CN103751182B - The application of a kind of compound in treatment myocardial ischemia drug - Google Patents
The application of a kind of compound in treatment myocardial ischemia drug Download PDFInfo
- Publication number
- CN103751182B CN103751182B CN201310635141.6A CN201310635141A CN103751182B CN 103751182 B CN103751182 B CN 103751182B CN 201310635141 A CN201310635141 A CN 201310635141A CN 103751182 B CN103751182 B CN 103751182B
- Authority
- CN
- China
- Prior art keywords
- myocardial ischemia
- compound
- mollolide
- application
- treatment myocardial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 208000031225 myocardial ischemia Diseases 0.000 title claims abstract description 19
- 150000001875 compounds Chemical class 0.000 title claims abstract description 16
- 239000003814 drug Substances 0.000 title claims abstract description 11
- 229940079593 drug Drugs 0.000 title claims description 7
- LDBZVNJHWKNRTA-GYLJPACSSA-N mollolide A Natural products C([C@@]12[C@H](O)[C@H]([C@](C2)(C)O)[C@H](O)C[C@H]1C(=O)C)[C@H]1OC(=O)C(C)(C)[C@]1(O)CCO LDBZVNJHWKNRTA-GYLJPACSSA-N 0.000 claims abstract description 23
- 238000002360 preparation method Methods 0.000 claims abstract description 7
- 230000000694 effects Effects 0.000 abstract description 3
- 230000000302 ischemic effect Effects 0.000 abstract description 3
- 230000002265 prevention Effects 0.000 abstract description 3
- 230000010410 reperfusion Effects 0.000 abstract description 2
- 238000002474 experimental method Methods 0.000 description 8
- 241000700159 Rattus Species 0.000 description 7
- 238000003304 gavage Methods 0.000 description 7
- 239000007924 injection Substances 0.000 description 7
- 238000002347 injection Methods 0.000 description 7
- 210000004165 myocardium Anatomy 0.000 description 7
- 239000013641 positive control Substances 0.000 description 7
- JLTCWSBVQSZVLT-CDIPANDDSA-N (2s)-n-[(2s)-6-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxohexan-2-yl]-1-[(4r,7s,10s,13s,16s,19r)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosan Chemical compound NCCCC[C@@H](C(=O)NCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](N)CSSC1.C([C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1=CC=CC=C1 JLTCWSBVQSZVLT-CDIPANDDSA-N 0.000 description 6
- 102000005320 Posterior Pituitary Hormones Human genes 0.000 description 6
- 108010070873 Posterior Pituitary Hormones Proteins 0.000 description 6
- 239000013642 negative control Substances 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 206010063837 Reperfusion injury Diseases 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 150000004141 diterpene derivatives Chemical class 0.000 description 3
- 230000003203 everyday effect Effects 0.000 description 3
- 230000002496 gastric effect Effects 0.000 description 3
- 238000001802 infusion Methods 0.000 description 3
- 208000010125 myocardial infarction Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000000004 hemodynamic effect Effects 0.000 description 2
- 208000028867 ischemia Diseases 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229940011964 pentobarbital sodium 30 mg Drugs 0.000 description 2
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- 230000002861 ventricular Effects 0.000 description 2
- 241000237970 Conus <genus> Species 0.000 description 1
- 206010011086 Coronary artery occlusion Diseases 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 208000007201 Myocardial reperfusion injury Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 210000001168 carotid artery common Anatomy 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 210000003017 ductus arteriosus Anatomy 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 210000001105 femoral artery Anatomy 0.000 description 1
- 230000012447 hatching Effects 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000003601 intercostal effect Effects 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 229940079448 nitroglycerin 5 mg Drugs 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229960003712 propranolol Drugs 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 238000002627 tracheal intubation Methods 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
Abstract
Description
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310635141.6A CN103751182B (en) | 2013-11-29 | 2013-11-29 | The application of a kind of compound in treatment myocardial ischemia drug |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310635141.6A CN103751182B (en) | 2013-11-29 | 2013-11-29 | The application of a kind of compound in treatment myocardial ischemia drug |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103751182A CN103751182A (en) | 2014-04-30 |
CN103751182B true CN103751182B (en) | 2015-10-07 |
Family
ID=50518615
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201310635141.6A Expired - Fee Related CN103751182B (en) | 2013-11-29 | 2013-11-29 | The application of a kind of compound in treatment myocardial ischemia drug |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN103751182B (en) |
-
2013
- 2013-11-29 CN CN201310635141.6A patent/CN103751182B/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CN103751182A (en) | 2014-04-30 |
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Inventor after: Tu Ruiqiang Inventor after: Wang Shanshan Inventor after: He Wuchun Inventor before: Wu Wenyuan |
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Free format text: CORRECT: INVENTOR; FROM: WU WENYUAN TO: TU RUIQIANG WANG SHANSHAN HE WUCHUN |
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Effective date of registration: 20150902 Address after: 325055 Zhejiang, Wenzhou, Longwan District, Haicheng street, Central South Road, No. 81 Applicant after: Tu Ruiqiang Address before: Jiaxing City, Zhejiang province 314050 East Gate Nanhu District Economic Park Road and junction 2, spinning room 210 Applicant before: JIAXING XINGTONG ELECTRONIC TECHNOLOGY CO., LTD. |
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Inventor after: Gu Jinzhou Inventor after: Xu Lina Inventor before: Tu Ruiqiang Inventor before: Wang Shanshan Inventor before: He Wuchun |
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Effective date of registration: 20170302 Address after: 052263 Jinzhou Province in the east of the town of Hebei village in the village of Xiangyang Street, No. 6 Patentee after: Gu Jinzhou Patentee after: Xu Lina Address before: 325055 Zhejiang, Wenzhou, Longwan District, Haicheng street, Central South Road, No. 81 Patentee before: Tu Ruiqiang |
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Effective date of registration: 20200317 Address after: 201914 room a3-8786, 58 Fumin Road, Hengsha Township, Chongming District, Shanghai (Hengtai Economic Development Zone, Shanghai) Patentee after: Shanghai Kangyuan Biotechnology Center Address before: 233000 Xianghe Home Floor No.9, Xinhuai Road, Dongsheng Street, Longzihu District, Bengbu City, Anhui Province Patentee before: Bengbu Qibang Science and Technology Information Consulting Co., Ltd. |
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Effective date of registration: 20200416 Address after: Room 1808-2, No. 3737, Gonghe new road, Jing'an District, Shanghai 200071 Patentee after: Shanghai Xinhe Pharmaceutical Co., Ltd Address before: 201914 room a3-8786, 58 Fumin Road, Hengsha Township, Chongming District, Shanghai (Hengtai Economic Development Zone, Shanghai) Patentee before: Shanghai Kangyuan Biotechnology Center |
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