特医药股份有限公司 | 抑制淀粉样前体蛋白(APP)基因表达的siRNA、药物及其应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI1012971A2 (pt) | 2018-01-16 |
| EP2440581A1 (en) | 2012-04-18 |
| WO2010142035A1 (en) | 2010-12-16 |
| US20120196803A1 (en) | 2012-08-02 |
| AU2010258052A1 (en) | 2012-01-12 |
| JP2012529272A (ja) | 2012-11-22 |
| MX2011013258A (es) | 2012-02-28 |
| CA2764777A1 (en) | 2010-12-16 |
| EP2440581A4 (en) | 2013-03-27 |
| CN102459348A (zh) | 2012-05-16 |
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Application publication date: 20140528 |