CN103784565B

CN103784565B - A kind of Chinese medicine preparation for the treatment of active stage rheumatism pattern of fever rheumatoid arthritis

Info

Publication number: CN103784565B
Application number: CN201410050523.7A
Authority: CN
Inventors: 牛悦祥
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-02-08
Filing date: 2014-02-08
Publication date: 2015-11-25
Anticipated expiration: 2034-02-08
Also published as: CN103784565A

Abstract

The invention discloses a kind of Chinese medicine preparation for the treatment of active stage rheumatism pattern of fever rheumatoid arthritis.Primary disease belongs to the categories such as traditional Chinese medical science arthromyodynia, severe and migratory arthralgia, and multidigit scholar, to the cause of disease of RA, thinks there are inside and outside two aspects: interior because ferritic weak, insufficiency of vital energy and blood, and space between skin and muscles is hollow, caused by liver and kidney deficiency; Exopathogenic factor is the heresy invasion of the six climate exopathogens such as wind and cold is damp and hot, and inside and outside causes this sick because being harmonious.The present invention selects Chinese medicine Folium et Cacumen Psychotriae Rubrae, Flos et Folium Lactucae elatae, Radix Fici Angustipoliae, Radix Evodiae Leptae, Herba Schisandrae intermediae, Radix Clinopodii polycephali, Foliumet Ramulus Evodiae, Radix Crataevae Unilocularis, and decocting becomes decoction, and through clinical trial, total effective rate reaches 97.06%, curative effect highly significant.

Description

A kind of Chinese medicine preparation for the treatment of active stage rheumatism pattern of fever rheumatoid arthritis

Technical field

The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine preparation for the treatment of active stage rheumatism pattern of fever rheumatoid arthritis.

Background technology

Rheumatoid arthritis (Rheumatoidarthritis, RA) is a kind of based on the systemic autoimmune disease of the non-infectious inflammation of joint and periarticular tissue.Its cause and onset of disease mechanism is failed to understand so far.The infiltration of synovial hyperplasia and inflammation cell, easily causes chondro-osseous destruction, even can cause multi viscera, the Multisystem damage such as the heart, lung, kidney.Primary disease is more common in female middle-aged, and within 25 ~ 50 years old, to be primary disease send out well the age, clinically shows as symmetry, chronic, progressive polyarthritis more, affected joints swelling, pain, movable unfavorable, and function of joint is impaired.Pathological changes is many in lasting, recurrent exerbation process, the course of disease is delayed, and the disability rate of 5-10 up to 60%, and can have a strong impact on the work capacity of patient, having become one of universally acknowledged refractory disease, is the one of the main reasons causing population of China disability He disable.At present, clinical treatment many employings NSAID (non-steroidal anti-inflammatory drug), 17-hydroxy-11-dehydrocorticosterone and treatment by Chinese herbs, because front two class medicines can only relief of symptoms, effectively can not stop the development of destructive pathological changes, and life-time service can show untoward reaction, therefore unsuitablely conventionally to use.Therefore, treatment by Chinese herbs just has more wide prospect.The author, under the guidance of theory of Chinese medical science, uses clearing away heat-damp and promoting diuresis, dispelling wind and removing obstruction in the collateral method, takes Chinese medicine preparation of the present invention treatment Active Rheumatoid Arthritis, receives comparatively satisfied curative effect.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine preparation for the treatment of active stage rheumatism pattern of fever rheumatoid arthritis.Primary disease belongs to the categories such as traditional Chinese medical science arthromyodynia, severe and migratory arthralgia, and multidigit scholar, to the cause of disease of RA, thinks there are inside and outside two aspects: interior because ferritic weak, insufficiency of vital energy and blood, and space between skin and muscles is hollow, caused by liver and kidney deficiency; Exopathogenic factor is the heresy invasion of the six climate exopathogens such as wind and cold is damp and hot, and inside and outside causes this sick because being harmonious.

The object of the invention is to be achieved through the following technical solutions, the Chinese medicine preparation of this treatment active stage rheumatism pattern of fever rheumatoid arthritis is made up of the Chinese medicine of following weight portion: Folium et Cacumen Psychotriae Rubrae 30-60 part, Flos et Folium Lactucae elatae 3-9 part, Radix Fici Angustipoliae 15-30 part, Radix Evodiae Leptae 15-30 part, Herba Schisandrae intermediae 12-18 part, Radix Clinopodii polycephali 9-15 part, Foliumet Ramulus Evodiae 15-30 part, Radix Crataevae Unilocularis 15-30 part.

Preferred: Folium et Cacumen Psychotriae Rubrae 45 parts, Flos et Folium Lactucae elatae 6 parts, Radix Fici Angustipoliae 22.5 parts, Radix Evodiae Leptae 22.5 parts, Herba Schisandrae intermediae 15 parts, Radix Clinopodii polycephali 12 parts, Foliumet Ramulus Evodiae 22.5 parts, Radix Crataevae Unilocularis 22.5 parts.

Preparation method: above-mentioned Chinese medicine decocting is become decoction by traditional method.

Fang Zhong: Folium et Cacumen Psychotriae Rubrae: heat-clearing and toxic substances removing, expelling wind and removing dampness; Flos et Folium Lactucae elatae: heat-clearing and toxic substances removing, expelling wind and removing dampness, analgesia; Radix Fici Angustipoliae: heat-clearing and toxic substances removing, expelling wind and removing dampness; Radix Evodiae Leptae: heat-clearing and toxic substances removing, expelling wind and removing dampness, eliminating stasis to stop pain; Herba Schisandrae intermediae: heat-clearing and toxic substances removing, relaxing muscles and tendons and activating QI and blood in the collateral, reducing swelling and alleviating pain; Radix Clinopodii polycephali: heat-clearing and toxic substances removing, dampness removing are active; Foliumet Ramulus Evodiae: heat-clearing and toxic substances removing, expelling wind and removing dampness, eliminating stasis to stop pain; Radix Crataevae Unilocularis: heat-clearing and toxic substances removing, relaxing muscles and tendons and activating QI and blood in the collateral.

Clinical data

1. physical data patient derives from this Out-patient Department, selects case totally 68 examples meeting inclusive criteria, wherein man 23 example, female 45 example; 31 ~ 69 years old age, average 47.63 ± 15.12 years old; The course of disease 8 weeks ~ 14 years, average 3.78 ± 3.11 years.Companion's anemia 10 example, hypertension 6 example, coronary heart disease 3 example, 3 cases of cerebral, hormone and analgesic rely on 9 examples.Be divided into two groups at random, treatment group 34 example, wherein man 11 example, female 23 example; 32 ~ 69 years old age, average 46.95 ± 13.77 years old; The course of disease 8 weeks ~ 14 years, average 3.90 ± 3.01 years.Companion's anemia 6 example, hypertension 3 example, coronary heart disease 2 example, cerebral infarction 1 example, hormone and analgesic rely on 5 examples.Matched group 34 example, wherein man 12 example, female 22 example; 31 ~ 69 years old age, average 45.87 ± 14.63 years old; The course of disease 10 weeks ~ 14 years, average 3.89 ± 3.04 years.Companion's anemia 4 example, hypertension 3 example, coronary heart disease 1 example, cerebral infarction 2 example, hormone and analgesic rely on 4 examples.Two groups are carried out t inspection and compare, without statistical discrepancy (P > 0.05), have comparability in sex, age, the course of disease etc.

2. inclusive criteria: allly meet the active stage diagnostic criteria of doctor trained in Western medicine rheumatoid arthritis, and meet that traditional Chinese medical science rheumatoid arthritis is damp and hot holds stasis of blood type diagnostic criteria person under the arm, include observation treatment target in.

3. diagnostic criteria: (1) met the diagnostic criteria of the rheumatoid arthritis that Americanism damp disease association (ARA) formulates for 1987: 1. deadlock in morning at least 1h, more than 6 weeks; 2. be no less than 3 arthroncuss, meet or exceed 6 weeks; 3. wrist, the palm referred to or proximal interphalangeal joint swelling, more than 6 weeks; 4. symmetry arthroncus, more than 6 weeks; 5. subcutaneous nodule; 6. × line shows osteoporosis or bone erosion; 7. rheumatoid factor positive, titre is more than 1:32.Possess in above 74 namely diagnosable.RA active stage standard: erythrocyte sedimentation rate (ESR) > 40mm/h, C mono-react egg (caP) > 20mg/L.(2) traditional Chinese medical science rheumatoid arthritis (rheumatoid arthritis) is damp and hot holds stasis of blood type (active stage) diagnostic criteria under the arm: arthroncus causalgia as fire burn, tenderness, morning is stiff, limitation of activity or subcutaneous nodule, restlessness and thirst, urinate red, red tongue is purple or dark, have ecchymosis, petechia, yellow and greasy fur, thready,rolling and rapid pulse or puckery number.

4. Therapeutic Method treatment group patient takes Chinese medicine preparation of the present invention: take Folium et Cacumen Psychotriae Rubrae 45g, Flos et Folium Lactucae elatae 6g, Radix Fici Angustipoliae 22.5g, Radix Evodiae Leptae 22.5g, Herba Schisandrae intermediae 15g, Radix Clinopodii polycephali 12g, Foliumet Ramulus Evodiae 22.5g, Radix Crataevae Unilocularis 22.5g, by traditional method, above-mentioned Chinese medicine decocting is become decoction, 2 times/d, 1 dose/d, 30d are 1 course for the treatment of.Matched group patient takes clearing away heat-damp and promoting diuresis oral liquid (Hospital No.1 Attached to Tianjin Traditional Chinese Medicine College's preparation), 3 times/d, 20mL/ time, and serveing on 30d is 1 course for the treatment of, and two groups of patients all treat 3 courses for the treatment of.

5. criterion of therapeutical effect clinical cure: arthralgia, swelling disappear, and movable function is normal, and lab testing is normal.Effective: arthralgia, swelling alleviate, movable function takes a turn for the better, and lab testing obviously improves.Take a turn for the better: arthralgia, swelling alleviate to some extent, movable function takes a turn for the better, and lab testing is improved.Invalid: to have no significant change compared with before treatment.

6. after therapeutic outcome two groups treats 3 courses for the treatment of, comparitive study is in table 1.

Comparitive study after 3 courses for the treatment of of table 1 liang group treatment

P＜0.05

The cure rate of two groups of comparison therapy groups, total effective rate are obviously better than cure rate, the total effective rate of matched group.There is comparability P < 0.05.

Detailed description of the invention

Embodiment one: Folium et Cacumen Psychotriae Rubrae 45g, Flos et Folium Lactucae elatae 6g, Radix Fici Angustipoliae 22.5g, Radix Evodiae Leptae 22.5g, Herba Schisandrae intermediae 15g, Radix Clinopodii polycephali 12g, Foliumet Ramulus Evodiae 22.5g, Radix Crataevae Unilocularis 22.5g, becomes decoction by traditional method by above-mentioned Chinese medicine decocting.

Embodiment two: Folium et Cacumen Psychotriae Rubrae 30g, Flos et Folium Lactucae elatae 3g, Radix Fici Angustipoliae 15g, Radix Evodiae Leptae 15g, Herba Schisandrae intermediae 12g, Radix Clinopodii polycephali 9g, Foliumet Ramulus Evodiae 15g, Radix Crataevae Unilocularis 15g, becomes decoction by traditional method by above-mentioned Chinese medicine decocting.

Embodiment three: Folium et Cacumen Psychotriae Rubrae 60g, Flos et Folium Lactucae elatae 9g, Radix Fici Angustipoliae 30g, Radix Evodiae Leptae 30g, Herba Schisandrae intermediae 18g, Radix Clinopodii polycephali 15g, Foliumet Ramulus Evodiae 30g, Radix Crataevae Unilocularis 30g, becomes decoction by traditional method by above-mentioned Chinese medicine decocting.

Claims

1. treat a Chinese medicine preparation for active stage rheumatism pattern of fever rheumatoid arthritis, it is characterized in that this Chinese medicine preparation is made up of the Chinese medicine of following weight portion: Folium et Cacumen Psychotriae Rubrae 30-60 part, Flos et Folium Lactucae elatae 3-9 part, Radix Fici Angustipoliae 15-3O part, Radix Evodiae Leptae 15-30 part, Herba Schisandrae intermediae 12-18 part, Radix Clinopodii polycephali 9-15 part, Foliumet Ramulus Evodiae 15-30 part, Radix Crataevae Unilocularis 15-30 part.

2. a kind of Chinese medicine preparation for the treatment of active stage rheumatism pattern of fever rheumatoid arthritis as claimed in claim 1, is characterized in that this Chinese medicine preparation is made up of the Chinese medicine of following weight portion: Folium et Cacumen Psychotriae Rubrae 45 parts, Flos et Folium Lactucae elatae 6 parts, Radix Fici Angustipoliae 22.5 parts, Radix Evodiae Leptae 22.5 parts, Herba Schisandrae intermediae 15 parts, Radix Clinopodii polycephali 12 parts, Foliumet Ramulus Evodiae 22.5 parts, Radix Crataevae Unilocularis 22.5 parts.