CN1037270C - 1,6-二磷酸果糖的干燥方法 - Google Patents

1,6-二磷酸果糖的干燥方法 Download PDF

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CN1037270C
CN1037270C CN93110527A CN93110527A CN1037270C CN 1037270 C CN1037270 C CN 1037270C CN 93110527 A CN93110527 A CN 93110527A CN 93110527 A CN93110527 A CN 93110527A CN 1037270 C CN1037270 C CN 1037270C
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fdp
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high temperature
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aqueous solution
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CN1089616A (zh
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欧阳平凯
殷志敏
应汉杰
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Abstract

本发明是一种生化药品的干燥方法，特别涉及1，6-二磷酸果糖的干燥方法。本文明突破了国内外同行普遍认为FDP-遇高温就会分解而变成废物的偏见，采用喷雾装置将FDP水溶液雾化，再输入高温空气，在极短时间内使水分迅速蒸发而不使FDP分解，然后得到FDP干粉。解决了目前普遍采用的冷冻干燥法提取率低、设备价格昂贵、耗电多、水分含量仍高，不能大批量工业化生产的缺陷，也解决了FDP不需冷冻而作为FDP水溶液制品所存在的易变质、保存期且运输困难、运费高的毛病。

Description

1，6-二磷酸果糖的干燥方法
本发明是一种对生化药品浓缩液的干燥方法，特别涉及一种对1，6-二磷酸果糖(FDP)浓缩液的干燥方法。
在制药行业中，对FDP浓缩液的干燥，大多采用冷冻干燥方法，即将FDP浓缩液放入冷冻干燥机内，经零下20℃左右的低温冷冻、结冰，抽真空后水份被吸掉，得到FDP干燥品。但缺点是冷冻干燥机价格昂贵(大多数是进口设备)、体积小，大工业化生产受到限制，又耗电多，并且时间长，而最致命的是FDP干燥品中水份含量仍偏高，极易变质。近年来，出现了一种不须冷冻干燥的FDP水溶液，虽生产成本低，但FDP水溶液难以长期保存，一般保存期只有180天左右，体积庞大造成运输困难且运费也高。而国内外同行一致认为FDP浓缩液中的FDP不耐高温，不能进行高温干燥，否则一旦遇到高温，则FDP就会分解而变成废物，使生产、提纯的成品前功尽弃。
本发明的目的就是要解决上述干燥方法的缺陷，并突破国内外同行对FDP不耐高温，不能采用高温方法进行干燥的偏见，使得本发明的干燥方法简便易行，周期短，效果佳，不仅其设备、运行过程价格低廉，而且不受量的限制，易于大工业化生产，减少成品中的水份含量。
本发明的其它目的和优点将在下面的说明中得到进一步阐述。
本发明的基本设想就是虽然FDP极怕高温，一遇高温就会分解，但在极短时间内，FDP遇高温并不会立即分解。所以，若要采用高温干燥，必须在数秒钟内达到干燥目的。本发明正是在这个基本设想上，通过下面的实施例完成了对FDP浓缩液进行高温干燥得到含量极高的FDP干粉。
实施例：
取8升FDP三钠盐浓缩液，该浓缩液中含FDP三钠盐279克。将该浓缩液注入喷雾干燥机中，喷雾干燥机中的高速圆盘以数万转/分的高速将FDP浓缩液击打成雾状，再将160℃的高温无菌干燥空气吹入，同时启动旋风分离器，高温无菌干燥空气与FDP雾状液滴相遇，接触在8秒内，其中的水份被迅速蒸发，去除了水份的FDP干粉自然落下，经旋风分离器分离进入FDP储槽，收集得到FDP干燥成品288克，其中含水量只占2％，大大低于冷冻干燥法。

Claims (1)

1. 1，6-二磷酸果糖(FDP)的干燥方法，其特征在于：
(1)将FDP的浓缩液缓缓注入到喷雾装置中，喷雾装置中的高速圆盘将FDP浓缩液击打成雾状；
(2)将加热至160℃的无菌干燥空气连续吹入至喷雾装置中；
(3)根据原液中FDP的浓度不同，料液在喷雾干燥装置中的时间应在8秒内；
(4)经旋风分离器分离水份，收集到FDP干粉。
CN93110527A 1993-01-11 1993-01-11 1,6-二磷酸果糖的干燥方法 Expired - Fee Related CN1037270C (zh)

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CN93110527A CN1037270C (zh) 1993-01-11 1993-01-11 1,6-二磷酸果糖的干燥方法

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CN93110527A CN1037270C (zh) 1993-01-11 1993-01-11 1,6-二磷酸果糖的干燥方法

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CN1037270C true CN1037270C (zh) 1998-02-04

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Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5731291A (en) * 1996-05-08 1998-03-24 Cypros Pharmaceutical Corp. Partially lyophilized fructose-1,6-diphosphate (FDP) for injection into humans
EP0814087A3 (en) 1996-05-08 1999-04-07 Cypros Pharmaceutical Corporation Partially lyophilized fructose-1,6-diphosphate (FDP) for injection into humans
US6076528A (en) * 1996-05-09 2000-06-20 Cypros Pharmaceutical Corp. Injection of fructose-1,6-diphosphate (FDP) prior to coronary artery bypass grafting surgery
US5944020A (en) * 1997-02-25 1999-08-31 Cypros Pharmaceutical Corp. Use of fructose-1 6-diphosphate as an inotrope drug after cardiopulmonary bypass surgery
US6074658A (en) 1997-10-03 2000-06-13 Cypros Pharmaceutical Corp. Treatment of sickle cell anemia crises with fructose-1, 6-diphosphate as an analgesic drug

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3501580A1 (de) * 1984-01-18 1985-07-25 Biomedica Foscama Industria Chimico-Farmaceutica S.p.A., Rom/Roma Verfahren zur reinigung von fructose-2,6-diphosphat (f-2,6-p2) enthaltenden loesungen und therapeutische verwendung der so erhaltenen verbindung

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3501580A1 (de) * 1984-01-18 1985-07-25 Biomedica Foscama Industria Chimico-Farmaceutica S.p.A., Rom/Roma Verfahren zur reinigung von fructose-2,6-diphosphat (f-2,6-p2) enthaltenden loesungen und therapeutische verwendung der so erhaltenen verbindung

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