CN103651484B - Pesticide composition containing spiromesifen and carbamates - Google Patents
Pesticide composition containing spiromesifen and carbamates Download PDFInfo
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- CN103651484B CN103651484B CN201210318690.6A CN201210318690A CN103651484B CN 103651484 B CN103651484 B CN 103651484B CN 201210318690 A CN201210318690 A CN 201210318690A CN 103651484 B CN103651484 B CN 103651484B
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Abstract
The invention discloses a pesticide composition containing spiromesifen and carbamates. The pesticide composition contains an active ingredient A and an active ingredient B, wherein the active ingredient A is selected from spiromesifen; the active ingredient B is selected from any one of the following compounds: isoprocarb, metolcarb, indoxacarb and carbaryl; the weight ratio of the active ingredient A to the active ingredient B is (1:80)-(60:1). The composition disclosed by the invention has a synergistic effect on various pests generating hazards to agricultural production and is capable of reducing the pesticide dosage, the pesticide residue on crops and environment pollution, safe to human and livestock, good in environment compatibility and not easy to cause pest resistance to pesticides.
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of application of composition pesticide on crop pests containing Spiromesifen and carbamates.
Background technology
Spiromesifen (Spiromesifen) molecular formula: C
23h
30o
4.The mechanism of action of Spiromesifen is the growth affecting aleyrodid and acarid, disturb the biosynthesis of its liposome, especially have good activity to larval stage, ovarian duct closure function can also be produced simultaneously, reduce the fertility of acarid and adult whitefly, greatly reduce quantity of laying eggs.
Mobucin (isoprocarb) chemical name: o-isopropylphenyl-N-methylcarbamate, molecular formula: C
11h
15nO
2.Mobucin belongs to carbamate insecticide, to insect mainly acetylcholine esterase inhibition, causes insect paralysis to dead.
Meta-tolyl-N-methylcarbamate (MTMC) (metolcarb) chemical name: a tolyl-N-methyl carbamate, molecular formula: C
9h
11nO
2.Meta-tolyl-N-methylcarbamate (MTMC) has tags and fumigation action, and power of knocking down is strong, and the lasting period is short, generally only has 3-4 days, and to rice fulgorid, rice leafhopper and rice thrips, and tea lesser leafhopper etc. has special efficacy.
Chloro-2,3,4a, the 5-tetrahydrochysene-2-of indoxacarb (indoxacarb) chemical name: 7-[methoxycarbonyl (4-Trifluoromethoxyphen-l) carbamoyl] indeno [1,2-e] [1,3,4-] oxadiazines-4a-carboxylate methyl ester, molecular formula: C
22h
17clF
3n
3o
7.Indoxacarb mainly blocks the sodium channel in insect nerve cell, causes target pest to coordinate poor, paralysis, finally dead.Medicament enters polypide by tagging and ingesting, and the behavior of insect changes rapidly, causes insect to stop rapidly ingesting, thus fabulous protects Target crops.Test shows with other insecticide without cross resistance.
Carbaryl (carbaryl) chemical name: 1 naphthyl N methyl carbamate, molecular formula: C
12h
11nO
2.Carbaryl tool broad spectrum activity, suppresses the acetylcholinesterase in pest body, and have favorable effect to insect such as the pink bollworm of leafhopper, plant hopper and biting mouthparts that some are are not easily prevented and treated, insect preventive effect hexachlorcyclohexane, dichlorodiphenyl trichloroethane, parathion etc. having been produced to resistance is good.This medicine toxic action is slow, can be mixed with some organophosphorous pesticides, anti-heterodyne during low temperature.
But in the real process of agricultural production, the problem that pest control the most easily produces is the generation of pest resistance to insecticide.Different cultivars composition carries out composite, is to prevent and treat the very common method of resistant insect.Heterogeneity is carried out composite, according to practical application effect, judge certain composite be synergy, add and or antagonism.In most cases, the composite effect of agricultural chemicals is all additive effect, really has the seldom composite of synergistic effect, especially synergistic effect clearly, very high composite just less of co-toxicity coefficient.Study through inventor, find Spiromesifen and Mobucin, meta-tolyl-N-methylcarbamate (MTMC), indoxacarb, carbaryl is composite after can produce good synergistic effect, and not yet open about the relevant report that Spiromesifen and Mobucin, meta-tolyl-N-methylcarbamate (MTMC), indoxacarb, carbaryl are composite.
Summary of the invention
The object of the invention is to propose a kind ofly have that synergistic function, use cost are low, preventive effect is good containing the composition pesticide of Spiromesifen and carbamates.
The composition pesticide containing Spiromesifen and carbamates that the present invention proposes contains active components A and active component B, active components A and active component B weight ratio are 1 ︰ 80 ~ 60 ︰ 1, described active components A is selected from Spiromesifen, active component B is selected from the one in Mobucin, meta-tolyl-N-methylcarbamate (MTMC), indoxacarb, carbaryl, and active components A and the preferred weight ratio of active component B are 1 ︰ 60 ~ 40 ︰ 1; The weight ratio being more preferably Spiromesifen and Mobucin is 1 ︰ 25 ~ 10 ︰ 1, the weight ratio of Spiromesifen and meta-tolyl-N-methylcarbamate (MTMC) is 1 ︰ 25 ~ 10 ︰ 1, the weight ratio of Spiromesifen and indoxacarb is 1 ︰ 10 ~ 30 ︰ 1, and the weight ratio of Spiromesifen and carbaryl is 1 ︰ 30 ~ 10 ︰ 1; The weight ratio most preferably being Spiromesifen and Mobucin is 1 ︰ 15 ~ 5 ︰ 1, and the weight ratio of Spiromesifen and meta-tolyl-N-methylcarbamate (MTMC) is 1 ︰ 15 ~ 5 ︰ 1, and the weight ratio of Spiromesifen and indoxacarb is 1 ︰ 5 ~ 15 ︰ 1, and the weight ratio of Spiromesifen and carbaryl is 1 ︰ 20 ~ 1 ︰ 1.
The composition pesticide containing Spiromesifen and carbamates that the present invention proposes is for preventing and treating the purposes of insect on crops, and described crops comprise cereal crops, legume crop, fiber crop, sugar [yielding, melon crop, fruits crop, dry fruit crop, hobby crop, root crop, oil crop, flower crop, medicinal crop, crop, green manure pasture crop; Described insect comprises aleyrodid, Tetranychus urticae, two spotted spider mite, aphid, rice fulgorid, leafhopper, diamond-back moth, cotton bollworm, cabbage caterpillar, beet armyworm, rice leaf roller, cutworm, thrips, tea lesser leafhopper.
The weight ratio of active components A, active component B is 1 ︰ 80 ~ 60 ︰ 1.In usual composition, the weight percentage of active component is 0.5% ~ 90% of gross weight, is preferably 5% ~ 80%.According to different preparation types, active component content scope is different.Usually, liquid preparation contains the active substance of by weight 1% ~ 70%, is preferably 5% ~ 50%; Solid pharmaceutical preparation contains the active substance of by weight 5% ~ 80%, is preferably 10% ~ 80%.
At least containing a kind of surfactant in composition pesticide of the present invention, the dispersion of active component in water when being beneficial to use.Surface-active contents is 5% ~ 30% of total formulation weight amount, and surplus is solid or liquid diluent.
Composition pesticide of the present invention can by user before use through diluting or directly using.Its preparation can be prepared by common processing method known in those skilled in the art, after mixing with liquid flux or solid carrier by active substance, then add surfactant as one or more in dispersant, stabilizing agent, wetting agent, binding agent, defoamer, disintegrant, antifreeze etc.
Composition pesticide of the present invention, can be processed into acceptable formulation on any agricultural chemicals on demand, wherein more preferably formulation is wetting powder, water dispersible granules, suspending agent, suspension emulsion, aqueous emulsion, microemulsion, microcapsule suspending agent, microcapsule suspension-suspendinagent agent.
Composition comprises following constituent content when making wetting powder: active components A 0.5% ~ 60%, active component B0.5% ~ 80%, dispersant 2% ~ 10%, wetting agent 2% ~ 10%, filler surplus.
Composition comprises following constituent content when making water dispersible granules: active components A 0.5% ~ 60%, active component B0.5% ~ 80%, dispersant 3% ~ 12%, wetting agent 1% ~ 8%, disintegrant 1% ~ 10%, binding agent 0 ~ 8%, filler surplus.
Composition comprises following constituent content when making suspending agent: active components A 0.5% ~ 50%, active component B0.5% ~ 50%, dispersant 2% ~ 10%, wetting agent 2% ~ 10%, defoamer 0.01% ~ 2%, thickener 0 ~ 2%, antifreeze 0 ~ 8%, deionized water add to 100%.
Composition comprises following constituent content when making suspension emulsion: active components A 0.5% ~ 50%, active component B0.5% ~ 50%, dispersant 2% ~ 10%, defoamer 0.01% ~ 2%, solvent 1% ~ 15%, thickener 0 ~ 2%, emulsifier 2% ~ 12%, antifreeze 0 ~ 8%, deionized water add to 100%.
Composition comprises following constituent content when making aqueous emulsion: active components A 0.5% ~ 50%, active component B0.5% ~ 50%, solvent 1% ~ 30%, emulsifier 1% ~ 15%, antifreeze 0 ~ 8%, thickener 0 ~ 2%, defoamer 0.01% ~ 2%, deionized water supply surplus.
Composition comprises following constituent content when making microcapsule suspending agent: active components A 0.5% ~ 50%, active component B0.5% ~ 50%, macromolecule cyst material 2% ~ 10%, dispersant 1% ~ 10%, organic solvent 1% ~ 10%, defoamer 0.01% ~ 2%, emulsifier 1% ~ 7%, pH adjusting agent 0.01% ~ 5%, deionized water add to 100%.
Composition comprises following constituent content when making microcapsule suspension-suspendinagent agent: active components A 0.5% ~ 50%, active component B0.5% ~ 50%, macromolecule cyst material 2% ~ 10%, dispersant 1% ~ 12%, wetting agent 1% ~ 8%, organic solvent 1% ~ 15%, emulsifier 1% ~ 6%, defoamer 0.01% ~ 2%, thickener 0 ~ 2%, pH adjusting agent 0.01% ~ 5%, deionized water add to 100%.
Wetting powder the key technical indexes of the present invention:
Water dispersible granules the key technical indexes of the present invention:
Suspending agent the key technical indexes of the present invention:
Suspension emulsion the key technical indexes of the present invention:
Aqueous emulsion the key technical indexes of the present invention:
Microcapsule suspending agent the key technical indexes of the present invention:
Microcapsule suspension-suspendinagent agent the key technical indexes of the present invention:
The invention has the advantages that:
(1) Spiromesifen and Mobucin, meta-tolyl-N-methylcarbamate (MTMC), indoxacarb, carbaryl composite after, there is obvious synergy and lasting effect; (2) all greater activity is had to cereal crops, legume crop, fiber crop, sugar [yielding, melon crop, fruits crop, dry fruit crop, hobby crop, root crop, oil crop, flower crop, medicinal crop, crop, green manure pasture crop insect; (3) decrease pesticide usage amount, reduce the residual quantity of agricultural chemicals on crop, alleviate environmental pollution; (4) to person poultry safety, Environmental compatibility is good; And preparation adhesion strength strengthens, resistance of rainwater washing against.
Embodiment
Below in conjunction with embodiment to further instruction of the present invention, the percentage in embodiment is all weight percentage, but the present invention is not limited thereto.
Application Example one
Example 1 ~ 14 wetting powder
Spiromesifen, active component B, dispersant, wetting agent, filler are mixed in mixed cylinder, mixes again after airslide disintegrating mill is pulverized, wetting powder product of the present invention can be obtained, specifically in table 1.
The each component of table 1 embodiment 1 ~ 14 and weight portion
Example 15 ~ 28 water dispersible granules
Spiromesifen, active component B, dispersant, wetting agent, disintegrant, filler etc. are obtained together the particle diameter needed through air-flow crushing, then add other auxiliary agents such as binding agent (can add and can not add), obtain granulation materials.Item is quantitatively sent in fluidized bed granulating dryer through granulating and after drying, water dispersible granules product of the present invention can being obtained, specifically in table 2.
The each component of table 2 embodiment 15 ~ 28 and weight portion
Example 29 ~ 42 suspending agent
By dispersant, wetting agent, defoamer, thickener (can add and can not add), antifreeze (can add and can not add), mix through high speed shear, add Spiromesifen, active component B, ball milling 2 ~ 3 hours in ball mill, make diameter of particle all below 5 μm, surplus deionized water is supplied, and can obtain suspending agent product of the present invention, specifically in table 3.
The each component of table 3 embodiment 29 ~ 42 and weight portion
Example 43 ~ 52 suspension emulsion
Dispersant, defoamer, thickener (can add and can not add), antifreeze (can add and can not add) are mixed through high speed shear, add Spiromesifen, ball milling 2 ~ 3 hours in ball mill, make diameter of particle all below 5 μm, obtained Spiromesifen suspending agent, then by active component B, solvent, emulsifier and the direct emulsification of various auxiliary agent high speed agitators in suspending agent, surplus deionized water is supplied, obtained suspension emulsion product of the present invention, specifically in table 4,5.
The each component of table 4 embodiment 43 ~ 47 and weight portion
The each component of table 5 embodiment 48 ~ 52 and weight portion
Example 53 ~ 59 aqueous emulsion
Spiromesifen, active component B, solvent, emulsifier are added together, make to be dissolved into homogeneous oil phase; Deionized water, antifreeze (can add and can not add), thickener (can add and can not add), defoamer are mixed, becomes homogeneous aqueous phase.Under high velocity agitation, aqueous phase is added oil phase, surplus deionized water is supplied; Aqueous emulsion product of the present invention can be obtained, specifically in table 6.The each component of table 6 embodiment 53 ~ 59 and weight portion
Mobucin, meta-tolyl-N-methylcarbamate (MTMC), indoxacarb, carbaryl in table 1 ~ 6 are exchanged, can novel formulation be obtained.
Example 60 ~ 62 microemulsion
Spiromesifen, active component B are dissolved in and are equipped with in the homogenizer of solvent, emulsifier, antifreeze (can add and can not add), defoamer are joined in the homogenizer that above-mentioned solution is housed, surplus deionized water gives strong mixing and homogenize after supplying, finally obtain the microemulsion product of the present invention that clear appearance is transparent.Specifically in table 7.
The each component of table 7 example 60 ~ 62 and content
Example 63 ~ 65 microcapsule suspending agent
By Spiromesifen, active component B, macromolecule cyst material, solvent, defoamer mixing, make to be dissolved into homogeneous oil phase, in a shear condition, oil phase is joined in the aqueous phase solution containing emulsifier, pH adjusting agent, dispersant, surplus deionized water is supplied, bi-material reacts at oil-water interfaces, forms macromolecule cyst wall, makes the finely disseminated microcapsule suspending agent product of the present composition.Specifically in table 8.
The each component of table 8 embodiment 63 ~ 65 and weight portion
Example 66 ~ 68 microcapsule suspension-suspendinagent agent
By active component B, macromolecule cyst material, solvent, make to be dissolved into homogeneous oil phase, oil phase is joined in a shear condition in the aqueous phase solution containing emulsifier, pH adjusting agent, make finely disseminated microcapsule suspending agent.Dispersant, wetting agent, defoamer, thickener (can add and can not add) are mixed through high speed shear, add Spiromesifen, ball milling 2 ~ 3 hours in ball mill, make diameter of particle all below 5 μm, obtained suspending agent, then join in the aqueous phase solution of micro-capsule suspension by suspending agent, deionized water supplies surplus, make the finely disseminated microcapsule suspension-suspendinagent agent product of the present composition, specifically in table 9.
The each component of table 9 embodiment 66 ~ 68 and weight portion
The embodiment of the present invention is the method adopting Toxicity Determination and field trial to combine.First pass through Toxicity Determination, co-toxicity coefficient (CTC) after clear and definite two kinds of medicaments are composite by a certain percentage, CTC < 80 is antagonism, 80≤CTC≤120 are summation action, CTC > 120 is synergistic effect, on this basis, then carry out field trial.
Test method: respectively the mother liquor of each mixed agent is diluted to five series concentration during test, is placed in beaker respectively for subsequent use.Adopt the method connecing worm after first soaking leaf, take out after the blade of the same size not contacting any medicament is soaked 5s in the liquid configured, naturally dry, put into insect box, then connect for examination larva, raise under 25 DEG C of conditions, often process and repeat for 3 times, often repeating examination borer population used is 50, establishes blank simultaneously, checks dead borer population in 72h, calculate lethality and corrected mortality, try to achieve virulence regression equation and calculate LC
50value.If contrast lethality is greater than 10%, be then considered as invalid test.Computing formula is as follows:
Insect corrected mortality is converted into probit value (y), and concentration for the treatment of (μ g/ml) converts logarithm value to (x), draws virulence regression equation, and calculate the value of often kind of medicament thus with method of least squares, calculates co-toxicity coefficient CTC according to the abundant equation of Sun Yun.Computing formula following (take Spiromesifen as standard agent, its toxicity index is 100):
TI × the P of theoretical toxicity index (the TTI)=Spiromesifen of M
spiromesifentI × the P of+effective active composition B
effective active compositionb
In formula: M is the mixture of different ratio
P
effective active compositionb is the shared in the composition ratio of effective active composition B
P
spiromesifenfor the ratio that Spiromesifen is shared in the composition
B is selected from the one in Mobucin, meta-tolyl-N-methylcarbamate (MTMC), indoxacarb, carbaryl.
Application Example two:
For examination insect: cucumber trialeurodes vaporariorum
Test medicine provides by Shaanxi Meibang Pesticide Co., Ltd..
Experimental scheme: through effective lethal concentration scope of preliminary experiment determination Spiromesifen and the former medicine of Mobucin and the two different ratio mixture.
Toxicity test result
Table 10 Spiromesifen and the composite toxicity test analysis of results table to cucumber trialeurodes vaporariorum of Mobucin
| Reagent agent | Proportioning | LC 50(ug/mL) | Co-toxicity coefficient (CTC) |
| Spiromesifen | - | 1.69 | - |
| Mobucin | - | 7.69 | - |
| Luo first Man Zhi ︰ Mobucin | 60：1 | 0.89 | 192.35 |
| Luo first Man Zhi ︰ Mobucin | 40：1 | 0.88 | 195.77 |
| Luo first Man Zhi ︰ Mobucin | 20：1 | 0.87 | 201.75 |
| Luo first Man Zhi ︰ Mobucin | 10：1 | 0.82 | 221.83 |
| Luo first Man Zhi ︰ Mobucin | 5：1 | 0.85 | 228.54 |
| Luo first Man Zhi ︰ Mobucin | 1：1 | 1.17 | 236.84 |
| Luo first Man Zhi ︰ Mobucin | 1：5 | 2.00 | 241.56 |
| Luo first Man Zhi ︰ Mobucin | 1：9 | 2.39 | 237.45 |
| Luo first Man Zhi ︰ Mobucin | 1：15 | 2.71 | 232.23 |
| Luo first Man Zhi ︰ Mobucin | 1：25 | 3.04 | 222.57 |
| Luo first Man Zhi ︰ Mobucin | 1：40 | 3.45 | 205.14 |
| Luo first Man Zhi ︰ Mobucin | 1：60 | 3.65 | 199.10 |
| Luo first Man Zhi ︰ Mobucin | 1：80 | 3.81 | 193.36 |
As shown in Table 10, Spiromesifen and Mobucin to cucumber trialeurodes vaporariorum proportioning when 1 ︰ 80 ~ 60 ︰ 1, co-toxicity coefficient is all greater than 120, both explanations mixture in 1 ︰ 80 ~ 60 ︰ 1 scope all shows synergistic effect, when the proportioning of Spiromesifen and Mobucin is at 1 ︰ 25 ~ 10 ︰ 1, synergistic effect is more obviously given prominence to, and co-toxicity coefficient is all greater than 220.Testing through applicant the optimum ratio finding Spiromesifen and Mobucin is 10:1,5:1,4:1,3:1,2:1,1:1,1:2,1:3,1:4,1:5,1:6,1:7,1:8,1:9,1:10,1:11,1:12,1:13,1:14,1:15,1:20,1:25, wherein when Spiromesifen and Mobucin weight ratio are 1:5, co-toxicity coefficient is maximum, and synergistic effect is the most obvious.
Application Example three
For examination insect: rice hoppers
Test medicine provides by Shaanxi Meibang Pesticide Co., Ltd..
Experimental scheme: through effective lethal concentration scope of preliminary experiment determination Spiromesifen and the former medicine of meta-tolyl-N-methylcarbamate (MTMC) and the two different ratio mixture.
Table 11 Spiromesifen and the composite toxicity test analysis of results table to rice hoppers of meta-tolyl-N-methylcarbamate (MTMC)
| Reagent agent | Proportioning | LC 50(ug/mL) | Co-toxicity coefficient (CTC) |
| Spiromesifen | - | 1.58 | - |
| Meta-tolyl-N-methylcarbamate (MTMC) | - | 7.10 | - |
| Luo first Man Zhi ︰ meta-tolyl-N-methylcarbamate (MTMC) | 60：1 | 0.82 | 195.17 |
| Luo first Man Zhi ︰ meta-tolyl-N-methylcarbamate (MTMC) | 40：1 | 0.81 | 198.83 |
| Luo first Man Zhi ︰ meta-tolyl-N-methylcarbamate (MTMC) | 20：1 | 0.80 | 205.09 |
| Luo first Man Zhi ︰ meta-tolyl-N-methylcarbamate (MTMC) | 10：1 | 0.77 | 220.80 |
| Luo first Man Zhi ︰ meta-tolyl-N-methylcarbamate (MTMC) | 5：1 | 0.76 | 238.84 |
| Luo first Man Zhi ︰ meta-tolyl-N-methylcarbamate (MTMC) | 1：1 | 1.05 | 246.17 |
| Luo first Man Zhi ︰ meta-tolyl-N-methylcarbamate (MTMC) | 1：5 | 1.80 | 249.29 |
| Luo first Man Zhi ︰ meta-tolyl-N-methylcarbamate (MTMC) | 1：9 | 2.18 | 241.36 |
| Luo first Man Zhi ︰ meta-tolyl-N-methylcarbamate (MTMC) | 1：15 | 2.45 | 237.86 |
| Luo first Man Zhi ︰ meta-tolyl-N-methylcarbamate (MTMC) | 1：25 | 2.84 | 220.39 |
| Luo first Man Zhi ︰ meta-tolyl-N-methylcarbamate (MTMC) | 1：40 | 3.21 | 203.82 |
| Luo first Man Zhi ︰ meta-tolyl-N-methylcarbamate (MTMC) | 1：60 | 3.42 | 196.36 |
| Luo first Man Zhi ︰ meta-tolyl-N-methylcarbamate (MTMC) | 1：80 | 3.51 | 193.92 |
As shown in Table 11, Spiromesifen and meta-tolyl-N-methylcarbamate (MTMC) to rice hoppers proportioning when 1 ︰ 80 ~ 60 ︰ 1, co-toxicity coefficient is all greater than 120, both explanations mixture in 1 ︰ 80 ~ 60 ︰ 1 scope all shows synergistic effect, when the proportioning of Spiromesifen and meta-tolyl-N-methylcarbamate (MTMC) is at 1 ︰ 25 ~ 10 ︰ 1, synergistic effect is more obviously given prominence to, and co-toxicity coefficient is all greater than 220.Testing through applicant the optimum ratio finding Spiromesifen and meta-tolyl-N-methylcarbamate (MTMC) is 10:1,5:1,4:1,3:1,2:1,1:1,1:2,1:3,1:4,1:5,1:6,1:7,1:8,1:9,1:10,1:11,1:12,1:13,1:14,1:15,1:20,1:25, wherein when Spiromesifen and meta-tolyl-N-methylcarbamate (MTMC) weight ratio are 1:5, co-toxicity coefficient is maximum, and synergistic effect is the most obvious.
Application Example four
For examination insect: paddy rice rice leaf roller
Test medicine provides by Shaanxi Meibang Pesticide Co., Ltd..
Experimental scheme: through effective lethal concentration scope of preliminary experiment determination Spiromesifen and the former medicine of indoxacarb and the two different ratio mixture.
Table 12 Spiromesifen and the composite toxicity test analysis of results table to paddy rice rice leaf roller of indoxacarb
| Reagent agent | Proportioning | LC 50(ug/mL) | Co-toxicity coefficient (CTC) |
| Spiromesifen | - | 1.96 | - |
| Indoxacarb | - | 0.67 | - |
| Luo first Man Zhi ︰ indoxacarb | 60：1 | 0.98 | 193.88 |
| Luo first Man Zhi ︰ indoxacarb | 40：1 | 0.95 | 197.06 |
| Luo first Man Zhi ︰ indoxacarb | 30：1 | 0.83 | 222.34 |
| Luo first Man Zhi ︰ indoxacarb | 19：1 | 0.79 | 226.31 |
| Luo first Man Zhi ︰ indoxacarb | 15：1 | 0.75 | 233.26 |
| Luo first Man Zhi ︰ indoxacarb | 9：1 | 0.69 | 238.20 |
| Luo first Man Zhi ︰ indoxacarb | 3：1 | 0.55 | 240.57 |
| Luo first Man Zhi ︰ indoxacarb | 1：1 | 0.42 | 237.77 |
| Luo first Man Zhi ︰ indoxacarb | 1：5 | 0.32 | 235.17 |
| Luo first Man Zhi ︰ indoxacarb | 1：10 | 0.32 | 222.70 |
| Luo first Man Zhi ︰ indoxacarb | 1：20 | 0.34 | 203.43 |
| Luo first Man Zhi ︰ indoxacarb | 1：40 | 0.35 | 194.55 |
| Luo first Man Zhi ︰ indoxacarb | 1：60 | 0.36 | 188.14 |
| Luo first Man Zhi ︰ indoxacarb | 1：80 | 0.37 | 182.56 |
As shown in Table 12, Spiromesifen and indoxacarb to paddy rice rice leaf roller proportioning when 1 ︰ 80 ~ 60 ︰ 1, co-toxicity coefficient is all greater than 120, both explanations mixture in 1 ︰ 80 ~ 60 ︰ 1 scope all shows synergistic effect, when the proportioning of Spiromesifen and indoxacarb is at 1 ︰ 10 ~ 30 ︰ 1, synergistic effect is more obviously given prominence to, and co-toxicity coefficient is all greater than 220.Testing through applicant the optimum ratio finding Spiromesifen and indoxacarb is 30:1,25:1,20:1,15:1,14:1,13:1,12:1,11:1,10:1,9:1,8:1,7:1,6:1,5:1,4:1,3:1,2:1,1:1,1:2,1:3,1:4,1:5,1:10, wherein when Spiromesifen and indoxacarb weight ratio are 3:1, co-toxicity coefficient is maximum, and synergistic effect is the most obvious.
Application Example five
For examination insect: cotton cotton bollworm
Test medicine provides by Shaanxi Meibang Pesticide Co., Ltd..
Experimental scheme: through effective lethal concentration scope of preliminary experiment determination Spiromesifen and the former medicine of carbaryl and the two different ratio mixture.
Table 13 Spiromesifen and the composite toxicity test analysis of results table to cotton cotton bollworm of carbaryl
| Reagent agent | Proportioning | LC 50(ug/mL) | Co-toxicity coefficient (CTC) |
| Spiromesifen | - | 1.78 | - |
| Carbaryl | - | 15.12 | - |
| Luo first Man Zhi ︰ carbaryl | 60：1 | 0.92 | 196.32 |
| Luo first Man Zhi ︰ carbaryl | 40：1 | 0.91 | 199.91 |
| Luo first Man Zhi ︰ carbaryl | 20：1 | 0.90 | 206.45 |
| Luo first Man Zhi ︰ carbaryl | 10：1 | 0.87 | 222.44 |
| Luo first Man Zhi ︰ carbaryl | 5：1 | 0.93 | 224.39 |
| Luo first Man Zhi ︰ carbaryl | 1：1 | 1.36 | 234.19 |
| Luo first Man Zhi ︰ carbaryl | 1：4 | 2.50 | 242.03 |
| Luo first Man Zhi ︰ carbaryl | 1：9 | 3.51 | 246.23 |
| Luo first Man Zhi ︰ carbaryl | 1：14 | 4.15 | 242.95 |
| Luo first Man Zhi ︰ carbaryl | 1：20 | 4.71 | 236.59 |
| Luo first Man Zhi ︰ carbaryl | 1：30 | 5.48 | 222.20 |
| Luo first Man Zhi ︰ carbaryl | 1：40 | 6.21 | 205.85 |
| Luo first Man Zhi ︰ carbaryl | 1：60 | 6.75 | 199.49 |
| Luo first Man Zhi ︰ carbaryl | 1：80 | 7.05 | 196.31 |
As shown in Table 13, Spiromesifen and carbaryl to cotton cotton bollworm proportioning when 1 ︰ 80 ~ 60 ︰ 1, co-toxicity coefficient is all greater than 120, both explanations mixture in 1 ︰ 80 ~ 60 ︰ 1 scope all shows synergistic effect, when the proportioning of Spiromesifen and carbaryl is at 1 ︰ 30 ~ 10 ︰ 1, synergistic effect is more obviously given prominence to, and co-toxicity coefficient is all greater than 220.Testing through applicant the optimum ratio finding Spiromesifen and carbaryl is 10:1,5:1,4:1,3:1,2:1,1:1,1:2,1:3,1:4,1:5,1:6,1:7,1:8,1:9,1:10,1:11,1:12,1:13,1:14,1:15,1:16,1:17,1:18,1:19,1:20,1:25,1:30, wherein when Spiromesifen and carbaryl weight ratio are 1:9, co-toxicity coefficient is maximum, and synergistic effect is the most obvious.
Through test find: Spiromesifen and active component B composite after have obvious synergistic effect to the control of the aleyrodid in various crop, Tetranychus urticae, two spotted spider mite, aphid, rice fulgorid, leafhopper, diamond-back moth, cotton bollworm, cabbage caterpillar, beet armyworm, rice leaf roller, cutworm, thrips, tea lesser leafhopper, co-toxicity coefficient is all more than 120.
Experimental section:
Test medicine is researched and developed by Shaanxi Meibang Pesticide Co., Ltd., is provided, contrast medicament 24% Spiromesifen suspending agent (autogamy), 20% Mobucin missible oil (commercial), 20% meta-tolyl-N-methylcarbamate (MTMC) missible oil (commercial), 30% indoxacarb water dispersible granule (commercial), 25% carbaryl wetting powder (commercial).
Application Example six Spiromesifen and active component B and the composite control cucumber aleyrodid test of pesticide effectiveness thereof
This test arrangement is at Xian District, Shanxi Province suburban area, and investigation cucumber powder mite evil index before medicine, in the dispenser of insect pest initial stage of origination, 3 days, 10 days, 20 days investigation insect pest indexes after dispenser also calculate preventive effect.Result of the test is as follows:
Table 14 Spiromesifen and active component B and the composite control cucumber aleyrodid test of pesticide effectiveness thereof
As can be seen from Table 14, Spiromesifen and active component B composite after can effectively prevent and treat cucumber aleyrodid, control efficiency, all higher than 96%, is better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example seven Spiromesifen and active component B and the composite control Laphygma exigua Hubner test of pesticide effectiveness thereof
This test arrangement is at Xian District, Shanxi Province suburban area, and investigation Laphygma exigua Hubner insect pest index before medicine, in the dispenser of insect pest initial stage of origination, 7 days, 10 days, 20 days investigation insect pest indexes after dispenser also calculate preventive effect.Result of the test is as follows:
Table 15 Spiromesifen and active component B and the composite control Laphygma exigua Hubner test of pesticide effectiveness thereof
As can be seen from Table 15, Spiromesifen and active component B composite after effectively can prevent and treat Laphygma exigua Hubner, through inventor test prove Spiromesifen and active component B composite after also can effectively prevent and treat wild cabbage diamond-back moth, cabbage caterpillar, control efficiency is all higher than 96%, be better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example eight Spiromesifen and active component B and the composite control cotton cotton bollworm test of pesticide effectiveness thereof
This test arrangement is in Weinan City Dali County, Shaanxi Province, and investigation cotton cotton bollworm insect pest index before medicine, in the dispenser of insect pest initial stage of origination, 3 days, 15 days, 30 days investigation insect pest indexes after dispenser also calculate preventive effect.Result of the test is as follows:
Table 16 Spiromesifen and active component B and the composite control cotton cotton bollworm test of pesticide effectiveness thereof
As can be seen from Table 16, Spiromesifen and active component B and composite control cotton cotton bollworm thereof, through inventor test prove Spiromesifen and active component B composite after also can effectively prevent and treat cotton red spider, aleyrodid, control efficiency is all higher than 96%, be better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example nine Spiromesifen and active component B and compositely prevent and treat the rice hoppers test of pesticide effectiveness
This test arrangement is at Shaanxi Province's Hanzhong City, and investigation rice hoppers insect pest index before medicine, in the dispenser of insect pest initial stage of origination, 3 days, 7 days, 15 days investigation insect pest indexes after dispenser also calculate preventive effect.Result of the test is as follows:
Table 17 Spiromesifen and active component B and compositely prevent and treat the rice hoppers test of pesticide effectiveness
As can be seen from Table 17, Spiromesifen and active component B composite after effectively can prevent and treat rice hoppers, through inventor test prove Spiromesifen and active component B composite after also can effectively prevent and treat paddy rice rice leaf roller, leafhopper, control efficiency is all higher than 96%, be better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.Application Example ten Spiromesifen and active component B and composite control apple Tetranychus urticae thereof
The test of pesticide effectiveness
This test arrangement is in Xianyang, Shanxi province city, and investigation apple Tetranychus urticae insect pest index before medicine, in the dispenser of insect pest initial stage of origination, 3 days, 10 days, 20 days investigation insect pest indexes after dispenser also calculate preventive effect.Result of the test is as follows:
Table 18 Spiromesifen and active component B and the composite control apple Tetranychus urticae test of pesticide effectiveness thereof
As can be seen from Table 18, Spiromesifen and active component B composite after can effectively prevent and treat apple Tetranychus urticae, through inventor test prove Spiromesifen and active component B composite after also effectively can prevent and treat European red mite, control efficiency is all higher than 96%, be better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example 11 Spiromesifen and active component B and the composite control flowering plant aphid test of pesticide effectiveness thereof
This test arrangement is in nursery, Xi'an City, Shanxi Province, and investigation flowering plant aphid insect pest index before medicine, in the dispenser of insect pest initial stage of origination, 3 days, 10 days, 20 days investigation insect pest indexes after dispenser also calculate preventive effect.Result of the test is as follows:
Table 19 Spiromesifen and active component B and the composite control flowering plant aphid test of pesticide effectiveness thereof
As can be seen from Table 19, Spiromesifen and active component B composite after effectively can prevent and treat flowering plant aphid, through inventor test prove Spiromesifen and active component B composite after also can effectively prevent and treat flowers thrips, control efficiency is all higher than 95%, be better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
After draw through tests different local throughout the country, Spiromesifen and Mobucin, meta-tolyl-N-methylcarbamate (MTMC), indoxacarb, the composite rear preventive effect to common insect pests such as the aleyrodid in various crop, Tetranychus urticae, two spotted spider mite, aphid, rice fulgorid, leafhopper, diamond-back moth, cotton bollworm, cabbage caterpillar, beet armyworm, rice leaf roller, cutworm, thrips, tea lesser leafhoppers of carbaryl are all more than 95%, be better than single dose preventive effect, synergistic effect is obvious.
Claims (6)
1. one kind contains the composition pesticide of Spiromesifen and carbamates, effective active composition is active components A and active component B, it is characterized in that: active components A and active component B weight ratio are 1 ︰ 80 ~ 60 ︰ 1, and described active components A is Spiromesifen, and active component B is indoxacarb.
2. the composition pesticide containing Spiromesifen and carbamates according to claim 1, is characterized in that: the weight ratio of active components A and active component B is 1 ︰ 60 ~ 40 ︰ 1.
3. the composition pesticide containing Spiromesifen and carbamates according to claim 2, is characterized in that: the weight ratio of Spiromesifen and indoxacarb is 1 ︰ 10 ~ 30 ︰ 1.
4. the composition pesticide containing Spiromesifen and carbamates according to any one of claim 1 to 3, is characterized in that: composition makes wetting powder, water dispersible granules, suspending agent, suspension emulsion, aqueous emulsion, microemulsion, microcapsule suspending agent, microcapsule suspension-suspendinagent agent.
5. the composition pesticide containing Spiromesifen and carbamates according to claim 4 is for preventing and treating the purposes of insect on crops.
6. purposes according to claim 5, is characterized in that: described insect comprises aleyrodid, Tetranychus urticae, two spotted spider mite, aphid, rice fulgorid, leafhopper, diamond-back moth, cotton bollworm, cabbage caterpillar, beet armyworm, rice leaf roller, cutworm, thrips, tea lesser leafhopper.
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| CN201210318690.6A CN103651484B (en) | 2012-08-31 | 2012-08-31 | Pesticide composition containing spiromesifen and carbamates |
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| CN201510088477.4A Expired - Fee Related CN104738064B (en) | 2012-08-31 | 2012-08-31 | A kind of composition pesticide containing Spiromesifen and carbamatess |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1419412A (en) * | 2000-03-28 | 2003-05-21 | 拜尔公司 | Active substance combinations having insecticidal and acaricidal properties |
| CN101250173A (en) * | 2008-04-01 | 2008-08-27 | 浙江大学 | Preparation method of spiromesifen |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| DE10013914A1 (en) * | 2000-03-21 | 2001-09-27 | Bayer Ag | Synergistic pesticidal composition comprising 4-hydroxy-3-phenyl-furan-2(5H)-one derivative and bifenazate, abamectin or bifenthrin, are useful as insecticide, acaricide, ectoparasiticide or antifouling agents |
| EP2039248A1 (en) * | 2007-09-21 | 2009-03-25 | Bayer CropScience AG | Active agent combinations with insecticide and acaricide properties |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1419412A (en) * | 2000-03-28 | 2003-05-21 | 拜尔公司 | Active substance combinations having insecticidal and acaricidal properties |
| CN101250173A (en) * | 2008-04-01 | 2008-08-27 | 浙江大学 | Preparation method of spiromesifen |
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| CN104738064A (en) | 2015-07-01 |
| CN104738064B (en) | 2017-03-01 |
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