CN103752288B - A kind of preparation method being applied to the adsorbent that rapamycin is separated - Google Patents
A kind of preparation method being applied to the adsorbent that rapamycin is separated Download PDFInfo
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- CN103752288B CN103752288B CN201410035278.2A CN201410035278A CN103752288B CN 103752288 B CN103752288 B CN 103752288B CN 201410035278 A CN201410035278 A CN 201410035278A CN 103752288 B CN103752288 B CN 103752288B
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- rapamycin
- preparation
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- adsorbent
- pore
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- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 title claims abstract description 48
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 title claims abstract description 45
- 229960002930 sirolimus Drugs 0.000 title claims abstract description 45
- 238000002360 preparation method Methods 0.000 title claims abstract description 22
- 239000003463 adsorbent Substances 0.000 title claims abstract description 12
- 238000006243 chemical reaction Methods 0.000 claims abstract description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims abstract description 13
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims abstract description 13
- 239000011976 maleic acid Substances 0.000 claims abstract description 13
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000004088 foaming agent Substances 0.000 claims abstract description 12
- 239000002270 dispersing agent Substances 0.000 claims abstract description 6
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000011837 N,N-methylenebisacrylamide Substances 0.000 claims abstract description 4
- ZIUHHBKFKCYYJD-UHFFFAOYSA-N n,n'-methylenebisacrylamide Chemical compound C=CC(=O)NCNC(=O)C=C ZIUHHBKFKCYYJD-UHFFFAOYSA-N 0.000 claims abstract description 4
- 239000012071 phase Substances 0.000 claims description 13
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- 125000001153 fluoro group Chemical group F* 0.000 abstract description 2
- 229920000642 polymer Polymers 0.000 abstract description 2
- 238000006116 polymerization reaction Methods 0.000 abstract description 2
- 238000010792 warming Methods 0.000 abstract description 2
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 abstract 2
- 239000011324 bead Substances 0.000 abstract 1
- 229960003276 erythromycin Drugs 0.000 abstract 1
- 239000000047 product Substances 0.000 description 21
- 238000000034 method Methods 0.000 description 8
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 6
- 238000001179 sorption measurement Methods 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 101000634900 Homo sapiens Transcriptional-regulating factor 1 Proteins 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 241001506137 Rapa Species 0.000 description 3
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- 239000003018 immunosuppressive agent Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
- 238000012710 chemistry, manufacturing and control Methods 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- QDGONURINHVBEW-UHFFFAOYSA-N dichlorodifluoroethylene Chemical group FC(F)=C(Cl)Cl QDGONURINHVBEW-UHFFFAOYSA-N 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
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- IOLCXVTUBQKXJR-UHFFFAOYSA-M potassium bromide Chemical compound [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- QFJCIRLUMZQUOT-KADBNGAOSA-N (1R,9S,12S,15R,16E,18R,19R,21R,23S,24Z,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)\C(C)=C\C=C\C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-KADBNGAOSA-N 0.000 description 1
- STGNLGBPLOVYMA-TZKOHIRVSA-N (z)-but-2-enedioic acid Chemical compound OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O STGNLGBPLOVYMA-TZKOHIRVSA-N 0.000 description 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical group NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
- 239000004342 Benzoyl peroxide Substances 0.000 description 1
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 1
- 230000010190 G1 phase Effects 0.000 description 1
- 230000018199 S phase Effects 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
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- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
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- 102000003675 cytokine receptors Human genes 0.000 description 1
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- 239000002594 sorbent Substances 0.000 description 1
- 239000002351 wastewater Substances 0.000 description 1
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- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Abstract
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Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201410035278.2A CN103752288B (en) | 2014-01-22 | 2014-01-22 | A kind of preparation method being applied to the adsorbent that rapamycin is separated |
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CN201410035278.2A CN103752288B (en) | 2014-01-22 | 2014-01-22 | A kind of preparation method being applied to the adsorbent that rapamycin is separated |
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CN103752288A CN103752288A (en) | 2014-04-30 |
CN103752288B true CN103752288B (en) | 2016-03-30 |
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CN201410035278.2A Active CN103752288B (en) | 2014-01-22 | 2014-01-22 | A kind of preparation method being applied to the adsorbent that rapamycin is separated |
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Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104262358B (en) * | 2014-09-29 | 2016-02-17 | 常州兰陵制药有限公司 | Extract the method for rapamycin |
CN105289545B (en) * | 2015-11-30 | 2017-12-01 | 王琪宇 | A kind of preparation of rapamycin separation adsorbent |
CN105582901B (en) * | 2015-12-21 | 2018-03-02 | 王金明 | A kind of preparation of the adsorbent of long carbochain biatomic acid zymotic fluid |
CN105597711B (en) * | 2016-03-09 | 2018-11-23 | 徐州鸿丰高分子材料有限公司 | A kind of preparation method of the adsorbent material of binary acid treating |
CN105646801A (en) * | 2016-03-09 | 2016-06-08 | 张玲 | Preparation of octylphenol ethoxylate adsorbing material |
CN105833854A (en) * | 2016-06-13 | 2016-08-10 | 王金明 | Preparation method of purified vanadium adsorption material |
CN106268688A (en) * | 2016-08-21 | 2017-01-04 | 王琪宇 | A kind of preparation method of expoxy propane purification adsorbent |
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Effective date of registration: 20191204 Address after: 233010 No. 409 Wuwan Road, Yuhui District, Bengbu City, Anhui Province Patentee after: BENGBU JINSHI NEW MATERIAL Co.,Ltd. Address before: 322000 Zhejiang province Yiwu City Binwang zipper Street 5 District No. 3 room 602 Patentee before: Wang Jinming |
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Effective date of registration: 20201028 Address after: 214500 Yuejiang village, Jingcheng Town, Jingjiang City, Taizhou City, Jiangsu Province Patentee after: Jiangsu Omega hose Co.,Ltd. Address before: 233010 No. 409 Wuwan Road, Yuhui District, Bengbu City, Anhui Province Patentee before: BENGBU JINSHI NEW MATERIAL Co.,Ltd. |
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Effective date of registration: 20220602 Address after: 214500 No. 28, Yingbin East Road, Jingjiang City, Taizhou City, Jiangsu Province Patentee after: Jiangsu Huarong Investment Development Co.,Ltd. Address before: 214500 Yuejiang village, Jingcheng Town, Jingjiang City, Taizhou City, Jiangsu Province Patentee before: Jiangsu Omega hose Co.,Ltd. |
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Effective date of registration: 20230410 Address after: 214500 No. 28, Yingbin East Road, Jingjiang City, Taizhou City, Jiangsu Province Patentee after: Jingjiang City Chengzhong Village Investment and Construction Co.,Ltd. Address before: 214500 No. 28, Yingbin East Road, Jingjiang City, Taizhou City, Jiangsu Province Patentee before: Jiangsu Huarong Investment Development Co.,Ltd. |
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