CN103655194A - Aureomycin premix fine powder granulating process - Google Patents
Aureomycin premix fine powder granulating process Download PDFInfo
- Publication number
- CN103655194A CN103655194A CN201310611852.XA CN201310611852A CN103655194A CN 103655194 A CN103655194 A CN 103655194A CN 201310611852 A CN201310611852 A CN 201310611852A CN 103655194 A CN103655194 A CN 103655194A
- Authority
- CN
- China
- Prior art keywords
- chlortetracycline
- fine powder
- mixing agent
- agent fine
- chlortetracycline pre
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
The invention discloses an aureomycin premix fine powder granulating process. The process mainly comprises the following steps: mixing aureomycin premix fine powder with aureomycin fermentation liquor according to a certain weight ratio to obtain an aureomycin wet product with the moisture weight ratio of 40-50%, and subjecting the wet product to granulation prior to fluidized drying to obtain an aureomycin premix semi-finished product. By the formula and the granulating process, granulation rate is high, the problem about transforming the aureomycin premix fine powder into granules is solved, product quality is stable, productivity of the granules is improved, and needs of customers are met.
Description
Technical field
The present invention relates to chlortetracycline production field, particularly a kind of chlortetracycline pre-mixing agent fine powder prilling.
Background technology
Chlortetracycline pre-mixing agent wet feed is to carry out fragmentation with wet feed disintegrating machine, obtain granular wet product and the powder of loose type, entering the process that drying machine carries out airpillow-dry can produce collision and produce a part of fine powder, dried semi-finished product are in being processed into the process of chlortetracycline pre-mixing agent finished product, owing to will can producing fine powder by fragmentation and the sieving of vibrosieve of disintegrating machine what process, broken from wet feed according to statistics chlortetracycline pre-mixing agent, be dried the left and right fine powder of meeting common property raw approximately 30% in the process of processing with finished product, the fine powder originally producing is sold to client uses except some, remaining fine powder is put in the band blowing liquid producing in Ferment of DM process and is mixed, filter, the dry chlortetracycline pre-mixing agent semi-finished product of producing.And the fine powder of use put in Ferment of DM process, produce with mixing in blowing liquid, filter, the dry chlortetracycline pre-mixing agent process of semi-finished of producing processes original fine powder and can constantly produce new fine powder.
Summary of the invention
Main purpose of the present invention is to provide a kind of chlortetracycline pre-mixing agent fine powder prilling, and this prilling can realize the recycling of chlortetracycline pre-mixing agent fine powder, and fine powder is processed into evengranular granule, adopts this technique can avoid the generation of fine powder.
For solving the problems of the technologies described above, the present invention adopts following scheme to realize:
Chlortetracycline pre-mixing agent fine powder prilling, is characterized in that, comprises the following steps:
Chlortetracycline pre-mixing agent fine powder and Aureomycin fermentation liquor are mixed by certain weight ratio, obtain moisture weight ratio in 40% ~ 50% chlortetracycline wet product, by this wet product through prilling by airpillow-dry, obtain chlortetracycline pre-mixing agent semi-finished product.
Wherein, described chlortetracycline pre-mixing agent semi-finished product, by mixing, are obtained to chlortetracycline pre-mixing agent finished product.
Wherein, the weight ratio of chlortetracycline pre-mixing agent fine powder and Aureomycin fermentation liquor is 2.0-2.5:1.0.
Wherein, the half-finished granularity≤1.0mm of gained chlortetracycline pre-mixing agent.
Wherein, described chlortetracycline pre-mixing agent semi-finished product granularity is 1.0mm.
Wherein, wet product prilling comprises the following steps: the pelletize charging aperture of first wet product being put into comminutor; By double-screw shaft, promote wet product again and enter extrusion chamber; Wet product extruding by crushing block in extrusion chamber constantly flows out from the sieve screen apertures on extrusion chamber both sides the wet feed that obtains strip.
Wherein, described wet feed airpillow-dry condition is temperature≤100 ℃, time≤2.0h.
Wherein, the moisture weight ratio of described chlortetracycline wet product is 45%.
Wherein, the main component of described chlortetracycline pre-mixing agent fine powder comprises chlortetracycline calcium salt and tropina; Described Aureomycin fermentation liquor main component is chlortetracycline calcium salt and tropina.
Remarkable advantage of the present invention is as follows: the one, and adopt this invention formula and the prilling granulating rate high, solved the problem that chlortetracycline pre-mixing agent fine powder is converted into granule, constant product quality, the production capacity having increased, meets client's demand; The 2nd, adopt this invention formula and prilling, owing to not adding in process of production any bonding raw material, only use chlortetracycline pre-mixing agent fine powder and Aureomycin fermentation liquor, thereby in converted products overall process, can effectively protect the active princlple content of product, do not have the generation of impurity component, improved the quality stability of product; The 3rd, the uniform particles, outward appearance homogeneous, the color and luster that adopt this invented technology to make are consistent, improve the aesthetics of product, do not need to pass through crusher in crushing again, thereby avoid the generation of fine powder.
Accompanying drawing explanation
The flow chart of Fig. 1 chlortetracycline pre-mixing agent of the present invention fine powder prilling embodiment.
The specific embodiment
By describing technology contents of the present invention, structural feature in detail, being realized object and effect, below in conjunction with embodiment and coordinate accompanying drawing to be explained in detail.
Refer to Fig. 1, chlortetracycline pre-mixing agent fine powder prilling, mainly comprises the following steps:
Chlortetracycline pre-mixing agent fine powder and Aureomycin fermentation liquor are mixed by certain weight ratio, obtain moisture weight ratio in 40% ~ 50% chlortetracycline pre-mixing agent wet product, by this wet product through prilling by airpillow-dry, obtain chlortetracycline pre-mixing agent semi-finished product.Here, the moisture weight ratio of chlortetracycline wet product is preferably 45%.
After obtaining above-mentioned chlortetracycline pre-mixing agent semi-finished product, by the difference of customer demand, chlortetracycline pre-mixing agent semi-finished product are mixed, obtain chlortetracycline pre-mixing agent finished product.
In the above-described embodiments, conventionally, the chlortetracycline pre-mixing agent semi-finished product granularity obtaining after prilling mostly is and is not more than 1.0mm left and right, or 1.0mm ~ 1.4mm, certainly, is also not limited to this, actual granularity can be adjusted by the sieve number of selecting, to meet client's actual demand.
The semi-finished product uniform particles obtaining through prilling, outward appearance homogeneous, not follow-up needs again by crusher in crushing, thus avoid the generation of fine powder.
Concrete, in the above-described embodiments, wet product prilling mainly comprises the following steps: the pelletize charging aperture of first chlortetracycline pre-mixing agent wet product being put into comminutor; By double-screw shaft, promote wet product again and enter extrusion chamber; Wet product extruding by crushing block in extrusion chamber constantly flows out from the sieve screen apertures on extrusion chamber both sides the wet feed that obtains strip.
In the present invention, the main component of chlortetracycline pre-mixing agent fine powder comprises chlortetracycline calcium salt and tropina; Described Aureomycin fermentation liquor main component is chlortetracycline calcium salt and tropina.
The present invention is owing to adopting prilling, solved the problem that chlortetracycline pre-mixing agent fine powder is converted into granule, and granulating rate is high, and constant product quality, uniform particles, outward appearance homogeneous, color and luster are consistent, improves the aesthetics of product, meets client's demand; Secondly; adopt this invention mixed proportion and prilling; owing to not adding in process of production any bonding raw material; only use chlortetracycline pre-mixing agent fine powder and Aureomycin fermentation liquor; thereby in converted products overall process, can effectively protect the active princlple content of product; do not have the generation of impurity component, improved the quality stability of product.
These are only embodiments of the invention; not thereby limit the scope of the claims of the present invention; every equivalent structure or conversion of equivalent flow process that utilizes description of the present invention and accompanying drawing content to do; or be directly or indirectly used in other relevant technical fields, be all in like manner included in scope of patent protection of the present invention.
Claims (9)
1. chlortetracycline pre-mixing agent fine powder prilling, is characterized in that, comprises the following steps:
Chlortetracycline pre-mixing agent fine powder and Aureomycin fermentation liquor are mixed by certain weight ratio, obtain moisture weight ratio in 40% ~ 50% chlortetracycline wet product, by this wet product through prilling by airpillow-dry, obtain chlortetracycline pre-mixing agent semi-finished product.
2. chlortetracycline pre-mixing agent fine powder prilling according to claim 1, is characterized in that, described chlortetracycline pre-mixing agent semi-finished product, by mixing, are obtained to chlortetracycline pre-mixing agent finished product.
3. chlortetracycline pre-mixing agent fine powder prilling according to claim 1, is characterized in that, the weight ratio of chlortetracycline pre-mixing agent fine powder and Aureomycin fermentation liquor is 2.0-2.5:1.0.
4. chlortetracycline pre-mixing agent fine powder prilling according to claim 1 and 2, is characterized in that the half-finished granularity≤1.0mm of gained chlortetracycline pre-mixing agent.
5. chlortetracycline pre-mixing agent fine powder prilling according to claim 1 and 2, is characterized in that, described chlortetracycline pre-mixing agent semi-finished product granularity is 1.0mm.
6. chlortetracycline pre-mixing agent fine powder prilling according to claim 1, is characterized in that, wet product prilling comprises the following steps: the pelletize charging aperture of first wet product being put into comminutor; By double-screw shaft, promote wet product again and enter extrusion chamber; Wet product extruding by crushing block in extrusion chamber constantly flows out from the sieve screen apertures on extrusion chamber both sides the wet feed that obtains strip.
7. chlortetracycline pre-mixing agent fine powder prilling according to claim 6, is characterized in that, described wet feed airpillow-dry condition is temperature≤100 ℃, time≤2.0h.
8. chlortetracycline pre-mixing agent fine powder prilling according to claim 1, is characterized in that, the moisture weight ratio of described chlortetracycline wet product is 45%.
9. chlortetracycline pre-mixing agent fine powder prilling according to claim 1, is characterized in that, the main component of described chlortetracycline pre-mixing agent fine powder comprises chlortetracycline calcium salt and tropina; Described Aureomycin fermentation liquor main component is chlortetracycline calcium salt and tropina.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310611852.XA CN103655194B (en) | 2013-11-27 | 2013-11-27 | Chlortetracycline premix fine powder prilling |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310611852.XA CN103655194B (en) | 2013-11-27 | 2013-11-27 | Chlortetracycline premix fine powder prilling |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103655194A true CN103655194A (en) | 2014-03-26 |
| CN103655194B CN103655194B (en) | 2015-09-23 |
Family
ID=50294763
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310611852.XA Active CN103655194B (en) | 2013-11-27 | 2013-11-27 | Chlortetracycline premix fine powder prilling |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103655194B (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1038751A (en) * | 1988-06-10 | 1990-01-17 | Basf公司 | Preparation is by the spray-dried granules agent of the riboflavin of microbial process generation or the method for fine granule |
| CN1170515A (en) * | 1996-05-31 | 1998-01-21 | 底古萨股份公司 | Process for preparation of animal feed supplement based on fermentation broth |
| CN100998370A (en) * | 2006-01-10 | 2007-07-18 | Cj（株） | Animal feed additives based on fermentation broth and production process thereof by granulation |
| CN101862443A (en) * | 2010-06-11 | 2010-10-20 | 濮阳泓天威药业有限公司 | Preparation method of enramycin premix |
| CN102716092A (en) * | 2012-07-06 | 2012-10-10 | 浦城正大生化有限公司 | Formula of aureomycin hydrochloride premix granule and granulating process |
-
2013
- 2013-11-27 CN CN201310611852.XA patent/CN103655194B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1038751A (en) * | 1988-06-10 | 1990-01-17 | Basf公司 | Preparation is by the spray-dried granules agent of the riboflavin of microbial process generation or the method for fine granule |
| CN1170515A (en) * | 1996-05-31 | 1998-01-21 | 底古萨股份公司 | Process for preparation of animal feed supplement based on fermentation broth |
| CN100998370A (en) * | 2006-01-10 | 2007-07-18 | Cj（株） | Animal feed additives based on fermentation broth and production process thereof by granulation |
| CN101862443A (en) * | 2010-06-11 | 2010-10-20 | 濮阳泓天威药业有限公司 | Preparation method of enramycin premix |
| CN102716092A (en) * | 2012-07-06 | 2012-10-10 | 浦城正大生化有限公司 | Formula of aureomycin hydrochloride premix granule and granulating process |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103655194B (en) | 2015-09-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103819271B (en) | A kind of manufacture method of novel particle Repone K fertilizer | |
| CN101648838B (en) | Method for producing granular ammonium sulfate by using crystalline ammonium sulfate or powdery ammonium sulfate | |
| CN102716092B (en) | Formula of aureomycin hydrochloride premix granule and granulating process | |
| CN101570455A (en) | Method for preparing particle ammonium sulfate product by organic-inorganic binder | |
| CN106278609A (en) | A kind of low concentration Multi-functional circular granular potash fertilizer and preparation method | |
| CN103056959A (en) | Ceramics raw material preparation dry method and short process craft | |
| CN103553800B (en) | Production method of high-concentration potassium chloride pellet | |
| CN101721949A (en) | Method for granulating powdery active lime, special equipment and midbody | |
| JPH0240001B2 (en) | ||
| CN103664356A (en) | Pellet potash fertilizer pelletizing technology | |
| CN103652388A (en) | Technology for producing suckling pig milk replacer by combination of non-drying fermentation and steam-free cold granulating | |
| CN102806051B (en) | Method for preparing raw material of pyrophyllite parts by mixing of fine pyrophyllite powder | |
| CN103655194B (en) | Chlortetracycline premix fine powder prilling | |
| CN202530005U (en) | Two-section granulation type organic fertilizer producing system | |
| CN105601454B (en) | The preparation method of granular chemical fertilizer | |
| CN203388243U (en) | Secondary granulating system for manufacturing piglet feed | |
| CN106242646A (en) | A kind of prilling process of circular granular potash fertilizer | |
| CN101606633B (en) | Half granulation of Dorking granular feed and production method thereof | |
| CN107365180A (en) | Manufacture the production method of potassium magnesium sulfate particle and the purposes of potassium magnesium sulfate particle | |
| CN101578989A (en) | Preparation method of emamectin benzoate 2-5 percent water granules | |
| CN103110515A (en) | Glucosamine potassium sulfate particle production method | |
| CN103110588A (en) | Production method of vitamin B6 granules | |
| CN101530920B (en) | Attapulgite molding method | |
| CN102825675B (en) | Double-screw pelletizing machine used for polyphenylene sulphide and primary pelletizing process | |
| CN102845460B (en) | Phosethyl-aluminum water dispersible granules and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |