CN103690790B - A kind of Chinese medicine composition for the treatment of chronic radiodermatitis - Google Patents

Abstract

The invention discloses a kind of Chinese medicine composition for the treatment of chronic radiodermatitis. Traditional Chinese medicine is thought, radioactive ray genus " burning hot poison is evil ", and " heat evil causes sore " is the Basic disease cause of radiodermatitis, and " deficiency of Yin is this, and scorching is mark " is basic pathogenesis, and asthenia in origin and asthenia in superficiality runs through whole disease all the time. The present invention selects taking clearing heat and detoxicating, promoting blood circulation and removing blood stasis as main, be aided with Chinese medicine Chinese lizardtail rhizome, ford nervilia leaf, daghestan sweetclover herb, geranium wilfordii, Huang Guoqie, Radix seu Herba Astilbes rivularis, tricephalous kyllinga herb, smoothfruit ventilago root and stem, ginkgo root, tendrilleaf solomonseal rhizome, chorion ovi, the Alectoria asiatica Du Rietz of enriching yin boost qi qi-restoratives, decocting becomes decoction, through clinical testing, total effective rate reaches 97.4%, evident in efficacy.

Description

A kind of Chinese medicine composition for the treatment of chronic radiodermatitis

Technical field

The present invention relates to a kind of Chinese medicine composition, relate in particular to one and treat chronic radioactive skinScorching Chinese medicine composition.

Background technology

Radiodermatitis is to draw because radioactive ray (being mainly β and gamma-rays and x-ray) irradiateThe mucocutaneous struvite infringement rising. This disease be mainly seen in accept radiocurable patient and fromThing radiation work and protect tight person. Chronic radiodermatitis polyphyly is long-term, repeatedly low dose ofContact radioactive source due to, or because of acute radiodermatitis change come, incubation period from the several months extremelyMany decades, inflammation performance is outstanding, atrophoderma is dry, atrophy, hardening, angling hyperplasia,Pigmentation or de-mistake, telangiectasis, nail becomes fragile, and variable color destroys no longer sometimesGrowth, conscious have itch or a burning heat sensation, and skin damages long-term existence, has the canceration may. Doctor trained in Western medicine is controlledTreat this disease and take as the case may be antibiotic or corticosteroid hormone. Side effect obviously andEffect is general. Chinese traditional treatment chronic radiodermatitis is conceived to comprehensive therapeutic effect, modern Chinese herbal medicine medicineReason research discovery, the active component that plurality of Chinese is rich in not only can directly act on affected part,Alleviate patient's symptom, adjusting physiological function that more can many target spots, tends to balance body. ?In therapeutic process, use the medicine of enriching yin boost qi qi-restoratives also to embody the think of that the traditional Chinese medical science is treated both principal and secondary aspect of diseaseThink, take precautions against state of an illness in-depth. And some Chinese medicine be exactly since ancient times can be used as medicine, eat dual-purpose.Therefore the chronic reflectivity dermatitis for the treatment of by Chinese herbs is with stable lasting, obviously malicious secondary work of nothing of curative effectCheap with, medicine valency, the advantage such as can use for a long time.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine composition for the treatment of chronic radiodermatitis.Traditional Chinese medicine is thought, radioactive ray genus " burning hot poison is evil ", and Changes of Radiation Damaged Skin is because heat is maliciousCross Sheng, pyretic damage of yin, cause that heat is accumulate the flesh natural fibre line of meat and caused furfur, erythema, convulsion to itch, the diseases such as ulcer,Belong to traditional Chinese medicine " sore " category. Golden Mirror of Medicine speech " carbuncle and cellulitis being originally caused by fire toxin, channels and collateralsIntercept qi and blood solidifying ", visible " heat evil causes sore " is the Basic disease cause of radiodermatitis, " the moonVoid is this, and scorching is mark " be basic pathogenesis, asthenia in origin and asthenia in superficiality runs through whole disease all the time.Therefore treat taking clearing heat and detoxicating, promoting blood circulation and removing blood stasis as main, be aided with enriching yin boost qi qi-restoratives.

The object of the invention is to be achieved through the following technical solutions this treatment chronic radioactiveThe Chinese medicine composition of dermatitis is made up of the Chinese medicine of following weight portion: Chinese lizardtail rhizome 15-25 part,Ford nervilia leaf 15-25 part, daghestan sweetclover herb 15-25 part, geranium wilfordii 5-9 part, yellow fruit eggplant 15-18Part, Radix seu Herba Astilbes rivularis 9-15 part, tricephalous kyllinga herb 30-60 part, smoothfruit ventilago root and stem 15-30 part, ginkgo root 45-50Part, tendrilleaf solomonseal rhizome 20-40 part, chorion ovi 5-15 part, Alectoria asiatica Du Rietz 10-20 part.

Preferred: 20 parts of Chinese lizardtail rhizomes, 20 parts of ford nervilia leafs, 20 parts of daghestan sweetclover herbs, geranium wilfordii7 parts, really 16 parts of eggplants, 12 parts of Radix seu Herba Astilbes rivularis, 45 parts of tricephalous kyllinga herbs, 25 parts of smoothfruit ventilago root and stems, white of Huang47 parts of roots of fruit, 30 parts of tendrilleaf solomonseal rhizomes, 10 parts of chorion ovis, 15 parts of Alectoria asiatica Du Rietzs.

Above-mentioned Chinese medicine decocting is made decoction by preparation method.

Fang Zhong: Chinese lizardtail rhizome is clearing heat and detoxicating, expelling wind and removing dampness; Ford nervilia leaf heat-clearing, the loose stasis of blood, separatesPoison; Daghestan sweetclover herb heat-clearing, removing toxic substances, dampness elimination; Geranium wilfordii is dispeled the wind, and invigorates blood circulation, clearing heat and detoxicating; YellowFruit eggplant clearing heat and promoting diuresis, the stasis of blood that disappears pain relieving; Radix seu Herba Astilbes rivularis, tricephalous kyllinga herb promoting qi circulation and relieving pain, promoting blood circulation to remove blood stasis,Wines used as antirheumatic; Smoothfruit ventilago root and stem tonifying Qi and blood, dispelling, collateral-activating; Ginkgo root benefit gas qi-restoratives; Tendrilleaf solomonseal rhizome profitLung yin-nourishing, strengthening the spleen and replenishing qi, the hemostasis of eliminating the phlegm, subdhing swelling and detoxicating; Chorion ovi nourishiing yin to clear away the lung-heat; HairSeven enriching yin and nourishing kidney, inducing diuresis for removing edema, improving eyesight.

Clinical data

1. this group of physical data patient 38 examples, are my Out-patient Department and inpatient, through examiningThe disconnected chronic radiodermatitis that is diagnosed as. Wherein male 17 examples, female's 21 examples, mean age 41.9Year; Protopathy is mainly nasopharyngeal carcinoma, hypopharyngeal cancer, carcinoma of mouth etc., before some patients were radiotherapyThe operation of row primary tumor and/or the clear art of neck. All patients all adopt German Siemens linear acceleratingDevice PrimuseE type 6MV-X line and 8MeV-electric wire are treated. According to clinical manifestation ISpend 12 examples, II degree 17 examples, III degree 9 examples.

2. diagnostic criteria (1) local skin is subject to exceeding the irradiation of dose equivalent limit for a long time,Intergal dose equivalent is generally greater than 15SV, is subject to occur that according to after the several years chronic dermatitis changes, and also canProlong silk floss by acute radiation skin injury. (2) clinical manifestation can divide three degree: I degree:Dry skin, coarse, follow the string, slight furfur, fingerprint shoal or disorderly, nail ashDark or longitudinal ridge, banded Se Jia, first is crisp easily splits. II degree: hyperkeratinization, chap, more wartShape projection or atrophoderma attenuation, fingerprint disorder or disappearance, nail thicken distortion. III degree:The long-term ulcer not healing, cutin thrust, the serious angling of finger tip and nail merge, and can mergeTendon contracture, dysarthrasis are tetanic, cutaneum carcinoma. (3) get rid of other skin diseases.

3. this group of methods for the treatment of patient takes Chinese medicine composition of the present invention, takes threeRoot of Pennisetum centrasiaticum Tzvel 20g, ford nervilia leaf 20g, daghestan sweetclover herb 20g, geranium wilfordii 7g, yellow fruit eggplant 16g, open countryChinese sorghum 12g, tricephalous kyllinga herb 45g, smoothfruit ventilago root and stem 25g, ginkgo root 47g, tendrilleaf solomonseal rhizome 30g, phoenixClothing 10g, Alectoria asiatica Du Rietz 15g, decocting becomes decoction, and potion, divided and sooner or later took for 2 times every day, connectedTake 1 month.

4. criterion of therapeutical effect is cured: transference cure, does not stay dysfunction. Take a turn for the better: symptom baseThis disappearance, also can leave some performance of I～II degree chronic skin injury; Ulcer healing,Leave over limbs disturbance. Invalid: symptom is without alleviating or increasing the weight of.

5. this group of result for the treatment of patient 38 example treatments, after one month, are wherein cured 26 examples(68.4%), 11 examples that take a turn for the better (28.9%), invalid 1 example (2.6%), total effective rate is 97.4％。

6. model case patient female, 56 years old, neck rubefaction companion itch after radiotherapy10 years, festered in part, pain 6 months. Patient before 10 years with " neurodermatitis " OKSuperficial X-ray radiotherapy 10 weeks, accumulated dose 800R. After 1 year radiotherapy local skin rubescent,Dry, furfur, with itch, gradually plays pigmentation, depigmentation spot, and itch increases the weight of, outerInstitute gives PIYANPINGSHUANG etc. and controls unsatisfactory curative effect, after half a year foreneck skin damage fester, sepage, redness andPain, and the face that festers expands. Previously body is strong, denies that hepatitis, pulmonary tuberculosis etc. infect medical history,Medicine-less allergy history. Health check-up: T36.2 DEG C, P76 time/min, R18 time/min, BP120/80mmHg, body weight 54kg. Systems inspection no abnormality seen. Dept. of dermatology's situation: can after neckSee the dark red spot of 8cm × 6cm, obscure boundary, edge is irregular, the faint yellow crust of surface knot,Periphery redness, obviously tenderness. Telangiectasis, pigmentation spots and look are seen in erythema surfaceThe de-spot that loses of element, is poikiloderma sample and changes. Skin damages the ulcer of the visible diameter 2cm of central authorities,Dark about 0.5cm, substrate is uneven, and there is a little purulent secretion on surface. Blood WBC8.2×109/L，N0.76，L0.24，RBC4.29×1012/L，Hb133g/L，ESR16mm/ 1h; Excrement, routine urinalysis liver, normal renal function; Abdominal B type ultrasonography x-ray rabat, electrocardiogram is not allSee abnormal. Chronic ulcer tissue pathology: skin blemish, surface red is dyed slough, granulation tissue shapeBecome proliferation of fibroblast, obviously cell infiltration. The other scaly epithelium of ulcer thickens, trueTheliolymphocyte infiltrates, and meets chronic ulcer of skin. Diagnosis: chronic radiodermatitis. ControlTreat: remove ulcer surface slough with curet, take Chinese medicine preparation of the present invention, takeChinese lizardtail rhizome 20g, ford nervilia leaf 20g, daghestan sweetclover herb 20g, geranium wilfordii 7g, yellow fruit eggplant 16g,Radix seu Herba Astilbes rivularis 12g, tricephalous kyllinga herb 45g, smoothfruit ventilago root and stem 25g, ginkgo root 47g, tendrilleaf solomonseal rhizome 30g, phoenixPhoenix clothing 10g, Alectoria asiatica Du Rietz 15g, decocting becomes decoction, and potion, divided and sooner or later took for 2 times every day,After treating 28 days necks, ulcer healing is left hospital. Follow up a case by regular visits to 1 year, ulcer does not recur, and erythema area slightlyDwindle.

Detailed description of the invention

Embodiment mono-: take Chinese lizardtail rhizome 20g, ford nervilia leaf 20g, daghestan sweetclover herb 20g, old storkGrass 7g, yellow fruit eggplant 16g, Radix seu Herba Astilbes rivularis 12g, tricephalous kyllinga herb 45g, smoothfruit ventilago root and stem 25g, ginkgo root47g, tendrilleaf solomonseal rhizome 30g, chorion ovi 10g, Alectoria asiatica Du Rietz 15g, become decoction by above-mentioned Chinese medicine decocting.

Embodiment bis-: take Chinese lizardtail rhizome 25g, ford nervilia leaf 15g, daghestan sweetclover herb 25g, old storkGrass 5g, yellow fruit eggplant 18g, Radix seu Herba Astilbes rivularis 9g, tricephalous kyllinga herb 60g, smoothfruit ventilago root and stem 15g, ginkgo root50g, tendrilleaf solomonseal rhizome 20g, chorion ovi 15g, Alectoria asiatica Du Rietz 10g, become decoction by above-mentioned Chinese medicine decocting.

Embodiment tri-: take Chinese lizardtail rhizome 15g, ford nervilia leaf 25g, daghestan sweetclover herb 15g, old storkGrass 9g, yellow fruit eggplant 15g, Radix seu Herba Astilbes rivularis 15g, tricephalous kyllinga herb 30g, smoothfruit ventilago root and stem 30g, ginkgo root45g, tendrilleaf solomonseal rhizome 40g, chorion ovi 5g, Alectoria asiatica Du Rietz 20g, become decoction by above-mentioned Chinese medicine decocting.

Claims (2)

1. treat a Chinese medicine composition for chronic radiodermatitis, it is characterized in that this Chinese medicineComposition is made up of the Chinese medicine of following weight portion: Chinese lizardtail rhizome 15-25 part, ford nervilia leaf 15-25Part, daghestan sweetclover herb 15-25 part, geranium wilfordii 5-9 part, yellow fruit eggplant 15-18 part, Radix seu Herba Astilbes rivularis 9-15Part, tricephalous kyllinga herb 30-60 part, smoothfruit ventilago root and stem 15-30 part, ginkgo root 45-50 part, tendrilleaf solomonseal rhizome20-40 part, chorion ovi 5-15 part, Alectoria asiatica Du Rietz 10-20 part.

2. a kind of Chinese traditional medicine composition for the treatment of chronic radiodermatitis according to claim 1Thing, is characterized in that this Chinese medicine composition is made up of the Chinese medicine of following weight portion: Chinese lizardtail rhizome20 parts, 20 parts of ford nervilia leafs, 20 parts of daghestan sweetclover herbs, 7 parts of geranium wilfordiis, yellow 16 parts of eggplants of fruit, open country12 parts of Chinese sorghums, 45 parts of tricephalous kyllinga herbs, 25 parts of smoothfruit ventilago root and stems, 47 parts of ginkgo roots, tendrilleaf solomonseal rhizome 30Part, 10 parts of chorion ovis, 15 parts of Alectoria asiatica Du Rietzs.