CN103656836B - Magnetic compatibility can not demulsification glueballs ductus bursae - Google Patents
Magnetic compatibility can not demulsification glueballs ductus bursae Download PDFInfo
- Publication number
- CN103656836B CN103656836B CN201210350377.0A CN201210350377A CN103656836B CN 103656836 B CN103656836 B CN 103656836B CN 201210350377 A CN201210350377 A CN 201210350377A CN 103656836 B CN103656836 B CN 103656836B
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- China
- Prior art keywords
- magnetic
- balloon catheter
- catheter device
- sacculus
- conduit
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/0105—Steering means as part of the catheter or advancing means; Markers for positioning
- A61M25/0127—Magnetic means; Magnetic markers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/1079—Balloon catheters with special features or adapted for special applications having radio-opaque markers in the region of the balloon
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Materials For Medical Uses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
The invention provides the compatible balloon catheter device of magnetic, it sacculus comprising a conduit and be positioned at catheter distal end portion, the conduit being wherein positioned at sacculus is provided with one, two or more magnetic marks.This balloon catheter device has magnetic compatibility, can be applicable in magnetic field environment, and then can be used for the Hemodynamic analysis after tremulous pulse Basilar artery, as can be used for measuring (brain) blood flow volume.
Description
Technical field
The invention belongs to medical apparatus and instruments and auxiliary device field, the magnetic compatibility that specifically, the present invention relates in surgical operation can not demulsification glueballs ductus bursae.
Background technology
Cerebrovascular disease therapy needs permanent blocking-up or feeding artery that long-time Basilar artery intracranial is main often, sometimes because cerebral arteries blocks, cerebral ischemia complication occurs, and severe patient can be disabled or lethal.Therefore, how accurately to judge that cerebral arteries blocks a rear side compensation most important.
Foley's tube is for the conventional apparatus in such operation.Such as, Zuo Feng etc. (wound magazine, 4(4): the detachable balloon conduit 204 ~ 206) reported.But because sacculus can depart from, causing displacement, is therefore more to take off foley's tube at present.Such as, foley's tube disclosed in Chinese patent 03815912,03819646,200410040075,200480028167,200480039959,200510020401,200510068053,200610025200, their common structural feature comprises the conduit of an elongated tubular and the sacculus for expanding on this distal end of catheter, in order to melt with body physiological environment facies, multiplex bio-compatible material is made, such as can with latex etc.
At present, the research of foley's tube focus mostly on coat activated thereon can on h substance (mainly medicine), such as Chinese patent application 200880109226,200910106169,200980153036,201010266758,201080027624 etc. disclose coat activated medicine on these foley's tubes, reach some therapeutic effect by the release of medicine in vivo.But, at present diagnosis or the research of measuring foley's tube used are not almost had, do not have especially sacculus accurate location on nuclear magnetic resonance image.
Carry out for utilizing foley's tube diagnosing or measuring, such as, measure blood flow volume, especially the cerebral arteries of blood flow extreme sensitivity is performed the operation, the accurate location of the sacculus of foley's tube and fixing extremely important.As long as can accurately locate, after sacculus is full, block corresponding blood vessel, then row nuclear magnetic resonance, in conjunction with blood pressure and caliber parameter, utilize and just can accurately calculate blood flow, thus accurately judge that cerebral arteries blocks a rear side compensation.According to the demand that the invention described above people finds, the present inventor is provided with magnetic mark on existing foley's tube, for magnetic location, as for telltale mark during magnetic resonance imaging, two magnetic marks are especially set, to correct conduit compressive deformation, slippage and the inaccurate problem in location caused.
Due in prior art, magnetic material One's name is legion, not often kind is all suitable as the magnetic mark of foley's tube, and the present inventor studies and finds to be applicable to need to possess following character as the magnetic mark of foley's tube: safety non-toxic; Can stick on foley's tube, as sticked on latex material, and adhere well, can not discharge in physiological conditions (research emphasis outside this and Present Domestic---coat activated can h substance, just in time character is contrary); And, have any different with the imaging of the nuclear magnetic resonance material of routine, thus do not disturb magnetic resonance imaging, do not disturb nuclear magnetic resonance.For this reason, the present inventor, through painstaking efforts, have found the material meeting above-mentioned requirements, the present invention is implemented from magnetic materials many as the astronomical figure of prior art.
Summary of the invention
The object of this invention is to provide new foley's tube, it has the characteristic of magnetic compatibility, can be used for accurate location, thus is widely used in operation, as can be used for measuring (brain) blood flow volume.
Specifically, in first aspect, the invention provides the compatible balloon catheter device of magnetic, it sacculus comprising a conduit and be positioned at catheter distal end portion, it is characterized in that, the conduit being positioned at sacculus is provided with one, two or more magnetic marks, is preferably provided with two magnetic marks, in conjunction with nuclear magnetic resonance image, balloon position can be determined.
In a first aspect, preferred described magnetic mark is near described sacculus end.So more easily demonstrate balloon position.
The compatible balloon catheter device of the magnetic of first aspect present invention can also comprise the parts of existing foley's tube (e.g., the document that background parts of the present invention is mentioned), as flexibility transition element, can seal wire etc. be detected.Therefore, in a first aspect, the compatible balloon catheter device of preferred described magnetic also comprises the seal wire being positioned at described conduit, and more preferably described seal wire is that magnetic resonance can detect seal wire, is namely can the wire of imaging on magnetic resonance device, this wire normally magnetic material.This wire can the wiring inlet of described tube at one end pass into, and is passed by the wire outlet of the described conduit other end.
The compatible balloon catheter device of magnetic of first aspect present invention can also use the material of existing foley's tube (e.g., the document that background parts of the present invention is mentioned) to prepare, as materials such as glass, (medical) latexes.Therefore, in a first aspect, the conduit portion being preferably provided with magnetic mark is latex material.Like this, be arranged on supravasal magnetic mark to need can be tightly adhered in latex material.
The compatible balloon catheter device of magnetic of first aspect present invention can also use the vibrational power flow of existing foley's tube (e.g., the document that background parts of the present invention is mentioned), as balloon position etc.Therefore, in a first aspect, preferred described sacculus is fixed on catheter distal end portion.
In a first aspect, preferred described magnetic mark is safety non-toxic and can be tightly adhered to described supravasal, and the imaging that optional described magnetic mark and magnetic resonance can detect the nuclear magnetic resonance material of seal wire is had any different.According to the present inventor's research, need the magnetic mark reaching above-mentioned requirements could be used for accurately locating in vivo, thus make foley's tube for measuring (brain) blood flow volume.
In a first aspect, described magnetic mark can be fixing or be applied to supravasal.Such as, magnetic coil is used to be wound around as described magnetic mark or to be pasted onto on described conduit.Wherein, the material of magnetic coil can to detect the nuclear magnetic resonance material of wire identical or different, preferably different with magnetic resonance, and nuclear magnetic resonance can be avoided like this to disturb.In the specific embodiment of the present invention, described magnetic mark be applied to by the following method supravasal:
A () gets phenyl-phosphonic acid and butanone, be heated to 60-69 DEG C, and drip the methyl ethyl ketone solution of bisphenol type epoxy, be then warming up to 70-75 DEG C, insulation reaction, then evaporation under reduced pressure removed solvent, obtains grease;
B () gets grease obtained above, with poly-adipic acid-BDO ester, BDO, 4,4-diphenylmethane isocyanate, oxolane and toluene mix homogeneously, be heated to 75-85 DEG C of reaction, then add butanone, obtain resin solution;
C () is milled after being mixed with cobalt improved γ ferroferric oxide magnetic powder, Ketohexamethylene and butanone by resin solution obtained above, then add isocyanates, then mill, obtain magnetic material; With
D () is coated with magnetic material obtained above on the conduit being positioned at sacculus of foley's tube, then dry.
In second aspect, the invention provides magnetic material and preparing the purposes in the compatible balloon catheter device of magnetic, described magnetic material is prepared by the following method:
A () gets phenyl-phosphonic acid and butanone, be heated to 60-69 DEG C, and drip the methyl ethyl ketone solution of bisphenol type epoxy, be then warming up to 70-75 DEG C, insulation reaction, then evaporation under reduced pressure removed solvent, obtains grease;
B () gets grease obtained above, with poly-adipic acid-BDO ester, BDO, 4,4-diphenylmethane isocyanate, oxolane and toluene mix homogeneously, be heated to 75-85 DEG C of reaction, then add butanone, obtain resin solution; With
C () is milled after being mixed with cobalt improved γ ferroferric oxide magnetic powder, Ketohexamethylene and butanone by resin solution obtained above, then add isocyanates, then mill.
In second aspect, the compatible balloon catheter device of preferred described magnetic is the compatible balloon catheter device of magnetic described in first aspect present invention.
The beneficial effect that the present invention obtains is: in magnetic field environment, do not produce extracurrent, does not produce tissue burn, brain displacement does not occur, and does not disturb magnetic resonance imaging, does not disturb nuclear magnetic resonance; Can in magnetic field environment safety applications, this equipment is implemented simple, safe and reliable, is convenient to clinical practice.
For the ease of understanding, the present invention refer to open source literature, and these documents are to more clearly describe the present invention, and its entire contents is all included in and carried out reference herein.Below will be described in detail the present invention by specific embodiment and accompanying drawing.It is important to note that these descriptions are only exemplary descriptions, do not form limitation of the scope of the invention.According to the discussion of this description, many changes of the present invention, to change concerning one of ordinary skill in the art be all obviously.
Accompanying drawing explanation
Fig. 1 foley's tube and connection diagram thereof, wherein description of reference numerals is as follows: 1, foley's tube; 11, conduit; 12, sacculus; 13, wire; 2, syringe connector; 3, coaxial pipe; 4, Y tube.
The partial enlarged drawing of Fig. 2 foley's tube of the present invention, wherein description of reference numerals is as follows: 10, magnetic mark; 11, conduit; 12, sacculus.
Detailed description of the invention
Be described below by way of specific embodiment, wherein used material and reagent, can be obtained by market sale channel; Wherein carried out test (comprising zoopery) is all guide according to the test of medical apparatus and instruments in SFDA body to carry out.
The manufacture of embodiment 1 foley's tube of the present invention
Get 101.5 grams of phenyl-phosphonic acids (can purchased from Jiaxing Alpha Fine Chemical Co., Ltd) and 101.5 grams of butanones (can purchased from Zibo Qi Xiang petrochemical industry group), be heated to 60 DEG C, slow dropping 240 grams of bisphenol type epoxy Epicoat 828(can purchased from the Shell Oil Company) methyl ethyl ketone solution (Epicoat 828: butanone=1:1(weight)), progressively increased complete with 25 minutes, then 70 DEG C are warming up to, insulation reaction 5 hours.Then evaporation under reduced pressure removed solvent, obtains grease.
Get 10 grams of above-mentioned grease, with 100 grams of poly-adipic acids-1,4-butanediol ester (molecular weight sizes 1000Da, can purchased from Chengdu Gracia chemical technology company limited), 7 gram 1,4-butanediol (can purchased from Chengdu Gracia chemical technology company limited), 45.0 gram 4,4-diphenylmethane isocyanate (can purchased from Milky Way Fine Chemical Co., Ltd of Shantou City), 270 grams of oxolanes and 270 grams of toluene mix homogeneously, be heated to 80 DEG C of reactions after 15 hours, add 100 grams of butanones, obtain resin solution.
Then mill in ball mill 48 hours after all resins solution obtained above and 600 grams of cobalt improved γ ferroferric oxide magnetic powders (can purchased from the rich Chemical Co., Ltd. of Quzhou City's riel), 350 grams of Ketohexamethylene and 650 grams of butanones being mixed, then adding 20 grams of isocyanates Desmodule L-75(can purchased from Beyer Co., Ltd), mill in ball mill again 1 hour, obtain magnetic material.
Then on the conduit being positioned at sacculus of foley's tube (can purchased from American OrbusNeich medical company), magnetic material obtained above is coated with respectively, respectively on conduit, be coated with a circle closing on sacculus two ends, the often above-mentioned magnetic material of circle 50mg, obtain two magnetic marks (as shown in Figure 2) altogether, then in room temperature (25 DEG C) drying under reduced pressure 24 hours, obtaining magnetic compatibility of the present invention can not demulsification glueballs ductus bursae.
The application of embodiment 2 foley's tube of the present invention
The dry thing of magnetic material that embodiment 1 obtains is tested, carries out security test with the injection volume of 500mg/Balb C mice, do not find the chronic poisoning symptoms such as acute poisoning symptom and teratogenesis; Magnetic compatibility embodiment 1 obtained can not insert Ink vessel transfusing by demulsification glueballs ductus bursae, can know in nuclear magnetic resonance analyser and manifest two labellings, after 1 hour there is not discernible decay in marking signal, shows that adhere well does not discharge, and this labelling and MR wire can be differentiated easily.
Claims (11)
1. the compatible balloon catheter device of magnetic, it sacculus comprising a conduit and be positioned at catheter distal end portion, it is characterized in that, the conduit being positioned at sacculus is provided with one, two or more magnetic marks, described magnetic mark be applied to by the following method described supravasal:
A () gets phenyl-phosphonic acid and butanone, be heated to 60-69 DEG C, and drip the methyl ethyl ketone solution of bisphenol type epoxy, be then warming up to 70-75 DEG C, insulation reaction, then evaporation under reduced pressure removed solvent, obtains grease;
B () gets grease obtained above, with poly-adipic acid-BDO ester, 1,4-butanediol, 4,4-diphenylmethane isocyanate, oxolane and toluene mix homogeneously, be heated to 75-85 DEG C of reaction, then add butanone, obtain resin solution;
C () is milled after being mixed with cobalt improved γ ferroferric oxide magnetic powder, Ketohexamethylene and butanone by resin solution obtained above, then add isocyanates, then mill, obtain magnetic material; With
D () is coated with magnetic material obtained above on the conduit being positioned at sacculus of foley's tube, then dry.
2. the compatible balloon catheter device of magnetic according to claim 1, it is characterized in that, described magnetic mark is near described sacculus end.
3. the compatible balloon catheter device of magnetic according to claim 1, it is characterized in that, the conduit portion being provided with magnetic mark is latex material.
4. the compatible balloon catheter device of magnetic according to claim 1, it is characterized in that, described sacculus is fixed on catheter distal end portion.
5. the compatible balloon catheter device of magnetic according to claim 1, is characterized in that, the compatible balloon catheter device of described magnetic also comprises the wire being positioned at described conduit.
6. the compatible balloon catheter device of magnetic according to claim 5, it is characterized in that, described wire is that magnetic resonance can detect wire.
7. the compatible balloon catheter device of magnetic according to claim 1, is characterized in that, the conduit being positioned at sacculus is provided with two magnetic marks.
8. the compatible balloon catheter device of arbitrary described magnetic of claim 1-7, it is characterized in that, described magnetic mark is safety non-toxic and can be tightly adhered to described supravasal, and the imaging that optional described magnetic mark and magnetic resonance can detect the nuclear magnetic resonance material of wire is had any different.
9. the purposes in the compatible balloon catheter device of magnetic prepared by magnetic material, and described magnetic material is prepared by the following method:
A () gets phenyl-phosphonic acid and butanone, be heated to 60-69 DEG C, and drip the methyl ethyl ketone solution of bisphenol type epoxy, be then warming up to 70-75 DEG C, insulation reaction, then evaporation under reduced pressure removed solvent, obtains grease;
B () gets grease obtained above, with poly-adipic acid-BDO ester, 1,4-butanediol, 4,4-diphenylmethane isocyanate, oxolane and toluene mix homogeneously, be heated to 75-85 DEG C of reaction, then add butanone, obtain resin solution; With
C () is milled after being mixed with cobalt improved γ ferroferric oxide magnetic powder, Ketohexamethylene and butanone by resin solution obtained above, then add isocyanates, then mill.
10. purposes according to claim 9, the compatible balloon catheter device of wherein said magnetic is the compatible balloon catheter device of arbitrary described magnetic of claim 1-8.
The purposes of the compatible balloon catheter device of arbitrary described magnetic in the device for the preparation of measurement cerebral artery blood flow amount of 11. claim 1-8.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210350377.0A CN103656836B (en) | 2012-09-19 | 2012-09-19 | Magnetic compatibility can not demulsification glueballs ductus bursae |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210350377.0A CN103656836B (en) | 2012-09-19 | 2012-09-19 | Magnetic compatibility can not demulsification glueballs ductus bursae |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103656836A CN103656836A (en) | 2014-03-26 |
| CN103656836B true CN103656836B (en) | 2015-10-14 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201210350377.0A Expired - Fee Related CN103656836B (en) | 2012-09-19 | 2012-09-19 | Magnetic compatibility can not demulsification glueballs ductus bursae |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EP3439728A4 (en) * | 2016-04-04 | 2019-12-04 | Innoventions Ltd. | Drug delivery apparatus and method |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201135683Y (en) * | 2007-11-07 | 2008-10-22 | 乐普（北京）医疗器械股份有限公司 | Conical saccule dilating catheter |
| CN102137643A (en) * | 2008-08-28 | 2011-07-27 | 卡洛斯·万得瓦尔德 | Directional expansion of intraluminal devices |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5403274A (en) * | 1993-03-15 | 1995-04-04 | Cannon; Louis A. | Perfusion catheter and method of use |
| CN1856337A (en) * | 2003-07-30 | 2006-11-01 | 日本瑞翁株式会社 | Intra-aortic balloon catheter |
| EP2663357A4 (en) * | 2011-01-10 | 2017-12-06 | Spotlight Technology Partners LLC | Apparatus and methods for accessing and treating a body cavity, lumen, or ostium |
| CN202822439U (en) * | 2012-09-19 | 2013-03-27 | 复旦大学附属华山医院 | Magnetic compatibility taken-off-incapable latex balloon catheter |
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2012
- 2012-09-19 CN CN201210350377.0A patent/CN103656836B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201135683Y (en) * | 2007-11-07 | 2008-10-22 | 乐普（北京）医疗器械股份有限公司 | Conical saccule dilating catheter |
| CN102137643A (en) * | 2008-08-28 | 2011-07-27 | 卡洛斯·万得瓦尔德 | Directional expansion of intraluminal devices |
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| CN103656836A (en) | 2014-03-26 |
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