CN103800281A - Method for preparing infant itching relieving gel preparation from saikosaponin A - Google Patents
Method for preparing infant itching relieving gel preparation from saikosaponin A Download PDFInfo
- Publication number
- CN103800281A CN103800281A CN201410034286.5A CN201410034286A CN103800281A CN 103800281 A CN103800281 A CN 103800281A CN 201410034286 A CN201410034286 A CN 201410034286A CN 103800281 A CN103800281 A CN 103800281A
- Authority
- CN
- China
- Prior art keywords
- saikoside
- gel
- gel preparation
- saikosaponin
- stirring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention discloses a method for preparing an infant itching relieving gel preparation from saikosaponin A. The method comprises the following steps: completely dissolving saikosaponin A, menthol, thymol, methyl salicylate, camphor and eucalyptus oil in 50-150 mL of ethanol solution with mass concentration not lower than 70% separately, stirring while adding 40-80 mL of distilled water, continuously stirring at room temperature for 2-5 h at a speed of 60-120 r/min, and after stirring, standing at 40-60DEG C for 12-18 h for crosslinking to obtain the infant itching relieving gel preparation with saikosaponin A as a gel matrix. The gel preparation with saikosaponin A as the gel matrix has good biocompatibility and biodegradability, and low irritation to biological tissues, and can reduce adsorption of proteins and cells on gel surface.
Description
Technical field
The present invention relates to a kind of preparation method of gel preparation, be specifically related to a kind of method of utilizing saikoside a to prepare children's's Itch Stopping Gel preparation.
Background technology
Gel is by medicine dissolution or is dispersed in gel and makes.Gel can closely stick with site of action, how by skin, mucosal drug delivery, and also can oral performance drug effect.The effect that has certain control to discharge to medicine due to the aquation gel layer of the water-soluble swollen rear formation of gel absorption, now be widely used in the slow-released system of medicine, in addition gel preparation itself have breathability good, not pollution clothes, act on feature lasting, easy to use, increasing to the research of gel preparation in recent years.High-molecular gel is the important substrate of gel.Macromolecule hydrogel is the network size of hydrophilic high mol, its swellable keep large quantity of moisture and do not dissolve in water.But most macromolecule hydrogel is not fully up to expectations in the performance of the aspect such as biocompatibility, biodegradable up to now, their application at field of medicaments are limited.
Radix Bupleuri is conventional Chinese medicine simply.At present, the saponin component of finding from this plant reaches hundreds of, belong to following 7 classes from structure type: ether epoxy (I), different ring diene (II), 12-alkene (III), with ring diene (IV), 12-alkene-28-carboxylic acid (V), different ring diene-30-carboxylic acid (VI), 18-alkene type (VII).Wherein, saikoside a belongs to ether epoxy (I) type, and its structure belongs to pentacyclic triterpene saponin constituent, as a kind of natural component, has much good character, as biocompatibility, degradability etc.Wherein, saikoside a and water effect can form the character of hydrogel, have no so far bibliographical information.
Summary of the invention
The object of the present invention is to provide a kind of method of utilizing saikoside a to prepare children's's Itch Stopping Gel preparation, utilize gel preparation prepared by saikoside a to there is good biocompatibility and biodegradability, in addition low to the zest of biological tissue, and can reduce the absorption in gel surface of protein and cell, and the method is simple, and cost is low, reaction reagent is nontoxic, reaction medium is water, and environmentally safe is harmless.
The technical scheme that the present invention realizes above-mentioned purpose employing is: utilize saikoside a to prepare the method for children's's Itch Stopping Gel preparation, comprise the following steps: get respectively 1g saikoside a, Mentholum 0.3g, thymol 0.75g, methyl salicylate 0.5g, Camphora 0.5g, Oleum Eucalypti 0.7g, add 50-150ml dissolve with ethanol solution complete, the mass concentration of alcoholic solution is not less than 70%, then add while stirring distilled water 40-80ml, and continue under room temperature and stir 2-5h, wherein mixing speed is 60-120r/min, after finishing, stirring places crosslinked 12-18 hour under 40-60 ℃ of condition, place crosslinked end, being able to saikoside a is children's's Itch Stopping Gel preparation of gel-type vehicle.
It is that in a saikoside a molecular structure, the oxygen atom between 13,28, by the b-OH of 16 in hydrone and another one saikoside a molecular structure, is connected to each other by hydrogen bond that saikoside a forms the mechanism of hydrogel.A large amount of hydrogen bonds by the link of saikoside a molecule, forms a large amount of lamellar structures as crosslinking points, and piles up mutually under intermolecular active force, and a large amount of hydrones is present in the gap of the lamellar structure of formation, forms saikoside a hydrogel.
beneficial effect of the present invention
It is matrix composition gel preparation that the present invention adopts saikoside a to react the biodegradable hydrogel preparing with water first.Because saikoside a is as the natural component in bupleurum Chinese, belong to pentacyclic triterpene constituents, there is good biocompatibility and biodegradability, thereby, the gel preparation that is substrate by saikoside a hydrogel has good biocompatibility and biodegradability, in addition low to the zest of biological tissue, and can reduce the absorption in gel surface of protein and cell.Preparation technology of the present invention is simple, and reaction reagent is nontoxic, and reaction medium is water, and reaction condition gentleness is conducive to keep the activity of medicine, and production process does not produce environmental pollution.In this gel, contain a large amount of, highdensity hydrogen bond, so mechanical strength and stability are higher.Saikoside a comes from bupleurum Chinese, and therefore the present invention is also for the comprehensive utilization of bupleurum Chinese provides an effective way.
The specific embodiment
Below by specific embodiment, the present invention will be further described, but the embodiment being to provide can not be served as the restriction to the method, method provided by the invention can also be prepared other gel preparation, or saikoside a is prepared gel preparation together with other gel raw material monomers.
Embodiment 1:
Utilize saikoside a to prepare the method for children's's Itch Stopping Gel preparation, comprise the following steps: get respectively 1g saikoside a, Mentholum 0.3g, thymol 0.75g, methyl salicylate 0.5g, Camphora 0.5g, Oleum Eucalypti 0.7g, add 50ml dissolve with ethanol solution complete, the mass concentration of alcoholic solution is not less than 70%, then add while stirring distilled water 40ml, and continue under room temperature and stir 2h, wherein mixing speed is 60r/min, after finishing, stirring under 40 ℃ of conditions, places crosslinked 12 hours, place crosslinked end, being able to saikoside a is children's's Itch Stopping Gel preparation of gel-type vehicle.
Embodiment 2:
Utilize saikoside a to prepare the method for children's's Itch Stopping Gel preparation, comprise the following steps: get respectively 1g saikoside a, Mentholum 0.3g, thymol 0.75g, methyl salicylate 0.5g, Camphora 0.5g, Oleum Eucalypti 0.7g, add 150ml dissolve with ethanol solution complete, the mass concentration of alcoholic solution is not less than 70%, then add while stirring distilled water 80ml, and continue under room temperature and stir 5h, wherein mixing speed is 120r/min, after finishing, stirring under 60 ℃ of conditions, places crosslinked 18 hours, place crosslinked end, being able to saikoside a is children's's Itch Stopping Gel preparation of gel-type vehicle.
Embodiment 3:
Utilize saikoside a to prepare the method for children's's Itch Stopping Gel preparation, comprise the following steps: get respectively 1g saikoside a, Mentholum 0.3g, thymol 0.75g, methyl salicylate 0.5g, Camphora 0.5g, Oleum Eucalypti 0.7g, add 100ml dissolve with ethanol solution complete, the mass concentration of alcoholic solution is not less than 70%, then add while stirring distilled water 60ml, and continue under room temperature and stir 3.5h, wherein mixing speed is 90r/min, after finishing, stirring under 50 ℃ of conditions, places crosslinked 15 hours, place crosslinked end, being able to saikoside a is children's's Itch Stopping Gel preparation of gel-type vehicle.
Embodiment 4:
Utilize saikoside a to prepare the method for children's's Itch Stopping Gel preparation, comprise the following steps: get respectively 1g saikoside a, Mentholum 0.3g, thymol 0.75g, methyl salicylate 0.5g, Camphora 0.5g, Oleum Eucalypti 0.7g, add 100ml dissolve with ethanol solution complete, the mass concentration of alcoholic solution is not less than 70%, then add while stirring distilled water 60ml, then add carrageenan 0.5g, and continue under room temperature and stir 3.5h, wherein mixing speed is 90r/min, after finishing, stirring under 50 ℃ of conditions, places crosslinked 15 hours, place crosslinked end, being able to saikoside a is children's's Itch Stopping Gel preparation of gel-type vehicle.
Claims (1)
1. utilize saikoside a to prepare the method for children's's Itch Stopping Gel preparation, it is characterized in that: comprise the following steps: get respectively 1g saikoside a, Mentholum 0.3g, thymol 0.75g, methyl salicylate 0.5g, Camphora 0.5g, Oleum Eucalypti 0.7g, add 50-150ml dissolve with ethanol solution complete, the mass concentration of alcoholic solution is not less than 70%, then add while stirring distilled water 40-80ml, and continue under room temperature and stir 2-5h, wherein mixing speed is 60-120r/min, after finishing, stirring places crosslinked 12-18 hour under 40-60 ℃ of condition, place crosslinked end, being able to saikoside a is children's's Itch Stopping Gel preparation of gel-type vehicle.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410034286.5A CN103800281B (en) | 2014-01-24 | 2014-01-24 | Saikoside a is utilized to prepare the method for children's's Itch Stopping Gel preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410034286.5A CN103800281B (en) | 2014-01-24 | 2014-01-24 | Saikoside a is utilized to prepare the method for children's's Itch Stopping Gel preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103800281A true CN103800281A (en) | 2014-05-21 |
CN103800281B CN103800281B (en) | 2015-09-30 |
Family
ID=50697987
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410034286.5A Expired - Fee Related CN103800281B (en) | 2014-01-24 | 2014-01-24 | Saikoside a is utilized to prepare the method for children's's Itch Stopping Gel preparation |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN103800281B (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101333240A (en) * | 2007-06-25 | 2008-12-31 | 孙蓉 | Process for extracting and separating high-purity saikosaponin A |
CN103446237A (en) * | 2012-05-28 | 2013-12-18 | 苏州玉森新药开发有限公司 | Rectal gelata of traditional Chinese medicine composition and preparation method thereof |
-
2014
- 2014-01-24 CN CN201410034286.5A patent/CN103800281B/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101333240A (en) * | 2007-06-25 | 2008-12-31 | 孙蓉 | Process for extracting and separating high-purity saikosaponin A |
CN103446237A (en) * | 2012-05-28 | 2013-12-18 | 苏州玉森新药开发有限公司 | Rectal gelata of traditional Chinese medicine composition and preparation method thereof |
Non-Patent Citations (1)
Title |
---|
陈恩 等: "柴胡鼻用pH敏感型原位凝胶的制备及退热效果评价", 《中国医药工业杂志》, vol. 39, no. 9, 31 December 2008 (2008-12-31), pages 666 - 670 * |
Also Published As
Publication number | Publication date |
---|---|
CN103800281B (en) | 2015-09-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101406704B (en) | Novel plant capsule film material and method for producing the same | |
WO2019062024A1 (en) | Method for preparing soil conditioner | |
CN100523070C (en) | Method of preparing cellulose hydrogel | |
CN104042449A (en) | High-temperature stable hydrogel mask | |
TW201034693A (en) | Gel sheet for cosmetic patching | |
Syed Azhar et al. | Nanostructured lipid carriers-hydrogels system for drug delivery: Nanohybrid technology perspective | |
CN103655482A (en) | Self-microemulsifying calcium alginate gel pellets for loading drugs and preparation method thereof | |
CN104027300B (en) | A kind of antibacterial chitosan gel rubber agent and preparation method thereof | |
CN105616426A (en) | Compound dexamethasone acetate nano-cream and preparation method therefor | |
CN102772386A (en) | Composite gel for plant capsules and preparation method for composite gel | |
CN106074437A (en) | The seaweed polysaccharide plant empty capsules of a kind of not plasticizer-containing and production method thereof | |
CN102362853A (en) | Genipin cross-linked soybean protein based theophylline controlled-release gel preparation and preparation method thereof | |
CN102952280A (en) | Hydroxypropyl methylcellulose copolymer for preparing plant capsules and preparation method thereof | |
CN1795229A (en) | Method for producing porous moulded bodies containing alginate | |
CN105330875A (en) | Crosslinked modified sodium alginate and preparation method thereof | |
CN101455654B (en) | Arginine ibuprofen gel and preparation method thereof | |
CN109158058A (en) | Recessed soil-chitosan plural gel and preparation method thereof | |
CN106236605A (en) | Porous microsphere and preparation method thereof, application | |
CN103800281B (en) | Saikoside a is utilized to prepare the method for children's's Itch Stopping Gel preparation | |
CN101757522A (en) | Swelling reducing and pain easing gel and preparation method thereof | |
Jin et al. | Glycyrrhizic acid assists anti-psoriatic efficacy of a self-deformable curcumin loaded transdermal gel | |
CN103127036A (en) | Method for preparing film agent by using chitosan and Arabic gum as matrix | |
CN103520232B (en) | A kind of preparation method of gel | |
CN103784393B (en) | Application of saikoside a in preparation of hydrogel and preparation method of hydrogel | |
CN101912357B (en) | Gel paste preparation and preparation method thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150930 Termination date: 20160124 |
|
EXPY | Termination of patent right or utility model |