CN103769022B - A kind of automatic biochemical analytical equipment and reaction cup group thereof - Google Patents

A kind of automatic biochemical analytical equipment and reaction cup group thereof Download PDF

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Publication number
CN103769022B
CN103769022B CN201410019870.3A CN201410019870A CN103769022B CN 103769022 B CN103769022 B CN 103769022B CN 201410019870 A CN201410019870 A CN 201410019870A CN 103769022 B CN103769022 B CN 103769022B
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cup
reaction cup
reaction
diluted
glass stand
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CN103769022A (en
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吴海波
郭成哲
邹豪
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Neusoft Whitman (Shenyang) limited biological technology
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NEUSOFT A&T MEDICAL TECHNOLOGY Co Ltd
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Abstract

The invention provides a kind of automatic biochemical analytical equipment and reaction cup group thereof, can process be simplified, improve detection efficiency.Described reaction cup group comprises glass stand and is arranged on the some reaction cup on described glass stand, and described glass stand is also provided with some diluted cups, and described diluted cup and described reaction cup all distribute along the circumference of described glass stand, and both are in circumferentially different.Sample directly can complete dilution in diluted cup, then radially moves in reaction cup and reacts, not only simple operation, also take full advantage of the inner space of reaction tray; Due to diluted cup and reaction cup separate, biochemical reaction then in reaction cup and the Sample Dilution in diluted cup can synchronously carry out, with take reaction cup in prior art and carry out compared with dilution, reaction cup group of the present invention can synchronously carry out diluting and reacting, avoid because dilution affects extent of reaction, effectively improve detection efficiency, for the research and development of full-automatic biochemical analytical equipment more at a high speed provide the foundation.

Description

A kind of automatic biochemical analytical equipment and reaction cup group thereof
Technical field
The present invention relates to technical field of medical treatment mechanical, particularly relate to a kind of reaction cup group of automatic biochemical analytical equipment.The invention still further relates to a kind of automatic biochemical analytical equipment with above-mentioned reaction cup group.
Background technology
In biochemical test and medicinal diagnosis, need, according to inspection criterion, sample and reagent are injected reaction cup and carry out biochemical reaction test, to analyze reaction result.
Reaction cup group of the prior art, comprises the some reaction cup along its circumference distribution; Under normal circumstances, the sample concentration that direct sample obtains is higher, easily exceeds the range of linearity.Need to carry out dilution and reduce concentration, to ensure that it is in the range of linearity.Then dilution is added in reaction cup and carry out biochemical analysis.For this reason, generally take a reaction cup in reaction cup group in prior art as diluted cup, sample diluted, to be diluted complete after, dilution is added in other reaction cup from the reaction cup being used as diluted cup, then carries out biochemical analysis.
Adopt above-mentioned existing reaction cup group, need to take the dilution that reaction cup carries out sample, just can carry out biochemical analysis after to be diluted the completing such as needing, have impact on detection efficiency largely.
In addition, in above-mentioned existing reaction cup group, reaction cup is directly installed in reaction tray, and reaction cup relies on the groove in reaction tray and flange to carry out contacting location completely, and its locating effect is poor; Meanwhile, higher to the requirement on machining accuracy of reaction tray upper groove and flanged structure, add processing cost; When reaction cup location is unreliable, easily causes beam center to depart from the center of reaction cup, make measure error larger.
Therefore, how looking for another way, design a kind of reaction cup group of automatic biochemical analytical equipment, to improve detection efficiency, is the current technical issues that need to address of those skilled in the art.
Summary of the invention
The object of this invention is to provide a kind of automatic biochemical analytical equipment and reaction cup group thereof, can process be simplified, improve detection efficiency.
For solving the problems of the technologies described above, the invention provides a kind of reaction cup group of automatic biochemical analytical equipment, comprise glass stand and be arranged on the some reaction cup on described glass stand, described glass stand is also provided with some diluted cups, described diluted cup and described reaction cup all distribute along the circumference of described glass stand, and both are in circumferentially different.
Reaction cup group of the present invention is provided with diluted cup, and diluted cup and reaction cup are all at glass stand circumferentially, the dilution of sample is then carried out without the need to taking reaction cup, sample directly can complete dilution in diluted cup, then radially move in reaction cup and react, not only simple operation, also takes full advantage of the inner space of reaction tray; Due to diluted cup and reaction cup separate, biochemical reaction then in reaction cup and the Sample Dilution in diluted cup can synchronously carry out, with take reaction cup in prior art and carry out compared with dilution, reaction cup group of the present invention can synchronously carry out diluting and reacting, avoid because dilution affects extent of reaction, effectively improve detection efficiency, for the research and development of full-automatic biochemical analytical equipment more at a high speed provide the foundation.
Preferably, described diluted cup and reaction cup are separately positioned on two of described glass stand difference circumferentially.
Diluted cup can be arranged on inner ring or the outer ring of glass stand, then after diluted cup completes Sample Dilution, sampling probe directly radially can move to reaction cup, completes the filling of sample; In whole application of sample process, sampling probe only needs radially straight reciprocating motion, and be then elevated to corresponding sampling and load position, it is simple to operate, and required time is shorter, and operating efficiency is higher.
Preferably, described diluted cup is set to the hollow cone shape of one end open, and its bottom surface is set to hemisphere face outwardly; When diluted cup is set to have hemispherical cone-shaped structure, unavailable liquid can be reduced, thus save sample; Meanwhile, said structure is also convenient to the cleaning of diluted cup.
Preferably, described glass stand has the mounting groove for fixing described reaction cup, then reaction cup can be fixed by mounting groove, as compared to being located with flange by the groove of reaction tray in prior art, mounting groove can be located reliably to reaction cup, improve positioning precision, reduce metrical error.
Preferably, described mounting groove is set to the square groove with described reaction cup adaptation, and the inwall on each limit is equipped with raised ribs, described raised ribs and described reaction cup interference fit.
The structure of square groove matches with the profile of reaction cup, and is fixed by raised ribs each limit by reaction cup, ensure that the reliability of location.
Preferably, described glass stand comprises the added and undercarriage be located by connecting up and down, and described mounting groove is arranged on described undercarriage, is describedly addedly provided with reaction cup aperture in the position corresponding with described mounting groove, and plays a protective role to reaction wall of cup.
Preferably, described added one end being provided with reaction cup aperture radially extends to form sector cover plate, and described sector cover plate is for covering the reactive tank of described reaction cup.
Addedly can extend to form sector cover plate, to cover on reactive tank, when avoiding sampling probe to sample or the time of cleaning reactive tank is polluted.
Preferably, the both sides of described undercarriage have bayonet socket, the described added buckle with described bayonet fittings that has.
The structure of bayonet socket and buckle can be adopted to carry out clamping location between added and undercarriage, while guarantee connection reliability, improve dismounting convenience.
Preferably, described added and undercarriage is also provided with coaxially through screw, and be bolted with hold-down screw in described screw, the outer surface of described hold-down screw has annular knurl, and top has yi word pattern gap, and gap width and unitary coin quite, are convenient to dismounting and change.
Preferably, described glass stand is also provided with some perforates, and described perforate is communicated with the openend of described diluted cup.
The present invention also provides a kind of automatic biochemical analytical equipment, and have reaction tray and be arranged on the reaction cup group in described reaction tray, described reaction cup group is the reaction cup group described in above-mentioned any one.
Automatic biochemical analytical equipment of the present invention has the reaction cup group described in above-mentioned any one, therefore the technique effect that the reaction cup group described in above-mentioned any one produces all is applicable to automatic biochemical analytical equipment of the present invention, repeats no more herein.
Preferably, described reaction tray has the diluted cup position for placing described diluted cup, described diluted cup compresses and is positioned in described diluted cup position by described glass stand.
Can be placed in reaction tray by diluted cup, due to glass stand and reaction tray compression fit, then diluted cup can be pressed in diluted cup position by glass stand, realize the fixing of diluted cup, without the need to carrying out special location to diluted cup, not only simplify assembling process, also improving the reliability of diluted cup location.
Accompanying drawing explanation
Fig. 1 is the partial structurtes schematic diagram of reaction tray in a kind of detailed description of the invention being provided with reaction cup group in automatic biochemical analytical equipment provided by the present invention;
Fig. 2 is that the assembling of reaction cup group provided by the present invention in a kind of detailed description of the invention completes perspective view;
Fig. 3 is the perspective view of the group of reaction cup shown in Fig. 2 assembling decomposing state;
Fig. 4 is the perspective view of a kind of set-up mode of glass stand provided by the present invention;
Fig. 5 is the three-dimensional side view of the assembling of glass stand shown in Fig. 4 decomposing state;
Fig. 6 is the front elevational view of the assembling of glass stand shown in Fig. 4 decomposing state;
Fig. 7 is the perspective view of a kind of set-up mode of undercarriage provided by the present invention;
Fig. 8 is the close-up schematic view of part A in Fig. 7;
Fig. 9 is the top view of undercarriage shown in Fig. 7;
Figure 10 is the perspective view of added a kind of set-up mode provided by the present invention;
Figure 11 is looking up the perspective view under state for added shown in Figure 10;
Figure 12 is the perspective view of a kind of set-up mode of diluted cup provided by the present invention;
Figure 13 is the perspective view of a kind of set-up mode of reaction cup provided by the present invention;
Figure 14 is the perspective view of a kind of set-up mode of hold-down screw provided by the present invention.
In Fig. 1-14:
1 glass stand, 11 mounting grooves, 111 raised ribs, 12 added, 121 reaction cup aperture, 122 sector cover plates, 123 buckles, 124 alignment pins, 13 undercarriages, 131 bayonet sockets, 132 connecting holes, 14 screws, 15 hold-down screws, 16 perforates, 2 reaction cup, 3 diluted cups, 31 convex edges, 4 reaction tray, 41 diluted cup positions
Detailed description of the invention
Core of the present invention is to provide a kind of reaction cup group of automatic biochemical analytical equipment, is provided with special diluted cup and carries out Sample Dilution, to improve detection efficiency.
In order to make those skilled in the art person understand the present invention program better, below in conjunction with the drawings and specific embodiments, the present invention is described in further detail.
Please refer to Fig. 1 and Fig. 2, Fig. 1 is the partial structurtes schematic diagram of reaction tray in a kind of detailed description of the invention being provided with reaction cup group in automatic biochemical analytical equipment provided by the present invention; Fig. 2 is that the assembling of reaction cup group provided by the present invention in a kind of detailed description of the invention completes perspective view.
The reaction cup group that automatic biochemical analytical equipment of the present invention comprises reaction tray 4 and is arranged in reaction tray 4, reaction cup group is for carrying sample, so that sample and reagent generation biochemical reaction, the result according to reaction carries out biochemical analysis.
Reaction cup group of the present invention comprises glass stand 1, some reaction cup 2 and some diluted cups 3, and reaction cup 2 and diluted cup 3 are all arranged on glass stand 1, and both all distribute along the circumference of glass stand 1, and the circumference residing for both is two different circumference; As shown in Figure 1, some reaction cup 2 are on circumference X, and some diluted cups 3 are on circumference Y, and circumference X and circumference Y is two different circumference, i.e. the not isometrical setting of circumference X and circumference Y.
With the reaction tray 4 at reaction cup group place for reference, in the direction at reaction tray 4 center is, the direction away from the center of reaction tray 4 is outward; Described glass stand 1 is arranged to the arc-shaped structure with reaction tray 4 adaptation, and described circumference refers to the circumference of reaction tray 4, then the circumference at the center near reaction tray 4 in glass stand 1 is its inner ring, and the circumference away from the center of reaction tray 4 is its outer ring; Circumference X and circumference Y be with the center of reaction tray 4 be the center of circle, with two different length distances for radius draws the circumference that obtains of circle.
With take reaction cup 2 in prior art and carry out compared with dilution, reaction cup group of the present invention is provided with special diluted cup 3, because diluted cup 3 and reaction cup 2 are in different circumference, then without the need to taking the cup position of reaction cup 2, directly sample can be added in diluted cup 3 and dilute, then the sample liquid after dilution is dispensed in each reaction cup 2, simple and convenient; What is more important, dilution in diluted cup 3 can not affect the reaction in reaction cup 2, therefore dilution and reaction can synchronously be carried out, and can not affect detection efficiency because of dilution, constant biochemical analysis speed can be ensured, for the research and development of more high speed biochemical analysis apparatus are laid a good foundation.
Can expect, as long as reaction cup 2 and diluted cup 3 are in circumferentially different, both just can keep relatively independent, and be not limited to reaction cup 2 and be on circumference X, diluted cup 3 is on circumference Y; Such as, reaction cup 2 can be set to inside and outside two circles, then diluted cup 3 is arranged on the centre of inside and outside two circle reaction cup 2, when namely can be transferred in the reaction cup 2 of inner ring or outer ring after sample liquid completes dilution in diluted cup 3, it is comparatively convenient to operate.
Particularly, diluted cup 3 can be arranged on the inner ring of glass stand 1, and reaction cup 2 can be arranged on the outer ring of glass stand 1, and diluted cup 3 and reaction cup 2 one_to_one corresponding, that is, a corresponding reaction cup 2 of diluted cup 3, the reaction cup 2 that diluted cup 3 is corresponding with it is on same extend radially line.
When diluted cup 3 and reaction cup 2 one_to_one corresponding, after diluted cup 3 completes the dilution of sample, sampling probe can draw sample liquid from diluted cup 3, then radially move linearly to reaction cup 2, complete the filling of sample liquid, in whole process, the motion path of sampling probe is the shortest, has saved the time of sampling and application of sample, has further increased detection efficiency; Simultaneously, due to diluted cup 3 and reaction cup 2 one_to_one corresponding, different samples can be diluted in each diluted cup 3, different sample liquids is filled in different reaction cup 2, then each reaction cup 2 can carry out different biochemical reactions, to complete the biochemical analysis of several samples simultaneously, meet the different needs.
Certainly, diluted cup 3 and reaction cup 2 may not be one to one, the corresponding relation of diluted cup 3 and reaction cup 2 can be set for the amount of sample liquid needed for the capacity of diluted cup 3 and reaction cup 2, such as, diluted cup 3 can two or more reaction cup 2 corresponding, and namely diluted cup 3 can be unequal with the number of reaction cup 2.
Or, diluted cup 3 can be arranged on the outer ring of glass stand 1, reaction cup 2 be arranged on the inner ring of glass stand 1, the sample liquid after dilution is moved in reaction cup 2 from outside to inside.
Please further refer to the perspective view of Fig. 3-6, Fig. 3 for the group of reaction cup shown in Fig. 2 assembling decomposing state; Fig. 4 is the perspective view of a kind of set-up mode of glass stand provided by the present invention; Fig. 5 is the three-dimensional side view of the assembling of glass stand shown in Fig. 4 decomposing state; Fig. 6 is the front elevational view of the assembling of glass stand shown in Fig. 4 decomposing state.
Glass stand 1 can be arranged the mounting groove 11 for fixation reaction cup 2, as compared to being fixed reaction cup 2 by the groove in reaction tray 4 and flange in prior art, glass stand 1 of the present invention is provided with special mounting groove 11, to locate reliably reaction cup 2, prevent from causing beam center depart from the center of reaction cup 2 and produce metrical error because locating effect is undesirable.
Glass stand 1 can comprise added 12 and undercarriage 13 that are located by connecting up and down, and mounting groove 11 can be arranged on undercarriage 13, and added 12 to be provided with in the position corresponding with mounting groove 11 and to react cup aperture 121; Each reaction cup 2 is installed and is positioned on undercarriage 13, and when behind added 12 and undercarriage about 13 assembling location, reaction cup aperture 121 UNICOM corresponding to the openend of reaction cup 2, so that sample liquid can instill in reaction cup 2 from reaction cup aperture 121 by sampling probe.
Described up and down with reaction tray 4 normal operating condition for reference, when normally using, the opening of reaction cup 2 towards direction be upper, correspondingly, under the direction opposing with top be.
Added 12 and undercarriage 13 can up and down clamping location, the both sides of undercarriage 13 can arrange bayonet socket 131, can arrange the buckle 123 coordinated with bayonet socket 131, as shown in Figure 5 and Figure 6 on added 12, added 12 and undercarriage 13 with buckle and bayonet socket upper and lower clamping location, form the glass stand 1 shown in Fig. 4.
Please further refer to the perspective view that Fig. 7-11, Fig. 7 is a kind of set-up mode of undercarriage provided by the present invention; Fig. 8 is the close-up schematic view of part A in Fig. 7; Fig. 9 is the top view of undercarriage shown in Fig. 7; Figure 10 is the perspective view of added a kind of set-up mode provided by the present invention; Figure 11 is looking up the perspective view under state for added shown in Figure 10.
In detail, reaction cup 2 is set to the square hollow rod structure of one end open usually, then mounting groove 11 can be set to the square groove with reaction cup adaptation, and the inwall on each limit of square groove is equipped with raised ribs 111, as shown in Figure 8; When reaction cup 2 puts into square groove, can form interference fit with raised ribs 111, then each limit of reaction cup 2 all can reliably be located, and improves the positioning precision of reaction cup 2.
Wherein, the inwall on each limit of square groove all can arrange two or more raised ribs 111, to carry out more efficiently location to reaction cup 2.
Added 12 can also arrange sector cover plate 122, and as shown in Figure 10 and Figure 11, added 12 radially extend to form fan-shaped entity structure in the one end being provided with reaction cup aperture 121, and described fan-shaped entity structure is sector cover plate 122; When behind added 12 and undercarriage 13 clamping location, reaction cup aperture 121 is corresponding with reaction cup 2, then sector cover plate 122 is in the outside of reaction cup 2, during owing to reacting, reaction cup 2 needs to be placed in reactive tank, and the area of reactive tank is greater than the area shared by reaction cup 2 usually, therefore sector cover plate 122 can cover above reactive tank, is covered by reactive tank.
Because reactive tank covers by sector cover plate 122, when sampling probe carries out sampling or cleaning reaction cup 2, can not pollute reactive tank.
Can expect, added 12 can also arrange alignment pin 124, and alignment pin 124 is extended downwards by the bottom surface of added 12; Undercarriage 13 can arrange connecting hole 132, as shown in figures 7 and 9, then added 12 with undercarriage 13 compression fit time, alignment pin 124 can pass connecting hole 132, then be connected with the pin-and-hole in reaction tray 4, thus undercarriage 13 is pressed between added 12 and reaction tray 4, realize the connection of added 12, undercarriage 13 and reaction tray 4.
On the basis of the above, glass stand 1 can also arrange screw 14 and hold-down screw 15, and screw 14 coaxially runs through added 12 and undercarriage 13, as shown in figs. 2-11; Hold-down screw 15 is screwed onto in screw 14, is threaded fixing by added 12 and undercarriage 13 and reaction tray 4.
Glass stand 1 can also arrange perforate 16, and perforate 16 runs through added 12 and undercarriage 13, to be communicated with the openend of diluted cup 3, to be convenient to sampling probe and to add sample in diluted cup 3, as shown in figs. 2-11.
Please refer to the perspective view that Figure 12-14, Figure 12 is a kind of set-up mode of diluted cup provided by the present invention; Figure 13 is the perspective view of a kind of set-up mode of reaction cup provided by the present invention; Figure 14 is the perspective view of a kind of set-up mode of hold-down screw provided by the present invention.
The outer surface of hold-down screw 15 can arrange annular knurl, and top can arrange the gap of yi word pattern, so that hold-down screw 15 dismounting, improves dismounting convenience, as shown in figure 14.
Diluted cup 3 can be set to the hollow cone shape of one end open, and from top to bottom slope inwardly setting usually, and namely in conical structure that is inverted, upper end open, and its bottom surface outwardly forms hemisphere face structure, as shown in figure 12; The structure of diluted cup 3 is convenient to sampling probe and is sampled, and reduces the volume of non-serviceable sample liquid, thus saves sample; The vibrational power flow of diluted cup 3 makes bottom residual liquid less, is convenient to clean.
In addition, reaction tray 4 can also being arranged the diluted cup position 41 for placing diluted cup 3, after glass stand 1 and reaction tray 4 compression fit, diluted cup 3 can be compressed and reserve in diluted cup position 41, as shown in Figure 1; For realizing the location of diluted cup 3 better, the openend of diluted cup 3 can arrange convex edge 31, and as shown in figure 12, then convex edge can be pressed in diluted cup position 41 by glass stand 1, reliably locates diluted cup 3.
Reaction cup 2 can adopt quartz glass to make, and not only can improve colorimetric light transmittance, repetitive cycling can also use, reduces and safeguard, reduce costs.
It will be understood by those skilled in the art that diluted cup 3 should select the material of acid and alkali-resistance to make; Added 12 and undercarriage 13 can be all resin molded article, conveniently process use.
Above automatic biochemical analytical equipment provided by the present invention and reaction cup group thereof are described in detail.Apply specific case herein to set forth principle of the present invention and embodiment, the explanation of above embodiment just understands core concept of the present invention for helping.It should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention, can also carry out some improvement and modification to the present invention, these improve and modify and also fall in the protection domain of the claims in the present invention.

Claims (9)

1. the reaction cup group of an automatic biochemical analytical equipment, comprise glass stand (1) and be arranged on the some reaction cup (2) on described glass stand (1), it is characterized in that, described glass stand (1) is also provided with some diluted cups (3), described diluted cup (3) and described reaction cup (2) all distribute along the circumference of described glass stand (1), and both are in circumferentially different;
Described glass stand (1) has the mounting groove (11) for fixing described reaction cup (2); Described glass stand (1) comprises added (12) and undercarriage (13) that are located by connecting up and down, described mounting groove (11) is arranged on described undercarriage (13), and described added (12) are provided with in the position corresponding with described mounting groove (11) and react cup aperture (121);
The both sides of described undercarriage (13) have bayonet socket (131), and described added (12) have the buckle (123) coordinated with described bayonet socket (131).
2. reaction cup group as claimed in claim 1, it is characterized in that, described diluted cup (3) and reaction cup (2) are separately positioned on two differences of described glass stand (1) circumferentially.
3. reaction cup group as claimed in claim 1, it is characterized in that, described diluted cup (3) is set to the hollow cone shape of one end open, and its bottom surface is set to hemisphere face outwardly.
4. the reaction cup group as described in any one of claim 1-3, it is characterized in that, described mounting groove (11) is set to the square groove adaptive with described reaction cup (2), and the inwall on each limit is equipped with raised ribs (111), described raised ribs (111) and described reaction cup (2) interference fit.
5. reaction cup group as claimed in claim 4, it is characterized in that, one end that described added (12) are provided with reaction cup aperture (121) radially extends to form sector cover plate (122), and described sector cover plate (122) is for covering the reactive tank of described reaction cup (2).
6. reaction cup group as claimed in claim 4, it is characterized in that, described added (12) and undercarriage (13) are also provided with coaxially through screw (14), hold-down screw (15) is bolted with in described screw (14), the outer surface of described hold-down screw (15) has annular knurl, and top has yi word pattern gap.
7. the reaction cup group as described in any one of claim 1-3, is characterized in that, described glass stand (1) is also provided with some perforates (16), and described perforate (16) is communicated with the openend of described diluted cup (3).
8. an automatic biochemical analytical equipment, the reaction cup group having reaction tray (4) and be arranged in described reaction tray (4), is characterized in that, described reaction cup group is the reaction cup group described in any one of the claims 1-7.
9. automatic biochemical analytical equipment as claimed in claim 8, it is characterized in that, described reaction tray (4) has the diluted cup position (41) for placing described diluted cup (3), described diluted cup (3) compresses and is positioned in described diluted cup position (41) by described glass stand (1).
CN201410019870.3A 2014-01-16 2014-01-16 A kind of automatic biochemical analytical equipment and reaction cup group thereof Active CN103769022B (en)

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CN105445084B (en) * 2015-12-11 2018-01-16 苏州长光华医生物医学工程有限公司 One kind dilution reusable Sample Dilution device in position
CN109444444A (en) * 2018-10-10 2019-03-08 深圳市国赛生物技术有限公司 A kind of detection analysis instrument and its application method
CN110441539B (en) * 2019-08-21 2023-08-01 东软威特曼生物科技(沈阳)有限公司 Reaction cup holder for solid direct heating type or air bath type reaction disk and full-automatic biochemical analyzer
CN113125777A (en) * 2019-12-31 2021-07-16 科美诊断技术股份有限公司 Sample test item arrangement method and device

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Address after: 110179 Liaoning city of Shenyang Province Hunnan New Century Road No. 16-B1

Patentee after: Neusoft Whitman (Shenyang) limited biological technology

Address before: Hunnan New District in Shenyang city of Shenyang province Liaoning 110179 Century Road No. 16

Patentee before: NEUSOFT A&T MEDICAL TECHNOLOGY CO., LTD.