CN103749331A - Animal simulated exhaustive swimming experimental device - Google Patents
Animal simulated exhaustive swimming experimental device Download PDFInfo
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- CN103749331A CN103749331A CN201310755672.9A CN201310755672A CN103749331A CN 103749331 A CN103749331 A CN 103749331A CN 201310755672 A CN201310755672 A CN 201310755672A CN 103749331 A CN103749331 A CN 103749331A
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Abstract
The invention discloses an animal simulated exhaustive swimming experimental device comprising an inner chamber, a low oxygen compartment chamber, and a box cover disposed on the low oxygen compartment chamber through connectors. The inner chamber is arranged within the low oxygen compartment chamber through a device driving the inner chamber to slide up and down. The sidewall of the low oxygen compartment chamber is provided with a control system, a gas regulation system, and a water level regulation system; the gas regulation system and the water level regulation system are respectively connected with the control system; a motor is connected with the control system. The low oxygen compartment chamber, the box cover and the sidewalls of the inner chamber are all made of transparent material. At least one sidewall of the inner chamber is provided with a plurality of elongated water inlets. After a small animal is put in the inner chamber, the device driving the inner chamber to slide up and down forces the small animal to exhaustively swim in the low oxygen environment for experiments, various physiological parameters in experiments such as the experiment of the small animal exhaustive swimming in the low oxygen environment are acquired, and accordingly, limitations of the existing exhaustive swimming equipment are eliminated and more convincing experimental results are obtained.
Description
Technical field
The device that the present invention relates to animal imitating experiment in laboratory, is specifically related to animal imitating power and exhausts swimming experiment device.
Background technology
The research of the specific caused normal pressure low oxygen of altitude environment aspect disease medicament, needs large (little) mouse, rabbit power to exhaust swimming test and verify conventionally.In prior art, adopt better simply Experimental Establishment to complete this experiment, such as the swimming pool equipment that only utilizes sealing is tested, preferably scheme is that the temperature that changes swimming pool inner water is tested more.But test under the limited water environment of oxygen content, because these equipment can not be controlled oxygen content, adopt it to carry out experiment and can have following shortcoming: due to the natural reaction of animal, animal enters in water, will find immediately can be for the sidewall of its attaching motionlessly or climbing is motionless to the higher point of cavity, so just can not realize the efficacy testing of medicine under low-oxygen environment; And if test under the lower environment of oxygen content, small animal can be breathed a dew face, or by being attached to, sidewall is motionless or climbing is motionless to reduce the consumption of oxygen content to the higher point of cavity in closed cavity.
For this reason, for the ease of the research test of altitude environment medicine, under a kind of low-oxygen environment, force animal to carry out the device that power exhausts swimming test and be urgently developed.
Summary of the invention
For above shortcomings in prior art, animal imitating power provided by the invention exhausts swimming experiment device and animal is placed in the inner chamber body of hypoxemia cabin inside cavity, during experiment, make the major part of whole inner chamber body be submerged in water, can make small animal carry out hypoxemia power in the situation that nothing is sought connections with and exhaust swimming test.
In order to reach foregoing invention object, the technical solution used in the present invention is: provide a kind of animal imitating power to exhaust swimming experiment device, comprise inner chamber body, hypoxemia cabin cavity and be arranged on the case lid on the cavity of hypoxemia cabin by connector; On the cavity wall of hypoxemia cabin, be provided with one for regulating the gas regulating system of hypoxemia cabin inside cavity gas content, one for regulating the Water Level Regulating System and of hypoxemia cabin inside cavity water level height for the control system to gas regulating system and Water Level Regulating System transmitted signal;
Inner chamber body makes its device sliding up and down be arranged on hypoxemia cabin inside cavity by one; The sidewall of described hypoxemia cabin cavity, case lid and inner chamber body all adopts transparent material to make, and is provided with the inlet opening of some strips at least one sidewall of inner chamber body.
Further, described in make device that inner chamber body slides up and down comprise that at least one screw mandrel and that is arranged on hypoxemia cabin cavity diapire is arranged on screw mandrel to provide the motor that slides up and down power to inner chamber body, described motor is connected with control system.
Beneficial effect of the present invention is: this device is placed in small animal in inner chamber body, by control system control Water Level Regulating System by injected water in the cavity of hypoxemia cabin, by controlling gas regulating system, make the environment of hypoxemia cabin cavity in hypoxemia situation, by control, make device that inner chamber body slides up and down force animal under low-oxygen environment, to carry out power and exhaust swimming test;
According to test case, regulating water level height, oxygen content and the small animal of hypoxemia cabin inside cavity to be forced to the parameters such as swimming time obtains under low-oxygen environment small animal and does power and exhaust the various physiological parameters such as swimming test, thereby eliminated existing power, exhaust the limitation of bathing facilities, thereby draw and have more the convictive experimental data about the caused normal pressure low oxygen of altitude environment aspect disease medicament.
Accompanying drawing explanation
Fig. 1 is the three-dimensional structure diagram that animal imitating power exhausts swimming experiment device;
Fig. 2 is the stereogram that hypoxemia cabin cavity and case lid link together.
Wherein, 1, hypoxemia cabin cavity; 2, oxygen measurement sensor; 3, air bleeding valve; 4, control system; 5, magnetic valve; 6, case lid; 7, enter nitrogen valve; 8, enter oxygen valve; 9, level sensor; 10, draining valve; 11, motor; 12, inner chamber body; 13, inlet opening; 14, water intaking valve; 15, screw mandrel; 16, hasp.
Embodiment
As depicted in figs. 1 and 2, this animal imitating power exhausts swimming experiment device and comprises inner chamber body 12, hypoxemia cabin cavity 1 and be arranged on the case lid 6 on hypoxemia cabin cavity 1 by connector; On cavity 1 sidewall of hypoxemia cabin, be provided with gas regulating system, Water Level Regulating System and control system 4; Inner chamber body 12 makes its device sliding up and down be arranged on cavity 1 inside, hypoxemia cabin by one; On inner chamber body 12 at least one sidewall, be provided with the inlet opening 13 of some strips.
Above-mentioned gas regulating system is mainly used in regulating oxygen content and nitrogen content of cavity 1 inside, hypoxemia cabin, and the nitrogen oxygen information of collection is passed to control system 4; Water Level Regulating System regulates the water yield of hypoxemia cabin cavity 1 according to small animal motion conditions and water level situation, and the water level information collecting is passed to control system 4; The collection signal that control system 4 is returned according to gas regulating system and Water Level Regulating System transmission is modulated to by the environmental parameter of hypoxemia cabin cavity 1 optimum state that experiment needs, in the lifting of controlling inner chamber body 12 to realize zoopery test.
Due to when testing, need the small animal motion conditions in omnibearing observation animal inner chamber body 12, described hypoxemia cabin cavity 1, case lid 6 and inner chamber body 12 form by aluminum alloy frame and the panel of being made by transparent plexiglass plate that is arranged on aluminum alloy frame.
For the ease of the manufacture of this experimental provision, the device that inner chamber body 12 is slided up and down comprises that at least one screw mandrel 15 and that is arranged on hypoxemia cabin cavity 1 diapire is arranged on screw mandrel 15 provides the motor 11 that slides up and down power to inner chamber body 12, and motor 11 is connected with control system 4.
Make device that inner chamber body slides up and down can also adopt any structure of prior art, as: be arranged on the hoistable platform of hypoxemia cabin cavity bottom and for controlling the motor of hoistable platform lifting, described inner chamber body 12 is placed on hoistable platform, and motor 11 is connected with control system 4; Described hoistable platform can adopt hydraulic up-down or gear & rack structure.
For the ease of experimenter, input as required the demonstration of various control parameters and hypoxemia cabin cavity 1 various parameters, microprocessor and the control panel of described control system 4 for linking together, and described control panel is by controlling button and LCDs forms, and LCDs shows hypoxemia cabin cavity 1 internal gas pressure, temperature, humidity and oxygen content in real time.
In the present embodiment, gas regulating system comprises the air bleeding valve 3 that is connected with control system 4 respectively, enters nitrogen valve 7, enters oxygen valve 8 and oxygen measurement sensor 2; Described Water Level Regulating System comprises the magnetic valve 5, level sensor 9, water intaking valve 14 and the draining valve 10 that are connected with control system 4 respectively.For the temperature of experimental provision inside is controlled, on cavity 1 sidewall of described hypoxemia cabin, be also provided with the temperature sensor being connected with control system 4.In order to guarantee the sealing of this experimental provision, on the contact-making surface of described case lid 6 and hypoxemia cabin cavity 1, be provided with sealing strip, described connector is outside equipped with to hasp 16.For the ease of picking and placeing article, described connector is arranged to hinge.
While carrying out simulated experiment, by inner chamber body 12 be contained in hypoxemia cabin cavity 1 bottom arrange screw mandrel 15 on or be placed on hypoxemia cabin cavity 1 bottom arrange hoistable platform on, inlet and outlet pipe lines in connection; Corresponding pipeline between oxygen bottle in connection outside hypoxemia cabin cavity 1 and nitrogen cylinder and hypoxemia cabin cavity 1; Connect the cable between oxygen measurement sensor 2, temperature sensor, magnetic valve 5 etc.The small animal (often selecting rat, mouse, bunny in simulation laboratory) that throwing has been taken to medicine is placed in inner chamber body 12, opening power, preset hypoxemia cabin cavity 1 interior oxygen concentration, confirm after errorless to press definite key, experimental provision just starts continuous sampling, detects hypoxemia cabin cavity 1 interior oxygen concentration, water level height show in real time oxygen content, temperature and hypoxemia cabin cavity 1 interior atmospheric pressure.When oxygen density value or water level height does not conform to preset value, automatically control corresponding gas circuit valve or Water path valve and open and close, until reach preset value.
At hypoxemia cabin cavity 1 oxygen content and water level, all reach after preset value, can pass through inner chamber body 12 elevating control buttons, control the decline of inner chamber body 12, water enters inner chamber body 12 by inlet opening 13, make the small animal of inner chamber body 12 in water environment, because the interior nothing of inner chamber body 12 is sought connections with mechanism, small animal can ceaselessly be swum in water, to reach the small animal forcing in inner chamber body 12, at hypoxemia cabin cavity 1, carry out strokes, time by small animal in inner chamber body 12 interior swimming, observe small animal physiological situation, finally obtain corresponding experiment parameter, to obtain the useful experimental data of the caused normal pressure low oxygen of altitude environment aspect disease medicament.
Although by reference to the accompanying drawings the specific embodiment of the present invention is described in detail, should not be construed as the restriction of the protection domain to this patent.In the described scope of claims, the various modifications that those skilled in the art can make without creative work and distortion still belong to the protection domain of this patent.
Claims (7)
1. animal imitating power exhausts a swimming experiment device, comprises hypoxemia cabin cavity and is arranged on the case lid on the cavity of hypoxemia cabin by connector; It is characterized in that: also comprise inner chamber body; On the cavity wall of hypoxemia cabin, be provided with one for regulating the gas regulating system of hypoxemia cabin inside cavity gas content, one for regulating the Water Level Regulating System and of hypoxemia cabin inside cavity water level height for the control system to gas regulating system and Water Level Regulating System transmitted signal;
Inner chamber body makes its device sliding up and down be arranged on hypoxemia cabin inside cavity by one; The sidewall of described hypoxemia cabin cavity, case lid and inner chamber body all adopts transparent material to make, and is provided with the inlet opening of some strips at least one sidewall of inner chamber body.
2. animal imitating power according to claim 1 exhausts swimming experiment device, it is characterized in that: described in make device that inner chamber body slides up and down comprise that at least one screw mandrel and that is arranged on hypoxemia cabin cavity diapire is arranged on screw mandrel to provide the motor that slides up and down power to inner chamber body; Described motor is connected with control system.
3. according to right, want the animal imitating power described in 2 to exhaust swimming experiment device, it is characterized in that: described control system is microprocessor and the control panel linking together, described control panel is by controlling button and LCDs forms.
4. animal imitating power according to claim 2 exhausts swimming experiment device, it is characterized in that: described gas regulating system comprises the air bleeding valve that is connected with control system respectively, enters nitrogen valve, enters oxygen valve and oxygen measurement sensor.
5. animal imitating power according to claim 2 exhausts swimming experiment device, it is characterized in that: described Water Level Regulating System comprises the magnetic valve, level sensor, water intaking valve and the draining valve that are connected with control system respectively.
6. animal imitating power according to claim 1 exhausts swimming experiment device, it is characterized in that: on the cavity wall of described hypoxemia cabin, be also provided with the temperature sensor being connected with control system.
7. according to the arbitrary described animal imitating power of claim 1-6, exhaust swimming experiment device, it is characterized in that: on the contact-making surface of described case lid and cavity, be provided with sealing strip, and select hinge at connector, and be outside equipped with hasp at it.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310755672.9A CN103749331B (en) | 2013-12-26 | 2013-12-26 | Animal imitating power exhausts swimming experiment device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310755672.9A CN103749331B (en) | 2013-12-26 | 2013-12-26 | Animal imitating power exhausts swimming experiment device |
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| Publication Number | Publication Date |
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| CN103749331A true CN103749331A (en) | 2014-04-30 |
| CN103749331B CN103749331B (en) | 2016-01-06 |
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| CN201310755672.9A Expired - Fee Related CN103749331B (en) | 2013-12-26 | 2013-12-26 | Animal imitating power exhausts swimming experiment device |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104720831A (en) * | 2015-04-16 | 2015-06-24 | 温州医科大学附属第一医院 | Measurement method and measurement equipment special for exhaustive swimming experiments of rats and mice |
| CN106508713A (en) * | 2016-10-31 | 2017-03-22 | 启安动物行为学科技股份有限公司 | Method and system for monitoring animal loaded swimming experiment |
| RU205095U1 (en) * | 2020-12-16 | 2021-06-28 | Федеральное государственное бюджетное учреждение "33 Центральный научно-исследовательский испытательный институт" Министерства обороны Российской Федерации | Test bench for forced swimming experiments |
| CN113243312A (en) * | 2021-04-11 | 2021-08-13 | 复旦大学 | A cylinder device that is used for automatic controllable lift platform of behavioural experiment |
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| JPH0420367A (en) * | 1990-03-05 | 1992-01-23 | Takeji Kuniya | Swimming device for water bird or the like in point water or the like |
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| CN102217552A (en) * | 2011-04-26 | 2011-10-19 | 广州医学院第一附属医院 | Full-automatic hypoxic animal model breeding box |
| CN102389294A (en) * | 2011-07-07 | 2012-03-28 | 中国人民解放军第三军医大学 | Exhaustive swimming test device for simulating special military environments |
| CN202554160U (en) * | 2012-04-19 | 2012-11-28 | 四川科伦药业股份有限公司 | Self-control type animal experiment hypoxia chamber |
| KR20130053150A (en) * | 2011-11-15 | 2013-05-23 | 신민규 | An animal sports device |
| GB2498950A (en) * | 2012-01-31 | 2013-08-07 | Trevor Sedley Pimlott | Boiler system comprising a waste oil burner |
| CN204259610U (en) * | 2013-12-26 | 2015-04-15 | 中国人民解放军成都军区总医院 | Animal imitating power exhausts swimming experiment device |
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2013
- 2013-12-26 CN CN201310755672.9A patent/CN103749331B/en not_active Expired - Fee Related
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0420367A (en) * | 1990-03-05 | 1992-01-23 | Takeji Kuniya | Swimming device for water bird or the like in point water or the like |
| JP2009051775A (en) * | 2007-08-28 | 2009-03-12 | Kokan Yakuhin Kenkyusho:Kk | Endurance-enhancing agent and anti-fatigue agent |
| CN102217552A (en) * | 2011-04-26 | 2011-10-19 | 广州医学院第一附属医院 | Full-automatic hypoxic animal model breeding box |
| CN102389294A (en) * | 2011-07-07 | 2012-03-28 | 中国人民解放军第三军医大学 | Exhaustive swimming test device for simulating special military environments |
| KR20130053150A (en) * | 2011-11-15 | 2013-05-23 | 신민규 | An animal sports device |
| GB2498950A (en) * | 2012-01-31 | 2013-08-07 | Trevor Sedley Pimlott | Boiler system comprising a waste oil burner |
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| CN204259610U (en) * | 2013-12-26 | 2015-04-15 | 中国人民解放军成都军区总医院 | Animal imitating power exhausts swimming experiment device |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104720831A (en) * | 2015-04-16 | 2015-06-24 | 温州医科大学附属第一医院 | Measurement method and measurement equipment special for exhaustive swimming experiments of rats and mice |
| CN106508713A (en) * | 2016-10-31 | 2017-03-22 | 启安动物行为学科技股份有限公司 | Method and system for monitoring animal loaded swimming experiment |
| CN106508713B (en) * | 2016-10-31 | 2019-07-12 | 东莞市尚慈生物医药科技有限公司 | A kind of animal swimming with a load attached to the body experiment monitoring method and system |
| RU205095U1 (en) * | 2020-12-16 | 2021-06-28 | Федеральное государственное бюджетное учреждение "33 Центральный научно-исследовательский испытательный институт" Министерства обороны Российской Федерации | Test bench for forced swimming experiments |
| CN113243312A (en) * | 2021-04-11 | 2021-08-13 | 复旦大学 | A cylinder device that is used for automatic controllable lift platform of behavioural experiment |
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|---|---|
| CN103749331B (en) | 2016-01-06 |
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Granted publication date: 20160106 Termination date: 20161226 |