CN103648294A - 具有防腐剂功效的动物饲料添加剂 - Google Patents
具有防腐剂功效的动物饲料添加剂 Download PDFInfo
- Publication number
- CN103648294A CN103648294A CN201280025197.3A CN201280025197A CN103648294A CN 103648294 A CN103648294 A CN 103648294A CN 201280025197 A CN201280025197 A CN 201280025197A CN 103648294 A CN103648294 A CN 103648294A
- Authority
- CN
- China
- Prior art keywords
- weight
- propionic acid
- animal feed
- feed additive
- alkali metal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 235000019730 animal feed additive Nutrition 0.000 title claims abstract description 19
- 239000003755 preservative agent Substances 0.000 title abstract description 4
- 230000002335 preservative effect Effects 0.000 title abstract description 4
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims abstract description 72
- 235000019260 propionic acid Nutrition 0.000 claims abstract description 36
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims abstract description 25
- -1 alkali metal salt Chemical class 0.000 claims abstract description 9
- 229910052783 alkali metal Inorganic materials 0.000 claims abstract description 8
- 239000003112 inhibitor Substances 0.000 claims abstract description 4
- 239000000203 mixture Substances 0.000 claims description 19
- 238000000034 method Methods 0.000 claims description 15
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 14
- 239000000376 reactant Substances 0.000 claims description 8
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid group Chemical group S(O)(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 8
- 239000003054 catalyst Substances 0.000 claims description 7
- 235000011187 glycerol Nutrition 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 230000002378 acidificating effect Effects 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 5
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims description 5
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims description 4
- 239000003513 alkali Substances 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 claims description 3
- 239000000908 ammonium hydroxide Substances 0.000 claims description 3
- YZWRNSARCRTXDS-UHFFFAOYSA-N tripropionin Chemical compound CCC(=O)OCC(OC(=O)CC)COC(=O)CC YZWRNSARCRTXDS-UHFFFAOYSA-N 0.000 claims description 3
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 150000008044 alkali metal hydroxides Chemical class 0.000 claims description 2
- 235000019253 formic acid Nutrition 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
- 238000010790 dilution Methods 0.000 claims 1
- 239000012895 dilution Substances 0.000 claims 1
- 150000004675 formic acid derivatives Chemical class 0.000 claims 1
- 125000005456 glyceride group Chemical group 0.000 claims 1
- 229910052700 potassium Inorganic materials 0.000 claims 1
- 239000011591 potassium Substances 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- AALUCPRYHRPMAG-UHFFFAOYSA-N Glycerol 1-propanoate Chemical class CCC(=O)OCC(O)CO AALUCPRYHRPMAG-UHFFFAOYSA-N 0.000 abstract 1
- 230000009972 noncorrosive effect Effects 0.000 abstract 1
- 241000233866 Fungi Species 0.000 description 7
- 235000013339 cereals Nutrition 0.000 description 6
- 241001465754 Metazoa Species 0.000 description 5
- 238000012360 testing method Methods 0.000 description 4
- 239000004280 Sodium formate Substances 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 230000000996 additive effect Effects 0.000 description 3
- HLBBKKJFGFRGMU-UHFFFAOYSA-M sodium formate Chemical compound [Na+].[O-]C=O HLBBKKJFGFRGMU-UHFFFAOYSA-M 0.000 description 3
- 235000019254 sodium formate Nutrition 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 230000007797 corrosion Effects 0.000 description 2
- 238000005260 corrosion Methods 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000004088 simulation Methods 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 240000005979 Hordeum vulgare Species 0.000 description 1
- 235000007340 Hordeum vulgare Nutrition 0.000 description 1
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 1
- 238000010306 acid treatment Methods 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940072033 potash Drugs 0.000 description 1
- 235000015320 potassium carbonate Nutrition 0.000 description 1
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Substances [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 231100000022 skin irritation / corrosion Toxicity 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
- A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
- A23L3/358—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K30/00—Processes specially adapted for preservation of materials in order to produce animal feeding-stuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K30/00—Processes specially adapted for preservation of materials in order to produce animal feeding-stuffs
- A23K30/10—Processes specially adapted for preservation of materials in order to produce animal feeding-stuffs of green fodder
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
- A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
- A23L3/3463—Organic compounds; Microorganisms; Enzymes
- A23L3/3481—Organic compounds containing oxygen
- A23L3/3508—Organic compounds containing oxygen containing carboxyl groups
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
- A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
- A23L3/3463—Organic compounds; Microorganisms; Enzymes
- A23L3/3481—Organic compounds containing oxygen
- A23L3/3508—Organic compounds containing oxygen containing carboxyl groups
- A23L3/3517—Carboxylic acid esters
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/02—Acid
- A23V2250/034—Formic acid
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/02—Acid
- A23V2250/05—Propionic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Microbiology (AREA)
- Inorganic Chemistry (AREA)
- Fodder In General (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
本发明公开了—种能有效作为防腐剂的新型动物饲料添加剂。所述饲料添加剂含有30-80％重量的丙酸，20-70％重量的丙酸甘油酯和任选地1-10％重量的碱金属盐。所述产品没有腐蚀性且能有效用作例如防霉剂。
Description
本发明涉及一种具有防腐剂功效的新型饲料添加剂，所述饲料添加剂包含作为活性成分的丙酸，丙酸甘油酯和任选的少量碱金属盐。另一方面，本发明涉及一种所述动物饲料添加剂的制造方法，再一方面，本发明还涉及其在动物饲料中作为防霉剂的用途。
由于更多精细耕作方法的推广，化学物质使用的增加会改变土壤和植物中的微生物种群，造成生态稳固变化，近年来从动物和人类福利的角度考虑，人类食品和动物饲料中感染性霉菌和毒素产生的增加已经成为人们越来越关注的问题。相当多的研究一直致力于开发抑制霉菌生长的方法，其通常直接作用于饲料的水分含量，即水分含量越高，霉菌生长的危害越大。
丙酸是目前在动物饲料中广泛使用的有效的且久经考验的防腐剂。然而，丙酸，对皮肤和金属有腐蚀性，且其闪点低于55℃，根据，例如ADR运输法规，在分类时被标记为腐蚀性和易燃性，因而限制了终端用户储存和运输这—材料的可能性。已建立的避免列入该分类的方法是，通过加入例如碱性化合物，如氨，和／或通过加入气压下降剂，至少部分地中和酸。所述方法需要昂贵的装置以处理碱性物。
现在非常出乎意料地发现，丙酸甘油酯和丙酸的混合物可以使所述分类变得多余，而防腐剂的性能，如作为防霉剂，基本上与纯丙酸相同。因此，本发明提供了—种饲料添加剂，基本上是无腐蚀性，具有挥发性和闪点在必要运输分类以外。新型饲料添加剂包含30-80％，如40-60％或35-65％重量的丙酸；20-70％，如30％-50％或35-55％重量的丙酸甘油酯，小于4％，如小于2％，如0.5-1％重量的丙三醇，和任选的1-10％，如1-5％重量的碱金属盐，优选甲酸盐，如碳酸钾或甲酸钠，加水至100％(重量)所述水如反应水和所用原料中包含的水。所述丙酸甘油酯是单、双和丙酸三甘酯的混合物，所述混合物具有10-30％重量的丙酸单甘酯，40％-70％重量的丙酸甘油二酯和10-30％重量的丙酸三甘酯的比例，平衡至100％重量。
另一方面，本发明提供—种动物饲料添加剂的制造方法，所述方法通过将含有70-90％重量丙酸和10-30％重量甘油的混合物在温度为50-70℃下反应直到反应平衡。任选地，所述反应是在酸性催化剂，如硫酸存在下进行，例如以反应物重量的0.05-0.5％的量。所述方法还可以任选地包含用附加量的丙酸稀释得到的反应混合物的步骤，以得到具有前述量的包含丙酸和丙酸甘油酯的组合物，和／或混合所述碱金属盐的步骤。所用的酸性催化剂可以通过加入根据化学式计算的量的碱性化合物，如氢氧化铵和／或碱金属氢氧化物适当地中和。由此得到的混合物或组合物适用于作为动物饲料的防霉添加剂。
当然，本发明实施方案中的动物饲料添加剂能够通过添加例如水，甲酸，丙酸，丁酸和／或其它防霉化合物来稀释到任何合适的活性组分的浓度。当然，该饲料添加剂也可以通过加入其它饲料添加剂、防腐剂、营养素和药物制剂如相容性抗生素和维生素得到补充。
无论以任何方式，下述优选的具体实施方案对于说明书的其余部分而言仅仅是说明性而非限制性解释。在下文中，实施例1-3涉及根据本发明实施方案的动物饲料添加剂的制备，而实施例4-7涉及得到的产品与市售丙酸基饲料添加剂的比较。评价结果列于表1-3中。
实施例1
将70kg丙酸，30kg甘油和作为催化剂的200g硫酸在反应容器中混合并加热至60℃。8小时后达到反应平衡。产生的反应混合物冷却至室温，并加入所述根据硫酸计算化学当量的量的氢氧化铵。
得到反应混合物具有以下组份：
实施例2
重复实施例1，其区别是向得到的反应混合物中加入2％(重量)的甲酸钠。
实施例3
重复实施例1，其区别是向得到的反应混合物中加入3％(重量)的甲酸钠。
实施例4
喷雾干燥实施例1得到的产品，以使用丙酸有氧保存湿谷物时的推荐使用量*的35，46和59％的比例使用，对大麦来说其水分含量为34％，而且喷雾干燥的谷物样品储存在模拟谷物储存正常的储存条件的玻璃瓶中。以基于丙酸含量计算的剂量将实施例1与纯丙酸和
(巴斯夫，德国)进行比较。18-22℃下将处理过的样品储存在模拟谷物储存正常的储存条件的玻璃瓶中。每周观察并记录霉菌的生长情况。由瑞典农业科学大学进行测试并使用下面的评分标准评估。
0=无可视的霉菌生长
1=可见1-3个小型酶斑
2=<10％的表面上有霉菌生长
3=10-30％的表面上有霉菌生长
4=30-50％的表面上有霉菌生长
5=>50％的表面上有霉菌生长
并且表1中给出了15个样品／产品的平均值。
推荐的施用率如下计算：
推荐的施用率(ml／kg潮湿谷物)=(水分含量×0.375)-1.125
实施例5
称取实施例2中得到的产品30g放入100ml烧杯中，在室温下储存65天。以重量百分比计算的剩余样品中通过间隔称重测定。在相同条件下测定比较样品
结果列于表2中。
实施例6
评估根据实施例1，2和3的产品对不锈钢盘的腐蚀情况。根据UN试验方法第III部分第37章进行腐蚀试验。以重量百分比表示的不锈钢表面重量损失以及以μm表示的侵蚀深度的结果，列于表3中。
实施例7
根据OECD指南NO.404，“急性皮肤刺激／腐蚀”，2002年4月，并根据评估委员会指导标准2001／59／EC进行皮肤刺激测试。使用实施例1的产品测试结果显示所述产品归类为对皮肤无刺激性。
表1
PA=丙酸
LG=
Ex.1=实施例1的产品
表2
表3
Claims (18)
1.有效作为防腐剂的动物饲料添加剂，其特征在于，其包含30-80％重量的丙酸，20-70％重量的丙酸甘油酯和小于4％重量的甘油，加水至100％重量。
2.根据权利要求1所述的动物饲料添加剂，其特征在于，其包含40-60％重量的丙酸，30-50％重量的丙酸甘油酯。
3.根据权利要求1所述的动物饲料添加剂，其特征在于，其包括35-65％重量的丙酸，35-55％重量的丙酸甘油酯。
4.根据权利要求1-3中任一项所述的动物饲料添加剂，其特征在于，其包含小于2％重量的甘油。
5.根据权利要求1-3中任一项所述的动物饲料添加剂，其特征在于，其包含0.5-1％重量的甘油。
6.根据权利要求1-5中任一项所述的动物饲料添加剂，其特征在于所述丙酸甘油酯是含有10-30％重量的一丙酸甘油酯，40-70％重量的二丙酸甘油酯、10-30％重量的三丙酸甘油酯且余量至100％重量的混合物。
7.根据权利要求1-6中任一项所述的动物饲料添加剂，其特征在于，其另外包含至少—种添加量为1-10％重量的碱金属盐。
8.根据权利要求1-6中任一项所述的动物饲料添加剂，其特征在于，其包含至少—种添加量为1-5％重量的碱金属盐。
9.根据权利要求7或8所述的动物饲料添加剂，其特征在于，所述碱金属盐是钾或钠的甲酸盐。
10.根据权利要求1-9中任一项所述的动物饲料添加剂，其特征在于，其用水、甲酸、丙酸和／或丁酸稀释。
11.根据权利要求1-9中任一项所述的动物饲料添加剂的制备方法，其特征在于，使含有70-90％重量丙酸和10-30％重量甘油的混合物在50-70℃的温度下进行反应，直到达到反应平衡，且任选地向得到的反应混合物中加入至少—种数量为1-10％重量的碱金属盐。
12.根据权利要求11所述的方法，其特征在于，所述反应是在酸性催化剂的存在下进行的。
13.根据权利要求12所述的方法，其特征在于，所述酸性催化剂是硫酸。
14.根据权利要求12或13所述的方法，其特征在于，所述酸性催化剂以基于反应物总量计算的0.05-0.5％重量的量存在。
15.根据权利要求12-14中任一项所述的方法，其特征在于，通过添加化学计算量的碱性化合物中和所述酸性催化剂。
16.根据权利要求15所述的方法，其特征在于，所述碱性化合物是氢氧化铵和／或碱金属氢氧化物。
17.根据权利要求11-16中任一项所述的方法，其特征在于，使用额外量的丙酸稀释所得到的反应混合物来获得含有30-80％重量丙酸和20-70％重量丙酸甘油酯的组合物。
18.根据权利要求1-10中任一项所述的饲料添加剂作为防霉剂的用途。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1100413-2 | 2011-05-24 | ||
| SE1100413A SE535688C2 (sv) | 2011-05-24 | 2011-05-24 | Djurfodertillsats vilken är verksam som konserveringsmedel |
| PCT/SE2012/000073 WO2012161633A1 (en) | 2011-05-24 | 2012-05-14 | Animal feed additive effective as preservative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103648294A true CN103648294A (zh) | 2014-03-19 |
| CN103648294B CN103648294B (zh) | 2015-05-27 |
Family
ID=47136865
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280025197.3A Active CN103648294B (zh) | 2011-05-24 | 2012-05-14 | 具有防腐剂功效的动物饲料添加剂 |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP2713769B1 (zh) |
| CN (1) | CN103648294B (zh) |
| DK (1) | DK2713769T3 (zh) |
| ES (1) | ES2605846T3 (zh) |
| HU (1) | HUE029643T2 (zh) |
| PL (1) | PL2713769T3 (zh) |
| SE (1) | SE535688C2 (zh) |
| WO (1) | WO2012161633A1 (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109219354A (zh) * | 2016-05-20 | 2019-01-15 | 佩什托普公司 | 有效作为广谱防腐剂的动物饲料添加剂 |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE541250C2 (en) * | 2017-05-04 | 2019-05-14 | Perstorp Ab | Method for reduction of deoxynivalenol levels in feed |
| MX2021000085A (es) * | 2018-06-22 | 2021-03-25 | Basf Se | Composiciones para animales, y sus usos. |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6183794B1 (en) * | 1997-03-21 | 2001-02-06 | Basf Aktiengesellschaft | Propionic acid, ammonia, propanediol and water solutions and the use thereof |
| US20040170729A1 (en) * | 2003-02-28 | 2004-09-02 | Jesuadimai Ignatius Xavier Antony | Mold inhibitor having reduced corrosiveness |
| WO2010106488A2 (en) * | 2009-03-16 | 2010-09-23 | Fernando Cantini | Compositions containing c1 to c7 organic acid monoglycerides and glycerol, their preparation and use as antibacterials and anti-mould agents |
| EP2294924A1 (en) * | 2009-08-17 | 2011-03-16 | Auster Nutricao Animal Ltda | 1-monopropionine compound and its isomer 3-monopropionine as preserving agents for animal feed, grains and animal-origin flours |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2005371A (en) * | 1934-08-18 | 1935-06-18 | Eastman Kodak Co | Process for the manufacture of tripropionin |
| US3394009A (en) * | 1964-07-24 | 1968-07-23 | Atlas Chem Ind | Preparation of baked products |
| SU701631A1 (ru) * | 1978-05-03 | 1979-12-05 | Казахский Филиал Всесоюзного Научно- Исследовательского Института Комбикормовой Промышленности | Способ консервировани кормов |
| CA1168078A (en) * | 1980-09-09 | 1984-05-29 | Gerhard J. Haas | Intermediate moisture food preservation |
| US4847067A (en) * | 1984-05-02 | 1989-07-11 | Thomas Richard D | Mold and dust inhibiting product and method |
| CN101691525B (zh) * | 2009-10-12 | 2011-11-30 | 河南兴泰科技实业有限公司 | 一种甘油脂肪酸酯及其制备方法 |
-
2011
- 2011-05-24 SE SE1100413A patent/SE535688C2/sv unknown
-
2012
- 2012-05-14 PL PL12790221T patent/PL2713769T3/pl unknown
- 2012-05-14 WO PCT/SE2012/000073 patent/WO2012161633A1/en active Application Filing
- 2012-05-14 DK DK12790221.1T patent/DK2713769T3/en active
- 2012-05-14 ES ES12790221.1T patent/ES2605846T3/es active Active
- 2012-05-14 HU HUE12790221A patent/HUE029643T2/en unknown
- 2012-05-14 EP EP12790221.1A patent/EP2713769B1/en active Active
- 2012-05-14 CN CN201280025197.3A patent/CN103648294B/zh active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6183794B1 (en) * | 1997-03-21 | 2001-02-06 | Basf Aktiengesellschaft | Propionic acid, ammonia, propanediol and water solutions and the use thereof |
| US20040170729A1 (en) * | 2003-02-28 | 2004-09-02 | Jesuadimai Ignatius Xavier Antony | Mold inhibitor having reduced corrosiveness |
| WO2010106488A2 (en) * | 2009-03-16 | 2010-09-23 | Fernando Cantini | Compositions containing c1 to c7 organic acid monoglycerides and glycerol, their preparation and use as antibacterials and anti-mould agents |
| EP2294924A1 (en) * | 2009-08-17 | 2011-03-16 | Auster Nutricao Animal Ltda | 1-monopropionine compound and its isomer 3-monopropionine as preserving agents for animal feed, grains and animal-origin flours |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109219354A (zh) * | 2016-05-20 | 2019-01-15 | 佩什托普公司 | 有效作为广谱防腐剂的动物饲料添加剂 |
Also Published As
| Publication number | Publication date |
|---|---|
| SE1100413A1 (sv) | 2012-11-06 |
| ES2605846T3 (es) | 2017-03-16 |
| CN103648294B (zh) | 2015-05-27 |
| EP2713769A4 (en) | 2014-12-24 |
| EP2713769A1 (en) | 2014-04-09 |
| HUE029643T2 (en) | 2017-02-28 |
| WO2012161633A1 (en) | 2012-11-29 |
| EP2713769B1 (en) | 2016-09-14 |
| SE535688C2 (sv) | 2012-11-06 |
| DK2713769T3 (en) | 2016-10-24 |
| PL2713769T3 (pl) | 2017-01-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2018222967B2 (en) | Nitrification inhibitors designed for urea and manure based fertilizers | |
| US10689308B2 (en) | Solvent for thiophosphoric triamide or dicyandiamide solutions, and related methods | |
| EP1997793B2 (en) | Heteromolecular metal-humic (chelate) complexes | |
| US8048189B2 (en) | Buffered amino alcohol solutions of N-(n-butyl)thiophosphoric triamide (NBPT) and urea fertilizers using such solutions as urease inhibitors | |
| US4179522A (en) | Certain complex salts of mono carboxylic acids used as preservatives | |
| US20100206031A1 (en) | Amino alcohol solutions of N-(n-butyl)thiophosphoric triamide (NBPT) and urea fertilizers using such solutions as urease inhibitors | |
| US10974999B2 (en) | Increased longevity of the nitrogen content of soil through improved liquid delivery formulations of nitrification inhibitors designed for urea and manure based fertilizers | |
| CN103648294B (zh) | 具有防腐剂功效的动物饲料添加剂 | |
| Rodríguez et al. | Biological effect of tannins from different vegetal origin on microbial and fermentation traits in vitro | |
| EP2294924B1 (en) | Method for obtaining 1-monopropionine and its isomer 3-monopropionine as preserving agents for animal feed, grains and animal-origin flours | |
| CN115334884A (zh) | 用于提高氮营养素使用效率并改善植物生长的氯草定组合物 | |
| Dall’Orsoletta et al. | Urea coated with poultry litter as an option in the control of nitrogen losses | |
| US4401624A (en) | Buffered solutions which have a reduced corrosive nature | |
| DK2462086T3 (da) | Flydende N/S-gødning med højt næringsstofindhold | |
| JP2016121251A (ja) | 六価クロム低減剤 | |
| EP2651826A1 (fr) | Solutions comprenant un complexe de bore, procede de preparation desdites solutions, leurs utilisations | |
| AU2013282720B2 (en) | Continuous process for manufacturing freely flowing solid acidic P/K fertilizer | |
| CN109219354A (zh) | 有效作为广谱防腐剂的动物饲料添加剂 | |
| CN113402548B (zh) | 一种油田注水用高效多功能阻垢剂及其制备方法和应用 | |
| US20220142156A1 (en) | Fruit blossom end rot-preventing agent comprising nitrophenol compound or salt thereof | |
| US5013481A (en) | Boiler chemicals and method of preventing corrosion of boilers | |
| WO2014142691A1 (en) | Foliar fertilizer and method for manufacture of foliar fertilizer | |
| US20200085061A1 (en) | Heavy metal-free calcium hydroxide-based active substance | |
| CN107373292A (zh) | 一种无刺激性的饲料防霉剂及其生产工艺 | |
| WO2014165258A1 (en) | Compositions and methods for lowering the amount of urea in soil |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |