CN103767688A - Implantable extracorporeal monitoring device of intracranial environment - Google Patents

Implantable extracorporeal monitoring device of intracranial environment Download PDF

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Publication number
CN103767688A
CN103767688A CN201410060295.1A CN201410060295A CN103767688A CN 103767688 A CN103767688 A CN 103767688A CN 201410060295 A CN201410060295 A CN 201410060295A CN 103767688 A CN103767688 A CN 103767688A
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singlechip
chip microcomputer
information
signal
box body
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CN201410060295.1A
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罗东
罗林丽
黄蔚
倪娟
吴兰
黄伟
冯世苗
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West China Second University Hospital of Sichuan University
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West China Second University Hospital of Sichuan University
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Abstract

An implantable extracorporeal monitoring device of an intracranial environment comprises a sensor, an intracorporeal signal acquisition system, a first power supply, an extracorporeal signal reading system and a second power supply; the sensor is used for collecting intracerebroventricular environmental information and converts the collected environmental information into electric signals so as to transmit the electric signals to a first single-chip microcomputer in the intracorporeal signal acquisition system; the first single-chip microcomputer processes the received electric signal of the environmental information and transmits the intracerebroventricular environmental conditions and the conditions of the first power supply to a second single-chip microcomputer in the extracorporeal signal reading system, and adjusts the category of obtained environmental information or/and working pattern parameters according to instructions of the second single-chip microcomputer and transmits the information to the second single-chip microcomputer; the second single-chip microcomputer transmits the received information to a display for displaying after processing the information, and instructions from man-machine interaction keys are processed and then transmitted to the first single-chip microcomputer.

Description

The external monitoring device of implanted intracranial environment
Technical field
The invention belongs to medical apparatus and instruments, particularly a kind of for intracranial environment being had to the device of wound monitoring.
Background technology
Intracranial environment is the important monitoring index of neural Medicine and Surgery, comprises temperature, intracranial pressure, blood oxygen saturation, cerebrospinal fluid proportion etc.The acute variation of intracranial environment is often indicating that disease and accident have occurred nervous system, once and neural disease and unexpected generation will be caused fatal threat to patient.Therefore, if the clinical symptoms that can cause at nervous system abnormality is found and treated in time before occurring, will greatly reduce the incidence rate of nervous system unexpected death event, save to greatest extent patient's life.
Conventional intracranial method of environmental monitoring is divided into noinvasive and has two kinds of modes of wound at present.Existing noinvasive is measured the shortcomings such as the mode of intracranial pressure exists certainty of measurement poor, and method is loaded down with trivial details indirectly, not generally application in clinical.Settle the external monitor of drainage tube to detect and the metering system that intracranial is pressed with wound is adopted more, due to exist intracranial infection may, be unsuitable for life-time service.Adopt rectal temperature, tympanic temperature and esophagus in temperature to replace intracranial temperature to intracranial temperature monitoring more, or adopt auxillary temperature to infer, poor accuracy.For the measurement of intracranial blood oxygen saturation, temporarily do not have at present reliable non-invasive methods, clinical many data that collect at limbs tip or ear-lobe according to blood oxygen saturation probe are estimated.Owing to being subject to the impact of the factors such as peripheral vessel spasm, accuracy is not high.Especially cause the patient of intracranial blood supply insufficiency for factors such as having sclerosis of blood vessels, the situation that this method can not the confession of accurate response intracranial oxygen.Therefore, the clinical extraction jugular vein blood blood gas analysis that adopts has wound mode to measure intracranial blood oxygen saturation more.Aspect the collection of the data such as the proportion of cerebrospinal fluid, lack clinically the non-invasive methods of Continuous Observation at present, can only be by there being wound lumbar puncture single acquisition cerebrospinal fluid to analyze.And if when the state of an illness needs the data such as density and proportion of dynamic monitoring cerebrospinal fluid, the complication hemorrhage and that infect that repeated localised puncture causes is also difficult to avoid.Therefore, how to intracranial environment realize for a long time, Real-Time Monitoring is neural Medicine and Surgery key technical problem urgently to be resolved hurrily accurately.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, provide a kind of implanted intracranial environment external monitoring device, so as to intracranial environment realize for a long time, Real-Time Monitoring accurately.
The external monitoring device of implanted intracranial environment of the present invention comprises signal acquisition system, the first power supply, external signal-obtaining system and second source in sensor, body; In described body signal acquisition system by the first single-chip microcomputer and the first wireless receiver and the first wireless transmitter that are connected with the first single-chip microcomputer respectively form, the first wireless transmitter is for sending information to external signal-obtaining system, the first wireless receiver for receive come from the information of external signal-obtaining system and by the information transmission receiving to the first single-chip microcomputer; Described external signal-obtaining system comprises second singlechip and the second wireless receiver being connected with second singlechip respectively, the second wireless transmitter, man-machine interactive operation button and display, the second wireless transmitter sends instruction for signal acquisition system in body, the second wireless receiver for receive come from the information of signal acquisition system in body and by the information transmission receiving to second singlechip, man-machine interactive operation button is for sending instruction to second singlechip, and display is for showing the information that second singlechip receives; Described the first power supply provides operating current for signal acquisition system in body, and described second source is for providing operating current to external signal-obtaining system; Described sensor is connected with the first single-chip microcomputer, gathers, and the environmental information signal collecting is transformed into electric signal transmission to the first single-chip microcomputer for the environmental information to intracranial; Described the first single-chip microcomputer is processed the environmental information signal of telecommunication receiving and the environmental aspect of intracranial and the first power supply status is transferred to second singlechip by the first wireless transmitter, the second wireless receiver; According to the instruction adjustment of second singlechip obtain environmental information kind or/and mode of operation parameter (the mode of operation parameter of obtaining environmental information comprises acquisition time, obtains frequency) and by adjust after information exchange cross the first wireless transmitter, the second wireless receiver is transferred to second singlechip; According to instruction start or the shutdown of second singlechip; Described second singlechip is processed and is transferred to display by the information that comes from the first single-chip microcomputer receiving and shown, after the instruction that comes from man-machine interactive operation button is processed, is transferred to the first single-chip microcomputer by the second wireless transmitter, the first wireless receiver; Signal acquisition system is encapsulated in a box body in described the first power supply and body, so that sterilization and to be embedded in patient subcutaneous.
The external monitoring device of above-mentioned implanted intracranial environment, its sensor is at least one in pressure transducer, temperature sensor, specific gravity sensor, oximetry sensor.
Consider from angle easy to use, in the external monitoring device of implanted intracranial environment of the present invention, second singlechip, second source are arranged in a box body, the second wireless receiver, the second wireless transmitter are arranged on outer wall or the inwall of this box body, and man-machine interactive operation button, display are arranged on the outer wall of this box body.
For the function of expanded body external signal reading system, second singlechip is also connected with alarm lamp, alarm buzzer, data storage and data output interface, and second source is connected with power supply indicator; Described data storage and second singlechip, second source are arranged in same box body, and described alarm buzzer is arranged on outer wall or the inwall of described box body, and described data output interface, alarm lamp and power supply indicator are arranged on the outer wall of described box body.
The external monitoring device of implanted intracranial environment of the present invention, its using method is as follows:
Sensor is inserted to patient's intracranial, the box body that signal acquisition system in the first power supply, body is housed is embedded in to patient subcutaneous, external signal-obtaining system is positioned at outside patient body.
The external monitoring device of implanted intracranial environment of the present invention, its operation principle is as follows:
By sensor at least one information in intracranial pressure, temperature, blood oxygen saturation, cerebrospinal fluid proportion, and the signal collecting is transformed into electric signal transmission to the first single-chip microcomputer, the first single-chip microcomputer is processed the environmental information signal of telecommunication receiving and is transferred to second singlechip by the first wireless transmitter, the second wireless receiver, and second singlechip is processed to the received signal and shown on display.Meanwhile, second singlechip is transferred to the first single-chip microcomputer by the second wireless transmitter, the first wireless receiver after the instruction that comes from man-machine interactive operation button can being processed.Aspect safety, in the time that the first single-chip microcomputer monitors abnormal information (as: intracranial pressure sharply changes), can realize warning by second singlechip, and can, by the arranging controls such as the first chip microcontroller power-off, shutdown of second singlechip, guarantee the safety using.
The present invention has following beneficial effect:
1, device of the present invention can carry out long-term Real-Time Monitoring, record and demonstration to environmental informations such as intracranial pressure, temperature, blood oxygen saturation, cerebrospinal fluid proportions, thereby be convenient to grasp in time the variation of intracranial environment, early time treatment before nervous system disease clinical manifestation occurs, reduces the occurrence probability that neural complication causes serious clinical thunder bolt.
2, device of the present invention is easy to use, get final product the data of the convenient and swift patient's of reading intracranial environment by the display being connected with second singlechip, the man-machine interactive operation button being connected with second singlechip by operation, can send instruction to the first single-chip microcomputer, in the time that the first single-chip microcomputer monitors abnormal information (as: intracranial pressure sharply changes), can realize warning by second singlechip, and can, by the arranging controls such as the first chip microcontroller power-off, shutdown of second singlechip, guarantee the safety using.
3, sensor is inserted patient's intracranial, it is subcutaneous that the box body that signal acquisition system in the first power supply, body is housed is embedded in patient, external signal-obtaining system is positioned at outside patient body, in body, between signal acquisition system and external signal-obtaining system, pass through wireless transmission, reduce open monitoring the probability infecting has occurred, also reduce the misery that repeatedly has wound Information Monitoring to bring patient, be particularly useful for carrying out intracranial environment the patient of long term monitoring.
4, device of the present invention is applied widely, also can be used for environment in canalis spinalis, environment in splanchnocoel, the monitoring of the interior environment of blood vessel etc.
Accompanying drawing explanation
Fig. 1 is a kind of structured flowchart of the external monitoring device of implanted intracranial environment of the present invention.
Fig. 2 is the another kind of structured flowchart of the external monitoring device of implanted intracranial environment of the present invention.
Fig. 3 is a kind of outline drawing of the external monitoring device of implanted intracranial environment of the present invention.
Fig. 4 is the another kind of outline drawing of the external monitoring device of implanted intracranial environment of the present invention.
Fig. 5 is the mounting means figure of the external monitoring device of implanted intracranial environment of the present invention.
In figure, the 1-the first box body, the 2-the second box body, 3-sensor, 4-data wire, the 5-the first wireless transmission/reception window, 6-display, 7-man-machine interactive operation button, the 8-the second wireless transmission/reception window, 9-alarm lamp, 10-alarm buzzer, 11-power supply indicator, 12-patient.
The specific embodiment
Below in conjunction with accompanying drawing, the external monitoring device of implanted intracranial environment of the present invention is described further in structure aspects.
Embodiment 1
In the present embodiment, the external monitoring device of implanted intracranial environment comprises signal acquisition system, the first power supply, external signal-obtaining system and second source in sensor 3, body.Described sensor 3 is pressure transducer and temperature sensor.In described body signal acquisition system as shown in Figure 1, by the first single-chip microcomputer and the first wireless receiver and the first wireless transmitter that are connected with the first single-chip microcomputer respectively form.Described external signal-obtaining system as shown in Figure 1, by second singlechip and the second wireless receiver being connected with second singlechip respectively, the second wireless transmitter, man-machine interactive operation button and display form.It is the pressure transducer (production of freescale company of the U.S.) of MPX5050 that pressure transducer is selected model, and WRTP thermal resistance temperature sensor is selected in temperature sensor; It is the single-chip microcomputer (American TI Company production) of MSP430F135 that the first single-chip microcomputer and second singlechip are all selected model, and the model of first, second wireless receiver and first, second wireless transmitter is that nRF905(Suzhou Tian Yi Electronic Science and Technology Co., Ltd. produces).
The compound mode of each member and device: as shown in Figure 1, the outfan of pressure transducer and temperature sensor is connected with the first single-chip microcomputer by data wire 4 respectively, the first power supply provides operating current for signal acquisition system in body, and second source is for providing operating current to external signal-obtaining system.
As shown in (1) figure in Fig. 3, in described the first power supply, body, signal acquisition system is encapsulated in the first box body 1, on described the first box body 1, offers the first wireless transmission/reception window 5, and described pressure transducer, temperature sensor are positioned at outside the first box body.As shown in (2) figure in Fig. 3, described second source, second singlechip are arranged in the second box body 2, described the second wireless receiver, the second wireless transmitter are arranged on the inwall of the second box body, described man-machine interactive operation button 7, display 6 are arranged on the outer wall of the second box body, on described the second box body 2, offer the second wireless transmission/reception window 8.
In the present embodiment, as shown in Figure 5, patient 12 intracranial is inserted in pressure transducer and temperature sensor to the external monitoring device of implanted intracranial environment mounting means in use, and it is subcutaneous that the first box body 1 is embedded in patient 12, the second box body 2 is positioned at outside patient body, by the hand-held operation of medical worker.
Embodiment 2
In the present embodiment, as shown in Figure 2, Figure 4 shows, difference from Example 1 is the external monitoring device of implanted intracranial environment:
1, sensor 3 is pressure transducer, temperature sensor, specific gravity sensor and oximetry sensor, each sensor is connected with the first single-chip microcomputer by data wire 4 respectively, it is the pressure transducer (production of freescale company of the U.S.) of MPX5050 that pressure transducer is selected model, WRTP thermal resistance temperature sensor is selected in temperature sensor, it is the specific gravity sensor of SG-601 that specific gravity sensor is selected model, and it is the blood oxygen probe (production of Nai Pute company) of Nellcor that oximetry sensor is selected model.
2, external signal-obtaining system has increased alarm lamp 9, alarm buzzer 10, data storage and data output interface, alarm lamp 9, alarm buzzer 10, data storage, data output interface are connected with second singlechip respectively, and second source is connected with power supply indicator 11.
3, as shown in (1) figure in Fig. 4, in described the first power supply, body, signal acquisition system is encapsulated in the first box body 1, and pressure transducer, temperature sensor, specific gravity sensor and oximetry sensor are positioned at outside the first box body.
4, as shown in (2) figure in Fig. 4, described second singlechip, second source and data storage are arranged in the second box body 2, described the second wireless receiver, the second wireless transmitter and alarm buzzer 10 are arranged on inwall or the outer wall of the second box body, and described man-machine interactive operation button 7, display 6, alarm lamp 9, power supply indicator 11 and data output interface are arranged on the outer wall of the second box body.
In the present embodiment, the external monitoring device of implanted intracranial environment mounting means in use as shown in Figure 5, pressure transducer, temperature sensor, specific gravity sensor and oximetry sensor are inserted patient 12 intracranial, it is subcutaneous that the first box body 1 is embedded in patient 12, the second box body 2 is positioned at outside patient body, by the hand-held operation of medical worker.

Claims (5)

1. the external monitoring device of implanted intracranial environment, is characterized in that comprising signal acquisition system, the first power supply, external signal-obtaining system and second source in sensor (3), body; In described body signal acquisition system by the first single-chip microcomputer and the first wireless receiver and the first wireless transmitter that are connected with the first single-chip microcomputer respectively form, the first wireless transmitter is for sending information to external signal-obtaining system, the first wireless receiver for receive come from the information of external signal-obtaining system and by the information transmission receiving to the first single-chip microcomputer; Described external signal-obtaining system comprises second singlechip and the second wireless receiver being connected with second singlechip respectively, the second wireless transmitter, man-machine interactive operation button and display, the second wireless transmitter sends instruction for signal acquisition system in body, the second wireless receiver for receive come from the information of signal acquisition system in body and by the information transmission receiving to second singlechip, man-machine interactive operation button is for sending instruction to second singlechip, and display is for showing the information that second singlechip receives;
Described the first power supply provides operating current for signal acquisition system in body, and described second source is for providing operating current to external signal-obtaining system;
Described sensor (3) is connected with the first single-chip microcomputer, gathers, and the environmental information signal collecting is transformed into electric signal transmission to the first single-chip microcomputer for the environmental information to intracranial;
Described the first single-chip microcomputer is processed the environmental information signal of telecommunication receiving and the environmental aspect of intracranial and the first power supply status is transferred to second singlechip by the first wireless transmitter, the second wireless receiver; According to the instruction adjustment of second singlechip obtain environmental information kind or/and mode of operation parameter and by adjust after information exchange cross the first wireless transmitter, the second wireless receiver is transferred to second singlechip; According to instruction start or the shutdown of second singlechip;
Described second singlechip is processed and is transferred to display by the information that comes from the first single-chip microcomputer receiving and shown, after the instruction that comes from man-machine interactive operation button is processed, is transferred to the first single-chip microcomputer by the second wireless transmitter, the first wireless receiver;
In described the first power supply and body, signal acquisition system is encapsulated in a box body.
2. the external monitoring device of implanted intracranial environment according to claim 1, is characterized in that described sensor (3) is at least one in pressure transducer, temperature sensor, specific gravity sensor, oximetry sensor.
3. according to the external monitoring device of implanted intracranial environment described in claim 1 or 2, it is characterized in that described external signal-obtaining system also comprises alarm lamp (9), alarm buzzer (10), data storage and data output interface, alarm lamp (9), alarm buzzer (10), data storage are connected with second singlechip respectively with data output interface, and described second source is connected with power supply indicator (11).
4. according to the external monitoring device of implanted intracranial environment described in claim 1 or 2, it is characterized in that described second singlechip, second source are arranged in a box body, described the second wireless receiver, the second wireless transmitter are arranged on outer wall or the inwall of this box body, and described man-machine interactive operation button (7), display (6) are arranged on the outer wall of this box body.
5. the external monitoring device of implanted intracranial environment according to claim 3, it is characterized in that described second singlechip, second source and data storage are arranged in a box body, described the second wireless receiver, the second wireless transmitter and alarm buzzer (10) are arranged on outer wall or the inwall of this box body, and described man-machine interactive operation button (7), display (6), data output interface, alarm lamp (9) and power supply indicator (11) are arranged on the outer wall of this box body.
CN201410060295.1A 2014-02-21 2014-02-21 Implantable extracorporeal monitoring device of intracranial environment Pending CN103767688A (en)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110013241A (en) * 2019-04-26 2019-07-16 侯立军 Intracranial pressure Multi probe monitors system
CN111568375A (en) * 2020-05-09 2020-08-25 四川大学华西第二医院 Neural sense of touch finder of paediatrics
CN112244809A (en) * 2020-11-16 2021-01-22 勃森生命科技(上海)有限公司 Noninvasive intracranial brain pressure detection system and method
CN112386241A (en) * 2020-11-13 2021-02-23 深圳大学 Implantable blood pressure meter based on NFC
CN112617768A (en) * 2020-12-30 2021-04-09 中国人民解放军总医院第一医学中心 Wireless multi-mode intracranial monitoring system

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US4186749A (en) * 1977-05-12 1980-02-05 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Induction powered biological radiosonde
US6248080B1 (en) * 1997-09-03 2001-06-19 Medtronic, Inc. Intracranial monitoring and therapy delivery control device, system and method
CN201333032Y (en) * 2008-12-05 2009-10-28 北京奥麦特科技有限公司 Implanted wireless automatic intracranial pressure monitoring system
CN204049611U (en) * 2014-02-21 2014-12-31 四川大学华西第二医院 Implanted intracranial environment monitored in vitro device

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4186749A (en) * 1977-05-12 1980-02-05 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Induction powered biological radiosonde
US6248080B1 (en) * 1997-09-03 2001-06-19 Medtronic, Inc. Intracranial monitoring and therapy delivery control device, system and method
CN201333032Y (en) * 2008-12-05 2009-10-28 北京奥麦特科技有限公司 Implanted wireless automatic intracranial pressure monitoring system
CN204049611U (en) * 2014-02-21 2014-12-31 四川大学华西第二医院 Implanted intracranial environment monitored in vitro device

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110013241A (en) * 2019-04-26 2019-07-16 侯立军 Intracranial pressure Multi probe monitors system
CN111568375A (en) * 2020-05-09 2020-08-25 四川大学华西第二医院 Neural sense of touch finder of paediatrics
CN111568375B (en) * 2020-05-09 2022-07-12 四川大学华西第二医院 Neural sense of touch finder of paediatrics
CN112386241A (en) * 2020-11-13 2021-02-23 深圳大学 Implantable blood pressure meter based on NFC
CN112244809A (en) * 2020-11-16 2021-01-22 勃森生命科技(上海)有限公司 Noninvasive intracranial brain pressure detection system and method
CN112617768A (en) * 2020-12-30 2021-04-09 中国人民解放军总医院第一医学中心 Wireless multi-mode intracranial monitoring system

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Application publication date: 20140507