CN103768229A - 一种治疗慢性溃疡性结肠炎的中药组合物 - Google Patents
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Abstract
本发明公开了一种治疗慢性溃疡性结肠炎的中药组合物。该中药组合物选择中药过坛龙、辫子草根、蕨麻、还阳草根、刀豆、羽叶丁香、金雀花、杨梅树、锡叶藤、赤地榆。治成汤剂。通过我院临床试验，中医认为慢性溃疡性结肠炎属于“久痢、泄泻、肠风、肠癖”等范畴，多因外感湿邪、饮食不当、情志失调、禀赋不足所致。脾肾两虚是本，湿、寒、热、气滞、血瘀等为标。通过我院临床试验，治疗组痊愈率、总有效率分别54.3％、97.8％，明显优于对照组痊愈率、总有效率分别23.9％、73.9％，而且副作用小，复发率低，值得临床推广应用。
Description
技术领域
本发明涉及一种中药组合物，尤其涉及一种治疗慢性溃疡性结肠炎的中药组合物。
背景技术
慢性溃疡性结肠炎是一种原因不明的直肠和结肠炎性疾病，病程长，病情轻重不一，易反复发作。该病为临床较常见病，发病机制目前尚不清楚，可能与自身免疫和遗传因素有关，主要病理改变以黏膜充血、水肿、溃疡为主。西医内科常以服用柳氮磺吡啶(SASP)进行治疗，近期和远期疗效不甚理想，复发率高，而且长期用可引起胃肠道反应：恶心、呕吐、食欲不振、腹胀、腹泻等副作用。中医治疗把握病机，辨证施医，脾肾双补，标本兼治，取得了良好的治疗效果，另外中药治疗具有价格低，无副作用，不易复发等优点。
发明内容
本发明的目的是提供一种治疗慢性溃疡性结肠炎的中药组合物。中医认为慢性溃疡性结肠炎属于“久痢、泄泻、肠风、肠癖”等范畴，多因外感湿邪、饮食不当、情志失调、禀赋不足所致。脾肾两虚是本，湿、寒、热、气滞、血瘀等为标。
本发明的目的是通过以下技术方案实现的，该治疗慢性溃疡性结肠炎的中药组合物由以下重量份的中药制成：过坛龙15-25份、辫子草根25-30份、蕨麻16-22份、还阳草根15-25份、刀豆9-15份、羽叶丁香4-5份、金雀花3-9份、杨梅树9-15份、锡叶藤6-15份、赤地榆9-15份。
优选的，过坛龙20份、辫子草根27份、蕨麻19份、还阳草根20份、刀豆12份、羽叶丁香4.5份、金雀花6份、杨梅树12份、锡叶藤10份、赤地榆12份。
制备方法将上述中药水煎制成汤剂。
方中：过坛龙清热利湿、散瘀消肿；辫子草根清热利湿、止血通络；蕨麻益气补血、健脾益胃、生津止渴、利湿；还阳草根补益气血、健脾利湿；刀豆温中下气、益肝补元；羽叶丁香降气温中暖肾；金雀花滋阴、和血、健脾；杨梅树收敛止泻、止血止痛、消炎；锡叶藤收敛止泻、止血、生肌收口；赤地榆涩肠、止血、止痛、消炎。
临床资料
1、一般资料92例患者均符合慢性溃疡性结肠炎诊断标准，随机分成治疗组和对照组各46例。治疗组：男25例，女21例，年龄20～60岁，平均41.2岁，病程6个月～9年。对照组：男26例，女20例，年龄18～61岁，平均42.6岁，病程6个月～9年。两组在性别、年龄、病程、病情等方面无显著差异(P＞0.05)，具有可比性。
2、诊断标准具有慢性腹泻、粘液血便、腹痛，呈慢性反复发作性或持续性，伴有不同程度的全身症状；病史在3个月以上；钡灌肠见结肠管缩短，结肠袋消失，结肠呈管状外观，部分病例有多发性假性息肉表现；纤维结肠镜检查见受累结肠黏膜呈现多发性浅表溃疡，伴有充血，水肿；大便培养排除菌痢、阿米巴痢疾、血吸虫病、肠结核等特异性感染性结肠炎及肉芽肿性结肠炎。
3、治疗方法治疗组患者服用本发明所述的中药组合物，称取过坛龙20g、辫子草根27g、蕨麻19g、还阳草根20g、刀豆12g、羽叶丁香4.5g、金雀花6g、杨梅树12g、锡叶藤10g、赤地榆12g。水煎成汤剂，每日一剂，分早晚2次服用。对照组患者口服柳氮磺吡啶，一日2g，分3-4次服用。两周一疗程，两组疗程均为4个疗程。
4、疗效标准治愈：临床症状消失，大便常规检查连续3次正常，结肠镜或钡灌肠肠黏膜恢复正常。停药后观察6个月无复发。显效：临床症状基本消失，结肠镜或钡灌肠检查肠黏膜轻度炎症反应及部分假息肉形成，大便常规正常或见红细胞、白细胞在5个以下。有效：临床症状、结肠镜或钡灌肠检查肠黏膜病变有所好转，大便常规正常或见红细胞、白细胞在5个以上、10个以下。无效：临床症状和结肠镜等检查无改善。
5、治疗结果治疗4个疗程后，两组治疗两个疗程后疗效比较，治疗组46例，其中治愈25例(54.3％)，显效11例(23.9％)，有效9例(19.6％)，无效1例(2.2％)，总有效率97.8％；对照组46例，其中治愈11例(23.9％)，显效7例(15.2％)，有效16例(34.8％)，无效12例(26.1％)，总有效率73.9％。两组比较，治疗组治愈率、总有效率明显优于对照组，具有可比性(P＜0.05)。
具体实施方式
实施例一：称取过坛龙20g、辫子草根27g、蕨麻19g、还阳草根20g、刀豆12g、羽叶丁香4。5g、金雀花6g、杨梅树12g、锡叶藤10g、赤地榆12g。将上述中药水煎成汤剂。
实施例二：称取过坛龙25g、辫子草根25g、蕨麻16g、还阳草根15g、刀豆15g、羽叶丁香4g、金雀花9g、杨梅树9g、锡叶藤15g、赤地榆9g。将上述中药水煎成汤剂。
实施例三：称取过坛龙15g、辫子草根30g、蕨麻22g、还阳草根25g、刀豆9g、羽叶丁香5g、金雀花3g、杨梅树15g、锡叶藤6g、赤地榆15g。将上述中药水煎成汤剂。
Claims (2)
1.一种治疗慢性溃疡性结肠炎的中药组合物，其特征在于该中药组合物由以下重量份的中药制成：过坛龙15-25份、辫子草根25-30份、蕨麻16-22份、还阳草根15-25份、刀豆9-15份、羽叶丁香4-5份、金雀花3-9份、杨梅树9-15份、锡叶藤6-15份、赤地榆9-15份。
2.根据权利要求1所述的一种治疗慢性溃疡性结肠炎的中药组合物其特征在于过坛龙20份、辫子草根27份、蕨麻19份、还阳草根20份、刀豆12份、羽叶丁香4.5份、金雀花6份、杨梅树12份、锡叶藤10份、赤地榆12份。
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