CN102716092B - Formula of aureomycin hydrochloride premix granule and granulating process - Google Patents

Abstract

The invention discloses a formula of aureomycin hydrochloride premix granule, which is characterized in that the following components are included: 80 percent or less than 80 percent of aureomycin hydrochloride, 80 percent or less than 80 percent of soluble starch or starch degradation products, 20 percent or less than 20 percent of carbohydrates, and 30 percent or less than 30 percent of purified water. The invention further discloses a granulating process. After the adoption of the formula and the granulating process, the invention achieves that the aureomycin hydrochloride premix granule is uniform, has a mellow appearance, is unanimous in tincture and high in percentage of ripened grains, the stability of product quality is excellent, the normal working conditions during the aureomycin hydrochloride premix granulating process can be ensured, and the improvement to production efficiency and quality is facilitated.

Description

A kind of prescription and granulating process of chlortetracycline hydrochloride pre-mixing agent granule

Technical field

The present invention relates to the chlortetracycline hydrochloride production field, particularly a kind of prescription and granulating process of chlortetracycline hydrochloride pre-mixing agent granule.

Background technology

The powder that returns after using the hydraulic pressure pinch roller to material and sub-sieve in the chlortetracycline hydrochloride pre-mixing agent granule dry granulation process carries out behind the tabletting the more broken granulate acquisition product that sieves, this tabletting process produces higher temperature the chlortetracycline hydrochloride of thermal sensitivity is caused losing of active princlple, also can cause the raising of product impurity component, product stability descends and the product color inequality, pass through simultaneously the broken granulate of lamellar so that the profile of granule lacks uniformity and mellow and full property, because the production of pre-mixing agent has certain requirement to cleanliness factor, the production overall process must be carried out in clean room, in batching, broken, granulate and product-collecting process all can produce dust Factory Building and surrounding are polluted, when having a strong impact on its cleanliness factor also the physical and mental health to operator have a significant impact.

Summary of the invention

For the problems referred to above, purpose of the present invention provides a kind of prescription and granulating process of chlortetracycline hydrochloride pre-mixing agent granule, this prescription can be realized chlortetracycline hydrochloride pre-mixing agent uniform particles, the product processing that outward appearance is mellow and full, color and luster is consistent, granulating rate is high, constant product quality is good with granulating process, guarantee the nominal situation of chlortetracycline hydrochloride pre-mixing agent pelletization, be conducive to enhance productivity and quality.

For achieving the above object, technical scheme proposed by the invention is: a kind of prescription of chlortetracycline hydrochloride pre-mixing agent granule is characterized in that: comprise following component:

Chlortetracycline hydrochloride≤80%;

Soluble starch or starch catabolin≤80%;

Glucide≤20%;

Pure water≤30%.

Further, described soluble starch is corn starch.

Further, described starch catabolin is dextrin.

Further, described glucide is glucose, liquid glucose, ribose or their mixture.

In addition, the present invention also comprises the granulating process of chlortetracycline hydrochloride pre-mixing agent granule, adopts above-mentioned prescription, it is characterized in that: described technique overall process temperature is controlled at≤and 60 ℃, also comprise the steps:

Step 1: said components is mixed ,≤60 ℃ of lower extruding in flakes;

Step 2: will push the broken granulate of pre-mixing agent in blocks, and get the pre-mixing agent granule;

Step 3: the pre-mixing agent granule is adopted 20 orders, 80 order classifying screen sub-sieves, dry 20-80 order pre-mixing agent granule, will＞20 orders and＜80 order granules get back to push in the step 1 in blocks.

Adopt technique scheme, the prescription of chlortetracycline hydrochloride pre-mixing agent granule of the present invention and the remarkable advantage of granulating process are as follows: the one, and adopt this invention prescription and granulating process granulating rate high, improved production efficiency, increase production capacity; The 2nd, adopt this invention prescription and granulating process converted products overall process temperature all to be controlled at below the material thermal sensitivity, effectively protect the active princlple content of product, reduce the generation of impurity component, improved the quality stability of product; The 3rd, uniform particles, the outward appearance that adopts this invented technology to make is mellow and full, color and luster is consistent, improves the aesthetics of product; The 4th, adopt this invented technology converted products overall process almost to produce without dust, for product processing overall process is created favourable operating mode.

The specific embodiment

Below in conjunction with the specific embodiment, the present invention will be further described.

Each material that provides by prescription is transported to extruder through even mixing of blender; carry out flowing to classifying screen behind the broken granulate through flowing to a machine that rolls after the extruding slivering; satisfactory single-size is transported to drying machine, and the undesirable particles circulating that classified sieve of while sifts out is transported to extruder.

Embodiment 1

Chlortetracycline hydrochloride 50%;

Corn starch 45%;

Glucose 5%;

Pure water 30%.

Embodiment 2

Chlortetracycline hydrochloride 80%;

Corn starch 5%;

Glucose 5%;

Pure water 10%.

Embodiment 3

Chlortetracycline hydrochloride 5%;

Corn starch 80%;

Glucose 10%;

Pure water 5%.

Embodiment 4

Chlortetracycline hydrochloride 25%;

Corn starch 25%;

Glucose 20%;

Pure water 30%.

Adopt that said method makes the index of chlortetracycline hydrochloride pre-mixing agent granule be:

Need to prove, the specific targets of product are mainly determined with the content specification of chlortetracycline hydrochloride and the proportioning content of other adjuvant.

Although specifically show and introduced the present invention in conjunction with preferred embodiment; but the those skilled in the art should be understood that; within not breaking away from the spirit and scope of the present invention that appended claims limits; in the form and details the present invention is made a variety of changes, be protection scope of the present invention.

Claims (1)

1. chlortetracycline hydrochloride pre-mixing agent granule, it is characterized in that: described chlortetracycline hydrochloride pre-mixing agent granule comprises following component:

Chlortetracycline hydrochloride≤80%;

Soluble starch or starch catabolin≤80%;

Glucide≤20%;

Pure water≤30%;

Described soluble starch is corn starch; Described starch catabolin is dextrin; Described glucide is glucose, liquid glucose, ribose or their mixture;

Preparation technology's overall process temperature of described chlortetracycline hydrochloride pre-mixing agent granule is controlled at≤and 60 ℃, also comprise the steps:

Step 1: said components is mixed ,≤60 ℃ of lower extruding in flakes;

Step 2: will push the broken granulate of pre-mixing agent in blocks, and get the pre-mixing agent granule;

Step 3: the pre-mixing agent granule is adopted 20 orders, 80 order classifying screen sub-sieves, dry 20-80 order pre-mixing agent granule, will＞20 orders and＜80 order granules get back to push in the step 1 in blocks.