CN103715192A - Biosensor platform chip and integration method - Google Patents
Biosensor platform chip and integration method Download PDFInfo
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- CN103715192A CN103715192A CN201310277528.9A CN201310277528A CN103715192A CN 103715192 A CN103715192 A CN 103715192A CN 201310277528 A CN201310277528 A CN 201310277528A CN 103715192 A CN103715192 A CN 103715192A
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Abstract
The invention relates to a biosensor platform chip and an integration method. According to a large scale integration circuit CMOS process with a mature technology, the biosensor platform chip is created; a unified integration platform and an interface are provided for various types of biosensors; complicated, independent and special design and manufacture are avoided; and simple and effective integration is realized. According to the invention, digital processing is carried out on a biological sample collected by an integrated biosensor; with the help of wireless data and a power supply technology, high speed sampling, wireless transmission, external storage and flexible detection and analysis are carried out on a large amount of biological data; the wireless platform chip provided by the invention is not limited to the integration of single micro biosensors and is combined with biological compatible package, so that an effective implantable product is realized; the chip can be used in vitro, is integrated with various biosensors on a printed circuit board, so as to form a 'mini laboratory'; various types of biological samples can be simultaneously collected and analyzed.
Description
Technical field
The present invention relates to a kind of bio-sensing applicator platform chip and integrated approach.This technology is utilized cheap, and the CMOS technique of technology maturation, for various dissimilar biology sensors provide one to facilitate integrated unified chip platform and interface; And by wireless data and power supply technique, realize high speed acquisition, wireless transmission, exterior storage, the flexible determination and analysis of large number of biological data.
Technical background
Biology sensor is the cross discipline organically combining with bioactive materials (enzyme, protein, DNA, antibody, antigen, biomembrane etc.) and physical chemistry transducer, being the requisite a kind of advanced person's of development biotechnology detection method and method for supervising, is also quick, the micro-analysis method of material molecule level.In the researchs such as clinical diagnosis, Industry Control, food and the Pharmaceutical Analysis of biosensor technology in national economy (comprising bio-pharmaceutical research and development), environmental protection and biotechnology, biochip, have a wide range of applications.In present stage, there is separately greatly difference in various biology sensor products, substantially also only rest on the stage that particular design is manufactured for specific application, and implantable biologic sensor chip is very few especially in form, size, design.In general, biology sensor utilizes be subject to body device and the sensing device of its special manufacture to gather after biological specimen, need to utilize follow-up signal processing and digital processing circuit by sample digitlization, just can effectively read and analyze.In the situation of doing things in his own way at present, each specific application needs for its redesign and manufactures corresponding signal and process and digital processing circuit, thereby wastes a large amount of human and material resources and time.Meanwhile, owing to lacking the support of wireless data and power supply technique, traditional biology sensor product is kept away unavoidable electric wire and battery, causes oversize and cannot realize implantation.The micro radio biologic sensor chip of application-specific is also only present in the laboratory of research institution at present.In order to break through this situation, the present invention has created the concept of bio-sensing applicator platform chip in good time, utilize cheaply, the CMOS technique of technology maturation, has made one the wireless chip technology of a general platform and interface can be provided for integrated different kind organism transducer.
Summary of the invention
The object of the present invention is to provide a kind of bio-sensing applicator platform chip and integrated approach, and then be all kinds of different biology sensors, comprise electrochemical sensor, visible light sensor, Magnetic Sensor, heat sensor etc., a unified integrated platform and interface are provided, avoid complicated independent particular design manufacture, realize integrated simply and effectively.By using the CMOS chip of large scale integrated circuit design, the biological specimen that the present invention collects integrated biology sensor carries out digitized processing, and by wireless data and power supply technique, realize high-speed sampling, wireless transmission, exterior storage, the flexible determination and analysis of large number of biological data.The scope of application of the present invention includes but are not limited to integrated single microbiosensor on wireless platform chip, and in conjunction with the encapsulation of bio-compatible, thereby realize the effectively property implanted product.This technology also, applicable in vitro, is integrated in this platform chip and multiple biology sensor on printed circuit board (PCB), thereby forms one " miniature laboratory ", can the multiple different biological specimen of collection analysis.This " miniature laboratory " is used in environmental protection aspect, can realize the comprehensive detection analysis to various environmental parameters; If for family, can become " family doctor ", realize facilitate determination and analysis and the historical record of various common biological parameters (as blood pressure, pulse, blood sugar, routine blood test etc.) are followed the trail of and warning etc.
The technical scheme of a kind of bio-sensing applicator platform chip provided by the invention and integrated approach is: a kind of bio-sensing applicator platform chip, comprise independent multichannel input interface, low noise pre-amplification circuit (Low-Noise-Preamplifier), multiplexer channel is selected circuit (Multiplexer), analog to digital conversion circuit (Analog to Digital Converter, ADC), logic control circuit (Digital Controller), storage inside circuit (Memory), wireless receiver circuit (Wireless Transceiver), wireless power circuit (Wireless Power Recovery).By foregoing circuit module, the mode by large scale integrated circuit is integrated on chip piece this platform chip, thereby provides a unified platform and interface for various dissimilar biology sensors provide a unified biology sensor.
As preferably, described bio-sensing applicator platform chip adopts complementary metal oxide semiconductors (CMOS) CMOS (Complementary Metal Oxide Semiconductors) art designs manufacture.CMOS technique is cheap, and design and fabrication technology is ripe, stable performance, and development rapidly, is therefore the first-selection of large scale integrated chip standardization, microminiaturization, is also the first-selection of bio-sensing applicator platform chip of the present invention.
As preferably, described independent multichannel input interface has the independent input passage of high density (be quantity reaches up to a hundred), can be used for gathering different biological specimens, or gathers the sample of zones of different; The sample that simultaneously gathers One's name is legion detects to analyze can greatly increase operating efficiency, and guarantees the reliability of testing result; For reaching chip high density, the requirement of small size, adopting nano level CMOS technique is an effective means.
As preferably, described multiplexer channel selects circuit under the control of logic control circuit, for different application, only can select the required passage of using; Be that the high density passage that platform chip of the present invention has might not all can be used, in different application, the passage that has varying number is idle; Chip is to arrange by receiving order and the configuration information of external equipment to the selection of passage; This design has great flexibility, makes on a unified platform chip biology sensor can be integrated dissimilar, varying number, thereby has successfully avoided the complicated independent particular design of different product.
As preferably, the sequential that analog-digital conversion circuit as described provides according to described logic control circuit and order are digital signal by the sample conversion of a plurality of acquisition channels in an orderly manner; This analog to digital conversion circuit should have large dynamically input range to meet the specification demands of different sensors.
As preferably, the sample rate of analog-digital conversion circuit as described has reasonably larger Dynamic Selection scope, and can send configuration information by external command is the different different sample rates of channel setting; This design can be advantageously applied to when a plurality of biology sensors of this platform integrated chip, and the requirement of the sample rate of different biological specimens is had to the situation of bigger difference in different input channels.
As preferably, described logic control circuit is responsible for multiplexer channel and is selected circuit to the selection of passage and sequencing control; Be responsible for the setting of analog to digital conversion circuit sample frequency; Be responsible for reading and the processing of packing data from internal storage; Be responsible for the communication with wireless receiver circuit; Logic control circuit is except by the orderly sample of collecting successively input channel used of normal mode, can also realize the switch that any input channel is carried out to any duration by order and control; The design of the logic control circuit of this Series Intelligent provides great flexibility and fail safe, can and require for different application this platform chip to control and adjust.
As preferably, the digital signal that described storage inside circuit obtains each Channel-shifted is temporarily stored; This design can make multiplexer channel select circuit and analog to digital conversion circuit to sample with faster rate, but chip can send data to external equipment with lower data transfer rate.
As preferably, described wireless receiver circuit will be as required, use different transmission frequencies and agreement: as implantable products, can adopt medical treatment implantation Communications service frequency range (Medical Implant Communication Service Band, MICS) or inductance coupling high mode (Inductive Coupling) to dock with taking the external equipment of same protocol; As non-built-in mode product, can take IEEE802.11 agreement or Bluetooth technology and external smart equipment Direct Communication; The large number of biological data wireless that this design gathers chip is sent to external equipment and stores, detects, analyzes and report to the police.
As preferably, described wireless power circuit, can utilize coil coupling mode to carry out wireless power to whole chip, to use when integrated implantable products, avoids Operation battery and electric wire; Meanwhile, this circuit also provides DC power supply direct input interface; When using as non-built-in mode product, can take battery or DC power supply directly to power.
As preferably, above-described all circuit modules are integrated on chip piece by the mode of large scale integrated circuit, for various dissimilar biology sensors provide a unified platform and interface, thereby form bio-sensing applicator platform chip of the present invention; Rely on highdensity acquisition channel and control able to programme extremely flexibly, and carry ripe wireless data and power delivery technology, that the present invention has really realized is dissimilar, the biology sensor of quantity simple and effective integrated, safe and reliable implanted scheme and flexible non-built-in mode scheme are provided, and when having realized a large amount of different biological data, high speed acquisition, wireless transmission, exterior storage, detection are in real time analyzed, historical record is followed the trail of and warning; The present invention will greatly promote the development of association area science and technology.
The integrated method of work that the invention provides a kind of bio-sensing applicator platform chip, comprises the following steps:
A, single or multiple biology sensors are integrated in to this platform chip, the output channel that the is about to biology sensor therewith independent multichannel input interface of platform chip connects;
B, integrated transducer, by the sensor sensing device with bioactive materials contact, gather electrochemical signals, visible light signal, magnetic signal or thermal signal that bioactive materials produces etc., and these signals be converted into micro-signal of telecommunication;
C, the low noise pre-amplification circuit providing by chip generate the micro-signal of telecommunication gathering to each passage proportional " amplifying signal ";
D, the multiplexer channel providing by chip are selected circuit, according to certain sequential, select in an orderly manner " amplifying signal " of each paths, are passed to analog to digital conversion circuit;
E, the sample rate providing according to logic control circuit by analog to digital conversion circuit convert " amplifying signal " digital signal to and are stored in internal storage;
F, the logic control circuit that the digital signal in memory is provided by chip and wireless receiver circuit send in an orderly manner external equipment (smart machine such as special external equipment or computer, smart mobile phone, palmtop PC) and analyze and show, and store the data storage of external equipment into.
As preferably, the quantity of the independent multichannel input interface in step a, should possess highdensity requirement (be quantity reaches up to a hundred); For different application, only need, according to the number of its interface used, select the input interface of respective numbers, and change as required corresponding interface panel (pad) at the location layout of chip surface metal level; The quantity of input interface and concrete channel selecting is able to programme (establishes by external command
Answer the input interface of quantity, and change as required corresponding interface panel (pad) at the location layout of chip surface metal level; The quantity of input interface and concrete channel selecting (by external command, arranging) able to programme.
As preferably, in step a, integrated as the single biology sensor of implantable products and integrated employing inversion chip (flip-chip) binding technology of bio-sensing applicator platform chip; Now the number of bio-sensing applicator platform chip independent multichannel input interface used with and the position that is positioned at chip by number and the relative position of the output channel (interface) of institute's integral biosensor, determined; Complete the encapsulation of taking again airtight bio-compatible after integrated, can be implanted safely and effectively.
As preferably, in step a, integrated as a plurality of biology sensors of non-built-in mode product and the integrated employing printed circuit board (PCB) of bio-sensing applicator platform chip.Now bio-sensing applicator platform chip can first encapsulate to facilitate integrated; Now the number of bio-sensing applicator platform chip independent multichannel input interface used by the number of institute's integral biosensor with and the number of output channel (interface) determine.
As preferably, in step c, the low noise pre-amplification circuit on each road should have low noise, low-power consumption, high cmrr (CMRR), high PSRR (PSRR), performance and changes the characteristics such as little with flow-route and temperature.
As preferably, order and frequency (duration) that the multiplexer channel in steps d selects circuit to set in advance according to logic control circuit are selected " amplifying signal " in a-road-through road and input to analog to digital conversion circuit; Multiplexer channel selects circuit for different application, only to select the required passage of using under the control of logic control circuit; The order that this path is selected and frequency (duration) can change setting by receiving order and the configuration information of external equipment by logic control circuit.
As preferably, the sample rate that the analog to digital conversion circuit in step e sets in advance according to logic control circuit is sampled and is converted to digital signal " amplifying signal " of selected passage; Conventionally the sample rate of analog to digital conversion circuit should select the frequency of circuit selector channel high a lot of than multiplexer channel, so that every paths collects abundant sample point; Sample rate can change setting by receiving order and the configuration information of external equipment by logic control circuit.
As preferably, the sample rate of the analog to digital conversion circuit in step e has reasonably larger Dynamic Selection scope, can under the control of logic control circuit, be the different different sample rates of channel setting.When multiplexer channel selects circuit to select a certain paths, the sample rate of analog to digital conversion circuit will be transformed into the sample rate of selected channel setting automatically; This design can be applicable to when a plurality of biology sensors of this platform integrated chip, and in different input channels, the requirement of the sample rate of different biological specimens is had the situation of bigger difference.
As preferably, the digital signal converting in step e is temporarily stored by storage inside circuit; This design can make multiplexer channel select circuit and analog to digital conversion circuit to sample with faster rate, but chip can send data to external equipment with lower data transfer rate.
As preferably, in step f, wireless receiver circuit is by according to application compatible different transmission frequencies and agreement: as implantable products, can adopt medical treatment to implant Communications service frequency range (Medical Implant Communication Service Band, MICS) or inductance coupling high mode (Inductive Coupling) is docked with taking the external equipment of same protocol; As non-built-in mode product, can take IEEE802.11 agreement or Bluetooth technology and external smart equipment Direct Communication.
As preferably, step f peripheral equipment, except possessing data real-time analysis, demonstration and warning function, can also carry out exterior storage to data by data storage elements, so as to call that historical data is followed the tracks of, trend analysis research etc.
The present invention is by providing the design of the bio-sensing applicator platform chip of a unified standard, for various microbiosensors provide a unified platform and interface, avoid the complicated independent particular design manufacture of biology sensor product, realized integrated simply and effectively.Bio-sensing applicator platform chip of the present invention adopts the encapsulation of bio-compatibility after both can integrated single-sensor, is implanted safely, utilizes wireless power and the communication technology effectively to work; Also after can encapsulating on printed circuit board (PCB) integrated a plurality of transducers, form in " miniature laboratory ", and utilize conventional wireless technical communication.In two kinds of modes, wireless data all can be stored, analyze and be called by external smart equipment.
Accompanying drawing explanation
Fig. 1 is that the present invention uses schematic diagram as implantable products.
Fig. 2 is that the present invention uses schematic diagram as non-built-in mode product.
Fig. 3 is the schematic diagram of the concrete framework of bio-sensing applicator platform chip of the present invention.
Embodiment
Below by the present invention is further described by reference to the accompanying drawings.
Embodiment: the execution mode that the present invention uses as implantable products as shown in Figure 1.
Implant part is comprised of bio-sensing applicator platform chip 10, biology sensor 11, bio-compatible encapsulation 12, inductance-coupled coil 13 and antenna 14.Wherein bio-sensing applicator platform chip 10 is connected with biology sensor 11 to be inverted chip bonding (Flip Chip Bonding) mode.The micro-signal of telecommunication of multichannel producing after the sensing device contact biological specimen of biology sensor 11 through bio-sensing applicator platform chip 10 gather amplify after through a series of digitized signal processing procedures 150, generated data bag (being referred to as forward data) then adopts medical treatment to implant Communications service frequency range 121 by antenna 14 and sends after modulation in an orderly manner.In another kind design ventrocephalad data, also can adopt the technology of load-modulate (Load Modulation) to send by inductance-coupled coil 13.
The basic comprising of special external equipment 22 comprises data transmit-receive and power drives device 20, data storage controller part 21, data analysis processing apparatus 25, display alarm device 26, inductance-coupled coil 23 and antenna 24.By electric energy, the mode 120 by inductance coupling high passes to the inductance-coupled coil 13 on implant to inductance-coupled coil 23, thereby is whole bio-sensing applicator platform chip 10 power supplies.Antenna 24 adopts medical treatment to implant Communications service frequency ranges 121 and 14 communications of implant antenna, the data that antenna 24 receives after data transmit-receive and 20 demodulation of power drives device in the interior storage of data storage controller part 21.The related data of data analysis processing apparatus 25 calling data storage control part 21 interior storages is calculated, analyzing and processing, and correlated results is shown and reported to the police by display alarm device 26.Under another kind design, data communication also can complete by the mode 120 of inductance coupling high.The forward data that bio-sensing applicator platform chip produces can adopt load-modulate technology to change the load of inductance-coupled coil 13, and the induction by inductance-coupled coil 23 passes to special external equipment 22.
It should be noted that, no matter be to adopt antenna or adopt inductance-coupled coil to carry out data communication, data link is all two-way.Special external equipment can produce different order and configuration information by storage control part 21, and the bio-sensing applicator platform chip of implant part is carried out to certain operations control.These orders and configuration information are referred to as reverse data.Reverse data can adopt medical treatment to implant Communications service frequency range 121 by antenna 24 and 14, equally also can design modulated in power driving signal at another kind, by inductance-coupled coil 23 and 13, adopts the mode 120 of inductance coupling high to transmit.
Embodiment: the execution mode that the present invention uses as non-built-in mode product as shown in Figure 2.
Bio-sensing applicator platform chip 10 is integrated with a plurality of biology sensors on printed circuit board (PCB) 28 after encapsulating 50, forms " a miniature laboratory " with the multiple biological specimen ability of check.Numbering 60,61 to 70,71, numbering 80,81 to 90,91 all represents dissimilar a plurality of biology sensors, its actual quantity is irrelevant with numbering, but determined by concrete application, the number of the number of independent multichannel input interface that its maximum quantity is provided by bio-sensing applicator platform chip 10 and the output channel of each biology sensor (interface) determines.Bio-sensing applicator platform chip 10 gathers the biological specimen of each passage, and generated data bag (being referred to as forward data) then adopts IEEE802.11 wireless protocols or Bluetooth technology 122 to send by antenna 14 after modulation in an orderly manner.Under this kind of use pattern, the power supply of whole printed circuit board (PCB) is powered by battery 51 or external dc power.
External smart equipment 103 (computer, smart mobile phone, palmtop PC etc.) can adopt antenna 14 communications of IEEE802.11 wireless protocols or Bluetooth technology and bio-sensing applicator platform chip by its antenna 102, its data that receive are in the interior storage of data storage controller part 100 of smart machine inside.Under the control of relative application software (Applications), the related data of data operation processing apparatus 101 calling data storage control part 100 interior storages is calculated, analyzing and processing, shows correlated results and warning.Equally, external smart equipment 103 can produce different orders and configuration information, and bio-sensing applicator platform chip 10 is carried out to certain operations control.These orders and configuration information are referred to as reverse data.Reverse data adopts IEEE802.11 wireless protocols or Bluetooth technology to transmit by antenna 102 and 14 equally.Therefore data link is two-way.
Embodiment: the concrete structure of bio-sensing applicator platform chip 10 of the present invention as shown in Figure 3.
The power supply of first whole chip can come from inductance-coupled coil 13 and by the mode of inductance coupling high, receive the radio source driving signal of external equipment transmission when using as implantable products, and is direct voltage by wireless power circuit 18 shaping filters.Wireless power circuit 18 also can drive recovered clock signal signal from radio source simultaneously, as the basic clock signal of whole chip, supplies with logic control circuit 19.When using as non-built-in mode product, chip of the present invention does not need to use radio source power supply, can directly power by external dc power or battery 51, and now the system-based clock signal of chip is supplied with by outside crystal oscillator 56.Micro-signal of telecommunication that the integrated single or multiple biology sensors of chip of the present invention produce is first by independent multichannel input interface 130 to 141.Low noise pre-amplification circuit 30 to 41 is amplified to desirable proportional to it " amplifying signal " by micro-signal of telecommunication of each paths.Here number 130 to 141,30 to 41 just as signal purposes, represent a plurality of passage used, do not represent the actual quantity of used passage.These " amplifying signals " are selected circuit 52 through multiplexer channel, under the control of logic control circuit 19 in certain sequence and frequency (duration) select successively a wherein road signal to be input to analog to digital conversion circuit 53.For different application, multiplexer channel selects circuit 52 only can select the required passage of using under the control of logic control circuit 19, and the passage not used will can not be selected.The sample rate that analog to digital conversion circuit 53 provides according to logic control circuit 19 is carried out analog-to-digital conversion to " amplifying signal " of selected passage, is changed into storage in storage inside circuit 54 after digital signal.Analog to digital conversion circuit 53 has the ability by logic control circuit, different sample rates to be set for different passages.Logic control circuit 19 is packed the data in storage inside circuit 54 read in forward data transtation mission circuit 16 with certain sequential again and modulates.Forward data can send by antenna 14, also can under another kind design, adopt load-modulate technology 58 to send by inductance-coupled coil 13.Chip of the present invention can also receive order, configuration information or the confirmation signal etc. from external equipment simultaneously, is referred to as reverse data.Reverse data can receive by antenna 14, selects circuit 17 under the control of logic control circuit 19, according to relevant communications protocol, to decide the control of forward data transtation mission circuit 16 and 15 pairs of antennas 14 of reverse data receiving circuit.Order or configuration information by 15 demodulation of reverse data receiving circuit after and be sent to logic control circuit 19 and carry out some and operate extremely flexibly and control, such as changing the selection setting of 52 pairs of passages of multiplexer channel selection circuit, the setting of selecting sequence and frequency (duration), has the ability to select selected passage arbitrarily with duration arbitrarily; Such as changing the setting of the sample rate of analog to digital conversion circuit 53, to identical or different sample rate of different channel settings etc.Under another kind design, the reverse data of external equipment is modulated at radio source and drives signal to send, and now reverse data can receive by inductance-coupled coil 13, sends reverse data receiving circuit 15 to and carry out demodulation after the range of decrease processes 57.
Claims (22)
1. a bio-sensing applicator platform chip, it is characterized in that: comprise independent multichannel input interface, low noise pre-amplification circuit (Low-Noise-Preamplifier), multiplexer channel selection circuit (Multiplexer), analog to digital conversion circuit (Analog to Digital Converter, ADC), logic control circuit (Digital Controller), storage inside circuit (Memory), wireless receiver circuit (Wireless Transceiver), wireless power circuit (Wireless Power Recovery); By foregoing circuit module, the mode by large scale integrated circuit is integrated on chip piece this platform chip, thereby provides a unified platform and interface for various dissimilar biology sensors.
2. bio-sensing applicator platform chip according to claim 1, is characterized in that: adopt complementary metal oxide semiconductors (CMOS) (Complementary Metal Oxide Semiconductors) art designs manufacture.
3. bio-sensing applicator platform chip according to claim 1, it is characterized in that: described independent multichannel input interface has the independently input channel of high density (be quantity reaches up to a hundred), can be used for gathering different biological specimens, or gather the sample of zones of different.
4. bio-sensing applicator platform chip according to claim 1, is characterized in that: described multiplexer channel selects circuit under the control of described logic control circuit, for different application, only can select the required passage of using; Be that the high density passage that platform chip of the present invention has might not all can be used, in different application, the passage that has varying number is idle; Chip is to arrange by receiving order and the configuration information of external equipment to the selection of passage.
5. bio-sensing applicator platform chip according to claim 1, is characterized in that: the sequential that analog-digital conversion circuit as described provides according to described logic control circuit and order are digital signal by the sample conversion of a plurality of acquisition channels in an orderly manner; This analog to digital conversion circuit should have large dynamically input range to meet the specification demands of different sensors.
6. bio-sensing applicator platform chip according to claim 1 or 5, it is characterized in that: the sample rate of analog-digital conversion circuit as described has reasonably larger Dynamic Selection scope, and can send configuration information by external command is the different different sample rates of channel setting.
7. bio-sensing applicator platform chip according to claim 1, is characterized in that: described logic control circuit is responsible for multiplexer channel and is selected circuit to the selection of passage and sequencing control; Be responsible for the setting of analog to digital conversion circuit sample frequency; Be responsible for reading and the processing of packing data from internal storage; Be responsible for the communication with wireless receiver circuit; Logic control circuit is except by the orderly sample of collecting successively input channel used of normal mode, and the switch that can also carry out any duration to any input channel by transmission order is controlled.
8. bio-sensing applicator platform chip according to claim 1, is characterized in that: the digital signal that described storage inside circuit obtains each Channel-shifted is temporarily stored; This design can make multiplexer channel select circuit and analog to digital conversion circuit to sample with faster rate, but chip can send data to external equipment with lower data transfer rate.
9. bio-sensing applicator platform chip according to claim 1, it is characterized in that: described wireless receiver circuit will be as required, use different transmission frequencies and agreement: as implantable products, can adopt medical treatment implantation Communications service frequency range (Medical Implant Communication Service Band, MICS) or inductance coupling high mode (Inductive Coupling) to dock with taking the external equipment of same protocol; As non-built-in mode product, can take IEEE802.11 agreement or Bluetooth technology and external smart equipment Direct Communication.
10. bio-sensing applicator platform chip according to claim 1, it is characterized in that: described wireless power circuit, can utilize coil coupling mode to carry out wireless power to whole chip, to use, avoid Operation battery and electric wire when integrated implantable products; Meanwhile, this circuit also provides DC power supply direct input interface; When using as non-built-in mode product, can take direct battery or DC power supply.
11. according to the bio-sensing applicator platform chip described in the arbitrary top of claim 1 to 10, it is characterized in that: above-described all circuit modules are integrated on chip piece by the mode of large scale integrated circuit, thereby form bio-sensing applicator platform chip of the present invention; Rely on highdensity acquisition channel and control able to programme extremely flexibly, and carry ripe wireless data and power delivery technology, that the present invention has really realized is dissimilar, the biology sensor of quantity simple and effective integrated, safe and reliable implanted scheme and flexible non-built-in mode scheme are provided, and when having realized a large amount of different biological data, high speed acquisition, wireless transmission, exterior storage, detection are in real time analyzed, historical record is followed the trail of and warning.
The integrated method of work of 12. 1 kinds of bio-sensing applicator platform chips, comprises the bio-sensing applicator platform chip described in 1 to 11 any one, it is characterized in that: comprise the following steps:
A, single or multiple biology sensors are integrated in to this platform chip, the output channel that the is about to biology sensor therewith independent multichannel input interface of platform chip connects;
B, integrated transducer, by the sensor sensing device with bioactive materials contact, gather electrochemical signals, visible light signal, magnetic signal or thermal signal that bioactive materials produces etc., and these signals be converted into micro-signal of telecommunication;
C, the low noise pre-amplification circuit providing by chip generate the micro-signal of telecommunication gathering to each passage proportional " amplifying signal ";
D, the multiplexer channel providing by chip are selected circuit, according to certain sequential, select in an orderly manner " amplifying signal " of each paths, are passed to analog to digital conversion circuit;
E, the sample rate providing according to logic control circuit by analog to digital conversion circuit convert " amplifying signal " digital signal to and are stored in internal storage;
F, the logic control circuit that the digital signal in memory is provided by chip and wireless receiver circuit send in an orderly manner external equipment (smart machine such as special external equipment or computer, smart mobile phone, palmtop PC) and analyze and show, and store the data storage of external equipment into.
The integrated method of work of 13. bio-sensing applicator platform chips according to claim 12, is characterized in that: the quantity of the independent multichannel input interface in step a, should possess highdensity requirement (be quantity reaches up to a hundred); For different application, only need, according to the number of its interface used, select the input interface of respective numbers, and change as required corresponding interface panel (pad) at the location layout of chip surface metal level; The quantity of input interface and concrete channel selecting (by external command, arranging) able to programme.
14. according to the integrated method of work of the bio-sensing applicator platform chip described in claim 12 or 13, it is characterized in that: in step a, integrated as the single biology sensor of implantable products and integrated employing inversion chip (flip-chip) binding technology of bio-sensing applicator platform chip; Now the number of bio-sensing applicator platform chip independent multichannel input interface used with and the position that is positioned at chip by number and the relative position of the output channel (interface) of concrete application and institute's integral biosensor, determined; Complete the encapsulation of taking again airtight bio-compatible after integrated, can be implanted safely and effectively.
15. according to the integrated method of work of the bio-sensing applicator platform chip described in claim 12 or 13, it is characterized in that: in step a, integrated as a plurality of biology sensors of non-built-in mode product and the integrated employing printed circuit board (PCB) of bio-sensing applicator platform chip; Now bio-sensing applicator platform chip can first encapsulate to facilitate integrated; Now the number of bio-sensing applicator platform chip independent multichannel input interface used by the number of institute's integral biosensor with and the number of output channel (interface) determine.
The integrated method of work of 16. bio-sensing applicator platform chips according to claim 12, is characterized in that: in step c, the low noise pre-amplification circuit on each road has low noise, low-power consumption, high cmrr (CMRR), high PSRR (PSRR), performance and changes the characteristics such as little with flow-route and temperature.
The integrated method of work of 17. bio-sensing applicator platform chips according to claim 12, is characterized in that: order and frequency (duration) that the multiplexer channel in steps d selects circuit to set in advance according to logic control circuit are selected " amplifying signal " in a-road-through road and input to analog to digital conversion circuit; Multiplexer channel selects circuit for different application, only to select the required passage of using under the control of logic control circuit; The order that this path is selected and frequency (duration) can change setting by receiving order and the configuration information of external equipment by logic control circuit.
The integrated method of work of 18. bio-sensing applicator platform chips according to claim 12, is characterized in that: the sample rate that the analog to digital conversion circuit in step e sets in advance according to logic control circuit is sampled and is converted to digital signal " amplifying signal " of selected passage; Conventionally the sample rate of analog to digital conversion circuit should select the frequency of circuit selector channel high a lot of than multiplexer channel, so that every paths collects abundant sample point; Sample rate can change setting by receiving order and the configuration information of external equipment by logic control circuit.
19. according to the integrated method of work of the bio-sensing applicator platform chip described in claim 12 or 18, it is characterized in that: the sample rate of the analog to digital conversion circuit in step e has reasonably larger Dynamic Selection scope, can under the control of logic control circuit, be the different different sample rates of channel setting; When multiplexer channel selects circuit to select a certain paths, the sample rate of analog to digital conversion circuit will be transformed into the sample rate of selected channel setting automatically; This design can be applicable to when a plurality of biology sensors of this platform integrated chip, and in different input channels, the requirement of the sample rate of different biological specimens is had the situation of bigger difference.
The integrated method of work of 20. bio-sensing applicator platform chips according to claim 12, is characterized in that: the digital signal converting in step e is temporarily stored by storage inside circuit; This design can make multiplexer channel select circuit and analog to digital conversion circuit to sample with faster rate, but chip can send data to external equipment with lower data transfer rate.
The integrated method of work of 21. bio-sensing applicator platform chips according to claim 12, it is characterized in that: in step f, wireless receiver circuit is by according to application compatible different transmission frequencies and agreement: as implantable products, can adopt medical treatment to implant Communications service frequency range (Medical Implant Communication Service Band, MICS) or inductance coupling high mode (Inductive Coupling) is docked with taking the external equipment of same protocol; As non-built-in mode product, can take IEEE802.11 agreement or Bluetooth technology and external smart equipment Direct Communication.
The integrated method of work of 22. bio-sensing applicator platform chips according to claim 12, it is characterized in that: step f peripheral equipment is except possessing data real-time analysis, demonstration and warning function, can also to data, carry out exterior storage by data storage elements, so as to call that historical data is followed the tracks of, trend analysis research etc.
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