CN102988559B - 一种治疗溃疡性结肠炎的中药灌肠剂 - Google Patents
一种治疗溃疡性结肠炎的中药灌肠剂 Download PDFInfo
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Abstract
本发明公开了一种治疗溃疡性结肠炎的中药灌肠剂。溃疡性结肠炎属中医“泄泻”，痢疾”范畴。认为与六淫邪袭，尤其是湿热之邪、饮食所伤、情志郁结及禀赋不足有关。为此，本发明选择具有清热化湿、和血调气、清热解毒的中药野冬青皮、古山龙、井口边草、鱼腥草、小叶金花草、大鹅儿肠、黄柏、小糪、苦参、延胡索、白芍、樱额、甘草，由本院制剂室制成灌肠剂，保留灌肠，经临床试验，总有效率达到97.3％，免疫指标有了明显的改善，特别是治疗组无不良反应，值得临床推广应用。
Description
技术领域
本发明涉及一种中药组合物，尤其涉及一种治疗溃疡性结肠炎的中药灌肠剂。
背景技术
溃疡性结肠炎是一种以腹痛、腹泻、黏液脓血便为主要临床表现的非特异性炎症性结肠疾病。本病多发于20～40岁青壮年，近年来，随着人们饮食结构、生活习惯和生活节奏的改变，发病率有明显的上升趋势。本病病因目前尚不明确，国内外文献报道尚无特效疗法，且治疗后易复发。西药由于口服用药量大，易引起较多的副反应，兼之位于结肠远段的病变采用口服治疗，疗效不尽人意。口服5-ASA缓释剂有一定的疗效，但价格高，长期使用患者难以承受。我们通过临床观察，认为采用中药保留灌肠治疗溃疡性结肠炎疗效确切。
发明内容
本发明的目的是提供一种治疗溃疡性结肠炎的中药灌肠剂。溃疡性结肠炎属中医“泄泻”，痢疾”、“肠澼”范畴。认为与六淫邪袭，尤其是湿热之邪、饮食所伤、情志郁结及禀赋不足有关。
本发明的目的是通过以下技术方案实现的，该治疗溃疡性结肠炎的中灌肠剂由以下重量份的中药制成：野冬青皮20-25份、古山龙21-23份、井口边草10-12份、鱼腥草7-9份、小叶金花草18-20份、大鹅儿肠15-17份、黄柏7-9份、小檗8-10份、苦参6-8份、延胡索12-15份、白芍10-12份、樱额7-9份、甘草4-6份。
优选的，野冬青皮23份、古山龙22份、井口边草11份、鱼腥草8份、小叶金花草19份、大鹅儿肠16份、黄柏8份、小檗9份、苦参7份、延胡索14份、白芍11份、樱额8份、甘草5份。
制备方法：将上述中药先浸泡1h后水煎取液150mL，加入热水二煎取液约150mL，混合浓缩至180ml。
方中：野冬青皮、古山龙清热解毒；井口边草清热利湿，止血生肌，解毒消肿；鱼腥草清热解毒，消痈排脓，利尿通淋；小叶金花草清热利湿，解毒止血；大鹅儿肠理气化湿，活血止血，消积解毒；黄柏清热燥湿，泻火解毒，退热除蒸；小檗清热燥湿，泻火解毒；苦参清热燥湿，杀虫利尿；延胡索活血行气止痛；白芍养血调经，平肝止痛，敛阴止汗；樱额补脾，止泄泻；甘草益气补中，清热解毒，祛痰止咳，缓解止痛。
临床资料
1、一般资料所选病例为2009年5月至2010年11月我院门诊患者150例，按就诊顺序随机分为治疗组和对照组，治疗组75例，其中男49例，女26例；年龄19～70岁，平均46.8±4.1岁；病程6～55个月，平均22.5±2.6月；病情中度32例，轻度43例。对照组75例，男46例，女29例；年龄20～65岁，平均45.8±3.6岁；病程5～60个月，平均21.0±3.0月；病情中度34例，轻度41例。两组患者年龄、病程、病情比较差异无统计学意义(P＞0.05)，两组具有可比性。
2、治疗方法治疗组使用本发明中药灌肠剂，即取野冬青皮23g、古山龙22g、井口边草11g、鱼腥草8g、小叶金花草19g、大鹅儿肠16g、黄柏8g、小檗9g、苦参7g、延胡索14g、白芍11g、樱额8g、甘草5g，将上述中药先浸泡1h后水煎取液150mL，加入热水二煎取液约150mL，混合浓缩至180ml，以温度和人体温度适应为宜，保留灌肠。对照组予柳氮磺胺嘧啶1g、思密达3g溶解于100ml生理盐水，保留灌肠。两组均每天保留灌肠2次，上、下午各1次，两组均10日为1个疗程。
3、疗效标准(1)临床治愈：临床主症消失，次症消失或基本消失，病变恢复正常或溃疡病灶已形成瘢痕，大便常规连续3次正常；(2)显效：临床主症基本消失，次症改善程度达1级以上(腹部轻微隐痛，下腹坠痛减轻，肠鸣音轻微，腹胀减轻)，肠粘膜病变恢复达1级以上(轻度充血水肿，无溃疡)大便常规红、白细胞＜3个/HP；(3)好转：临床主症改善达1级以上(腹泻＜3次/日，少量脓血便，腹痛轻微)，肠粘膜病变恢复程度达2级以上(肠粘膜轻、中度水肿，散在溃疡＜3个)，大便常规红、白细胞在5个/HP左右；(4)无效：达不到以上标准。
4、治疗结果两组患者治疗三个疗程后观察疗效
(1)两组临床疗效比较见表1。
表1两组患者临床疗效比较
与对照组比较，P＜0.05
治疗组总有效率为97.3％，对照组总有效率为82.7％，治疗组总有效率、治愈率明显优于对照组，两组比较，差异有显著性意义(P＜0.05)。
(2)两组患者治疗前后免疫指标变化比较
见表2。
表2两组患者治疗前后免疫指标变化比较
注：与本组治疗前比较，ΔΔP＜0.01，#P＞0.05，与对照组治疗后比较，*P＜0.05
5、不良反应：对照组75例中，有恶心、呕吐31例，19例白细胞减少，经对症支持治疗后症状减轻；治疗组无不良反应。
具体实施方式
实施例一：称取野冬青皮23g、古山龙22g、井口边草11g、鱼腥草8g、小叶金花草19g、大鹅儿肠16g、黄柏8g、小檗9g、苦参7g、延胡索14g、白芍11g、樱额8g、甘草5g，将上述中药先浸泡1h后水煎取液150mL，加入热水二煎取液约150mL，混合浓缩至180ml。
实施例二：称取野冬青皮20g、古山龙21g、井口边草10g、鱼腥草7g、小叶金花草18g、大鹅儿肠15g、黄柏7g、小檗8g、苦参6g、延胡索12g、白芍10g、樱额7g、甘草4g，将上述中药先浸泡1h后水煎取液150mL，加入热水二煎取液约150mL，混合浓缩至180ml。
实施例三：称取野冬青皮25g、古山龙23g、井口边草12g、鱼腥草9g、小叶金花草20g、大鹅儿肠17g、黄柏9g、小檗10g、苦参8g、延胡索15g、白芍12g、樱额9g、甘草6g，将上述中药先浸泡1h后水煎取液150mL，加入热水二煎取液约150mL，混合浓缩至180ml。
Claims (2)
1.一种治疗溃疡性结肠炎的中药灌肠剂，其特征在于该中药灌肠剂由以下重量份的中药制成：野冬青皮20-25份、古山龙21-23份、井口边草10-12份、鱼腥草7-9份、小叶金花草18-20份、大鹅儿肠15-17份、黄柏7-9份、小檗8-10份、苦参6-8份、延胡索12-15份、白芍10-12份、樱额7-9份、甘草4-6份。
2.根据权利要求1所述的一种治疗溃疡性结肠炎的中药灌肠剂，其特征在于该中药灌肠剂由以下重量份的中药制成：野冬青皮23份、古山龙22份、井口边草11份、鱼腥草8份、小叶金花草19份、大鹅儿肠16份、黄柏8份、小檗9份、苦参7份、延胡索14份、白芍11份、樱额8份、甘草5份。
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| 张卫平.中医药治疗溃疡性结肠炎机制研究进展.《中国中医急症》.2011,第20卷(第9期),第1468-1471页. |
| 溃疡性结肠炎的中医药治疗研究进展;陈一斌 等;《甘肃中医》;20051231;第18卷(第7期);第76-78页 * |
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