CN103815924B - A kind of CT/FT/PET tri-mode synchronous imaging device - Google Patents
A kind of CT/FT/PET tri-mode synchronous imaging device Download PDFInfo
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- CN103815924B CN103815924B CN201410068948.0A CN201410068948A CN103815924B CN 103815924 B CN103815924 B CN 103815924B CN 201410068948 A CN201410068948 A CN 201410068948A CN 103815924 B CN103815924 B CN 103815924B
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Abstract
The invention discloses a kind of CT/FT/PET tri-mode synchronous imaging device, described device includes translation stage, detection bed, centered by tested petty action object axle axle rotate discoid CT frame and PET/FT frame, X-ray tube, X-ray detector, 4 pieces of PET detecting heads being made up of 6 pieces of basic probe units of PET, laser instrument, CCD camera, x-ray collimator, filter wheel and for building the computer of image processing platform.The present invention combines the advantage of tri-kinds of image modes of CT, FT, PET, can provide more comprehensively in body research for toy, more accurate function and structural information, can greatly improve the detection performance of infantile tumour.
Description
Technical field
The present invention relates to molecular image technical field of imaging, be specifically related to a kind of CT/FT/PET tri-mould
State synchronous imaging device.
Background technology
Toy is widely used in the multiple pre-clinic such as tumor research, drug development at body research method
Research field, but toy must be by means of imagings such as CT, PET, SPECT, MRI in body research
Method.The formation method of single mode can only provide structure or the functional image of toy, has very
Big limitation, therefore the development of multi-modality imaging equipment becomes Medical image documentation equipment research neck
The focus in territory.
Up to now, multiple research team and commercial undertaking has been had to have developed multiple for petty action
The multimodal systems of thing research, Inveon PET/CT, UCLA of such as Siemens Medical Instr Pte Ltd.
The systems such as exploitation Sofie Biosciences business-like GENISYS PET/CT, in addition, also
The bimodals such as CT/SPECT, PET/FT of You Duojia research team or company or three mode image systems
System, the fair and clear professor team of domestic Tsing-Hua University has succeeded in developing for small animal research
PET/FT system.But, there is not yet now a by CT (or MRI), tri-kinds of imagings of PET and FT
The multi-modality imaging equipment studied at body for toy of modality fusion.
Optical sectioning imaging technology (FT) is a kind of image mode of new proposition in recent years, by it
High-sensitivity characteristic, cheap price and ease for operation are widely used in small animal research.
But the imaging depth of FT is shallower, the imageable target of 2～3cm typically can only be differentiated；PET can be to deep layer
Target well distinguishes, but shallow-layer target this for Subcutaneous tumor, and its imaging effect is relatively
Difference；CT can be supplied to high-resolution structural images, but cannot detect infantile tumour, and
PET, FT can just make up such defect.
Summary of the invention
It is an object of the invention to overcome the multi-modal tomography such as CT/PET, PET/FT, MRI/CT/PET
Deficiency present in imaging technique, proposes a kind of CT/FT/PET tri-mode synchronous imaging device, energy
Target, raising infantile tumour and the detectivity of shallow-layer target in the toy body of enough effectively location, with
Time owing to using with the design of rack construction so that the acquisition that multi-modality images merges is simpler.
To achieve these goals, the technical solution used in the present invention is as follows:
A kind of CT/FT/PET tri-mode synchronous imaging device, including the toy for observation, institute
State device include can the movable translation stage of level, the detection bed being connected with described translation stage, CT
Frame and PET/FT frame, described CT frame is provided with the first imaging hole, described PET/FT
Frame is provided with the second imaging hole, to be placed on during the body axle of the toy in described detection bed is
Mandrel, described first imaging hole, the center of circle of the second imaging hole and described central shaft are in same straight line；
Described CT frame one side roof part is provided with X-ray tube, on the position relative with described X-ray tube
It is provided with X-ray detector, and described first imaging hole is positioned at described X-ray tube and described X-ray
Between detector；
Described PET/FT frame one side roof part is provided with lasing light emitter, on the position relative with described lasing light emitter
Being provided with CCD camera, the input port dead ahead of described CCD camera is provided with filter wheel, described the second one-tenth
As hole is between described lasing light emitter and filter wheel；
Also include the flat board PET detecting head being circumferentially distributed with described second imaging hole, be used for detecting
The annihilation photon launched in described toy body.
At the x-ray collimator that described X-ray tube delivery outlet is installed, defeated for about beam X-ray
Go out wave beam.
Need it is further noted that the delivery outlet dead ahead of described X-ray tube is provided with X-ray
Collimator, the beamformer output of the reducible beam X-ray of described x-ray collimator, make X-ray cover X
Effective search coverage of ray detector, prevent simultaneously described in be observed toy by too much radiation
Dosage.
Need it is further noted that described filter wheel is provided with filter plate, be used for filtering FT imaging not
The fluorescence bands needed.
Need it is further noted that described flat board PET detecting head is 4, each flat board PET
Detecting head is combined by 6 pieces of basic probe units of PET, and a combination thereof mode is axial 3 pieces of * radial direction
2 pieces.
As the preferred technical scheme of one, described flat board PET detecting head, quasiconductor can be used to visit
Survey device replaces.
Need it is further noted that present invention additionally comprises CT image processing platform, be used for processing institute
State data that X-ray detector collected and carry out CT image reconstruction；
PET image processing platform, for processing data that described PET detecting head collects and carrying out
PET image reconstruction；
FT image processing platform, for processing data that described CCD camera collects and carrying out FT
Image reconstruction；
Image co-registration, Visualization Platform, be used for processing CT, PET and FT image, according to experiment need
Seek fusion bimodal or three modality images, and realize single mode or multi-modal fusion image can
Depending on changing；
Need it is further noted that described translation stage, frame and electronic equipment use same control
Case processed is controlled, and image processing platform and image co-registration, the Visualization Platform of each single mode make
Build with computer.
The present invention has the advantage that compared with prior art imaging device
The present invention combines the advantage of tri-kinds of image modes of CT, FT, PET, utilizes CT imaging to provide
High-resolution structural images, utilize PET imaging provide petty action object further object source function letter
Cease, utilize FT imaging to provide the function information of petty action object shallow-layer target source, grind for toy is relevant
Study carefully offer more comprehensively, accurate 26S Proteasome Structure and Function information；
Accompanying drawing explanation
Fig. 1 is the system structure schematic diagram of the present invention；
Fig. 2 is the PET/FT part-structure schematic diagram of the present invention；
Fig. 3 is CT part and the translation stage structural representation of the present invention；
Fig. 4 is the image output principle schematic diagram of the present invention.
Detailed description of the invention
Below in conjunction with accompanying drawing, the present invention will be further described.It should be noted that this enforcement
Example is implemented under premised on technical solution of the present invention, gives detailed embodiment and tool
The operating process of body, but protection scope of the present invention is not limited to following embodiment.
As shown in figures 1-4, the present invention is a kind of CT/FT/PET tri-mode synchronous imaging device, bag
Include the toy for observation, described device include can the movable translation stage 1 of level, with institute
State the detection bed 2 that translation stage 1 connects, CT frame 3 and PET/FT frame 4, described CT machine
Frame 3 is provided with the first imaging hole 31, and described PET/FT frame 4 is provided with the second imaging hole 41,
Axle centered by the body axle being placed on the toy in described detection bed 2, described first imaging hole
31, the center of circle of the second imaging hole 41 and described central shaft are in same straight line；
Described CT frame 3 one side roof part is provided with X-ray tube 5, relative with described X-ray tube 5
Position is provided with X-ray detector 6, and described first imaging hole 31 is positioned at described X-ray tube 5
And between described X-ray detector 6；
Described PET/FT frame 4 one side roof part is provided with lasing light emitter 7, relative with described lasing light emitter 7
Position is provided with CCD camera 8, and the input port dead ahead of described CCD camera 8 is provided with filter wheel 11,
Described second imaging hole 41 is between described lasing light emitter 7 and filter wheel 11；
Also include the flat board PET detecting head 9 being circumferentially distributed with described second imaging hole 41, be used for
The annihilation photon that detection is launched in described toy body；
Need it is further noted that the delivery outlet dead ahead of described X-ray tube 5 is provided with X and penetrates
Line collimator 10, the beamformer output of the described reducible beam X-ray of x-ray collimator 10, make X penetrate
Line covers effective search coverage of X-ray detector 6, prevent simultaneously described in be observed toy and be subject to
Too much radiation dose.
Need it is further noted that described filter wheel 11 is provided with filter plate, be used for filtering FT
As unwanted fluorescence bands.
Need it is further noted that described flat board PET detecting head 9 is 4, each flat board PET
Detecting head 9 is combined by 6 pieces of basic probe units of PET, and a combination thereof mode is axial 3 pieces of *
Radially 2 pieces.
As the preferred technical scheme of one, described flat board PET detecting head 9, quasiconductor can be used
Detector replaces.
Need it is further noted that present invention additionally comprises CT image processing platform, be used for processing institute
State data that X-ray detector collected and carry out CT image reconstruction；
PET image processing platform, for processing data that described PET detecting head collects and carrying out
PET image reconstruction；
FT image processing platform, for processing data that described CCD camera collects and carrying out FT
Image reconstruction；
Image co-registration, Visualization Platform, be used for processing CT, PET and FT image, according to experiment need
Seek fusion bimodal or three modality images, and realize single mode or multi-modal fusion image can
Depending on changing；
Need it is further noted that described translation stage, frame and electronic equipment use same control
Case processed is controlled, and image processing platform and image co-registration, the Visualization Platform of each single mode make
Build with computer.
It should be noted that described PET/FT frame 4 should be close proximity to peace with described CT frame 3
Dress, but should be ensured that CT frame 3 will not be with the equipment in PET/FT frame 4 when frame rotates
Rub；
Further, the present invention can be used for any PET, FT, CT single mode imaging it can also be used to
Bimodal or three modality, according to the actual requirements depending on；
When carrying out CT data acquisition, rotate CT frame 3.The rotation mode of CT frame 3 uses
The pattern turn-stopped-turn, the rotary speed of frame is not particularly limited, according to actual needs by calculating
Machine controls；
When carrying out PET/FT data acquisition, rotate PET/FT frame 4.If only gathering PET number
According to, arrange according to reality, PET/FT frame 4 can be kept static or carry out rotating acquisition；Gather
During FT data, need to rotate PET/FT frame 4, in the range of 360 degree, gather multi-angle FT number
According to；
When carrying out three modality, first gather CT data, then control detection bed and arrive PET/FT
The visual field of subsystem gathers PET and FT data.When gathering PET and FT data, can be right
The CT collected carries out synchronization process, reconstruction.
For a person skilled in the art, can technical scheme as described above and design,
Make other various corresponding changes and deformation, and all these changes and deformation all should
Within belonging to the protection domain of the claims in the present invention.
Claims (5)
1. a CT/FT/PET tri-mode synchronous imaging device, including the toy for observation, it is characterized in that, described device includes can the movable translation stage of level, the detection bed being connected with described translation stage, CT frame and PET/FT frame, described CT frame is provided with the first imaging hole, described PET/FT frame is provided with the second imaging hole, axle centered by the body axle being placed on the toy in described detection bed, described first imaging hole, the center of circle of the second imaging hole and described central shaft are in same straight line；
Described CT frame one side roof part is provided with X-ray tube, and the position relative with described X-ray tube is provided with X-ray detector, and described first imaging hole is between described X-ray tube and described X-ray detector；
Described PET/FT frame one side roof part is provided with lasing light emitter, and the position relative with described lasing light emitter is provided with CCD camera, and the input port dead ahead of described CCD camera is provided with filter wheel, and described second imaging hole is between described lasing light emitter and filter wheel；
Also include the flat board PET detecting head being circumferentially distributed with described second imaging hole, the annihilation photon launched in described toy body for detection.
Three mode synchronous imaging devices the most according to claim 1, it is characterized in that, the delivery outlet dead ahead of described X-ray tube is provided with x-ray collimator, the beamformer output of the reducible beam X-ray of described x-ray collimator, make X-ray cover X-ray detector effective search coverage, prevent simultaneously described in be observed toy by too much radiation dose.
Three mode synchronous imaging devices the most according to claim 1, it is characterised in that described filter wheel is provided with filter plate, are used for filtering the unwanted fluorescence bands of FT imaging.
Three mode synchronous imaging devices the most according to claim 1, it is characterised in that described flat board PET detecting head is 4, each flat board PET detecting head is combined by 6 pieces of basic probe units of PET, and a combination thereof mode is axial 3 pieces of * radially 2 pieces.
Three mode synchronous imaging devices the most according to claim 1, it is characterised in that described flat board PET detecting head, can use semiconductor detector to replace.
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| CN201410068948.0A CN103815924B (en) | 2014-02-27 | 2014-02-27 | A kind of CT/FT/PET tri-mode synchronous imaging device |
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| CN201410068948.0A CN103815924B (en) | 2014-02-27 | 2014-02-27 | A kind of CT/FT/PET tri-mode synchronous imaging device |
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| CN103815924B true CN103815924B (en) | 2016-11-02 |
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104517293B (en) * | 2014-12-25 | 2016-03-23 | 东南大学 | Toy Multimodal medical image registration and emerging system |
| CN104939858B (en) * | 2015-04-29 | 2018-12-28 | 北京航空航天大学 | A kind of multi-modal computed tomography (SPECT) system and method for combination X-ray and fluorescence |
| CN105520742A (en) * | 2016-01-12 | 2016-04-27 | 东南大学 | X-ray CT-fluorescence imaging apparatus and method of single-source-emission and dual-mode imaging |
| EP3632326B1 (en) * | 2016-12-30 | 2023-07-05 | Shanghai United Imaging Healthcare Co., Ltd. | Medical imaging system and method |
| CN111068186B (en) * | 2018-10-22 | 2021-03-02 | 清华大学 | CT imaging and image-guided radiotherapy device |
| CN114697538B (en) * | 2020-12-31 | 2023-09-12 | 武汉联影生命科学仪器有限公司 | Animal imaging equipment, focusing method of monitoring camera of animal imaging equipment and video monitoring method of animal imaging equipment |
| CN113520434B (en) * | 2021-06-03 | 2024-02-13 | 苏州动影信息科技有限公司 | Energy spectrum rapid imaging cone beam CT system suitable for small animals and design method |
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| US7412027B2 (en) * | 2004-01-12 | 2008-08-12 | Ge Medical Systems Global Technology Company, Llc | Methods and system for multi-modality imaging |
| EP1815420B1 (en) * | 2004-11-19 | 2018-01-10 | Koninklijke Philips N.V. | Optimal conversion of 3d image sets between different spaces |
| CN100469324C (en) * | 2006-09-29 | 2009-03-18 | 清华大学 | Data acquisition system for nuclein and fluorescent dual module integral small animal molecules imaging |
| US20130023765A1 (en) * | 2011-01-05 | 2013-01-24 | The Regents Of The University Of California | Apparatus and method for quantitative noncontact in vivo fluorescence tomography using a priori information |
| CN102319058B (en) * | 2011-09-09 | 2013-03-06 | 清华大学 | Three-mode small animal imaging system integrating fluorescence, nuclei and X rays |
| CN102488493B (en) * | 2011-11-15 | 2014-07-23 | 西安电子科技大学 | Small animal living body multi-mode molecule imaging system and imaging method |
| CN102764138B (en) * | 2012-08-02 | 2014-07-02 | 北京大学 | Multi-mode little animal molecular image imaging device and imaging method |
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