CN103816251A - Plant active composition for drug-free breeding and preparation method thereof - Google Patents
Plant active composition for drug-free breeding and preparation method thereof Download PDFInfo
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- CN103816251A CN103816251A CN201410062840.0A CN201410062840A CN103816251A CN 103816251 A CN103816251 A CN 103816251A CN 201410062840 A CN201410062840 A CN 201410062840A CN 103816251 A CN103816251 A CN 103816251A
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Abstract
The invention discloses a plant active composition for drug-free breeding and a preparation method thereof. According to the preparation method, medicinal materials such as isatis root, coptis, lithospermum, haw and licorice, etc. are mainly used; each medicinal material respectively passes through water, ethanol and an ethyl acetate solvent for extraction; each medicinal material is concentrated and mixed to obtain an extract product of each medicinal material; and the medicinal materials can be firstly mixed and then extracted, or the medicinal materials are firstly extracted and then mixed. Thus, the plant active composition is obtained. In addition, the plant active composition also can be used along with dandelion, Radix Astragali or probiotics. Bacteriostatic plant active components are used, and combination ratio of extracted plant active composition is adjusted. Then, the plant active composition has synergistic interaction effects. By the use of the plant active composition, immunity of animals can be raised, feed conversion ratio is good, and a natural drug-free health breeding condition is provided.
Description
Technical field
The present invention relates to a kind of vegetable active extract, particularly relate to one and grow with reactive composition of plants and preparation method thereof without health preserving with drugs.
Background technology
Aquaculture covering scope is very wide, and it is not only supplied raw materials for industries such as food, pharmacy, oils and fatss, also for people's life provides the abundant foods such as meat, breast, egg, fowl.But, in the process of animal cultivation, for avoiding its unlikely infection source of disease bacterium, and then sick, or for improving cultured output, cultivation dealer generally gets used to using in feeding process antibiotic or even some chemicals, by being added into feeding cultivated animals in feedstuff, to improve by this animal resistance or its alimentation efficiency.
Eaten these antibiotic or chemicals when these cultivated animals, be just easy to develop immunity to drugs, through food chain, we mankind eat into these cultivated animals or its product, can develop immunity to drugs at human body equally, and then cause having the generation of superbacteria; Food chain relation in the middle of this, produces like this.Because in the antibiotic of produced worldwide, having more than 70 percent quantity is nearly all to use on aquaculture, and the mankind itself use less than 30 percent; But, through the relation of food chain, be used in the antibiotic in aquaculture, finally still get back on the mankind's body, and long-term edible medicine residual quantity exceedes the animal products of legal permissible criterion, very large to human injury, the superbacteria that produced when the time comes by without any antibiotic or medicine can resist, this will be the large great calamity of one in mankind's public health.
Therefore, many countries start the antibiotic use of standard, or even directly ban use of the antibiotic that some impact is very large.But reverting to aquaculture but may affect cultivation or its product of poultry because not using the antibacterial such as antibiotic, and causes its price to rise steadily.In view of this, grow with reactive composition of plants and preparation method thereof without health preserving with drugs so the present invention proposes one, the antibiotic and other chemical drugss etc. that while cultivation to replace, are used, and then solve the awkward situation that current aquaculture faces.
Summary of the invention
Main purpose of the present invention is to provide a kind of and grows with reactive composition of plants and preparation method thereof without health preserving with drugs, it is to extract with vegetable active that can be antibacterial the antibiotic and other chemical drugss that when composition replaces cultivation, are used, and the effect of the powerful Synergistic making it have by the portfolio ratio of each medical material in adjustment reactive composition of plants, improve the immunity of animal, improve breeding environment, and then the natural livestock product without medicine healthy aquaculture is provided.
Another object of the present invention is to provide a kind of and grow with reactive composition of plants and preparation method thereof without health preserving with drugs, prepare reactive composition of plants more can add the probiotic bacteria use of arranging in pairs or groups, to strengthen the effect of its Synergistic.
For achieving the above object, the present invention proposes one and grows with reactive composition of plants without health preserving with drugs, comprises the extract of following medical material: Radix Isatidis, Rhizoma Coptidis, Radix Arnebiae (Radix Lithospermi), Fructus Crataegi and Radix Glycyrrhizae;
By following two kinds of methods, any one prepares described reactive composition of plants:
First method: by Radix Isatidis, Rhizoma Coptidis, Radix Arnebiae (Radix Lithospermi), Fructus Crataegi and Radix Glycyrrhizae respectively first take water, ethanol and ethyl acetate after solvent extracts, concentrate drying, obtain respectively Radix Isatidis extract, Rhizoma Coptidis extract, Radix Arnebiae extract, Fructus Crataegi extract and Radix Glycyrrhizae extract, the part by weight that is 1～1.5:1～1.5:1～1.5:1～1.5:1～1.5 by Radix Isatidis extract, Rhizoma Coptidis extract, Radix Arnebiae extract, Fructus Crataegi extract and Radix Glycyrrhizae extract according to weight ratio again mixes, and obtains described reactive composition of plants; Or
Second method: the ratio that is 1～1.5:1～1.5:1～1.5:1～1.5:1～1.5 according to weight ratio by Radix Isatidis, Rhizoma Coptidis, Radix Arnebiae (Radix Lithospermi), Fructus Crataegi and Radix Glycyrrhizae is mixed, again by mixed medical material respectively take water, ethanol and ethyl acetate after solvent extracts, concentrate drying, obtains the reactive composition of plants that contains Radix Isatidis extract, Rhizoma Coptidis extract, Radix Arnebiae extract, Fructus Crataegi extract and Radix Glycyrrhizae extract.
In addition, the present invention also proposes a kind of preparation method of reactive composition of plants, and wherein, the present invention can be by all medical materials, at least comprises after the extract mixing of Radix Isatidis, Rhizoma Coptidis, Radix Arnebiae (Radix Lithospermi), Fructus Crataegi and Radix Glycyrrhizae, can obtain reactive composition of plants; Or be carrying out before the extraction of three stages, first will Radix Isatidis, Rhizoma Coptidis, Radix Arnebiae (Radix Lithospermi), Fructus Crataegi and Radix Glycyrrhizae etc. medical material carry out again subsequent step after mixing.
Concrete, by following two kinds of methods, any one prepares:
First method:
Provide respectively following medical material: comprise Radix Isatidis, Rhizoma Coptidis, Radix Arnebiae (Radix Lithospermi), Fructus Crataegi and Radix Glycyrrhizae;
By each medical material respectively after the water soaking of 3～10 times with its weight, first, after reflux for the first time, sequentially, after supercooling, filtering, to obtain respectively the first filtrate and the first residue, this first filtrate forms the first concentrated solution after concentrating under reduced pressure;
By this first residue take 3～10 times of its weight and concentration after 50～95% soak with ethanol, first after reflux for the second time, sequentially, after supercooling, filtering, to obtain respectively the second filtrate and the second residue, this second filtrate forms the second concentrated solution after concentrating under reduced pressure;
By this second residue take 3～10 times of its weight and concentration after 50～95% ethyl acetate is soaked, first, after reflux for the third time, sequentially, after supercooling, filtering, to obtain the 3rd filtrate, the 3rd filtrate forms the 3rd concentrated solution after concentrating under reduced pressure; And
After being mixed, this first concentrated solution, this second concentrated solution and the 3rd concentrated solution be dried, to obtain the extract of each medical material, make respectively Radix Isatidis extract, Rhizoma Coptidis extract, Radix Arnebiae extract, Fructus Crataegi extract and Radix Glycyrrhizae extract according to above method;
After being mixed in proportion, the Radix Isatidis extract preparing, Rhizoma Coptidis extract, Radix Arnebiae extract, Fructus Crataegi extract and Radix Glycyrrhizae extract obtain reactive composition of plants;
Second method:
Provide respectively following medical material: comprise Radix Isatidis, Rhizoma Coptidis, Radix Arnebiae (Radix Lithospermi), Fructus Crataegi and Radix Glycyrrhizae, each medical material is mixed in proportion;
After the water soaking of 3～10 times by mixed medical material with its weight, first, after reflux for the first time, sequentially, after supercooling, filtering, to obtain respectively the first filtrate and the first residue, this first filtrate forms the first concentrated solution after concentrating under reduced pressure;
By this first residue take 3～10 times of its weight and concentration after 50～95% soak with ethanol, first after reflux for the second time, sequentially, after supercooling, filtering, to obtain respectively the second filtrate and the second residue, this second filtrate forms the second concentrated solution after concentrating under reduced pressure;
By this second residue take 3～10 times of its weight and concentration after 50～95% ethyl acetate is soaked, first, after reflux for the third time, sequentially, after supercooling, filtering, to obtain the 3rd filtrate, the 3rd filtrate forms the 3rd concentrated solution after concentrating under reduced pressure;
After this first concentrated solution, this second concentrated solution and the 3rd concentrated solution are mixed, be dried, obtain reactive composition of plants.
Coordinate appended graphic explanation in detail by specific embodiment below, when the effect that is easier to understand object of the present invention, technology contents, feature and reaches.
Accompanying drawing explanation
Fig. 1 is the medicinal material extract schematic flow sheet that reactive composition of plants of the present invention uses.
The simple declaration of symbol:
10 first filtrates
12 first residues
14 first concentrated solutions
16 second filtrates
18 second residues
20 second concentrated solutions
22 the 3rd filtrates
24 the 3rd concentrated solutions
26 extracts
The specific embodiment
In order to solve the problem of the abuse of antibiotics that current aquaculture faces, the present invention replaces when cultivation antibiotic and other chemical drugss used with the compositions of active components of plants that can be antibacterial, and the effect of the powerful Synergistic having by the portfolio ratio of reactive composition of plants, effectively improve the immunity of animal, improve breeding environment, so that the natural livestock product without medicine healthy aquaculture to be provided.
Reactive composition of plants proposed by the invention, mainly include five kinds of medical materials such as Radix Isatidis, Rhizoma Coptidis, Radix Arnebiae (Radix Lithospermi), Fructus Crataegi and Radix Glycyrrhizae, its composition part by weight is Radix Isatidis: Rhizoma Coptidis: Radix Arnebiae (Radix Lithospermi): Fructus Crataegi: Radix Glycyrrhizae ﹦ 1～1.5:1～1.5:1～1.5:1～1.5:1～1.5, and be mixed into reactive composition of plants with this proportion of composing, wherein each medical material is sequentially to extract rear concentrate drying with three kinds of solvents such as water, ethanol and ethyl acetate respectively to be obtained.That is Radix Isatidis, Rhizoma Coptidis, Radix Arnebiae (Radix Lithospermi), Fructus Crataegi and Radix Glycyrrhizae are respectively after the ethyl acetate of the water of too high polarity, semipolar ethanol and low polarity is extracted, reconcentration is dried and generates respectively Radix Isatidis extract, Rhizoma Coptidis extract, Radix Arnebiae extract, Fructus Crataegi extract and Radix Glycyrrhizae extract, then the extract of these medical materials is mixed into reactive composition of plants of the present invention with aforementioned proportion; Or be, after first the medicinal herbs such as Radix Isatidis, Rhizoma Coptidis, Radix Arnebiae (Radix Lithospermi), Fructus Crataegi and Radix Glycyrrhizae being mixed with aforementioned proportion, after three kinds of solvents such as water, ethanol and ethyl acetate extract, concentrate drying directly generates reactive composition of plants of the present invention again, with by the particular combinations ratio of these medical materials, make the effect of this reactive composition of plants performance Synergistic.
Wherein, at above-mentioned reactive composition of plants, more include the Herba Taraxaci of 1～1.5 part by weight or the Radix Astragali or its extract of its extract and/or 1～1.5 part by weight; On the other hand, for improving better synergy, also can be by probiotic bacteria, for example bacillus subtilis, lactobacillus or the two exist simultaneously, add so far in vegetable active constituent, make the probiotic bacteria of intestines and stomach become dominant bacteria, thereby cause pathogen to survive, increase feed nutrition absorption efficiency simultaneously; Both generations add takes advantage of effect, makes, in whole actual breeding process, all need not add any antibiotic or chemical bactericide, can reach the healthy meat without any drug residue.
Illustrating that, after the composition medical material of reactive composition of plants of the present invention, connecting needle describes the needed extracting method of medical material, and coordinating graphic being described in detail as follows.
Shown in Fig. 1, first, as shown in step S10, provide respectively the medical materials such as Radix Isatidis, Rhizoma Coptidis, Radix Arnebiae (Radix Lithospermi), Fructus Crataegi and Radix Glycyrrhizae, to prepare to carry out the extraction procedure of medical material; Then start to carry out first stage extraction, as shown in step S12, by medical material, take Radix Isatidis as example, use the water soaking of 3～10 times of its weight after 1～5 hour, first as shown in step S14, carry out for the first time reflux 1～5 hour, this for the first time reflux temperature can be 100 ℃, through as after cooling, the filtration step of step S16, obtain respectively the first filtrate 10 and the first residue 12 again; Then as shown in step S18, this first filtrate 10 through be evaporated to volume originally 1/3rd after form the first concentrated solution 14.Then carry out second stage extraction, as shown in step S20, soak with ethanol by the first residue 12 take 3～10 times of its weight and concentration as 50～95% is after 1～5 hour, the first reflux for the second time through step S22 is after 1～5 hour, this for the second time reflux temperature can be 78 ℃, after cooling, the filtration step of step S24, obtain respectively the second filtrate 16 and the second residue 18, this second filtrate 16 is reclaimed ethanol through the concentrating under reduced pressure of step S26 can form the second concentrated solution 20 after existing without ethanol.Then, the second residue 18 is proceeded the phase III again and is extracted, as shown in step S28, the second residue 18 is soaked 1～5 hour take 3～10 times of its weight and concentration as 50～95% ethyl acetate, first pass through the reflux for the third time 1～5 hour of step S30, this for the third time reflux temperature can be 77 ℃, again after cooling, the filtration step of step S32, to obtain the 3rd filtrate 22, this 3rd filtrate 22 is reclaimed ethyl acetate through step S34 concentrating under reduced pressure and form the 3rd concentrated solution 24 after being existed without ethyl acetate.Finally as shown in step S36 and S38, after being mixed, aforementioned the first concentrated solution 14, the second concentrated solution 20 and the 3rd concentrated solution 24 sequentially obtaining be dried, this drying steps can use Direct spraying to be dried or lyophilization, or be first to add to carry out again the dry or lyophilization of Direct spraying after 5～80% excipient of reactive composition of plants weight, to obtain the extract 26 of medical material, that is Radix Isatidis extract.Proving by the same methods, the present invention can extract respectively Rhizoma Coptidis extract, Radix Arnebiae extract, Fructus Crataegi extract and Radix Glycyrrhizae extract etc. by the flow process of above-mentioned steps S10～step S38; Obtain all medical materials extract after, can, according to aforesaid ratio, all medicinal substances extracts such as Radix Isatidis extract, Rhizoma Coptidis extract, Radix Arnebiae extract, Fructus Crataegi extract and Radix Glycyrrhizae extract be mixed into reactive composition of plants.
Wherein, if wish is added Herba Taraxaci or the Radix Astragali, or the two adds together, also extracts respectively Herba Taraxaci extract, Radix Astragali extract by the flow process of above-mentioned steps S10～step S38, mixes to scale more afterwards with aforementioned various extracts.
Certainly, the explanation of previous embodiment be after first each medical material first being extracted with water, ethanol and ethyl acetate solvent respectively after concentrate drying is generated, then be mixed into reactive composition of plants with above-mentioned part by weight.In addition, the present invention also can first mix the medical materials such as Radix Isatidis, Rhizoma Coptidis, Radix Arnebiae (Radix Lithospermi), Fructus Crataegi and Radix Glycyrrhizae in advance with the part by weight of above-mentioned 1～1.5:1～1.5:1～1.5:1～1.5:1～1.5 after, again this mixing medical material is sequentially extracted to rear concentrate drying with water, ethanol and ethyl acetate solvent and directly extract reactive composition of plants, detailed extraction flow process is also identical with Fig. 1 and corresponding explanation thereof, therefore repeat no more in this.
Continue with actual culture experiment, prove that the reactive composition of plants that the present invention uses is conducive to grow without health preserving with drugs really, and there is preferably feedstuff meat change rate.
Take LDY three wat cross pig as subjects, in wheat small house area, Yu Lin County, test with general open pig house.90 pigletss, are divided into five groups, every group three repetitions, six of every repetitions (hurdle), and the additives different with identical feed collocation carry out feeding, from supporting the large pig of 120 kg from newborn piglets approximately 15 kilograms (kg).
90 pigletss are divided into 5 groups, as described below respectively:
(1) matched group: without adding any Chinese herbal medicine active matter or antibiotic.
(2) antibiotic: add 0.2% antibiotic.
(3) extract A: add 0.2% plant extract A, this is the aforementioned reactive composition of plants being mixed into the part by weight of 1.1:1.2:1.4:1.3:1.2 by Radix Isatidis extract, Rhizoma Coptidis extract, Radix Arnebiae extract, Fructus Crataegi extract and Radix Glycyrrhizae extract.
(4) probiotic bacteria B: add 0.2% probiotic bacteria B, comprise bacillus subtilis and lactobacillus, its bacterium is counted concentration and is 109(cfu/g).
(5) A+B: simultaneously add 0.1% plant extract A+0.1% probiotic bacteria B.
After this reactive composition of plants system first extracts each composition respectively, fully mix to scale, it is as shown in table 1 below that result is tested in the test completing again:
Table 1
Wherein, feedstuff meat change rate (FCR) is that the meat of one kilogram of every growth needs the feedstuff of how many kilograms, and meat change rate is better lower.For example: the meat change rate of rear cattle is 7, just represent the long one kilogram of meat of cattle, need the feedstuff of 7 kilograms; The meat change rate of pig is 3, represents long one kilogram of meat, needs the feedstuff of 3 kilograms; Different animals, different growing stages have various criterion meat change rate.Result of the test by above-mentioned table 1 can be found, what feedstuff meat change rate was best is is added with plant extract A and probiotic bacteria B the 5th group simultaneously, second-best is the 4th group that is added with the 3rd group of plant extract A and is added with probiotic bacteria, this feedstuff meat change rate of three groups is all than being added with antibiotic the 2nd group low, certainly also low many than matched group; Hence one can see that, and the feedstuff that is added with plant extract A can replace antibiotic really, reaches better culture efficiency, and be added with the feedstuff of plant extract A and probiotic bacteria B simultaneously, and, because of the effect of Synergistic, its effect is the most remarkable.
In addition, the present invention also provides other a series of culture experiment again, this with test above identical, be divided into equally 5 groups and test, difference is only, the 0.2% plant extract A using in this culture experiment, it is after first Radix Isatidis, Rhizoma Coptidis, Radix Arnebiae (Radix Lithospermi), Fructus Crataegi and Radix Glycyrrhizae being mixed with the medical material of the part by weight of 1.1:1.2:1.4:1.3:1.2, after aforementioned leaching process, the reactive composition of plants directly obtaining is tested again, and result of the test refers to shown in table 2.
Table 2
Wherein, result of the test by above-mentioned table 2 can be found, what feedstuff meat change rate was best is is also added with plant extract A and probiotic bacteria B the 5th group simultaneously, second-best is to be added with the 3rd group of plant extract A, this feedstuff meat change rate of two groups is all than being added with antibiotic the 2nd group low, certainly also low many than matched group; Be added with the 4th group of probiotic bacteria B the performance of feedstuff meat change rate be added with antibiotic the 2nd group suitable, but the effect of its feedstuff meat change rate is still good than matched group; Hence one can see that, and the feedstuff that is added with plant extract A still can replace antibiotic, keeps good culture efficiency, and be added with the feedstuff of plant extract A and probiotic bacteria B simultaneously, and, because of the effect of Synergistic, its effect is the most remarkable.
In sum, the reactive composition of plants that the present invention proposes, mix to scale again after first extracting respectively no matter be, or row extraction again after first mixing to scale, the two all can effectively improve the immunity of animal, obtain good feedstuff meat change rate, and then the natural livestock product without medicine healthy aquaculture is provided.
Above-described embodiment is only explanation technological thought of the present invention and feature, its object makes those skilled in the art can understand content of the present invention and implement according to this, when can not with restriction the scope of the claims of the present invention, the equalization of generally doing according to disclosed spirit changes or modifies, and must be encompassed in the scope of the claims of the present invention.
Claims (13)
1. grow with a reactive composition of plants without health preserving with drugs, it is characterized in that comprising the extract of following medical material: Radix Isatidis, Rhizoma Coptidis, Radix Arnebiae (Radix Lithospermi), Fructus Crataegi and Radix Glycyrrhizae;
By following two kinds of methods, any one prepares described reactive composition of plants:
First method: by Radix Isatidis, Rhizoma Coptidis, Radix Arnebiae (Radix Lithospermi), Fructus Crataegi and Radix Glycyrrhizae respectively first take water, ethanol and ethyl acetate after solvent extracts, concentrate drying, obtain respectively Radix Isatidis extract, Rhizoma Coptidis extract, Radix Arnebiae extract, Fructus Crataegi extract and Radix Glycyrrhizae extract, the part by weight that is 1～1.5:1～1.5:1～1.5:1～1.5:1～1.5 by Radix Isatidis extract, Rhizoma Coptidis extract, Radix Arnebiae extract, Fructus Crataegi extract and Radix Glycyrrhizae extract according to weight ratio again mixes, and obtains described reactive composition of plants; Or
Second method: the ratio that is 1～1.5:1～1.5:1～1.5:1～1.5:1～1.5 according to weight ratio by Radix Isatidis, Rhizoma Coptidis, Radix Arnebiae (Radix Lithospermi), Fructus Crataegi and Radix Glycyrrhizae is mixed, again by mixed medical material respectively take water, ethanol and ethyl acetate after solvent extracts, concentrate drying, obtains the reactive composition of plants that contains Radix Isatidis extract, Rhizoma Coptidis extract, Radix Arnebiae extract, Fructus Crataegi extract and Radix Glycyrrhizae extract.
2. as claimed in claim 1ly grow with reactive composition of plants without health preserving with drugs, it is characterized in that more including Herba Taraxaci or its extract of 1～1.5 part by weight.
3. as claimed in claim 2ly grow with reactive composition of plants without health preserving with drugs, it is characterized in that more including the Radix Astragali or its extract of 1～1.5 part by weight.
4. growing with reactive composition of plants without health preserving with drugs as described in claims 1 to 3 any one, is characterized in that more including probiotic bacteria and is added in this vegetable active constituent.
5. as claimed in claim 4ly grow with reactive composition of plants without health preserving with drugs, it is characterized in that this probiotic bacteria is that bacillus subtilis, lactobacillus or the two exist simultaneously.
6. grow the preparation method with reactive composition of plants without health preserving with drugs, it is characterized in that any one prepares by following two kinds of methods:
First method:
Provide respectively following medical material: comprise Radix Isatidis, Rhizoma Coptidis, Radix Arnebiae (Radix Lithospermi), Fructus Crataegi and Radix Glycyrrhizae;
By each medical material respectively after the water soaking of 3～10 times with its weight, first, after reflux for the first time, sequentially, after supercooling, filtering, to obtain respectively the first filtrate and the first residue, this first filtrate forms the first concentrated solution after concentrating under reduced pressure;
By this first residue take 3～10 times of its weight and concentration after 50～95% soak with ethanol, first after reflux for the second time, sequentially, after supercooling, filtering, to obtain respectively the second filtrate and the second residue, this second filtrate forms the second concentrated solution after concentrating under reduced pressure;
By this second residue take 3～10 times of its weight and concentration after 50～95% ethyl acetate is soaked, first, after reflux for the third time, sequentially, after supercooling, filtering, to obtain the 3rd filtrate, the 3rd filtrate forms the 3rd concentrated solution after concentrating under reduced pressure; And
After being mixed, this first concentrated solution, this second concentrated solution and the 3rd concentrated solution be dried, to obtain the extract of each medical material, make respectively Radix Isatidis extract, Rhizoma Coptidis extract, Radix Arnebiae extract, Fructus Crataegi extract and Radix Glycyrrhizae extract according to above method;
After being mixed in proportion, the Radix Isatidis extract preparing, Rhizoma Coptidis extract, Radix Arnebiae extract, Fructus Crataegi extract and Radix Glycyrrhizae extract obtain reactive composition of plants;
Second method:
Provide respectively following medical material: comprise Radix Isatidis, Rhizoma Coptidis, Radix Arnebiae (Radix Lithospermi), Fructus Crataegi and Radix Glycyrrhizae, each medical material is mixed in proportion;
After the water soaking of 3～10 times by mixed medical material with its weight, first, after reflux for the first time, sequentially, after supercooling, filtering, to obtain respectively the first filtrate and the first residue, this first filtrate forms the first concentrated solution after concentrating under reduced pressure;
By this first residue take 3～10 times of its weight and concentration after 50～95% soak with ethanol, first after reflux for the second time, sequentially, after supercooling, filtering, to obtain respectively the second filtrate and the second residue, this second filtrate forms the second concentrated solution after concentrating under reduced pressure;
By this second residue take 3～10 times of its weight and concentration after 50～95% ethyl acetate is soaked, first, after reflux for the third time, sequentially, after supercooling, filtering, to obtain the 3rd filtrate, the 3rd filtrate forms the 3rd concentrated solution after concentrating under reduced pressure;
After this first concentrated solution, this second concentrated solution and the 3rd concentrated solution are mixed, be dried, obtain reactive composition of plants.
7. the preparation method of using reactive composition of plants of growing without health preserving with drugs as claimed in claim 6, the ratio that the extract that it is characterized in that this Radix Isatidis, this Rhizoma Coptidis, this Radix Arnebiae (Radix Lithospermi), this Fructus Crataegi and this Radix Glycyrrhizae in first method is is 1～1.5:1～1.5:1～1.5:1～1.5:1～1.5 according to weight ratio is mixed into this reactive composition of plants.
8. the preparation method of using reactive composition of plants of growing without health preserving with drugs as claimed in claim 6, it is characterized in that in the second approach before carrying out water soaking, the ratio that is 1～1.5:1～1.5:1～1.5:1～1.5:1～1.5 according to weight ratio by this Radix Isatidis, this Rhizoma Coptidis, this Radix Arnebiae (Radix Lithospermi), this Fructus Crataegi and this licorice medicinal materials is mixed.
9. grow the preparation method with reactive composition of plants without health preserving with drugs as claimed in claim 7 or 8, it is characterized in that wherein this medical material more comprises Herba Taraxaci and the Radix Astragali.
10. the preparation method of using reactive composition of plants of growing without health preserving with drugs as claimed in claim 6, is characterized in that the time that this water soaking, this soak with ethanol and this ethyl acetate are soaked is respectively 1～5 hour.
11. as claimed in claim 6ly grow the preparation methoies with reactive composition of plants without health preserving with drugs, it is characterized in that this reflux, reflux and the time of reflux is respectively 1～5 hour for the third time for the second time for the first time.
12. preparation methoies of using reactive composition of plants of growing without health preserving with drugs as claimed in claim 6, is characterized in that this is dried as Direct spraying is dry or lyophilization.
13. as claimed in claim 12ly grow the preparation methoies with reactive composition of plants without health preserving with drugs, it is characterized in that first adding before dry carrying out the dry or lyophilization of Direct spraying after 5～80% excipient of reactive composition of plants weight again.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108938781A (en) * | 2018-08-06 | 2018-12-07 | 恩施土家族苗族自治州农业科学院 | A kind of herbal medicine and preparation method thereof of the enhancing chicken resistance containing selenium-enriched probiotics |
| CN109128214A (en) * | 2018-09-03 | 2019-01-04 | 黄冈师范学院 | A kind of method that Radix Isatidis residue prepares copper nanoparticle |
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| CN101085066A (en) * | 2007-06-08 | 2007-12-12 | 张玉柱 | Medicine for curing viral hepatitis of duckling |
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| CN103110027A (en) * | 2013-03-14 | 2013-05-22 | 哈尔滨圣杰麦克威生物科技有限公司 | Preparation method of EM (Effective Microorganism) high-immunity feed |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108938781A (en) * | 2018-08-06 | 2018-12-07 | 恩施土家族苗族自治州农业科学院 | A kind of herbal medicine and preparation method thereof of the enhancing chicken resistance containing selenium-enriched probiotics |
| CN109128214A (en) * | 2018-09-03 | 2019-01-04 | 黄冈师范学院 | A kind of method that Radix Isatidis residue prepares copper nanoparticle |
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