CN103676198A - Corneal contact lens with high biocompatibility and preparation method thereof - Google Patents
Corneal contact lens with high biocompatibility and preparation method thereof Download PDFInfo
- Publication number
- CN103676198A CN103676198A CN201310678011.0A CN201310678011A CN103676198A CN 103676198 A CN103676198 A CN 103676198A CN 201310678011 A CN201310678011 A CN 201310678011A CN 103676198 A CN103676198 A CN 103676198A
- Authority
- CN
- China
- Prior art keywords
- contact lens
- corneal contact
- preparation
- high biocompatibility
- collagen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Abstract
The invention discloses a corneal contact lens with high biocompatibility and a preparation method thereof. The corneal contact lens with the high biocompatibility comprises a spherical lens body 1, wherein the diameter of the spherical lens body is 0.8 to 1mm; the lens body consists of chitosan and collagen. The preparation method comprises the following steps: (1) placing 20 to 40g of chitosan and 10 to 30g of collagen into 100ml of normal saline for swelling overnight, and uniformly mixing the viscous liquid obtained by swelling; (2) adding 100ml of 75 percent ethyl alcohol, mixing, centrifuging at the speed of 300rpm for 30 minutes, and removing supernatant; (3) baking and drying precipitate in a baking box at the temperature of 50 to 60 DEG C; and (4) polishing the dried precipitate to be of a spherical shape by using a polishing machine so as to obtain the corneal contact lens. The corneal contact lens with high biocompatibility and the preparation method thereof have the benefits that the corneal contact lens having the characteristics of high light transmittance, high oxygen transmittance, and high biocompatibility with human eyes is prepared.
Description
Technical field
The present invention relates to a kind of design and preparation field of contact lens, relate in particular to a kind of high-biocompatibility contact lens design and preparation field.
technical background:
Contact lens is a kind of being worn on cornea, in order to correct defects of vision or to protect the eyeglass of eyes.Contact lens is not only from having brought very large improvement to convenience aspect in appearance the ametropia patients such as myopia, long sight, astigmatism, and the visual field is broad, to look thing true to nature, this external control adolescent myopia, astigmatism development, treat the special aspects such as illness in eye and also brought into play special effect.Good contact lens need to have good transmittance, and high oxygen flow, with the biocompatible feature of human eye.
According to the soft or hard contact lens of material, comprise rigid, semi-hard, soft three kinds, hard corneal contact lens is because it has high oxygen flow, superior optical quality and to features such as wearer's physiology of eye health effect are little, compare with soft corneal contact lens with frame eyeglasses, hard corneal contact lens eyeglass can produce more superior optics picture element, give retina to stimulate clearly, can suppress the growth of axis oculi, can delay to a certain extent the development of child myopia, be the developing direction of contact lens in recent years.
But due to starting late of China, the kind of current hard corneal contact lens, and performance can not meet wearer's needs completely.Therefore, the permeability that need to open ion permeability and oxygen is high, the good biocompatibility of eyeglass and people's ocular environment, the contact lens that the comfort level that patient wears and rectification effect are good.
summary of the invention:
Goal of the invention: design a kind of novel rigid contact lens, have good transmittance, high oxygen flow, with the biocompatible feature of human eye.
Technical scheme:
The invention provides a kind of high-biocompatibility contact lens and preparation method thereof.Technical scheme is to comprise spherical mirror phosphor bodies, and diameter is 0.8-1mm.Mirror preparation is shitosan 20-40g and collagen 10-30g to be put into 100ml physiological saline swelling spend the night, and the thick liquid that swelling is obtained mixes.75% ethanol that adds 100ml, mixes, centrifugal 3000rpm, and 30min, removes supernatant.Precipitation is put into 50-60 ℃ of baking oven, dry.The sediment of drying is polished to spherical with buffing machine, obtains.
Accompanying drawing explanation
Accompanying drawing 1 contact lens illustraton of model.1. mirror body.
useful benefit:
Contact lens prepared by the present invention, has good transmittance, and high oxygen flow, with the biocompatible feature of human eye.
embodiment:
embodiment 1:shitosan 40g and collagen 20g are put into 100ml physiological saline swelling and spend the night, the thick liquid that swelling is obtained mixes.75% ethanol that adds 100ml, mixes, centrifugal 3000rpm, and 30min, removes supernatant.Precipitation is put into 50-60 ℃ of baking oven, dry.The sediment of drying is polished to spherical with buffing machine, obtains.
embodiment 2:shitosan 20g and collagen 30g are put into 100ml physiological saline swelling and spend the night, the thick liquid that swelling is obtained mixes.75% ethanol that adds 100ml, mixes, centrifugal 3000rpm, and 30min, removes supernatant.Precipitation is put into 50-60 ℃ of baking oven, dry.The sediment of drying is become to spherical with buffing machine, obtain.
Claims (3)
1. a high-biocompatibility contact lens, is characterized in that: described in comprise spherical mirror phosphor bodies, diameter is 0.8-1mm.
2. mirror body described in claims 1, is characterized in that: shitosan and collagen, consist of.
3. mirror preparation described in claims 1: it is characterized in that: step comprises that (1) put into 100ml physiological saline swelling by shitosan 20-40g and collagen 10-30g and spend the night, and the thick liquid that swelling is obtained mixes; (2) add 75% ethanol of 100ml, mix, centrifugal 3000rpm, 30min, removes supernatant; (3) precipitation is put into 50-60 ℃ of baking oven, dried; (4) sediment of drying is polished to spherical with buffing machine, obtains.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310678011.0A CN103676198A (en) | 2013-12-13 | 2013-12-13 | Corneal contact lens with high biocompatibility and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310678011.0A CN103676198A (en) | 2013-12-13 | 2013-12-13 | Corneal contact lens with high biocompatibility and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103676198A true CN103676198A (en) | 2014-03-26 |
Family
ID=50314255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310678011.0A Pending CN103676198A (en) | 2013-12-13 | 2013-12-13 | Corneal contact lens with high biocompatibility and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103676198A (en) |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62250412A (en) * | 1986-04-24 | 1987-10-31 | Nippon Bio Kemikaruzu Kk | Contact lens and its production |
| JPH07218878A (en) * | 1994-02-08 | 1995-08-18 | Seiko Epson Corp | Solvent for contact lens |
| CN2424477Y (en) * | 2000-02-01 | 2001-03-21 | 张越苏 | High oxygen permeable corneal contact hard lens |
| US20050287223A1 (en) * | 2004-06-23 | 2005-12-29 | Peyman Gholam A | Use of amniotic membrane as biocompatible devices |
| CN1936648A (en) * | 2006-10-20 | 2007-03-28 | 中山大学中山眼科中心 | Therapeutic hard air-permeable cornea contact mirror |
| CN200983040Y (en) * | 2006-10-20 | 2007-11-28 | 中山大学中山眼科中心 | Medical hard air penetration cornea contact lens |
| CN101112625A (en) * | 2006-07-24 | 2008-01-30 | 陶鹭 | Chitose shield for treating ceratonosus and method of manufacturing the same |
| CN101367947A (en) * | 2007-08-14 | 2009-02-18 | 南开大学 | Biological consistent natural polymer hydrogel and preparation method thereof |
| CN101480850A (en) * | 2008-01-10 | 2009-07-15 | 张志宏 | Method for producing silicon contact lens with hydrophilic surface |
-
2013
- 2013-12-13 CN CN201310678011.0A patent/CN103676198A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62250412A (en) * | 1986-04-24 | 1987-10-31 | Nippon Bio Kemikaruzu Kk | Contact lens and its production |
| JPH07218878A (en) * | 1994-02-08 | 1995-08-18 | Seiko Epson Corp | Solvent for contact lens |
| CN2424477Y (en) * | 2000-02-01 | 2001-03-21 | 张越苏 | High oxygen permeable corneal contact hard lens |
| US20050287223A1 (en) * | 2004-06-23 | 2005-12-29 | Peyman Gholam A | Use of amniotic membrane as biocompatible devices |
| CN101112625A (en) * | 2006-07-24 | 2008-01-30 | 陶鹭 | Chitose shield for treating ceratonosus and method of manufacturing the same |
| CN1936648A (en) * | 2006-10-20 | 2007-03-28 | 中山大学中山眼科中心 | Therapeutic hard air-permeable cornea contact mirror |
| CN200983040Y (en) * | 2006-10-20 | 2007-11-28 | 中山大学中山眼科中心 | Medical hard air penetration cornea contact lens |
| CN101367947A (en) * | 2007-08-14 | 2009-02-18 | 南开大学 | Biological consistent natural polymer hydrogel and preparation method thereof |
| CN101480850A (en) * | 2008-01-10 | 2009-07-15 | 张志宏 | Method for producing silicon contact lens with hydrophilic surface |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2724357C2 (en) | Contact lens comprising non-coaxial elementary lenses for preventing and/or slowing the progression of myopia | |
| TWI587035B (en) | Asymmetric lens design and method for preventing and/or slowing myopia progression | |
| CN102763025B (en) | Systems and methods for the regulation of emerging myopia | |
| CA2807846C (en) | Multi-axis lens design for astigmatism | |
| CN105765445B (en) | Ametropia treatment glasses | |
| CN104749791A (en) | Optical focusing regulating lens and optical focusing regulating method | |
| CN201845140U (en) | Peripheral defocusing corrective glasses for presbyopia | |
| ES2529378A1 (en) | Multifocal, hybrid diffractive-refractive ophthalmic lens, use of the lens and method for the production thereof | |
| TWI507763B (en) | Control the growth of the optical axis of the lens | |
| CN204269941U (en) | A kind of adjustable paracentral fixation glasses | |
| CN106896525B (en) | The production method of the curved free form surface sunglasses of big base | |
| CN204719331U (en) | A kind of 3D glasses with massage functions | |
| CN204694936U (en) | A kind of 360 degree of complete burnt near-sighted prevention and control eyeglasses | |
| CN208756305U (en) | Ortho-K for presbyopic correction | |
| CN103676198A (en) | Corneal contact lens with high biocompatibility and preparation method thereof | |
| CN201503518U (en) | dual-purpose sunglasses | |
| CN206120553U (en) | A glasses for treating stravismus | |
| KR101123644B1 (en) | Contact lens comprising titanium dioxide and preparation method thereof | |
| CN205507274U (en) | Hide crack lens and remove scattered crack combination mirror that hides | |
| CN202870411U (en) | Eyeglasses lenses | |
| CN203037948U (en) | Sphere and prism combined bifocal physiotherapy glasses | |
| CN102830506A (en) | Multiple-efficacy eye disease protection eyeglass and finished eyeglasses assembled by same | |
| CN207164387U (en) | A kind of myopia recovery glasses for solving retina image-forming defocus and preventing axis oculi from elongating | |
| CN205659049U (en) | Lens in cornea | |
| CN204613534U (en) | The glasses of lens optical focal ophthalmic lens and formation thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20140326 |