CN103638305A - Traditional Chinese medicinal composition for treating radiation-induced lung injury - Google Patents

Abstract

The invention discloses a traditional Chinese medicinal composition for treating radiation-induced lung injury. In traditional Chinese medicine, the radiation-induced lung injury belongs to 'consumptive lung disease' and 'gasp syndrome', and is caused by invasion of heat toxin, damage of collaterals in lung, intermingled phlegm and blood stasis, impairment of fluid and qi, and qi and yin injury. The traditional Chinese medicinal composition is prepared from the following traditional Chinese medicines capable of nourishing yin and clearing away heat, and moistening lung to arrest cough: rhizoma tupistrae chinensis, tendrilleaf solomonseal rhizome, unpleasant swallowwort herb, mountain oreas herb, brooklet anemone root, botrychiam ternatum, narrow-leaved lindernia, pleurotus albellus, paraphlonia, affine cudweed, laminated sanicle herb and mulberry leaf. The traditional Chinese medicinal composition is prepared into a decoction; a clinical test shows that total effective rate of the traditional Chinese medicinal composition is 97.1%, which is obviously excellent than that of a control group; the traditional Chinese medicinal composition is low in side effect.

Description

A kind of Chinese medicine composition of radiotherapy injury of lung

Technical field

The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine composition of radiotherapy injury of lung.

Background technology

Induced lung injury is that breast tumor (pulmonary carcinoma, breast carcinoma, the esophageal carcinoma etc.) is accepted the common complication of radiotherapy, essence is that lung tissue is subject to after inflammatory damage that ray causes, be subject to the mediation of various cytokines and cause the synthetic unbalance with degraded of collagen fiber, and cause the change of collagen over-deposit and each Collagen Type VI arrangement, distribution and content, thereby the process that pulmonary parenchyma is replaced by collagenous tissue.If the early stage drug main 17-hydroxy-11-dehydrocorticosterone of this disease of western medical treatment, also has on-steroidal AID, antibiotic is for secondary infection, and the later stage is applied anticoagulant therapy and penicillamine etc., but its erious adverse reaction is difficult to tolerance.In recent years, Chinese medicine is being obtained certain progress aspect control induced lung injury, and clinical efficacy is better, and strengthening immunologic function, improves the quality of living, and protection hemopoietic system and radiotherapy attenuation aspect have obtained the curative effect of certainty.

Summary of the invention

The Chinese medicine composition that the object of this invention is to provide a kind of induced lung injury.Traditional Chinese medical science scholar generally believes that this disease symptoms belongs to the traditional Chinese medical science " consumptive lung disease " " the syndrome of dyspnea " category, and its cause of disease surely belongs in pyretic toxicity the lung network of invading, burn, phlegm and blood stasis, impairment of body fluid consumption gas, impairment of both QI and YIN.We think that lonizing radiation belong to pyretic toxicity pathogenic dryness, because it has penetrance, thus coup injury lung network, lung network stasis blocking, phlegm and blood stasis, consumption impairment of QI is cloudy.General performance is immunologic function degression, bone marrow depression, tissue fibering, topical manifestations is impairment of purifying function of the lung, the cloudy QI consumed of losing, water Tianjin compress can not, and see cough, breathe heavily, uncomfortable in chest, breathe hard, the primary symptom performance such as dry mouth and throat, red tongue thready pulse, therefore with reference to the basic principle of " strengthening vital QI to eliminate pathogenic factors ", for the main symptom of impairment of both QI and YIN and dryness of the lung cough with asthma, reuse the principle for the treatment of of replenishing YIN and removing heat, nourishing the lung to arrest cough.

The object of the invention is to be achieved through the following technical solutions, the Chinese medicine composition of this induced lung injury is made by the Chinese medicine of following weight portion: Rhizoma Tupistrae Chinensis 15-25 part, Rhizoma Polygonati Cirrhifolii 25-30 part, Radix Tylophorae arenicolae 35-45 part, Oreas martiana (Hopp. Et Hornsch.) Brid. 15-25 part, Radix Anemones Rivularis 10-15 part, Herba Botrychii 10-20 part, Lindernia angustifolia (Benth.) Wettst. 25-50 part, Herba Parnassiae foliosae 10-20 part, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu 15-25 part, Herba Gnaphalii Affinis 5-10 part, Herba Saniculae lamelligerae 8-16 part, Folium Mori 6-8 part.

Preferred: 20 parts of Rhizoma Tupistrae Chinensis, 28 parts of Rhizoma Polygonati Cirrhifoliis, 40 parts of Radix Tylophorae arenicolaes, 20 parts of Oreas martiana (Hopp. Et Hornsch.) Brid., 12 parts of Radix Anemones Rivulariss, 15 parts of Herba Botrychii, 35 parts of Lindernia angustifolia (Benth.) Wettst.s, 15 parts of Herba Parnassiae foliosaes, 20 parts of Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu, 7 parts of Herba Gnaphalii Affinis, 12 parts of Herba Saniculae lamelligeraes, 7 parts, Folium Mori.

Preparation method is made decoction by above-mentioned Chinese medicine decocting.

In side: Rhizoma Tupistrae Chinensis nourishing yin and purging fire, promoting blood flow to regulate menstruation; Rhizoma Polygonati Cirrhifolii nourishing lung-YIN, invigorating the spleen and benefiting QI, the hemostasis of eliminating the phlegm, subduing swelling and detoxicating; Radix Tylophorae arenicolae YIN nourishing tonify deficiency, kidney and spleen invigorating; Oreas martiana (Hopp. Et Hornsch.) Brid. replenishing YIN and removing heat, tranquilizing the mind, expelling wind and removing dampness; Radix Anemones Rivularis, Herba Botrychii heat clearing away and internal heat reducing; Lindernia angustifolia (Benth.) Wettst. clearing away heat-damp and promoting diuresis; Herba Parnassiae foliosae antitussive, hemostasis, dampness removing; Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu is nourshing Yin and drynsessmoistening prescription, cough-relieving; Herba Gnaphalii Affinis relieving cough and resolving phlegm, during damp eliminating is adjusted; The Herba Saniculae lamelligerae wind lung heat clearing of faling apart, the promoting the circulation of blood of reducing phlegm; Folium Mori dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, suppressing the hyperactive liver improving eyesight.

Clinical data

1. the routine treatment target of physical data 70 is all made a definite diagnosis through pathology, is divided at random two groups of each 35 examples.Treatment group is male's 20 examples wherein, women's 15 examples; Age minimum is 43 years old, is 70 years old to the maximum, 62 years old mean age; Pulmonary carcinoma 18 examples, breast carcinoma 5 examples, the esophageal carcinoma 5 examples, malignant lymphoma 5 examples, pulmonary carcinoma thoracic wall transferase 12 example; Matched group is male's 18 examples wherein, women's 17 examples; Age minimum is 43 years old, is 72 years old to the maximum, 61 years old mean age; Pulmonary carcinoma 19 examples, breast carcinoma 5 examples, the esophageal carcinoma 6 examples, malignant lymphoma 4 examples, pulmonary carcinoma thoracic wall shifts 1 example; Two groups of all patients carry out radiotherapy after being operation.All 2 morbidities in thoughtful 3 months after radiotherapy finishes of patient, clinical cardinal symptom is cough, dyspnea, chest pain, with heating, uncomfortable in chest etc.Two groups of Genders, age, the equal not statistically significant of sick species diversity (P > 0.05).

2. diagnostic criteria is with reference to the induced lung injury diagnostic criteria in < < disease clinical diagnosis and criterion of therapeutical effect > >.(1) there are radioactivity breast, lung irradiation treatment history; (2) cardinal symptom is zest dry cough, uncomfortable in chest, chest pain, breathing is out of breath or with low grade fever; In pulmonary radioactive area, can hear dry, moist rales; (3) x-ray inspection is shown in that clear-cut diffuse haze shade appears in radiation area lung field.

3. Therapeutic Method matched group patient uses adrenocortical hormone (dexamethasone injection 10ml/d, is used in conjunction 14d, and decrement gradually; Infection (Cefixime tablets, Jiangsu ZhengDa QingJiang Pharmaceutical Co., Ltd, specification: 0.1g/ sheet) 0.1g/ time, 2 times/d, serve on 14d treatment.Treatment group adds on matched group basis uses Chinese medicine preparation of the present invention, take Rhizoma Tupistrae Chinensis 20g, Rhizoma Polygonati Cirrhifolii 28g, Radix Tylophorae arenicolae 40g, Oreas martiana (Hopp. Et Hornsch.) Brid. 20g, Radix Anemones Rivularis 12g, Herba Botrychii 15g, Lindernia angustifolia (Benth.) Wettst. 35g, Herba Parnassiae foliosae 15g, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu 20g, Herba Gnaphalii Affinis 7g, Herba Saniculae lamelligerae 12g, Folium Mori 7g, decocting becomes decoction, every day potion, dividing and sooner or later take for 2 times, 7th is 1 course for the treatment of.

4. criterion of therapeutical effect is effective: in January, symptom is eliminated completely, and the wild corresponding site inflammation of x sheet check radiation disappears or substantially disappears; Effective: bimester in symptom eliminate, x line is levied obviously and is alleviated; Invalid: bimester after symptom still exist or have repeated infection symptom, or hydrothorax increases, x line is levied without taking a turn for the better and oriented pulmonary fibrosis development sign.

5. therapeutic effect treatment is carried out effect assessment, treatment group 35 examples, effective 21 examples (60%), effective 13 examples (37.1%), invalid 1 example (2.9%), total effective rate 97.1% after 2 courses for the treatment of.Matched group 35 examples, effective 10 examples (28.6%), effective 16 examples (45.7%), no effect 9 (25.7%), total effective rate 74.3%.Two groups of comparisons, treatment group total effective rate is obviously better than matched group, has comparability.P＜0.05。After treatment group patient treatment, have no the abnormal of the aspects such as the blood, urine, stool routine examination and the liver that cause because taking traditional Chinese medicine, renal function, the no abnormal phenomenon of Ecg also occurs without allergic phenomena.Matched group has 7 routine patients to occur the untoward reaction such as nausea and vomiting, and unprocessed symptom spontaneous remission is followed up a case by regular visits to without abnormal.

The specific embodiment

Embodiment mono-: take Rhizoma Tupistrae Chinensis 20g, Rhizoma Polygonati Cirrhifolii 28g, Radix Tylophorae arenicolae 40g, Oreas martiana (Hopp. Et Hornsch.) Brid. 20g, Radix Anemones Rivularis 12g, Herba Botrychii 15g, Lindernia angustifolia (Benth.) Wettst. 35g, Herba Parnassiae foliosae 15g, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu 20g, Herba Gnaphalii Affinis 7g, Herba Saniculae lamelligerae 12g, Folium Mori 7g, above-mentioned Chinese medicine decocting is become to decoction.

Embodiment bis-: take Rhizoma Tupistrae Chinensis 25g, Rhizoma Polygonati Cirrhifolii 30g, Radix Tylophorae arenicolae 35g, Oreas martiana (Hopp. Et Hornsch.) Brid. 15g, Radix Anemones Rivularis 15g, Herba Botrychii 10g, Lindernia angustifolia (Benth.) Wettst. 50g, Herba Parnassiae foliosae 10g, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu 25g, Herba Gnaphalii Affinis 5g, Herba Saniculae lamelligerae 16g, Folium Mori 6g, above-mentioned Chinese medicine decocting is become to decoction.

Embodiment tri-: take Rhizoma Tupistrae Chinensis 15g, Rhizoma Polygonati Cirrhifolii 25g, Radix Tylophorae arenicolae 45g, Oreas martiana (Hopp. Et Hornsch.) Brid. 25g, Radix Anemones Rivularis 10g, Herba Botrychii 20g, Lindernia angustifolia (Benth.) Wettst. 25g, Herba Parnassiae foliosae 20g, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu 15g, Herba Gnaphalii Affinis 10g, Herba Saniculae lamelligerae 8g, Folium Mori 8g, above-mentioned Chinese medicine decocting is become to decoction.

Claims (2)

1. a Chinese medicine composition for radiotherapy injury of lung, is characterized in that this Chinese medicine composition made by the Chinese medicine of following weight portion: Rhizoma Tupistrae Chinensis 15-25 part, Rhizoma Polygonati Cirrhifolii 25-30 part, Radix Tylophorae arenicolae 35-45 part, Oreas martiana (Hopp. Et Hornsch.) Brid. 15-25 part, Radix Anemones Rivularis 10-15 part, Herba Botrychii 10-20 part, Lindernia angustifolia (Benth.) Wettst. 25-50 part, Herba Parnassiae foliosae 10-20 part, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu 15-25 part, Herba Gnaphalii Affinis 5-10 part, Herba Saniculae lamelligerae 8-16 part, Folium Mori 6-8 part.

2. the Chinese medicine composition of a kind of radiotherapy injury of lung according to claim 1, is characterized in that this Chinese medicine composition made by the Chinese medicine of following weight portion: 20 parts of Rhizoma Tupistrae Chinensis, 28 parts of Rhizoma Polygonati Cirrhifoliis, 40 parts of Radix Tylophorae arenicolaes, 20 parts of Oreas martiana (Hopp. Et Hornsch.) Brid., 12 parts of Radix Anemones Rivulariss, 15 parts of Herba Botrychii, 35 parts of Lindernia angustifolia (Benth.) Wettst.s, 15 parts of Herba Parnassiae foliosaes, 20 parts of Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu, 7 parts of Herba Gnaphalii Affinis, 12 parts of Herba Saniculae lamelligeraes, 7 parts, Folium Mori.