CN103816256B - A kind of composition with physiological function - Google Patents
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- CN103816256B CN103816256B CN201410073150.5A CN201410073150A CN103816256B CN 103816256 B CN103816256 B CN 103816256B CN 201410073150 A CN201410073150 A CN 201410073150A CN 103816256 B CN103816256 B CN 103816256B
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- 239000000203 mixture Substances 0.000 title claims abstract description 59
- 230000035790 physiological processes and functions Effects 0.000 title claims abstract description 7
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims abstract description 43
- HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 claims abstract description 25
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 claims abstract description 25
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 claims abstract description 25
- 229960003080 taurine Drugs 0.000 claims abstract description 21
- 230000000694 effects Effects 0.000 claims abstract description 18
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- 235000013305 food Nutrition 0.000 claims abstract description 7
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims description 26
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- 238000002360 preparation method Methods 0.000 claims description 10
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- ZKHQWZAMYRWXGA-KQYNXXCUSA-N Adenosine triphosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-N 0.000 description 2
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- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 description 2
- FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 description 2
- 235000001368 chlorogenic acid Nutrition 0.000 description 2
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 description 2
- 235000019425 dextrin Nutrition 0.000 description 2
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
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- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- LPQOADBMXVRBNX-UHFFFAOYSA-N ac1ldcw0 Chemical compound Cl.C1CN(C)CCN1C1=C(F)C=C2C(=O)C(C(O)=O)=CN3CCSC1=C32 LPQOADBMXVRBNX-UHFFFAOYSA-N 0.000 description 1
- UDMBCSSLTHHNCD-KQYNXXCUSA-N adenosine 5'-monophosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O UDMBCSSLTHHNCD-KQYNXXCUSA-N 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of composition with physiological function, in said composition containing weight portion be 2～8 parts D ribose, weight portion be 1～5 part taurine, weight portion be the Guarana extract of 1～5 part or green coffee bean extract.The composition of said composition is simple, prescription is unique, usage ratio science, effect substantially, also there is easily prepared, production cost not advantages of higher, the upper acceptable method of production can be used to make multiple medicine, food, health food particularly drinks, it is adaptable to because of excessively work, night life, body is empty, assault and take an examination or the fatigue of the reason appearance such as mental illness, the crowd of the symptom such as depressed.
Description
Technical field
The present invention relates to a kind of composition, relate in particular to a kind of Orally administered composition with antifatigue or antidepressant effect.The invention still further relates to the multiple use of this Orally administered composition.
Background technology
In daily life; usually can there is tired sensation because of the most mental, manual labor or body void etc. or even produce the symptoms such as depressed in people; therefore in addition to suitably having a rest, adjusting; can also take and there is antifatigue, the product of the effect of regaining one's strength etc., including medicine, health food or food.Prior art has many Related products, but lack that formula is simple and few side effects, effect are definite, can long-term taking and there is the product particularly functional beverage of antidepressant effect.
D ribose is the monose containing five carbon atoms, is the important composition material of genetic materials ribonucleic acid (RNA) in organism, and formation and the regeneration of atriphos (ATP) with adenylate have substantial connection.Research confirms, supplements D ribose and can improve the locomitivity of human body, effective antifatigue, alleviates DOMS.But the product containing D ribose is little in existing medicine and health food.
Taurine, also known as beta-amino ethyl sulfonic acid, is the non-protein amino acid of a kind of sulfur-bearing, has multiple beneficial in the physiological function of human body, but the taurine of human body synthesis is little, relies primarily on the taurine in pickuping food to meet body requirement.
Guarana (Guarana) is to be grown in rare fruit rare in Brazil's Ya Maxun jungle, its Main Ingredients and Appearance is that Guarana is because of (Guaranaine), chemical analysis is similar to caffeine, and people can spiritedness and fresh sensation after taking Guarana.Also it is believed that, its contained natural caffeine effect relaxes than the caffeine of synthesis, and therefore effect is more preferable.The common commercially available specification of Guarana extract is 10: 1-20: 1, and component content is usually 10%-20%.
Green coffee bean extract derives from the seed of the multiple coffee of madder wort such as Coffea arabica L..It is mainly composed of chlorogenic acid or total chlorogenic acid, and it is the highest that the content of commercially available prod mostly is 10%-50%, and specification is 5: 1-20: 1, has step-down, antitumor, kidney tonifying, the effect such as anti-oxidant.
CN102150724A discloses a kind of functional mixture refreshed oneself and alleviate muscle power with visual fatigue, plants composition containing taurine, caffeine, green-tea extract, American ginseng extract, guarana extract, ginkgo biloba p.e, wolfberry fruit extract etc. more than ten.But the prior art is with taurine as main component, content of caffeine is higher, and does not has antidepressant effect.
CN101961345A discloses a kind of pharmaceutical composition with antifatigue effect, including Cordyceps sinensis polysaccharide or ferment cordyceps sinensis bacterium solution, D ribose and taurine.But the prior art is with Cordyceps sinensis polysaccharide or ferment cordyceps sinensis bacterium solution as main component, and cost is the highest, does not also have antidepressant effect.
Summary of the invention
The technical problem that the present invention solves is to provide a kind of comparison of ingredients composition simple, each can produce synergy and the relatively low Orally administered composition of the content of caffeine particularly has the health food of physiological function.
Another technical problem that the present invention solves be to provide above-mentioned Orally administered composition antifatigue, regain one's strength, the multiple use of the aspect such as antidepression.
The technical solution used in the present invention is:
The primary raw material of this composition with physiological function be weight portion be 2～8 parts D ribose, weight portion be 1～5 part taurine, weight portion be the Guarana extract of 1～5 part or green coffee bean extract.The preferred weight ratio of primary raw material is: D ribose is 3～7 parts, and taurine is 2～4 parts, and Guarana extract or green coffee bean extract are 2～4 parts.Preferred weight ratio is: D ribose is 4～6 parts, and taurine is 2.8～3 parts, and Guarana extract or green coffee bean extract are 2.8～3 parts.The weight portion of preferably D ribose is 5 parts.
Described composition is possibly together with kind acceptable on galenic pharmacy and the auxiliary material of weight portion, the product of the multiple formulation that can make, and the product being preferably made is oral bio energy drink.
Containing D ribose in the product that the people that described composition is made each takes is 0.05～0.35g, and preferably containing D ribose is 0.1～0.2g or 0.06～0.14g.
Containing caffeine less than 80mg, preferably more than 40mg, more preferably no more than 20mg or 10mg, most preferably not more than 5mg in the product that the people that described composition is made each takes.
Described composition has antifatigue or fatigue-relieving effect, the effect of regaining one's strength and antidepressant effect, it is possible to use the above acceptable method that produces to make multiple medicine, food, particularly can be with the health food of long-term taking.
The present invention has carried out creative research to the raw material in described Orally administered composition and its weight portion; found that the combination of D ribose, taurine and Guarana extract or green coffee bean extract creates synergy; obtained product has antifatigue, regain one's strength and the effect such as antidepression, creates unforeseeable technique effect.The present invention have selected the content of Related Component in the manufactured goods that made people takes every day always according to experimental result is excellent, takes measures again preferably to go out and control the content of caffeine in manufactured goods, and result achieves superior technique effect.Obtained product is applicable to because of excessively work, night life, body is empty, assault and take an examination or the fatigue of the reason appearance such as mental illness, the crowd of the symptom such as depressed.The composition of this Orally administered composition is simple, prescription is unique, usage ratio science, effect substantially, also there is easily prepared, production cost not advantages of higher.
Detailed description of the invention
The formula of the present composition, manufactured goods and beneficial effect being expanded on further below by detailed description of the invention, these detailed description of the invention contain the preparation of the present composition and the preliminary experiment situation of effect.
Embodiment 1: the preparation of present composition powder
Take the raw material of following weight: D ribose 300g, taurine 500g, content are the Guarana extract 200g of 10%, add appropriate dextrin, mix after drying, are distributed into 2000 bags.Usage and consumption: oral, one time 0.5～1 bag, 2～3 times on the one.This product also can add in flour, is eaten for a long time making wheaten food.
Embodiment 2: the preparation of present composition syrup
Take the raw material of following weight: D ribose 50g, taurine 30g, the Guarana extract 28g of 10% content, soluble in water, addition suitable amount of sucrose makes syrup 8000ml, packing.Recording its content of caffeine is 0.4mg/ml.Usage and consumption: oral, one time 10～20ml, 3～4 times on the one.
Embodiment 3: the preparation of present composition tablet
Take the raw material of following weight: D ribose 70g, taurine 20g, content are the green coffee bean extract 40g of 30%, add appropriate dextrin and pelletize, and add appropriate magnesium stearate compressing tablet, make 1000 after whole grain.Recording its content of caffeine is 3.8mg/ sheet.Usage and consumption: oral, one time 2～5,2～3 times on the one.
Embodiment 4: the preparation of present composition granule
Take the raw material of following weight: D ribose 500g, taurine 280g, content are green coffee bean extract 30g, the Tea Polyphenols 20g of 50%, pelletize with appropriate amount of starch, are distributed into 5000 bags, every bag of 1g.Usage and consumption: oral, one time 1～2 bag, 2～3 times on the one.
Embodiment 5: the preparation of present composition capsule
Take the raw material of following weight: D ribose 300g, taurine 400g, content are the Guarana extract 200g of 15%, be granulation into 2000g with appropriate amount of starch, dispense capsule 10000.Recording its content of caffeine is 3.5mg/ grain.Usage and consumption: oral, one time 5～10,2～3 times on the one.
Embodiment 6: the preparation of present composition oral liquid
Take the raw material of following weight: D ribose 5g, taurine 2.8g, content are the green coffee bean extract 3g of 30%, are dissolved in hot water, add appropriate sweetener, essence, filter, make 1000ml oral liquid, packing.Recording its content of caffeine is 0.9mg/ml.Usage and consumption: oral, one time 10～20ml, 2～6 times on the one.
Experimental example 1: the mouse swimming test of product of the present invention
Selecting Kunming mouse 20, body weight 18-22g, stochastic averagina is divided into 2 groups, the oral liquid gavage that medication group is filled a prescription by embodiment 6, every mouse 0.1ml；Blank group gavage normal saline；Each 1 time of every day at upper and lower noon, totally 14 days.0.5h after being administered in last 1 time, the galvanized wire being equivalent to its body weight 7.5% it is wrapped with at mouse tail root, being placed in the water tank went swimming that water temperature is about 25 DEG C, record mouse starts to the water-bed dead time that sinks as mouse swimming time from swimming, carries out statistical disposition using the second as unit.The results are shown in Table 1.
Table 1 mouse swimming test result
Note: 1. compare P ＜ 0.05 with physiological saline group
Experimental example 2: the Tail suspension test of product of the present invention
Tail suspension test is a kind of behavioral despair model experiment, sensitive to antidepressants, simple to operate, quick, is widely used in the primary dcreening operation of antidepressant.Selecting Kunming mouse 30, body weight 18-22g, stochastic averagina is divided into 3 groups, and medication group every mouse every time takes the syrup 0.1ml or the particle 0.01g that embodiment 5 is the most encapsulated of embodiment 2 respectively, all adds water to gavage after 0.3ml；Blank group 0.3ml physiological saline gavage；Each 1 time of every day at upper and lower noon, totally 14 days.After last is administered 1h, mouse is fixed on horizon bar at tail end 2cm, make it in the state of hanging by the feet, head is from desktop about 10cm, surrounding isolates mouse sight line with plank, after 2min, the accumulative dead time (i.e. animal is in addition to breathing, the time that all limbs are the most motionless) of mouse in record 4min, the results are shown in Table 2.The results show, the product of the present invention has the effect significantly better than blank group, and the effect of embodiment 2 product is better than the product of embodiment 5.
The result of table 2 Tail suspension test
Note: 1. compare P ＜ 0.05 with control group, 2. compare P ＜ 0.01 with control group.
Claims (17)
1. a composition with physiological function, it is characterised in that: described composition is made up of following raw materials according: weight portion is 2～8
Part D ribose, weight portion be 1～5 part taurine, weight portion be the Guarana extract of 1～5 part or green coffee bean
Extract.
Composition the most according to claim 1, it is characterised in that: the weight portion of described D ribose is 3～7 parts, described taurine
Weight portion be 2～4 parts, the weight portion of described Guarana extract or green coffee bean extract is 2～4 parts.
Composition the most according to claim 1, it is characterised in that: the weight portion of described D ribose is 4～6 parts, described taurine
Weight portion be 2.8～3 parts, the weight portion of described Guarana extract or green coffee bean extract is 2.8～3 parts.
Composition the most according to claim 1, it is characterised in that: the weight portion of described D ribose is 5 parts, described taurine
Weight portion is 2.8 parts, and the weight portion of described Guarana extract or green coffee bean extract is 3 parts.
Composition the most according to claim 1, it is characterised in that: possibly together with acceptable kind and the auxiliary material of weight portion.
Composition the most according to claim 1, it is characterised in that: the product that described composition is made is medicine, food or health care
Food.
Composition the most according to claim 1, it is characterised in that: the product that described composition is made is oral beverage.
Composition the most according to claim 1, it is characterised in that: containing D in the product that the people that described composition is made each takes
Ribose is 0.05～0.35g.
Composition the most according to claim 1, it is characterised in that: containing D in the product that the people that described composition is made each takes
Ribose is 0.1～0.2g.
Composition the most according to claim 1, it is characterised in that: in the product that the people that described composition is made each takes
It is 0.06～0.14g containing D ribose.
11. compositions according to claim 1, it is characterised in that: in the product that the people that described composition is made each takes
Containing caffeine less than 80mg.
12. compositions according to claim 1, it is characterised in that: in the product that the people that described composition is made each takes
Containing coffee because less than 40mg.
13. compositions according to claim 1, it is characterised in that: in the product that the people that described composition is made each takes
Containing coffee because less than 20mg.
14. compositions according to claim 1, it is characterised in that: in the product that the people that described composition is made each takes
Containing coffee because less than 10mg or 5mg.
15. as described in one of claim 1-10 composition purposes in preparation has the product of antidepressant effect.
16. as described in one of claim 1-10 composition use in preparation has the product of antifatigue or fatigue-relieving effect
On the way.
17. compositions as described in one of claim 1-10 have the purposes regained one's strength in the product acted in preparation.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410073150.5A CN103816256B (en) | 2014-02-24 | 2014-02-24 | A kind of composition with physiological function |
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| CN201410073150.5A CN103816256B (en) | 2014-02-24 | 2014-02-24 | A kind of composition with physiological function |
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| CN103816256A CN103816256A (en) | 2014-05-28 |
| CN103816256B true CN103816256B (en) | 2016-08-24 |
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| CN104012739B (en) * | 2014-06-09 | 2016-05-04 | 天地壹号饮料股份有限公司 | A kind of beverage with compound functions and its preparation method and application |
| CN105661234A (en) * | 2016-01-22 | 2016-06-15 | 江苏艾兰得营养品有限公司 | Beverage with function of quick physical energy recovery and method for preparing beverage with function of quick physical energy recovery |
| CN114868924A (en) * | 2022-05-13 | 2022-08-09 | 武汉工程大学 | Composition based on D-ribose and amino acid and application thereof |
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| CN101919801A (en) * | 2009-07-14 | 2010-12-22 | 无锡健而乐医药科技有限公司 | Solid effervescent mixture for oral absorption |
| CN102150859A (en) * | 2011-01-31 | 2011-08-17 | 上海东锦食品集团有限公司 | Composition with functions of relieving physical fatigue and improving memory as well as preparation method and application thereof |
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| US9414615B2 (en) * | 2010-01-18 | 2016-08-16 | PepciCo, Inc. | Gel-based compositions and methods of making same |
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| CN101919801A (en) * | 2009-07-14 | 2010-12-22 | 无锡健而乐医药科技有限公司 | Solid effervescent mixture for oral absorption |
| CN102150859A (en) * | 2011-01-31 | 2011-08-17 | 上海东锦食品集团有限公司 | Composition with functions of relieving physical fatigue and improving memory as well as preparation method and application thereof |
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| CN103816256A (en) | 2014-05-28 |
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