CN103735658A - Formula and preparation process of blueberry compound oral liquid for prostatitis - Google Patents
Formula and preparation process of blueberry compound oral liquid for prostatitis Download PDFInfo
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- CN103735658A CN103735658A CN201310549498.2A CN201310549498A CN103735658A CN 103735658 A CN103735658 A CN 103735658A CN 201310549498 A CN201310549498 A CN 201310549498A CN 103735658 A CN103735658 A CN 103735658A
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Abstract
The present invention discloses a formula and a preparation process of a blueberry compound oral liquid for prostatitis. The oral liquid is prepared from the following raw materials, by weight: 40-60 parts of vacciniumvitis-idaea, 10-20 parts of blueberry, 15-20 parts of black currant, 5-15 parts of rubus corchorifolius, and 10-20 parts of clerodendranthus spicatus, wherein the raw materials are subjected to extraction and concentration, and the obtained material is added to a macroporous resin to enrich active ingredients so as to prepare the oral liquid. According to the present invention, the blueberry compound oral liquid is prepared by adopting green plant raw materials, clinical trial results show that clinical symptoms of prostatitis patients can be significantly improved with the traditional Chinese medicine composition of the invention, the cure rate is high, no adverse reaction exists in the clinic, the treatment effect is exact, and safety and reliability are provided.
Description
Technical field
The invention belongs to and want medicine, field of health care food, in particular to a kind of for prostatitic blueberry compound oral liquid and preparation technology thereof.
Background technology
Prostatitis refers to the active chronic inflammation due to prostate specific and non-specific infection, thus the whole body causing or local symptom.Prostatitis can be divided into prostatitis, congestion of prostate, prostatic hyperplasia and the prostatodynia that non-specific bacterial prostatitis, idiopathic bacterial prostatitis (claiming again prostatosis), specific prostatitis (being caused by gonococcus, tulase, fungus, parasite etc.), nonspecific granulomatous prostatitis, other pathogen (as virus, mycoplasma, chlamydia etc.) cause.
Prostatitis becomes the common infectious disease of male reproductive system, although be not fatal disease, but have a strong impact on patients ' life quality, because prostate anatomical position is special, prostate conduit at right angles or diagonal enter urethra, be unfavorable for body of gland drain, and be beneficial to urethra pathogenic microorganism, enter body of gland, prostatic epithelium has adipose membrane to exist, antibacterials are difficult for entering prostate acinus from blood plasma disperse, prostate focus is easy fibrosis around, affecting antibacterials spreads to focus, therefore clinical use antibiotic therapy chronic prostatitis fails to obtain satisfactory effect so far, and clothes for patients is with adding heavy patient after Western medicine as the visceral organ injury of kidney, cause the state of an illness further to worsen.
At present, Chinese medicine has shown good effect in control prostatitis disease, but prostatitis is longer the course for the treatment of, need long-term taking, drug metabolism causes very large burden to kidney liver, so be necessary, for prostatitic pathogenesis, to research and develop a kind of clinical efficacy definite the health food compound recipe that untoward reaction is low.
China Changbai Mountain and the Xing'anling mountains one band many wild blueberries of self-sow (Vaccinium spp), unique flavor, sour-sweet suitable, mouthfeel is good, can be used to eat, make the use of beverage, spice, wine brewing, have higher health care and be worth, nowadays the fashionable world, is one of five large healthy fruit of the World Food Programme's recommendation.Blue berry just successfully carried out domestication's cultivation in recent years, in Blueberry, contain abundant nutritional labeling, it not only has good nutrition health-care functions, can strengthen human organism's immunity, also there is very strong antiinflammatory action, in addition, Vaccinium vitis-idaea (Vaccinium Vitisidaea L.), black currant (Ribes nigrum L.), Rubus corchorifolius Linn. f. (Rubus corchorifolius Linn.f.) be inner all contains abundant procyanidin, there is stronger antioxidation, can diminish inflammation, improve immunity of organisms.
Herba clerodendranthi spicati (Clerodendranthus spicatus) derives from the herb of Clerodendranthus spicatus (Thunb.) C.Y.Wu eX H.W.Li, there is heat-clearing and toxic substances removing, inducing diuresis to remove edema, the functions such as diuresis fossil are that traditional Dai Nationality is medical in the first-selected medical material that prevents and treat the infection diseases of urinary system such as kidney, bladder, urethra.Modern study shows, clerodendranthus spicatus extract has diuresis and expelling stone, antioxidation, blood pressure lowering, protects the liver isoreactivity, in kidney tea, active component is mainly methoxy flavone, by sinensetin, eupatorin, eupatorin-5-methyl ether etc., formed, have obvious antiinflammatory action, liposoluble ingredient wherein has good anti-oxidation health function.
Summary of the invention
Goal of the invention: for above-mentioned situation, choose best proportioning, invent a kind of curative effect clear and definite, the prostatitic blueberry compound oral liquid of control of safety non-toxic.
Technical solution of the present invention is: take following weight portion raw material, comprise Vaccinium vitis-idaea (Vaccinium Vitisidaea L.) 40-60 part, blue berry (Vaccinium spp) 10-20 part, black currant (Ribes nigrum L.) 15-20 part, Rubus corchorifolius Linn. f. (Rubus corchorifolius Linn.f.) 5-15 part, Herba clerodendranthi spicati (Clerodendranthus spicatus (Thunb.) C.Y.Wu ex H.W.Li) 10-20 part, take the Vaccinium vitis-idaea of dry rear (water content is 10-25%) of described weight portion, blue berry, black currant, Rubus corchorifolius Linn. f., add 20-50 water doubly, preheat 80-90 ℃, fully water suction is 2 hours, after softening, beater is pulverized, it is consistent that colloid mill is ground to granule, 100 mesh sieves filter and obtain fruit juice, Herba clerodendranthi spicati was pulverized to 80 mesh sieves, after mixing, add 5-20 times of water, reflux, extract, 1-3 hour, filter, filtrate decompression is concentrated into relative density 1.05-1.15, obtain concentrated solution.Abundant mixed concentrated liquid and fruit juice, upper macroporous resin column, by different concentration ethanol eluant solution, collects 30-70% ethanol elution, and concentrating under reduced pressure, reclaims ethanol, obtains eluting concentrated solution.Get eluting concentrated solution 10-30 part, add 1-5 part correctives, 1-5 part precipitant, with deionized water standardize solution to 100 part, filtration, sterilizing, fill, obtain oral liquid.
Advantage of the present invention: after rational formula, can bring into play the specific of advantages of nontoxic raw materials, strengthen anti-inflammatory activity, can obviously prevent and treat prostatosis.
Below in conjunction with embodiment, embodiment of the present invention are explained in further detail.
The specific embodiment
The following examples are exemplary; only for explaining the present invention; and can not be interpreted as limitation of the present invention; should be understood that; for those skilled in the art; under the premise without departing from the principles of the invention, can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
The preparation of embodiment 1 oral liquid
45 parts of Vaccinium vitis-idaea, 10 parts of blue berries, 15 parts of black currant, 10 parts of Rubus corchorifolius Linn. f.s, 20 parts of Herba clerodendranthi spicati, take Vaccinium vitis-idaea, blue berry, black currant, the Rubus corchorifolius Linn. f. of dry rear (water content 10%) of described weight portion, the water that adds 20 times, preheat 80 ℃, fully water suction is 2 hours, after softening, beater is pulverized, it is consistent that colloid mill is ground to granule, 100 mesh sieves filter and obtain fruit juice, and Herba clerodendranthi spicati was pulverized to 80 mesh sieves, add 5 times of water after mixing, reflux, extract, 1 hour, filter, filtrate decompression is concentrated into relative density 1.05, obtains concentrated solution.Abundant mixed concentrated liquid and fruit juice, upper macroporous resin column, by different concentration ethanol eluant solution, collection 30% is alcohol eluen, and concentrating under reduced pressure reclaims ethanol, obtains eluting concentrated solution.Get 10 parts of eluting concentrated solutions, add 1 part of correctives, 1 part of precipitant, with deionized water standardize solution to 100 part, filtration, sterilizing, fill, obtain oral liquid.
The preparation of embodiment 2 oral liquids
50 parts of Vaccinium vitis-idaea, 20 parts of blue berries, 10 parts of black currant, 10 parts of Rubus corchorifolius Linn. f.s, 10 parts of Herba clerodendranthi spicati, take Vaccinium vitis-idaea, blue berry, black currant, the Rubus corchorifolius Linn. f. of dry rear (water content 25%) of described weight portion, the water that adds 50 times, preheat 90 ℃, fully water suction is 2 hours, after softening, beater is pulverized, it is consistent that colloid mill is ground to granule, 100 mesh sieves filter and obtain fruit juice, and Herba clerodendranthi spicati was pulverized to 80 mesh sieves, add 20 times of water after mixing, reflux, extract, 3 hours, filter, filtrate decompression is concentrated into relative density 1.15, obtains concentrated solution.Abundant mixed concentrated liquid and fruit juice, upper macroporous resin column, by different concentration ethanol eluant solution, collects 70% ethanol elution, and concentrating under reduced pressure, reclaims ethanol, obtains eluting concentrated solution.Get 30 parts of eluting concentrated solutions, add 5 parts of correctivess, 5 parts of precipitant, with deionized water standardize solution to 100 part, filtration, sterilizing, fill, obtain oral liquid.
The preparation of embodiment 3 oral liquids
45 parts of Vaccinium vitis-idaea, 15 parts of blue berries, 15 parts of black currant, 10 parts of Rubus corchorifolius Linn. f.s, 15 parts of Herba clerodendranthi spicati, take Vaccinium vitis-idaea, blue berry, black currant, the Rubus corchorifolius Linn. f. of dry rear (water content 15%) of described weight portion, the water that adds 40 times, preheat 85 ℃, fully water suction is 2 hours, after softening, beater is pulverized, it is consistent that colloid mill is ground to granule, 100 mesh sieves filter and obtain fruit juice, and Herba clerodendranthi spicati was pulverized to 80 mesh sieves, add 10 times of water after mixing, reflux, extract, 2 hours, filter, filtrate decompression is concentrated into relative density 1.00, obtains concentrated solution.Abundant mixed concentrated liquid and fruit juice, upper macroporous resin column, by different concentration ethanol eluant solution, collects 50% ethanol elution, and concentrating under reduced pressure, reclaims ethanol, obtains eluting concentrated solution.Get 20 parts of eluting concentrated solutions, add 2 parts of correctivess, 3 parts of precipitant, with deionized water standardize solution to 100 part, filtration, sterilizing, fill, obtain oral liquid.
The preparation of embodiment 4 oral liquids
50 parts of Vaccinium vitis-idaea, 10 parts of blue berries, 15 parts of black currant, 15 parts of Rubus corchorifolius Linn. f.s, 10 parts of Herba clerodendranthi spicati, take Vaccinium vitis-idaea, blue berry, black currant, the Rubus corchorifolius Linn. f. of dry rear (water content 20%) of described weight portion, the water that adds 20 times, preheat 80-90 ℃, fully water suction is 2 hours, after softening, beater is pulverized, it is consistent that colloid mill is ground to granule, 100 mesh sieves filter and obtain fruit juice, and Herba clerodendranthi spicati was pulverized to 80 mesh sieves, add 20 times of water after mixing, reflux, extract, 1-3 hour, filter, filtrate decompression is concentrated into relative density 1.15, obtains concentrated solution.Abundant mixed concentrated liquid and fruit juice, upper macroporous resin column, by different concentration ethanol eluant solution, collects 60% alcohol eluen, and concentrating under reduced pressure, reclaims ethanol, obtains eluting concentrated solution.Get 15 parts of eluting concentrated solutions, add 35 parts of correctivess, 5 parts of precipitant, with deionized water standardize solution to 100 part, filtration, sterilizing, fill, obtain oral liquid.
Embodiment 5 oral liquid pharmacodynamic evaluations
1, clinical data
320 routine chronic prostate cases all derive from attached the second andrology of hospital of Heilongjiang University of Chinese Medicine, inclusive criteria: (1) frequent micturition, urgent micturition, dysurea, dysuria; Perineum, rear urethra or rectal tenesmus discomfort or pain, urethral orifice has milky secretions, especially in abdominal pressure increase situation, oozes when urinating eventually end or stool etc.; (2) the full visual field or in heaps in a large number of examination of prostatic fluid leukocyte; (3) perineal position, rear urethral irritation or long-time dull pain are uncomfortable, and in prostatic fluid (EPS), leukocyte count WBC counting is higher than 15/HP.
2, Therapeutic Method
Experiment grouping: above 320 routine chronic prostate patients are divided into 3 groups, the oral liquid that the embodiment of the present invention 1 prepares, low dose group (30mL/ time, every day 3 times) 100 examples, high dose are (60mL/ time, every day 3 times) 120 examples, each 4 of the QIANLIEKANG that matched group Zhejiang Kang Enbei drugmaker produces, every day 3 times, 100 examples, taking one month is a course for the treatment of.The inactive prostatitic Chinese and western drugs of all treatments during treatment, the wine of simultaneously banning on opium-smoking and the opium trade, avoids cold and uncooked food, happy feelings will, joint sexual life etc., follow up a case by regular visits to 12 months.
3, efficacy assessment standard
Clinical recent healing: transference cure; prostate palpation tenderness disappears; prostate quality is recovered normal or is approached normal; apply international prostatitis symptom grade form (NIH-CPSI) test and appraisal severity of symptom; EPS routine test counting WBC number; to WBC in EPS, count, have or not the relation of pus cell and CPSI scoring to carry out statistical analysis, EPS checks normal.Effective: symptom disappears (treating rear than reducing 70%～89% before treatment) substantially, and prostate palpation tenderness and quality are all improved, and EPS checks the front minimizing 1/2 of WBC value or <15/Hp.Effective: symptom alleviates (treatment is rear reduces 30～69% than before treating), the front improvement of WBC count check in prostate palpation and EPS.Invalid: symptom alleviates integration and reduces <30% or unchanged or increase the weight of, in prostate palpation and EPS, WBC count check is also without improvement or increase the weight of.
4, therapeutic outcome
The high and low dose group of the oral liquid that the embodiment of the present invention 1 prepares and the prostate patient of matched group are after taking a course for the treatment of, and concrete clinical diagnosis result is as shown in table 1:
The Clinical efficacy comparison of table 1 Chinese medicine compound and matched group
Clinical experiment result by table 1 shows, blueberry compound oral liquid provided by the invention has good therapeutical effect to chronic prostatitis, low, the cure rate of high dose group is respectively 27% and 31.7%, and total obvious effective rate is respectively 42% and 66.7%, total effective rate is up to 92% and 95%, all than matched group better efficacy, and there is not toxic and side effects in clinical experiment, show that blueberry compound oral liquid provided by the invention is safe and reliable, in 12 months follow-up follow-up investigations, heal the sick and do not occur and cross the state of an illness and rebound, effect stability, this drug oral is convenient, drug effect is clear and definite, be expected to be developed to the medicine of a new generation's treatment chronic prostatitis.
Claims (6)
1. a blueberry compound oral liquid, it is characterized in that, described oral liquid prescription is made by following weight portion raw material, comprises dried Vaccinium vitis-idaea (Vaccinium Vitisidaea L.) 40-60 part, blue berry (Vaccinium spp) 10-20 part, black currant (Ribes nigmm L.) 15-20 part, Rubus corchorifolius Linn. f. (Rubus corchorifolius Linn.f.) 5-15 part, Herba clerodendranthi spicati (Clerodendranthus spicatus (Thunb.) C.Y.Wu eX H.W.Li) 10-20 part.
2. a preparation technology who prepares blueberry compound oral liquid as claimed in claim 1, is characterized in that, preparation technology comprises the following steps:
(1) take Vaccinium vitis-idaea, blue berry, black currant, the Rubus corchorifolius Linn. f. of dry rear (water content is 10-25%) of described weight portion, add 20-50 water doubly, preheat 80-90 ℃, fully water suction is 2 hours, after softening, beater is pulverized, it is consistent that colloid mill is ground to granule, and 100 mesh sieves filter and obtain fruit juice;
(2) Herba clerodendranthi spicati was pulverized to 80 mesh sieves, and added 5-20 times of water after mixing, reflux, extract, 1-3 hour, filters, and filtrate decompression is concentrated into relative density 1.05-1.15, obtains concentrated solution;
(3) abundant mixed concentrated liquid and fruit juice, upper macroporous resin column, by different concentration ethanol eluant solution, collects 30-70% alcohol eluen, and concentrating under reduced pressure, reclaims ethanol, obtains eluting concentrated solution.
3. preparation technology as claimed in claim 2, is characterized in that getting eluting concentrated solution 10-30 part, adds 1-5 part correctives, 1-5 part precipitant, and with deionized water standardize solution to 100 part, filtration, sterilizing, fill, obtain oral liquid.
4. the preparation technology as described in any one in claim 2 and 3, is characterized in that the correctives, the precipitant that add are the food additive that medicine can receive.
5. the preparation technology as described in any one in claim 2 and 3, is characterized in that the oral liquid for preparing having the prostatitis of alleviating, and alleviates the effect of dysurea symptom.
6. the application of blueberry compound oral liquid claimed in claim 1 in treatment chronic prostatitis.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102726792A (en) * | 2012-07-03 | 2012-10-17 | 哈尔滨怡康药业有限公司 | Composite fruit juice and its processing method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102726792A (en) * | 2012-07-03 | 2012-10-17 | 哈尔滨怡康药业有限公司 | Composite fruit juice and its processing method |
Non-Patent Citations (2)
| Title |
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| 李金雨、康龙泉: "猫须草的研究和开发利用进展", 《江西农业学报》, vol. 22, no. 3, 31 December 2010 (2010-12-31), pages 99 - 104 * |
| 王华等: "几种小浆果生物活性物质研究进展", 《北方园艺》, no. 8, 31 December 2011 (2011-12-31), pages 198 - 203 * |
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Inventor after: Liu Bin Inventor after: Qu Yan Inventor after: Liu Daxu Inventor after: Wang Jiatian Inventor after: Wu Di Inventor after: Wang Yeqiu Inventor after: Yu Haomiao Inventor after: Huo Changkun Inventor after: Li Yuying Inventor after: Liu Shiquan Inventor after: Tan Xiaolong Inventor after: Zhou Zhongguang Inventor after: Zhang Ning Inventor before: Yu Haomiao Inventor before: Li Yuying Inventor before: Huo Changkun Inventor before: Liu Shiquan Inventor before: Tan Xiaolong Inventor before: Zhou Zhongguang Inventor before: Zhang Ning |
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Effective date of registration: 20160601 Address after: 165302 Heilongjiang area of Greater Khingan Range Province, Mohe County County town of Amuer Forest Road No. 18 Applicant after: DAXINGANLING ICE BERRY MANOR BIOLOGICAL TECHNOLOGY DEVELOPMENT CO., LTD. Address before: Mohe County County in Heilongjiang Province town of Donghua road 165302 in Greater Khingan Range area Applicant before: Da Xing'an Ling Arctic Ice Blueberry Chateau Co., Ltd. |
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Effective date of registration: 20190401 Address after: Room 409, Office Building, Tonghe Economic Development Zone, Tonghe County, Harbin City, Heilongjiang Province Patentee after: Harbin Bingye Forest Berry Biotechnology Development Co., Ltd. Address before: 165302 No. 18 Linhai Road, Amur Town, Mohe County, Daxing'an Mountains, Heilongjiang Province Patentee before: DAXINGANLING ICE BERRY MANOR BIOLOGICAL TECHNOLOGY DEVELOPMENT CO., LTD. |
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