CN103679391A - Risk assessment system of leather chemicals - Google Patents
Risk assessment system of leather chemicals Download PDFInfo
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- CN103679391A CN103679391A CN201310737348.4A CN201310737348A CN103679391A CN 103679391 A CN103679391 A CN 103679391A CN 201310737348 A CN201310737348 A CN 201310737348A CN 103679391 A CN103679391 A CN 103679391A
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Abstract
The invention discloses a risk assessment system and relates to the risk assessment technology of chemicals in leather in the aspect of influence on human bodies, particularly to the technology of performing safety assessment through three databases including the LogKow coefficient, half-life period data and median lethal dose (LD50). The risk assessment system of the leather chemicals comprises three computer data processing modules including a name standardizing module, a safety determining module and a safety assessing module, and a weighing processing system for manually adding weighed value to the three computer data processing modules. The risk assessment system of the leather chemicals searches for the half-life period data of a substance in the safety determining module through a standard chemical name output by the standardizing module, determines whether to perform safety assessment on the substance and inputs the chemical name of the substance with the half-life period data larger than a set value into the safety assessing module for safety assessment, namely, the risk assessment. The risk assessment system of the leather chemicals solves the problems of lack of unified methods and no comparability of the assessment conclusions in safety assessment on existing common leather chemicals.
Description
technical field
The present invention relates to chemical producting safety assessment technology in a kind of leather that human body is affected to aspect, especially relate to by material half life period data, leather chemicals security ststem and the appraisal procedure of material to these three kinds of indexs of the half lethal dose of human toxicity (LD50) of the partition factor of the n-octyl alcohol/water of accumulation property aspect (LogKow), physical property variation aspect in vivo.
background technology
At present to the safe evaluation method with chemicals, generally adopt zoopery to carry out toxicological assessment.The chemical substance toxicological experiment integral method that European economy cooperation in 1975 and development institution (OECD) are recommended has become the risk assessment experiment guide of industry, government administration section and the common reference of scientific research team.
Yet, when carrying out biomedicine, toxicology evaluation by a large amount of zooperies people, find that different animal species is not identical to the internal metabolism of chemical substance, whether can indicate exactly on to some zoopery design the harm of human body to propose query.On the other hand, from science angle and economic angle, consider, the whole toxicological experiment influence factors that complete a kind of chemical substance are many, need a large amount of animals used as test, experimental period limit for length, and the environmental facility of letting animals feed, nutrition supply require high, and cost is large; From the angle of animal rights protection, it is also inhuman making animal suffer unnecessary misery and sacrifice.
3R principle: nineteen fifty-three british animal scholar William and microbiologist Rex put forward to reduce as far as possible animal consumption, optimize experimental arrangement or use other means and the zooperal 3R principle of material substitution, 3R reduces (reduction), optimizes the abbreviation of (refinement) and alternative (replacement).After the theory proposition of 3R principle as system, worldwide obtained numerous scientific research personnel's approval, US and European is using 3R principle as the basis of formulating animal welfare rules.3R principle is paid close attention to the development of global biological chemistry, pharmacology, toxicology and biomedical bound pair alternative method, checking more, because the research of alternative method is not merely animal rights protection problem, is also the problem of science development itself.For setting up a rational experimental design, make scientific research more humane, science and technology is more first evolved significant.
Traditional chemical substance safety evaluation need to spend a large amount of funds, human and material resources, animal used as test and time, carry out the investigation of a large amount of zooperies and Field epidemiology and can not adapt to the demand of the research and development speed of noval chemical compound, the toxicity of fast prediction chemicals is targets that modern chemistry product method for evaluating safety will be pursued.Predict that toxicologic target is exactly the relation disclosing between chemicals structure toxicity, sets up the model of predicting between vitro effect predictor internal effect and kind.By analyzing quantitative structure activity relationship, as the computing machine toxicology of one of important research content and the development of toxicogenomics, by the realization for this target, provide possibility.Compound quantitative structure activity relationship (quantitative structure-activity relationship, QSAR) research method is a kind of effective means of illustrating relation between compound structure feature and bio-toxicity.According to toxicity and architectural characteristic, set up the database of known toxicity compound, obtain the best quantitative math-model between toxicity and Three Dimensions Structure, just may set up the toxicity prediction system of unknown some toxicity data of toxic chemical of prediction.Toxicity prediction system is in chemical substance risk assessment, can be the compound that preferably enters relevant toxicological experiment, improve the work efficiency of safety evaluatio, for design and production security compound provide reference frame, and some toxicity datas incomplete chemicals risk assessment and administration of health are had to realistic meaning.
summary of the invention
The object of this invention is to provide conventional chemical substance in leather is carried out to the computer disposal system that fast and safely property is evaluated.
One, first set up chemical name database table, elimination half life values database table, the partition factor logKow database table of n-octyl alcohol/water, the toxicity data storehouse table of chemical substance for normal leather.Then data in these tables are deposited respectively in to the different memory of computer, obtain four corresponding archival memories.
(1) storer B: leather is selected by the title of chemical substance: chemical name conventional in the existing chemical substance register of < < China is selected leather industry in version > > in 2013 is as " standard chemical title " in the present invention, other another name of a certain standard chemical title, popular name obtain with other data or online collection.Both obtained the several chemical name database of B mono-thing, and deposited the storer B of computer in, as the several chemical name archival memory of B mono-thing of the present invention.
(2) storer D: the elimination half life values (unit: sky) that utilizes " the standard chemical title " of conventional chemical substance in EPIsuite inquiry leather chemical industry of the present invention by the SMILES of chemical substance, both obtained D half life period database, and deposit the storer D of computer in, as D of the present invention half life period archival memory.
(3) storer H: the partition factor logKow that utilizes the n-octyl alcohol/water of " the standard chemical title " of conventional chemical substance in EPIsuite inquiry leather chemical industry of the present invention by the SMILES of chemical substance.For logKow coefficient value, as separately there being data, be experiment measured value, generally with experiment, record logKow coefficient value preferentially for partition factor (logKow) database of n-octyl alcohol/water of the present invention.Both obtained the partition factor (LogKow) of H n-octyl alcohol/water, and deposited the storer H of computer in, as partition factor (LogKow) storer of H n-octyl alcohol/water of the present invention.
(4) storer K: inquire about conventional chemical substance, the both toxicity index of " standard chemical title " material, namely LD50(mouse, oral in leather chemical industry of the present invention by TOXNET) value.Both obtained K measured object toxicity index, and deposited the storer K of computer in, as K measured object toxicity index storer of the present invention.
Two, about elimination half life values, logKow coefficient value, toxicity index artificial, determine weighted value table and storer: the security of chemical substance for a kind of leather, can only, by a concept, can only be usually both to ignore risk, low-risk, medium risk, high risk, high risk some.So logKow coefficient value, elimination half life values, these three parameters of toxicity index will be merged into a parameter security are made to unique some judgements.So, be with these three parameters are merged into a total weighted value with the method for weighted value these three parameter weighting values.The weighted value table of these three parameters and the safety evaluatio table of total weighted value below:
(1) leather chemistry material elimination half life values weighted value table and storer D:
Elimination half life values 60--180 days, weighted value is 0.5;
Elimination half life values >180 days, weighted value is 1.0;
This elimination half life values weighted value table is deposited in to computer memory, obtain half life period archival memory D, be called for short storer D.
(2) leather chemistry material logKow coefficient value weighted value table and storer H:
LogKow value <5, weighted value is 0;
5<LogKow value <10, weighted value is 1;
LogKow value > 10, weighted value is 2.
This logKow coefficient weighted value table is deposited in to computer memory, obtain partition factor (LogKow) the storer H of n-octyl alcohol/water, be called for short storer H.
(3) leather chemistry material toxicity index weighted value table and memory I:
LD50>15.0 gkg-1, weighted value is 0.0;
5.0 gkg-1<LD50<15 .0gkg-1, weighted value is 1;
0.5 gkg-1<LD50<5.0 gkg-1, weighted value is 2;
50.0 mgkg-1<LD50<500.0 mgkg-1, weighted value is 3;
LD50<50 .0mgkg-1, weighted value is 4.
This toxicity index weighted value table is deposited in to computer memory, obtain material toxicity index table memory I, be called for short memory I.
(4) the safety evaluatio table of the total weighted value of leather chemistry material.
| Total weighted value | Safe class | Safety evaluatio |
| 0.5 | 1 | Can ignore risk |
| 1-1.5 | 2 | Low-risk |
| 2-2.5 | 3 | Medium risk |
| 3-4.5 | 4 | High risk |
| 5-7 | 5 | Excessive risk |
The risk evaluating system of leather chemicals, comprises three processing modules, and first title standardized module both became visual other standard chemical title of this risk evaluating system the chemical name of input computer; Second security judge module is the no safety assessment of carrying out of judgement; The 3rd security assessment module, both carried out safety assessment with three databases and three weighted value tables to this leather chemicals.
The several chemical name archival memory of first title standardized module: B mono-thing is connected with C measured object standard name validator with A input name memory respectively, C measured object standard name validator is communicated with computor-keyboard, and the several chemical name archival memory of B mono-thing is also communicated with computer display screen.
Second security judge module: D half life period archival memory is connected with E measured object half life period data-carrier store with C measured object standard name validator respectively, E measured object half life period data-carrier store is greater than the measured object standard name of 60 days with the F half life period respectively and is connected with elimination half life values storer, and is communicated with computer display screen.
The 3rd security assessment module
This module is used respectively different weights table by measured object half life period data, the partition factor (LogKow) of measured object H n-octyl alcohol/water, measured object toxicity index, be weighted to respectively three weighted values, again these three weighted values are merged into a total weighted value, by total weighted value, assess the security of chemical substance for this leather;
(1) obtain measured object half life period data coefficient weighted value sub-module: U measured object half life period data-carrier store is greater than measured object standard name and elimination half life values storer and the e people of 60 days with the F half life period respectively and is connected for the leather-like material half life period data weighting value table storer of establishment, e people is connected with the adder calculator of each weighted value of P measured object for the leather-like material half life period data weighting value table storer of working out.
(2) obtain measured object half life period data weighting value sub-module: measured object standard name and elimination half life values storer that G measured object standard name validator is greater than 60 days with the F half life period respectively, the partition factor of H n-octyl alcohol/water (LogKow) storer, computor-keyboard connects, the partition factor of H n-octyl alcohol/water (LogKow) storer and J measured object LogKow coefficient memory, J measured object LogKow coefficient memory is connected with the leather-like material LogKow coefficient weighted value table storer that j people is establishment, j people is that the leather-like material LogKow coefficient weighted value table storer of establishment is connected with the adder calculator of each weighted value of P measured object.
(3) obtain measured object toxicity index weighted value sub-module: measured object standard name and elimination half life values storer that G measured object standard name validator is greater than 60 days with the F half life period respectively, I material toxicity index table storer, computor-keyboard connects, I material toxicity index table storer is connected with K measured object toxicity index storer, K measured object toxicity index storer is connected with the leather-like material toxicity index weighted value table storer that m people is establishment, m people is that the leather-like material toxicity index weighted value table storer of establishment is connected with the adder calculator of each weighted value of P measured object.
(4) arithmetical unit weighted value module: the adder calculator of each weighted value of P measured object obtains total weighted value storer with the additive operation of Q measured object and is connected, the additive operation of Q measured object obtains total weighted value storer and is connected with the risk assessment table storer of R additive operation end value, and the risk assessment table storer of R additive operation end value is communicated with computer monitor.
The risk evaluating system of leather chemicals of the present invention and rear module data transmission line are as follows, risk evaluating system comprises three processing modules, first title standardized module, both became visual other standard chemical title of this risk evaluating system the chemical name of input computer; Second security judge module is the no safety assessment of carrying out of judgement; The 3rd security assessment module, both carried out safety assessment with three databases and three weighted value tables to this leather chemicals.
The several chemical name archival memory of first title standardized module: B mono-thing is connected with C measured object standard name validator with A input name memory respectively, C measured object standard name validator is communicated with computor-keyboard, and the several chemical name archival memory of B mono-thing is also communicated with computer display screen.
The first module data transmission line: A input name memory sends the leather of the pending risk assessment of input to B mono-thing several chemical name archival memory by the title of chemical substance, database B is subject to storer A to have the driving of input signal, to in archival memory B, send C measured object standard name validator to the corresponding standard chemical title of chemical name of storer A input, after a manual operation standard name has been confirmed the standard chemical title in validator C, both after computor-keyboard had been inputted chemical name in validator C and the chemical name in storer A and had been the confirmation signal of same chemical substance, namely confirm that this standard chemical title is to can be used for after follow-up operation, validator C imports this standard chemical title into second the D half life period archival memory in security judge module, if do not find the chemical name of storer A input in database B, archival memory B sends b without the signal of standard name, and first title standardized module quits work, and follow-up computer module does not start, first title standardized module has completed the chemical name of storer A has been converted into fiducial mark chemical name, and judges whether the chemical name of storer A belongs to the chemical name screening operation of this risk evaluating system scope.
Second security judge module: D half life period archival memory is connected with E measured object half life period data-carrier store with C measured object standard name validator respectively, E measured object half life period data-carrier store is greater than the measured object standard name of 60 days with the F half life period respectively and is connected with elimination half life values storer, and is communicated with computer display screen.
The second module data transmission line: D half life period archival memory is accepted C measured object standard name validator input fiducial mark chemical name and enlightened movingly, finds the half life period data of this fiducial mark chemical name with the fiducial mark chemical name of validator C in archival memory D; And import these half life period data into E measured object half life period data-carrier store and carry out numerical value judgement.
If it is safe material that V ought be less than 60 days the half life period, second security judge module is out of service, the subsequent module of computer does not start yet, and judgment result is that the fiducial mark chemical name material of validator C is safe, and the leather chemicals of both having treated risk assessment is safe;
If the half life period data value of fiducial mark chemical name is greater than 60 days in E measured object half life period data-carrier store, storer E reportedly enters this fiducial mark chemical name and corresponding measured object elimination half life values two item numbers measured object standard name and the elimination half life values storer that the F half life period is greater than 60 days, and this two item number is according to using as the 3rd security assessment module.
The 3rd security assessment module:
This module is used respectively different weights table by measured object half life period data, the partition factor (LogKow) of measured object H n-octyl alcohol/water, measured object toxicity index, be weighted to respectively three weighted values, again these three weighted values are merged into a total weighted value, by total weighted value, assess the security of chemical substance for this leather.
(1) obtain measured object half life period data coefficient weighted value sub-module: U measured object half life period data-carrier store is greater than measured object standard name and elimination half life values storer and the e people of 60 days with the F half life period respectively and is connected for the leather-like material half life period data weighting value table storer of establishment, e people is connected with the adder calculator of each weighted value of P measured object for the leather-like material half life period data weighting value table storer of working out.
Half life period data data transmission link: the F half life period is greater than measured object standard name and the elimination half life values storer of 60 days measured object half life period data are sent to U measured object half life period data-carrier store, U measured object half life period data-carrier store is sent to e people for the leather-like material half life period data weighting value table storer of establishment by these measured object half life period data, find the weighted value of N measured object half life period data, both obtained the weighted value N of measured object measured object half life period data.
(2) obtain measured object half life period data weighting value sub-module: measured object standard name and elimination half life values storer that G measured object standard name validator is greater than 60 days with the F half life period respectively, the partition factor of H n-octyl alcohol/water (LogKow) storer, computor-keyboard connects, the partition factor of H n-octyl alcohol/water (LogKow) storer and J measured object LogKow coefficient memory, J measured object LogKow coefficient memory is connected with the leather-like material LogKow coefficient weighted value table storer that j people is establishment, j people is that the leather-like material LogKow coefficient weighted value table storer of establishment is connected with the adder calculator of each weighted value of P measured object.
Half life period data transmission link: the F half life period is greater than measured object standard name and the elimination half life values storer of 60 days measured object standard name is sent to G measured object standard name validator, when G measured object standard name validator is by the name confirmation of h people's operation standard, both computor-keyboard input validation referred to after life, standard name in G measured object standard name validator is sent to partition factor (LogKow) storer of H n-octyl alcohol/water and finds corresponding this material LogKow coefficient, and deposit J measured object LogKow coefficient memory in, storer J is the leather-like material LogKow coefficient weighted value table storer of the artificial establishment of measured object LogKow coefficient input, find the weighted value of L measured object LogKow coefficient, both obtained the weighted value L of measured object LogKow coefficient.
(3) obtain measured object toxicity index weighted value sub-module: measured object standard name and elimination half life values storer that G measured object standard name validator is greater than 60 days with the F half life period respectively, I material toxicity index table storer, computor-keyboard connects, I material toxicity index table storer is connected with K measured object toxicity index storer, K measured object toxicity index storer is connected with the leather-like material toxicity index weighted value table storer that m people is establishment, m people is that the leather-like material toxicity index weighted value table storer of establishment is connected with the adder calculator of each weighted value of P measured object.
Toxicity index data transmission link: the F half life period is greater than measured object standard name and the elimination half life values storer of 60 days measured object standard name is sent to G measured object standard name validator, when G measured object standard name validator is by the name confirmation of h people's operation standard, both computor-keyboard input validation referred to after life, standard name in G measured object standard name validator is sent to I material toxicity index table storer and finds this corresponding material toxicity index, and deposit K measured object toxicity index storer in, the leather-like material toxicity index weighted value table storer that storer K is establishment measured object toxicity index input m people, find the weighted value of M measured object toxicity index, both obtained the weighted value M of measured object toxicity index.
(4) arithmetical unit weighted value module: the adder calculator of each weighted value of P measured object obtains total weighted value storer with the additive operation of Q measured object and is connected, the additive operation of Q measured object obtains total weighted value storer and is connected with the risk assessment table storer of R additive operation end value, and the risk assessment table storer of R additive operation end value is communicated with computer monitor;
Arithmetical unit data transmission link: the weighted value N of measured object bioconcentration coefficient, the weighted value L of measured object half life period data, the weighted value M of measured object toxicity index is input to respectively in the adder calculator of each weighted value of P measured object and is merged into a total weighted value computing, arithmetic expression is N+L+M=Q, the additive operation of its operation result input Q measured object obtains total weighted value storer, storer Q sends total weighted value Q to the risk assessment table storer of R additive operation end value, look into both safety evaluation conclusions of S output measured object risk that weighted value Q is corresponding, both the leather that had obtained pending risk assessment uses chemical substance in the safety evaluatio conclusion aspect leather.
Chemical substance risk of the present invention had been both chemical substance safety, and risk and safety are identical concept, because character narrate uses two vocabularys to show identical concept at different local idioms.
Fig. 1 is each module of system of the present invention, the connecting relation figure of each storer.
Advantage of the present invention: this risk evaluating system, comprise three computer deal with data modules: title standardized module, security judge module, security assessment module, also comprise these three computer processing module data are carried out artificially to the weighting disposal system with weighted value processing; This evaluating system is found the half life period data of this material in security judge module by the standard chemical title of standardized module output, determine whether to carry out safety evaluation, the material chemical name input safety evaluation module that is greater than a certain half life period data value of setting is carried out to safety evaluation, both risk assessments.
Risk assessment is that logKow coefficient value, elimination half life values, these three parameters of toxicity index of the conventional chemical substance of leather are merged into a parameter, and these three parameters are given and security weighted value respectively, and the weighted value of these three parameters is merged into a total weighted value, thereby can to the security of the conventional chemical substance of leather, make an appraisal by a total conclusion.The standardization of these three parameters and name of chemical substance is all stored with computer memory, and the weighted value table of these three parameters is also stored with computer memory.The present invention has carried out reasonable connection these data-carrier stores, makes these computer data storeies under the condition that has people with computer keyboard operation, just can make an appraisal to the security of the conventional chemical substance of leather.Having solved the existing safety evaluation to the conventional chemical substance of leather does not have unified approach, and evaluation conclusion does not have comparability problem.The present invention sets up the meaning with basic fundamental circuit allusion quotation base to the conventional chemical substance Safety Assessment System of leather.
embodiment
The risk evaluating system of embodiment 1, leather chemicals
As Fig. 1,
One, set up various databases and prepare the computer memory of these various databases
(1) first set up chemical name database table, elimination half life values database table, the partition factor logKow database table of n-octyl alcohol/water, the toxicity data storehouse table of chemical substance for normal leather.Then data in these tables are deposited respectively in to the different memory of computer, obtain four corresponding archival memories.
(1) storer B: leather is selected by the title of chemical substance: chemical name conventional in the existing chemical substance register of < < China is selected leather industry in version > > in 2013 is as " standard chemical title " in the present invention, other another name of a certain standard chemical title, popular name obtain with other data or online collection.Both obtained the several chemical name database of B mono-thing, and deposited the storer B of computer in, as the several chemical name archival memory of B mono-thing of the present invention.
(2) storer D: the elimination half life values (unit: sky) that utilizes " the standard chemical title " of conventional chemical substance in EPIsuite inquiry leather chemical industry of the present invention by the SMILES of chemical substance, both obtained D half life period database, and deposit the storer D of computer in, as D of the present invention half life period archival memory.
(3) storer H: the partition factor logKow that utilizes the n-octyl alcohol/water of " the standard chemical title " of conventional chemical substance in EPIsuite inquiry leather chemical industry of the present invention by the SMILES of chemical substance.For logKow coefficient value, as separately there being data, be experiment measured value, generally with experiment, record logKow coefficient value preferentially for partition factor (logKow) database of n-octyl alcohol/water of the present invention.Both obtained the partition factor (LogKow) of H n-octyl alcohol/water, and deposited the storer H of computer in, as partition factor (LogKow) storer of H n-octyl alcohol/water of the present invention.
(4) storer K: inquire about conventional chemical substance, the both toxicity index of " standard chemical title " material, namely LD50(mouse, oral in leather chemical industry of the present invention by TOXNET) value.Both obtained K measured object toxicity index, and deposited the storer K of computer in, as K measured object toxicity index storer of the present invention.
(2), about elimination half life values, logKow coefficient value, toxicity index artificial, determine weighted value table and storer: the security of chemical substance for a kind of leather, can only, by a concept, can only be usually both to ignore risk, low-risk, medium risk, high risk, high risk some.So logKow coefficient value, elimination half life values, these three parameters of toxicity index will be merged into a parameter security are made to unique some judgements.So, be with these three parameters are merged into a total weighted value with the method for weighted value these three parameter weighting values.The weighted value table of these three parameters and the safety evaluatio table of total weighted value below:
(1) leather chemistry material elimination half life values weighted value table and storer D:
Elimination half life values 60--180 days, weighted value is 0.5;
Elimination half life values >180 days, weighted value is 1.0;
This elimination half life values weighted value table is deposited in to computer memory, obtain half life period archival memory D, be called for short storer D.
(2) leather chemistry material logKow coefficient value weighted value table and storer H:
LogKow value <5, weighted value is 0;
5<LogKow value <10, weighted value is 1;
LogKow value > 10, weighted value is 2.
This logKow coefficient weighted value table is deposited in to computer memory, obtain partition factor (LogKow) the storer H of n-octyl alcohol/water, be called for short storer H.
(3) leather chemistry material toxicity index weighted value table and memory I:
LD50>15.0 gkg-1, weighted value is 0.0;
5.0 gkg-1<LD50<15 .0gkg-1, weighted value is 1;
0.5 gkg-1<LD50<5.0 gkg-1, weighted value is 2;
50.0 mgkg-1<LD50<500.0 mgkg-1, weighted value is 3;
LD50<50 .0mgkg-1, weighted value is 4.
This toxicity index weighted value table is deposited in to computer memory, obtain material toxicity index table memory I, be called for short memory I.
(4) the safety evaluatio table of the total weighted value of leather chemistry material.
| Total weighted value | Safe class | Safety evaluatio |
| 0.5 | 1 | Can ignore risk |
| 1-1.5 | 2 | Low-risk |
| 2-2.5 | 3 | Medium risk |
| 3-4.5 | 4 | High risk |
| 5-7 | 5 | Excessive risk |
Two, set up the risk evaluating system of leather chemicals
The risk evaluating system of leather chemicals comprises three processing modules, and first title standardized module both became visual other standard chemical title of this risk evaluating system the chemical name of input computer; Second security judge module is the no safety assessment of carrying out of judgement; The 3rd security assessment module, both carried out safety assessment with three databases and three weighted value tables to this leather chemicals.
The several chemical name archival memory of first title standardized module: B mono-thing is connected with C measured object standard name validator with A input name memory respectively, C measured object standard name validator is communicated with computor-keyboard, and the several chemical name archival memory of B mono-thing is also communicated with computer display screen.
Second security judge module: D half life period archival memory is connected with E measured object half life period data-carrier store with C measured object standard name validator respectively, E measured object half life period data-carrier store is greater than the measured object standard name of 60 days with the F half life period respectively and is connected with elimination half life values storer, and is communicated with computer display screen.
The 3rd security assessment module:
This module is used respectively different weights table by measured object half life period data, the partition factor (LogKow) of measured object H n-octyl alcohol/water, measured object toxicity index, be weighted to respectively three weighted values, again these three weighted values are merged into a total weighted value, by total weighted value, assess the security of chemical substance for this leather;
(1) obtain measured object half life period data coefficient weighted value sub-module: U measured object half life period data-carrier store is greater than measured object standard name and elimination half life values storer and the e people of 60 days with the F half life period respectively and is connected for the leather-like material half life period data weighting value table storer of establishment, e people is connected with the adder calculator of each weighted value of P measured object for the leather-like material half life period data weighting value table storer of working out;
(2) obtain measured object half life period data weighting value sub-module: measured object standard name and elimination half life values storer that G measured object standard name validator is greater than 60 days with the F half life period respectively, the partition factor of H n-octyl alcohol/water (LogKow) storer, computor-keyboard connects, the partition factor of H n-octyl alcohol/water (LogKow) storer and J measured object LogKow coefficient memory, J measured object LogKow coefficient memory is connected with the leather-like material LogKow coefficient weighted value table storer that j people is establishment, j people is that the leather-like material LogKow coefficient weighted value table storer of establishment is connected with the adder calculator of each weighted value of P measured object,
(3) obtain measured object toxicity index weighted value sub-module: measured object standard name and elimination half life values storer that G measured object standard name validator is greater than 60 days with the F half life period respectively, I material toxicity index table storer, computor-keyboard connects, I material toxicity index table storer is connected with K measured object toxicity index storer, K measured object toxicity index storer is connected with the leather-like material toxicity index weighted value table storer that m people is establishment, m people is that the leather-like material toxicity index weighted value table storer of establishment is connected with the adder calculator of each weighted value of P measured object,
(4) arithmetical unit weighted value: the adder calculator of each weighted value of P measured object obtains total weighted value storer with the additive operation of Q measured object and is connected, the additive operation of Q measured object obtains total weighted value storer and is connected with the risk assessment table storer of R additive operation end value, and the risk assessment table storer of R additive operation end value is communicated with computer monitor.
The data transmission link of each module in the risk evaluating system of embodiment 2, leather chemicals and this system
As Fig. 1, in the risk evaluating system of leather chemicals, the data transmission link of each module is as follows described in embodiment 1:
The risk evaluating system of leather chemicals of the present invention, comprises three processing modules, and first title standardized module both became visual other standard chemical title of this risk evaluating system the chemical name of input computer; Second security judge module is the no safety assessment of carrying out of judgement; The 3rd security assessment module, both carried out safety assessment with three databases and three weighted value tables to this leather chemicals.
The several chemical name archival memory of first title standardized module: B mono-thing is connected with C measured object standard name validator with A input name memory respectively, C measured object standard name validator is communicated with computor-keyboard, and the several chemical name archival memory of B mono-thing is also communicated with computer display screen.
The first module data transmission line: A input name memory sends the leather of the pending risk assessment of input to B mono-thing several chemical name archival memory by the title of chemical substance, database B is subject to storer A to have the driving of input signal, to in archival memory B, send C measured object standard name validator to the corresponding standard chemical title of chemical name of storer A input, after a manual operation standard name has been confirmed the standard chemical title in validator C, both after computor-keyboard had been inputted chemical name in validator C and the chemical name in storer A and had been the confirmation signal of same chemical substance, namely confirm that this standard chemical title is to can be used for after follow-up operation, validator C imports this standard chemical title into second the D half life period archival memory in security judge module, if do not find the chemical name of storer A input in database B, archival memory B sends b without the signal of standard name, and first title standardized module quits work, and follow-up computer module does not start, first title standardized module has completed the chemical name of storer A has been converted into fiducial mark chemical name, and judges whether the chemical name of storer A belongs to the chemical name screening operation of this risk evaluating system scope.
Second security judge module: D half life period archival memory is connected with E measured object half life period data-carrier store with C measured object standard name validator respectively, E measured object half life period data-carrier store is greater than the measured object standard name of 60 days with the F half life period respectively and is connected with elimination half life values storer, and is communicated with computer display screen.
The second module data transmission line: D half life period archival memory is accepted C measured object standard name validator input fiducial mark chemical name and enlightened movingly, finds the half life period data of this fiducial mark chemical name with the fiducial mark chemical name of validator C in archival memory D; And import these half life period data into E measured object half life period data-carrier store and carry out numerical value judgement.
If it is safe material that V ought be less than 60 days the half life period, second security judge module is out of service, the subsequent module of computer does not start yet, and judgment result is that the fiducial mark chemical name material of validator C is safe, and the leather chemicals of both having treated risk assessment is safe;
If the half life period data value of fiducial mark chemical name is greater than 60 days in E measured object half life period data-carrier store, storer E reportedly enters this fiducial mark chemical name and corresponding measured object elimination half life values two item numbers measured object standard name and the elimination half life values storer that the F half life period is greater than 60 days, and this two item number is according to using as the 3rd security assessment module.
The 3rd security assessment module:
This module is used respectively different weights table by measured object half life period data, the partition factor (LogKow) of measured object H n-octyl alcohol/water, measured object toxicity index, be weighted to respectively three weighted values, again these three weighted values are merged into a total weighted value, by total weighted value, assess the security of chemical substance for this leather;
(1) obtain measured object half life period data coefficient weighted value sub-module: U measured object half life period data-carrier store is greater than measured object standard name and elimination half life values storer and the e people of 60 days with the F half life period respectively and is connected for the leather-like material half life period data weighting value table storer of establishment, e people is connected with the adder calculator of each weighted value of P measured object for the leather-like material half life period data weighting value table storer of working out.
Half life period data data transmission link: the F half life period is greater than measured object standard name and the elimination half life values storer of 60 days measured object half life period data are sent to U measured object half life period data-carrier store, U measured object half life period data-carrier store is sent to e people for the leather-like material half life period data weighting value table storer of establishment by these measured object half life period data, find the weighted value of N measured object half life period data, both obtained the weighted value N of measured object measured object half life period data.
(2) obtain measured object half life period data weighting value sub-module: measured object standard name and elimination half life values storer that G measured object standard name validator is greater than 60 days with the F half life period respectively, the partition factor of H n-octyl alcohol/water (LogKow) storer, computor-keyboard connects, the partition factor of H n-octyl alcohol/water (LogKow) storer and J measured object LogKow coefficient memory, J measured object LogKow coefficient memory is connected with the leather-like material LogKow coefficient weighted value table storer that j people is establishment, j people is that the leather-like material LogKow coefficient weighted value table storer of establishment is connected with the adder calculator of each weighted value of P measured object.
Half life period data transmission link: the F half life period is greater than measured object standard name and the elimination half life values storer of 60 days measured object standard name is sent to G measured object standard name validator, when G measured object standard name validator is by the name confirmation of h people's operation standard, both computor-keyboard input validation referred to after life, standard name in G measured object standard name validator is sent to partition factor (LogKow) storer of H n-octyl alcohol/water and finds corresponding this material LogKow coefficient, and deposit J measured object LogKow coefficient memory in, storer J is the leather-like material LogKow coefficient weighted value table storer of the artificial establishment of measured object LogKow coefficient input, find the weighted value of L measured object LogKow coefficient, both obtained the weighted value L of measured object LogKow coefficient.
(3) obtain measured object toxicity index weighted value sub-module: measured object standard name and elimination half life values storer that G measured object standard name validator is greater than 60 days with the F half life period respectively, I material toxicity index table storer, computor-keyboard connects, I material toxicity index table storer is connected with K measured object toxicity index storer, K measured object toxicity index storer is connected with the leather-like material toxicity index weighted value table storer that m people is establishment, m people is that the leather-like material toxicity index weighted value table storer of establishment is connected with the adder calculator of each weighted value of P measured object.
Toxicity index data transmission link: the F half life period is greater than measured object standard name and the elimination half life values storer of 60 days measured object standard name is sent to G measured object standard name validator, when G measured object standard name validator is by the name confirmation of h people's operation standard, both computor-keyboard input validation referred to after life, standard name in G measured object standard name validator is sent to I material toxicity index table storer and finds this corresponding material toxicity index, and deposit K measured object toxicity index storer in, the leather-like material toxicity index weighted value table storer that storer K is establishment measured object toxicity index input m people, find the weighted value of M measured object toxicity index, both obtained the weighted value M of measured object toxicity index.
(4) arithmetical unit weighted value module: the adder calculator of each weighted value of P measured object obtains total weighted value storer with the additive operation of Q measured object and is connected, the additive operation of Q measured object obtains total weighted value storer and is connected with the risk assessment table storer of R additive operation end value, and the risk assessment table storer of R additive operation end value is communicated with computer monitor.
Arithmetical unit data transmission link: the weighted value N of measured object bioconcentration coefficient, the weighted value L of measured object half life period data, the weighted value M of measured object toxicity index is input to respectively in the adder calculator of each weighted value of P measured object and is merged into a total weighted value computing, arithmetic expression is N+L+M=Q, the additive operation of its operation result input Q measured object obtains total weighted value storer, storer Q sends total weighted value Q to the risk assessment table storer of R additive operation end value, look into the S output measured object risk assessment conclusion that weighted value Q is corresponding, both the leather that had obtained pending risk assessment uses chemical substance in the safety evaluatio conclusion aspect leather.
Claims (2)
1. the risk evaluating system of leather chemicals, comprises three processing modules, and first title standardized module both became visual other standard chemical title of this risk evaluating system the chemical name of input computer; Second security judge module is the no safety assessment of carrying out of judgement; The 3rd security assessment module, both carried out safety assessment with three databases and three weighted value tables to this leather chemicals;
The several chemical name archival memory of first title standardized module: B mono-thing is connected with C measured object standard name validator with A input name memory respectively, C measured object standard name validator is communicated with computor-keyboard, and the several chemical name archival memory of B mono-thing is also communicated with computer display screen;
Second security judge module: D half life period archival memory is connected with E measured object half life period data-carrier store with C measured object standard name validator respectively, E measured object half life period data-carrier store is greater than the measured object standard name of 60 days with the F half life period respectively and is connected with elimination half life values storer, and is communicated with computer display screen;
The 3rd security assessment module:
This module is used respectively different weights table by measured object half life period data, the partition factor (LogKow) of measured object H n-octyl alcohol/water, measured object toxicity index, be weighted to respectively three weighted values, again these three weighted values are merged into a total weighted value, by total weighted value, assess the security of chemical substance for this leather;
(1) obtain measured object half life period data coefficient weighted value sub-module: U measured object half life period data-carrier store is greater than measured object standard name and elimination half life values storer and the e people of 60 days with the F half life period respectively and is connected for the leather-like material half life period data weighting value table storer of establishment, e people is connected with the adder calculator of each weighted value of P measured object for the leather-like material half life period data weighting value table storer of working out;
(2) obtain measured object half life period data weighting value sub-module: measured object standard name and elimination half life values storer that G measured object standard name validator is greater than 60 days with the F half life period respectively, the partition factor of H n-octyl alcohol/water (LogKow) storer, computor-keyboard connects, the partition factor of H n-octyl alcohol/water (LogKow) storer and J measured object LogKow coefficient memory, J measured object LogKow coefficient memory is connected with the leather-like material LogKow coefficient weighted value table storer that j people is establishment, j people is that the leather-like material LogKow coefficient weighted value table storer of establishment is connected with the adder calculator of each weighted value of P measured object,
(3) obtain measured object toxicity index weighted value sub-module: measured object standard name and elimination half life values storer that G measured object standard name validator is greater than 60 days with the F half life period respectively, I material toxicity index table storer, computor-keyboard connects, I material toxicity index table storer is connected with K measured object toxicity index storer, K measured object toxicity index storer is connected with the leather-like material toxicity index weighted value table storer that m people is establishment, m people is that the leather-like material toxicity index weighted value table storer of establishment is connected with the adder calculator of each weighted value of P measured object,
(4) arithmetical unit weighted value module: the adder calculator of each weighted value of P measured object obtains total weighted value storer with the additive operation of Q measured object and is connected, the additive operation of Q measured object obtains total weighted value storer and is connected with the risk assessment table storer of R additive operation end value, and the risk assessment table storer of R additive operation end value is communicated with computer monitor.
2. the risk evaluating system of leather chemicals according to claim 1, is characterized in that:
First title standardized module data transmission link: A input name memory sends the leather of the pending risk assessment of input to B mono-thing several chemical name archival memory by the title of chemical substance, database B is subject to storer A to have the driving of input signal, to in archival memory B, send C measured object standard name validator to the corresponding standard chemical title of chemical name of storer A input, after a manual operation standard name has been confirmed the standard chemical title in validator C, both after computor-keyboard had been inputted chemical name in validator C and the chemical name in storer A and had been the confirmation signal of same chemical substance, namely confirm that this standard chemical title is to can be used for after follow-up operation, validator C imports this standard chemical title into second the D half life period archival memory in security judge module, if do not find the chemical name of storer A input in database B, archival memory B sends b without the signal of standard name, and first title standardized module quits work, and follow-up computer module does not start, first title standardized module has completed the chemical name of storer A has been converted into fiducial mark chemical name, and judges whether the chemical name of storer A belongs to the chemical name screening operation of this risk evaluating system scope,
Second security judge module data transmission link: D half life period archival memory is accepted C measured object standard name validator input fiducial mark chemical name and enlightened movingly, finds the half life period data of this fiducial mark chemical name with the fiducial mark chemical name of validator C in archival memory D; And import these half life period data into E measured object half life period data-carrier store and carry out numerical value judgement;
If it is safe material that V ought be less than 60 days the half life period, second security judge module is out of service, the subsequent module of computer does not start yet, and judgment result is that the fiducial mark chemical name material of validator C is safe, and the leather chemicals of both having treated risk assessment is safe;
If the half life period data value of fiducial mark chemical name is greater than 60 days in E measured object half life period data-carrier store, storer E reportedly enters this fiducial mark chemical name and corresponding measured object elimination half life values two item numbers measured object standard name and the elimination half life values storer that the F half life period is greater than 60 days, and this two item number is according to using as the 3rd security assessment module;
The 3rd security assessment module data transmission link:
(1) obtain the data transmission link of measured object half life period data coefficient weighted value sub-module: the F half life period is greater than measured object standard name and the elimination half life values storer of 60 days measured object half life period data are sent to U measured object half life period data-carrier store, U measured object half life period data-carrier store is sent to e people for the leather-like material half life period data weighting value table storer of establishment by these measured object half life period data, find the weighted value of N measured object half life period data, both obtained the weighted value N of measured object measured object half life period data;
(2) obtain the data transmission link of measured object half life period data weighting value sub-module: the F half life period is greater than measured object standard name and the elimination half life values storer of 60 days measured object standard name is sent to G measured object standard name validator, when G measured object standard name validator is by the name confirmation of h people's operation standard, both computor-keyboard input validation referred to after life, standard name in G measured object standard name validator is sent to partition factor (LogKow) storer of H n-octyl alcohol/water and finds corresponding this material LogKow coefficient, and deposit J measured object LogKow coefficient memory in, storer J is the leather-like material LogKow coefficient weighted value table storer of the artificial establishment of measured object LogKow coefficient input, find the weighted value of L measured object LogKow coefficient, both obtained the weighted value L of measured object LogKow coefficient,
(3) obtain measured object toxicity index weighted value sub-module mark data transmission link: the F half life period is greater than measured object standard name and the elimination half life values storer of 60 days measured object standard name is sent to G measured object standard name validator, when G measured object standard name validator is by the name confirmation of h people's operation standard, both computor-keyboard input validation referred to after life, standard name in G measured object standard name validator is sent to I material toxicity index table storer and finds this corresponding material toxicity index, and deposit K measured object toxicity index storer in, the leather-like material toxicity index weighted value table storer that storer K is establishment measured object toxicity index input m people, find the weighted value of M measured object toxicity index, both obtained the weighted value M of measured object toxicity index,
(4) arithmetical unit weighted value module data transmission line: the weighted value N of measured object bioconcentration coefficient, the weighted value L of measured object half life period data, the weighted value M of measured object toxicity index is input to respectively in the adder calculator of each weighted value of P measured object and is merged into a total weighted value computing, arithmetic expression is N+L+M=Q, the additive operation of its operation result input Q measured object obtains total weighted value storer, storer Q sends total weighted value Q to the risk assessment table storer of R additive operation end value, look into the S output measured object risk assessment conclusion that weighted value Q is corresponding, both the leather that had obtained pending risk assessment uses chemical substance in the safety evaluatio conclusion aspect leather.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109207652A (en) * | 2018-09-14 | 2019-01-15 | 许昌鑫瑞德化工科技有限公司 | A kind of leather chemicals production technology |
| CN109207653A (en) * | 2018-09-17 | 2019-01-15 | 许昌鑫瑞德化工科技有限公司 | A kind of leather chemicals preparation method |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102007051489A1 (en) * | 2007-10-27 | 2009-04-30 | Isa Industrial Ltd. Guangzhou Tan Tec Leather Ltd. | Classifying leather for its production, comprises measuringly detecting or computing power requirement, water consumption, carbon dioxide production and/or chemical oxygen demand of the production, and arranging production unit of leather |
| CN101847180A (en) * | 2010-04-30 | 2010-09-29 | 中国环境科学研究院 | Atmosphere pollution risk source identification method |
| CN102880800A (en) * | 2012-09-25 | 2013-01-16 | 常州大学 | Regional soil environment priority control pollutant screening method based on health risk |
-
2013
- 2013-12-30 CN CN201310737348.4A patent/CN103679391B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102007051489A1 (en) * | 2007-10-27 | 2009-04-30 | Isa Industrial Ltd. Guangzhou Tan Tec Leather Ltd. | Classifying leather for its production, comprises measuringly detecting or computing power requirement, water consumption, carbon dioxide production and/or chemical oxygen demand of the production, and arranging production unit of leather |
| CN101847180A (en) * | 2010-04-30 | 2010-09-29 | 中国环境科学研究院 | Atmosphere pollution risk source identification method |
| CN102880800A (en) * | 2012-09-25 | 2013-01-16 | 常州大学 | Regional soil environment priority control pollutant screening method based on health risk |
Non-Patent Citations (2)
| Title |
|---|
| XIAO-YING YU等: "Enhancing the chemical mixture methodology in emergency preparedness and consequence assessment analysis", 《TOXICOLOGY》 * |
| 李耘等: "混合化学物风险评估技术及研究进展", 《农产品质量与安全》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109207652A (en) * | 2018-09-14 | 2019-01-15 | 许昌鑫瑞德化工科技有限公司 | A kind of leather chemicals production technology |
| CN109207653A (en) * | 2018-09-17 | 2019-01-15 | 许昌鑫瑞德化工科技有限公司 | A kind of leather chemicals preparation method |
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