CN103702680A - 采用快速滴定递增剂量方案用于降低与肌肉内施用干扰素有关的流感样症状的方法 - Google Patents

采用快速滴定递增剂量方案用于降低与肌肉内施用干扰素有关的流感样症状的方法 Download PDF

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Publication number
CN103702680A
CN103702680A CN201280019863.2A CN201280019863A CN103702680A CN 103702680 A CN103702680 A CN 103702680A CN 201280019863 A CN201280019863 A CN 201280019863A CN 103702680 A CN103702680 A CN 103702680A
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interferon
week
titration
dose
pack
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CN201280019863.2A
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English (en)
Chinese (zh)
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A·戴肯
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Biogen Inc
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Biogen Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/215—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicinal Preparation (AREA)
CN201280019863.2A 2011-03-15 2012-03-15 采用快速滴定递增剂量方案用于降低与肌肉内施用干扰素有关的流感样症状的方法 Pending CN103702680A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161452807P 2011-03-15 2011-03-15
US61/452,807 2011-03-15
US201161476930P 2011-04-19 2011-04-19
US61/476,930 2011-04-19
PCT/US2012/029201 WO2012125809A1 (en) 2011-03-15 2012-03-15 Method for reducing flu-like symptoms associated with intramuscular administration of interferon using a fast titration escalating dosing regimen

Publications (1)

Publication Number Publication Date
CN103702680A true CN103702680A (zh) 2014-04-02

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CN201280019863.2A Pending CN103702680A (zh) 2011-03-15 2012-03-15 采用快速滴定递增剂量方案用于降低与肌肉内施用干扰素有关的流感样症状的方法

Country Status (25)

Country Link
US (6) US9198955B2 (https=)
EP (1) EP2686002B1 (https=)
JP (2) JP6279905B2 (https=)
KR (1) KR102050339B1 (https=)
CN (1) CN103702680A (https=)
AU (1) AU2012229104B2 (https=)
BR (1) BR112013023609A8 (https=)
CA (1) CA2846786C (https=)
CY (1) CY1120176T1 (https=)
DK (1) DK2686002T3 (https=)
EA (1) EA028448B1 (https=)
ES (1) ES2666850T3 (https=)
HR (1) HRP20180621T1 (https=)
HU (1) HUE036931T2 (https=)
IL (1) IL228425A (https=)
LT (1) LT2686002T (https=)
MX (1) MX359947B (https=)
PL (1) PL2686002T3 (https=)
PT (1) PT2686002T (https=)
RS (1) RS57175B1 (https=)
SG (1) SG193446A1 (https=)
SI (1) SI2686002T1 (https=)
SM (1) SMT201800221T1 (https=)
WO (1) WO2012125809A1 (https=)
ZA (1) ZA201306933B (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012229104B2 (en) * 2011-03-15 2017-03-16 Biogen Ma Inc. Method for reducing flu-like symptoms associated with intramuscular administration of interferon using a fast titration escalating dosing regimen
EP3092305B1 (en) * 2014-01-09 2023-08-02 Kyushu University, National University Corporation Method of producing microglial cells
US11266344B2 (en) 2016-09-21 2022-03-08 Samsung Electronics Co., Ltd. Method for measuring skin condition and electronic device therefor
CN116391233A (zh) * 2020-09-30 2023-07-04 皇家飞利浦有限公司 用于执行剂量滴定的方法和系统

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US4456748A (en) 1981-02-23 1984-06-26 Genentech, Inc. Hybrid human leukocyte interferons
EP0070906B1 (en) 1981-02-04 1986-10-15 Juridical Foundation Japanese Foundation For Cancer Research Human interferon-beta gene
US4695543A (en) 1982-03-23 1987-09-22 Bristol-Myers Company Alpha Interferon GX-1
CA1302320C (en) 1984-06-11 1992-06-02 Hideo Niwa Expression of human cromosomal interferon-_ in animal cells
US5231176A (en) 1984-08-27 1993-07-27 Genentech, Inc. Distinct family DNA encoding of human leukocyte interferons
FI90990C (fi) 1984-12-18 1994-04-25 Boehringer Ingelheim Int Rekombinantti-DNA-molekyyli, transformoitu isäntäorganismi ja menetelmä interferonin valmistamiseksi
EP0205404B1 (en) 1985-06-11 1992-07-15 Ciba-Geigy Ag Hybrid interferons
US5641656A (en) 1993-10-22 1997-06-24 University Of Connecticut Nucleic acids encoding avian interferon (IFN) proteins and recombinant methods using them
JP4878664B2 (ja) * 1996-12-24 2012-02-15 バイオジェン・アイデック・エムエイ・インコーポレイテッド 安定な液体インターフェロン処方物
JP2001104482A (ja) * 1999-10-07 2001-04-17 Terumo Corp ２室型プレフィルドシリンジ
WO2004069302A2 (en) * 2003-01-30 2004-08-19 Becton, Dickinson And Company Holder with safety shield for a drug delivery device
UA92146C2 (ru) * 2004-06-01 2010-10-11 Эйрэс Трейдинг С.А. Стабилизированная жидкая композиция, которая содержит интерферон
US20060089593A1 (en) * 2004-10-26 2006-04-27 Sergio Landau Needle-free injection device for individual users
EP1923085A1 (en) * 2006-11-17 2008-05-21 Sanofi-Aventis Deutschland GmbH Dosing and drive mechanism for drug delivery device
AU2007333959A1 (en) 2006-12-18 2008-06-26 Altus Pharmaceuticals Inc. Human growth hormone formulations
US9044378B2 (en) * 2007-05-31 2015-06-02 Safety Syringes, Inc. Anti-needle stick safety device or system for use with drugs requiring reconstitution
JP5549048B2 (ja) * 2007-08-16 2014-07-16 味の素株式会社 薬剤バイアルとプレフィルドシリンジの接続構造
AU2010263058A1 (en) * 2009-06-18 2012-01-12 Wyeth Llc Lyophilized formulations for small modular immunopharmaceuticals
AU2012229104B2 (en) * 2011-03-15 2017-03-16 Biogen Ma Inc. Method for reducing flu-like symptoms associated with intramuscular administration of interferon using a fast titration escalating dosing regimen

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BIOGEN IDEC INC: "medication guide appendix: instructions for preparing and giving a dose with an avonex prefilled syringe", 《HTTP://WWW.AVONEX.COM/PDFS/GUIDES/LIQUID_APPENDIX_L61023.PDF》 *
FROHMAN ET AL.: "Disease-Modifying Therapy in Multiple Sclerosis: Strategies For Optimizing Management", 《OPTIMIZING MANAGEMENT》 *
J. THEODORE PHILLIPS, MD ET AL.: "A Multicenter, Open-Label, Phase II Study of the Immunogenicity and Safety of a New Prefilled Syringe (Liquid) Formulation of Avonex in Patients with Multiple Sclerosis", 《CLINICAL THERAPEUTICS》 *
就医网: "多发性硬化新药培他干扰素-1α", 《WWW.91.CN/DRUG/XYDQ/XYDT/XYZT/2006-03-28/175978.HTM》 *

Also Published As

Publication number Publication date
US10500254B2 (en) 2019-12-10
US20170360890A1 (en) 2017-12-21
SI2686002T1 (en) 2018-06-29
SG193446A1 (en) 2013-10-30
US9198955B2 (en) 2015-12-01
EA028448B1 (ru) 2017-11-30
US20250276042A1 (en) 2025-09-04
KR102050339B1 (ko) 2019-11-29
BR112013023609A2 (pt) 2016-12-06
IL228425A (en) 2017-08-31
PT2686002T (pt) 2018-04-23
CA2846786C (en) 2022-05-17
IL228425A0 (en) 2013-12-31
BR112013023609A8 (pt) 2018-04-03
CA2846786A1 (en) 2012-09-20
KR20140038383A (ko) 2014-03-28
CY1120176T1 (el) 2018-12-12
LT2686002T (lt) 2018-05-10
US20200046804A1 (en) 2020-02-13
NZ616536A (en) 2015-10-30
JP6279905B2 (ja) 2018-02-14
WO2012125809A1 (en) 2012-09-20
AU2012229104A1 (en) 2013-10-03
HRP20180621T1 (hr) 2018-07-27
NZ712273A (en) 2016-09-30
RS57175B1 (sr) 2018-07-31
US20160101157A1 (en) 2016-04-14
SMT201800221T1 (it) 2018-07-17
PL2686002T3 (pl) 2018-10-31
MX359947B (es) 2018-10-17
ES2666850T3 (es) 2018-05-08
MX2013010507A (es) 2014-04-30
EA201301024A1 (ru) 2014-03-31
DK2686002T3 (en) 2018-04-30
JP6522069B2 (ja) 2019-05-29
ZA201306933B (en) 2016-07-27
AU2012229104B2 (en) 2017-03-16
JP2014508174A (ja) 2014-04-03
HUE036931T2 (hu) 2018-08-28
EP2686002B1 (en) 2018-01-24
US20220280610A1 (en) 2022-09-08
JP2018030847A (ja) 2018-03-01
US20120237479A1 (en) 2012-09-20
EP2686002A1 (en) 2014-01-22

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Address after: Massachusetts, USA

Applicant after: Golden Limited by Share Ltd

Address before: Massachusetts, USA

Applicant before: BIOGEN IDEC INC.

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Application publication date: 20140402