CN103815917A - Integrating sphere model for calibrating tissue oxygen indexes - Google Patents
Integrating sphere model for calibrating tissue oxygen indexes Download PDFInfo
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- CN103815917A CN103815917A CN201210460217.1A CN201210460217A CN103815917A CN 103815917 A CN103815917 A CN 103815917A CN 201210460217 A CN201210460217 A CN 201210460217A CN 103815917 A CN103815917 A CN 103815917A
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Abstract
The invention discloses an integrating sphere model for calibrating tissue oxygen indexes. The integrating sphere model comprises a hemispherical integrating sphere, a base, a color filter and a barrier. The hemispherical integrating sphere is supported by the base, the color filter is convenient to replace, the barrier covers the upper side of the hemispherical integrating sphere, a light hole of a light source and three light holes of receivers are formed in the barrier and are arrayed to form a straight line, the color filter comprises a group of light-transmittance films which have unequal absorptive actions on photons at wavelengths of 760nm and 840nm and nonlinear absorption lines near the wavelengths of 760nm and 840nm, and the color filter is selectively placed on one light hole of the receiver. The integrating sphere model has the advantages that the stable optical integrating sphere model is used as a calibrating medium of a blood oxygen instrument instead of a blood model and is stable and reliable in performance; the color filter is used during calibration, so that the integrating sphere model can have different attenuation actions on the photons at the different wavelengths, tissue oxygen index values measured by the blood oxygen instrument can be calibrated in a multi-point manner, and a calibration effect can be improved.
Description
Technical field
The present invention relates to medical simulation apparatus, relate in particular to a kind of integrating sphere model for tissue oxygenation saturation calibration.
Background technology
The oxygen saturation of tissue oxygenation saturation (Tissue Oxygen Index, hereinafter to be referred as TOI) for reflecting that tested tissue whole blood is total is the weighted average of tested tissue arterial blood oxygen saturation and Svo2.
Near infrared tissue blood oxygen parameter Dynamic Non-Destruction Measurement (Near Infrared Spectroscopy, NIRS) is a physiological parameter detection technique of rising gradually over nearly 20 years, and it is tissue oxygenation saturation that its core detects index.Near infrared tissue blood oxygen parameter non-destructive monitoring instrument (hereinafter to be referred as blood oxygen instrument) is based on NIRS technology, the light of three kinds of different wave lengths is incided in tested tissue, by measuring outgoing light intensity, obtain the Absorption of tissue to light, through a series of processes of resolving, finally obtain tested tissue oxygen saturation again.
For the core measurement index (TOI) to blood oxygen instrument on production line is effectively calibrated, need a set of stable, reliable, the device that can realize rapidly TOI calibration.This device can simulate the tissue of different oxygen saturations easily to the different Absorptions of light.Because the measurement index of blood oxygen instrument is subject to photoelectric device parameter influence of fluctuations maximum, in the time that the photoelectric device of two blood oxygen instrument there are differences, on this device, can obtain different TOI numerical value.
In prior art, there are two kinds of main method to can be used to blood oxygen instrument measurement parameter TOI to calibrate, are respectively:
One, Blood Model calibration steps: whole blood, scatterer and buffer for model in the method are allocated and formed according to a certain percentage, at the optical parametric of near infrared band close to tissue.Operator can, by passing into oxygen and add reducing agent in model, change the blood oxygen saturation of model.Operator can be placed on blood oxygen instrument probe liquid model liquid level top and measure the blood oxygen saturation of this model, can also extract the liquid in model out a part, measures its blood oxygen saturation with blood gas analyzer.Therefore, can be tested object with this model, blood oxygen instrument is calibrated with the blood gas analyzer that clinical generally acknowledged precision is higher.But there are following three major defects in this calibration steps:
1. the nucleus in Blood Model is blood of human body, and character is unstable, cannot preserve for a long time, must be carrying out before calibration testing on-the-spot allotment.And allocate required blood of human body at every turn, its index is difficult to be consistent.So there is the shortcoming of operation inconvenience, unstable properties in Blood Model calibration steps.
2. Blood Model calibration steps needs one to measure accurate blood gas analyzer, and this equipment cost is higher, and needs consumptive material.Therefore there is the problem that cost is high in this calibration steps.
3. in Blood Model, the adjusting of blood oxygen saturation needs the long period, so this calibration steps exists long problem of operating time.
Two, conventional optical integrating-sphere model calibration method: the patent case that application number is 200610040689.6 has disclosed the calibration steps of this kind of conventional optical integration spherical model of employing, still, there are following two major defects in this calibration steps:
1. can only to simulate oxygen saturation be 62% the tissue Absorption to light to this device, namely can only on 62% this point, carry out single-point calibration to the measured TOI of blood oxygen instrument.
2. this device cannot reflect the impact bringing to measurement result of fluctuating of the photoelectric device parameter of blood oxygen instrument.This means, in the time abnormal blood oxygen instrument of photoelectric device parameter being calibrated with it, its result remains normal value (62%), and this has just affected the calibration effect of this device greatly.
Therefore, for above-mentioned technical problem, effectively calibrate for the core measurement index (TOI) to blood oxygen instrument on production line, be necessary to provide a kind of structure improved integrating sphere model for tissue oxygenation saturation calibration, to overcome above-mentioned defect.
Summary of the invention
In view of this, the object of the present invention is to provide a kind of integrating sphere model for tissue oxygenation saturation calibration, this integrating sphere model that is used for tissue oxygenation saturation calibration has stable, reliable, easy and simple to handle, lower-cost advantage, and this integrating sphere model is convenient to switch between different optical parameter, to simulate the tissue of different oxygen saturations to the different Absorptions of light, and this integrating sphere model can reflect the impact bringing to measurement result of fluctuating of the photoelectric device parameter of blood oxygen instrument.
For achieving the above object, the invention provides following technical scheme:
A kind of integrating sphere model for tissue oxygenation saturation calibration, the base that it comprises hemispherical integrating sphere and supports hemispherical integrating sphere, described integrating sphere model also comprises the baffle plate of being convenient to the light filter of replacing and covering hemispherical integrating sphere top, described baffle plate is provided with a light source loophole and three receptor loopholes, described four loopholes are arranged in straight line, described light filter be one group to 760nm and the effect of 840nm photonic absorption near the non-directional light transmission film of absorption line not etc. and 760nm and 840nm wavelength, what described light filter was selected is positioned on a receptor loophole.
Preferably, at the above-mentioned integrating sphere model for tissue oxygenation saturation calibration, described baffle plate is rounded.
Preferably, at the above-mentioned integrating sphere model for tissue oxygenation saturation calibration, on described baffle plate, be also provided with the fixture for fix blood oxygen instrument probe.
Preferably, at the above-mentioned integrating sphere model for tissue oxygenation saturation calibration, described three receptor loopholes are along arranging away from the direction of light source loophole, be followed successively by the first receptor loophole, the second receptor loophole and the 3rd receptor loophole, the diameter of described the first receptor loophole is greater than the diameter of the second receptor loophole, and the diameter of described the second receptor loophole is greater than the diameter of the 3rd receptor loophole.
Preferably, at the above-mentioned integrating sphere model for tissue oxygenation saturation calibration, the distance at the centre distance light source loophole center of described first, second, third receptor loophole is 20mm/30mm/40mm.
Preferably, at the above-mentioned integrating sphere model for tissue oxygenation saturation calibration, the inwall of described integrating sphere is coated with the polyester fluoride material layer that 1.5-2mm is thick.
Can find out from technique scheme, the integrating sphere model for tissue oxygenation saturation calibration of the embodiment of the present invention uses stable optical integration spherical model to replace Blood Model as blood oxygen instrument calibrate medium, and it is stable and reliable for performance; Meanwhile, by use light filter in calibration, make integrating sphere model there is different attenuations to different wave length photon, realize the TOI value that blood oxygen instrument is measured and carry out multiple spot calibration, improved calibration effect.
Compared with prior art, the invention has the beneficial effects as follows:
(1) use stable optical integration spherical model to replace Blood Model as blood oxygen instrument calibrate medium, stable and reliable for performance.
(2) in calibration operation, do not need blood gas analyzer and consumables associated therewith, use cost is low.
(3) only different light filters need be placed on loophole, can realize the switching of optical parametric of the present invention, thereby simulate the tissue of different oxygen saturations to the attenuation of light, swift to operate, easy, can meet on production line the multiple spot alignment requirements of blood oxygen instrument in enormous quantities.
(4) because light filter has different attenuations to the photon of different wave length, therefore when the optics parameter using when blood oxygen instrument there are differences (when particularly luminous tube peak wavelength exists deviation), also can there is respective change in the light intensity by light filter outgoing, thereby affect calibration result, so, the impact bringing to measurement result of fluctuating of the photoelectric device parameter that can seek and visit hemorrhage oxygen instrument.
Accompanying drawing explanation
In order to be illustrated more clearly in the embodiment of the present invention or technical scheme of the prior art, to the accompanying drawing of required use in embodiment or description of the Prior Art be briefly described below, apparently, accompanying drawing relevant of the present invention in the following describes is only some embodiments of the present invention, for those of ordinary skills, do not paying under the prerequisite of creative work, can also obtain according to these accompanying drawings other accompanying drawing.
Fig. 1 is the structural representation of the present invention for the integrating sphere model of tissue oxygenation saturation calibration.
The specific embodiment
The invention discloses a kind of integrating sphere model for tissue oxygenation saturation calibration, this integrating sphere model that is used for tissue oxygenation saturation calibration has stable, reliable, easy and simple to handle, lower-cost advantage, and this integrating sphere model is convenient to switch between different optical parameter, to simulate the tissue of different oxygen saturations to the different Absorptions of light, and this integrating sphere model can reflect the impact bringing to measurement result of fluctuating of the photoelectric device parameter of blood oxygen instrument.
This integrating sphere model comprises hemispherical integrating sphere and supports the base of hemispherical integrating sphere, described integrating sphere model also comprises the baffle plate of being convenient to the light filter of replacing and covering hemispherical integrating sphere top, described baffle plate is provided with a light source loophole and three receptor loopholes, described four loopholes are arranged in straight line, described light filter be one group to 760nm and the effect of 840nm photonic absorption near the non-directional light transmission film of absorption line not etc. and 760nm and 840nm wavelength, what described light filter was selected is positioned on a receptor loophole.
Further, described baffle plate is rounded.
Further, on described baffle plate, be also provided with the fixture for fix blood oxygen instrument probe.
Further, described three receptor loopholes are along arranging away from the direction of light source loophole, be followed successively by the first receptor loophole, the second receptor loophole and the 3rd receptor loophole, the diameter of described the first receptor loophole is greater than the diameter of the second receptor loophole, and the diameter of described the second receptor loophole is greater than the diameter of the 3rd receptor loophole.
Further, the distance at the centre distance light source loophole center of described first, second, third receptor loophole is 20mm/30mm/40mm.
Further, the inwall of described integrating sphere is coated with the polyester fluoride material layer that 1.5-2mm is thick.
Below in conjunction with the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is described in detail, obviously, described embodiment is only the present invention's part embodiment, rather than whole embodiment.Based on the embodiment in the present invention, the every other embodiment that those of ordinary skills obtain under the prerequisite of not making creative work, belongs to the scope of protection of the invention.
As shown in Figure 1, integrating sphere model disclosed by the invention comprise hemispherical integrating sphere 1, support hemispherical integrating sphere 1 base 2, be convenient to the light filter of replacing and cover the rounded baffle plate 3 of hemispherical integrating sphere 1 top.Hemispherical integrating sphere 1 is a kind of hollow sphere.Baffle plate 3 is provided with for the fixture of fix blood oxygen instrument probe, a light source loophole 30 and three receptor loopholes.Light filter be one group to 760nm and the effect of 840nm photonic absorption near the non-directional light transmission film of absorption line not etc. and 760nm and 840nm wavelength, what light filter was selected is positioned on a receptor loophole.So arrange, by place different light filters on loophole, can make integrating sphere pattern die draw up the tissue of different tissues oxygen saturation to the attenuation of near infrared light, realize the TOI value that blood oxygen instrument is measured and carry out multiple spot calibration.
In the embodiment of the present invention, above-mentioned four loopholes are arranged in straight line.Three receptor loopholes are along arranging away from the direction of light source loophole 30, be followed successively by the first receptor loophole 31, the second receptor loophole 32 and the 3rd receptor loophole 33, the diameter of the first receptor loophole 31 is greater than the diameter of the second receptor loophole 32, and the diameter of the second receptor loophole 32 is greater than the diameter of the 3rd receptor loophole 33.
The distance at centre distance light source loophole 30 centers of first, second, third receptor loophole 31,32,33 is 20mm/30mm/40mm.
The inwall of integrating sphere is coated with the polyester fluoride material layer that 1.5-2mm is thick, and the coating that this material layer is diffuse all equates the illuminance in either direction in ball.
Below in conjunction with a specific embodiment, integrating sphere model of the present invention is set forth.
The diameter of the disclosed integrating sphere of this embodiment is 240mm, and baffle plate diameter is that 240mm, thickness are 2-5mm, and baffle plate is opaque black plastic plate.In the first receptor loophole center and light source loophole, distance is in the heart 20mm, and in the second receptor loophole center and light source loophole, distance is in the heart 30mm, and in the 3rd receptor loophole center and light source loophole, distance is in the heart 40mm.The diameter of light source loophole is 8mm, and the diameter of the first receptor loophole is 5mm, and the diameter of the second receptor loophole is 2.5mm, and the diameter of the 3rd receptor loophole is 0.5mm.
Adopting the concrete detecting step that above-mentioned integrating sphere model is calibrated is (being calibrated to example with 3 TOI):
1. baffle plate is fixed on integrating sphere, blood oxygen instrument probe is placed on baffle plate, and guarantee light source and detector corresponding one by one with the loophole on baffle plate, wherein, probe light source correspondence is at light source loophole, the first receptor loophole and the second receptor loophole on two corresponding baffle plates of detector loopholes difference of small size probe, the second receptor loophole and the 3rd receptor loophole on two corresponding baffle plates of detector loopholes difference of large scale probe.
2. start to detect, from liquid crystal screen display TOI numerical value, maintain one minute, record peak and the minimum of TOI in a minute, be designated as respectively TOI
3 maxand TOI
3 min.
3. optics light filter 1 is placed in to integrating sphere loophole 2 places, starts to detect, from liquid crystal screen display TOI numerical value, maintain one minute, record peak and the minimum of TOI in a minute, be designated as respectively TOI
2 maxand TOI
2 min.
4. optics light filter 2 is placed in to integrating sphere loophole 2 places, starts to detect, from liquid crystal screen display TOI numerical value, maintain one minute, record peak and the minimum of TOI in a minute, be designated as respectively TOI
1 maxand TOI
1 min.
Examination criteria:
As the TOI detecting
1 maxand TOI
1 min, TOI
2 maxand TOI
2 min, TOI
3 maxand TOI
3 minwhile meeting all following conditions, thinking that this instrument detects indicators and standards instrument suitable, is qualified products.
[1].|TOI
1 max-40％|≤3％
[2].|TOI
1 min-40％|≤3％
[3].|TOI
2 max-60％|≤3％
[4].|TOI
2 min-60％|≤3％
[5].|TOI
3 max-80％|≤3％
[6].|TOI
3 min-80％|≤3％
Above-mentioned detecting step is the step that small size probe blood oxygen instrument is carried out to 3 TOI calibrations, can on 40%, 60%, 80% 3 point, calibrate the small size TOI index that blood oxygen instrument surveys of popping one's head in.For example, if need to more carry out TOI calibration on multiple spot (N point), just need more light filter (needing N-1 light filter).Concrete operation step is the same, does not repeat them here.
The integrating sphere model for tissue oxygenation saturation calibration of the embodiment of the present invention uses stable optical integration spherical model to replace Blood Model as blood oxygen instrument calibrate medium, and it is stable and reliable for performance; Meanwhile, by use light filter in calibration, make integrating sphere model there is different attenuations to different wave length photon, realize the TOI value that blood oxygen instrument is measured and carry out multiple spot calibration, improved calibration effect.
Compared with prior art, the invention has the beneficial effects as follows:
(1) use stable optical integration spherical model to replace Blood Model as blood oxygen instrument calibrate medium, stable and reliable for performance.
(2) in calibration operation, do not need blood gas analyzer and consumables associated therewith, use cost is low.
(3) only different light filters need be placed on loophole, can realize the switching of optical parametric of the present invention, thereby simulate the tissue of different oxygen saturations to the attenuation of light, swift to operate, easy, can meet on production line the multiple spot alignment requirements of blood oxygen instrument in enormous quantities.
(4) because light filter has different attenuations to the photon of different wave length, therefore when the optics parameter using when blood oxygen instrument there are differences (when particularly luminous tube peak wavelength exists deviation), also can there is respective change in the light intensity by light filter outgoing, thereby affect calibration result, so, the impact bringing to measurement result of fluctuating of the photoelectric device parameter that can seek and visit hemorrhage oxygen instrument.
To those skilled in the art, obviously the invention is not restricted to the details of above-mentioned one exemplary embodiment, and in the situation that not deviating from spirit of the present invention or basic feature, can realize the present invention with other concrete form.Therefore, no matter from which point, all should regard embodiment as exemplary, and be nonrestrictive, scope of the present invention is limited by claims rather than above-mentioned explanation, is therefore intended to all changes that drop in the implication and the scope that are equal to important document of claim to include in the present invention.Any Reference numeral in claim should be considered as limiting related claim.
In addition, be to be understood that, although this description is described according to embodiment, but be not that each embodiment only comprises an independently technical scheme, this narrating mode of description is only for clarity sake, those skilled in the art should make description as a whole, and the technical scheme in each embodiment also can, through appropriately combined, form other embodiments that it will be appreciated by those skilled in the art that.
Claims (6)
1. the integrating sphere model for tissue oxygenation saturation calibration, the base that it comprises hemispherical integrating sphere and supports hemispherical integrating sphere, it is characterized in that: described integrating sphere model also comprises the baffle plate of being convenient to the light filter of replacing and covering hemispherical integrating sphere top, described baffle plate is provided with a light source loophole and three receptor loopholes, described four loopholes are arranged in straight line, described light filter be one group to 760nm and the effect of 840nm photonic absorption near the non-directional light transmission film of absorption line not etc. and 760nm and 840nm wavelength, what described light filter was selected is positioned on a receptor loophole.
2. the integrating sphere model for tissue oxygenation saturation calibration according to claim 1, is characterized in that: described baffle plate is rounded.
3. the integrating sphere model for tissue oxygenation saturation calibration according to claim 1, is characterized in that: on described baffle plate, be also provided with the fixture for fix blood oxygen instrument probe.
4. according to the arbitrary described integrating sphere model for tissue oxygenation saturation calibration of claims 1 to 3, it is characterized in that: described three receptor loopholes are along arranging away from the direction of light source loophole, be followed successively by the first receptor loophole, the second receptor loophole and the 3rd receptor loophole, the diameter of described the first receptor loophole is greater than the diameter of the second receptor loophole, and the diameter of described the second receptor loophole is greater than the diameter of the 3rd receptor loophole.
5. the integrating sphere model for tissue oxygenation saturation calibration according to claim 4, is characterized in that: the distance at the centre distance light source loophole center of described first, second, third receptor loophole is 20mm/30mm/40mm.
6. according to the arbitrary described integrating sphere model for tissue oxygenation saturation calibration of claims 1 to 3, it is characterized in that: the inwall of described integrating sphere is coated with the polyester fluoride material layer that 1.5-2mm is thick.
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| US11457846B2 (en) | 2019-10-31 | 2022-10-04 | Belun Technology (Ip) Company Limited | Tester for an optical measuring device |
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Application publication date: 20140528 |