CN103623053A - Yinhuang chewable tablet - Google Patents

Abstract

The invention discloses a yinhuang chewable tablet. The yinhuang chewable tablet consists of the following materials in parts by weight: 190-210 parts of honeysuckle extract, 75-85 parts of radix scutellariae extract, 280-320 parts of mannitol, 200-220 parts of sucrose, 4-6 parts of citric acid, 80-100 parts of magnesium stearate, 10-20 parts of silicon dioxide, 10-20 parts of stevioside and a proper amount of 95% alcohol. According to the invention, a flavoring agent, a disintegrating agent and a filling agent are added in the yinhuang chewable tablet, so that the surface area of the chewed product is increased, and therefore, absorption of the medicine in the body can be promoted and pesticide effect is improved. The product further can be chewable under a hydropenic condition, is especially suitable for children, the old as well as a patient with dysphagia or worse gastroenteric function, can reduce burden of the medicine on gastrointestinal tract, can be used for dry throat, pharyngalgia, throat node swelling, thirst and fever caused by wind-heat common cold and exuberant lung-stomach heat, as well as symptoms such as acute and chronic amygdalitis, acute and chronic pharyngitis and upper respiratory infection.

Description

A kind of silver yellow chewable tablet

Technical field

The present invention relates generally to a kind of silver yellow chewable tablet, belongs to field of medicaments.

Background technology

Silver yellow chewable tablet is Chinese medicine 9 kind new medicines, it is on the basis of YINHUANG PIAN, after scientifically technical study, quality research and study on the stability etc. are declared, State Food and Drug Administration approval domestic first be also domestic exclusive new drug, issued New Drug Certificate, New Drug Certificate is numbered traditional Chinese medicines card word Z20050576, and it has cleaning heat and expelling wind, liyan jiedu.For dry pharynx, pharyngalgia, pharyngeal tonsils enlargement, thirsty, the heating due to affection due to external wind and heat, exuberant lung-stomach heat; Acute and chronic tonsillitis, acute/chronic pharyngitis, upper respiratory tract infection are shown in above-mentioned patient.Normal release tablet formulations steady quality, taking convenience, but for the patient of child, old man and dysphagia, normal release tablet formulations is often taken difficulty, the psychological phenomenon of refusing to take medicine after can producing after Long-term taking medicine.Silver yellow chewable tablet has overcome above-mentioned shortcoming, has added correctives and disintegrating agent, filler simultaneously, makes this product chew the long-pending increase in rear surface, can promote medicine absorption in vivo, has improved drug effect.This product also has an advantage also can chew the in the situation that of hydropenia, is specially adapted to the poor patient of child, old man and dysphagia or gastrointestinal function, can reduce medicine gastrointestinal is born.

Summary of the invention

The object of the invention is exactly for a kind of silver yellow chewable tablet is provided.

The present invention is achieved by the following technical solutions:

A silver yellow chewable tablet, it is comprised of the raw material of following weight parts:

Flos Lonicerae extract 190-210, Radix Scutellariae extract 75-85, mannitol 280-320, sucrose 200-220, citric acid 4-6, magnesium stearate 80-100, silica 1 0-20, stevioside 10-20,95% appropriate amount of ethanol.

A preparation method for silver yellow chewable tablet, comprises the following steps:

(1) by above-mentioned mannitol, sucrose, citric acid co-grinding, and cross 80-100 mesh sieve, mix with above-mentioned Flos Lonicerae extract, Radix Scutellariae extract, stevioside, join in wet granulator dry powder blend 10-12 minute;

(2) divide and add above-mentioned 95% ethanol for 2-5 time, running wet granulator, stirring at low speed 12-20 minute, then carries out making for 4-6 minute soft material with low speed pelletizing simultaneously again, then soft material is crossed to 24 order nylon mesh, can be made into wet grain;

(3) open the negative pressure system of boiling drier, wet granular is moved in ebullated dryer, in the process of transfer particle, tackle granule heats simultaneously, the baking temperature of wet grain should be set in 50-52 ℃, be controlled at 10-15 minute drying time, the moisture content of dry granule should be controlled between 1.5-2.0%;

(4) total mixed, the tabletting of granulate.

Every heavy 0.92 gram, after chewing, swallows.A 1-2 sheet, 4 times on the one.

Advantage of the present invention is:

Silver yellow chewable tablet of the present invention has added correctives and disintegrating agent, filler, makes this product chew that rear surface is long-pending to increase, and can promote medicine absorption in vivo, has improved drug effect.This product also has an advantage also can chew the in the situation that of hydropenia, be specially adapted to the poor patient of child, old man and dysphagia or gastrointestinal function, can reduce medicine gastrointestinal is born, for the dry pharynx due to affection due to external wind and heat, exuberant lung-stomach heat, pharyngalgia, pharyngeal tonsils enlargement, thirsty, heating; The diseases such as acute and chronic tonsillitis, acute/chronic pharyngitis, upper respiratory tract infection.

The specific embodiment

Embodiment 1

A silver yellow chewable tablet, it is comprised of the raw material of following weight parts (g):

Flos Lonicerae extract 200, Radix Scutellariae extract 80, mannitol 300, sucrose 210, citric acid 5, magnesium stearate 90, silica 15, stevioside 15,95% appropriate amount of ethanol.

A preparation method for silver yellow chewable tablet, comprises the following steps:

(1) by above-mentioned mannitol, sucrose, citric acid co-grinding, and cross 80 mesh sieves, mix with above-mentioned Flos Lonicerae extract, Radix Scutellariae extract, stevioside, join in wet granulator dry powder blend 10 minutes;

(2) divide and add above-mentioned 95% ethanol for 3 times, running wet granulator, stirring at low speed 16 minutes, then carries out making for 6 minutes soft material with low speed pelletizing simultaneously again, then soft material is crossed to 24 order nylon mesh, can be made into wet grain;

(3) open the negative pressure system of boiling drier, wet granular is moved in ebullated dryer, in the process of transfer particle, tackle granule heats simultaneously, the baking temperature of wet grain should be set in 50 ℃, be controlled at 10-15 minute drying time, the moisture content of dry granule should be controlled between 1.5-2.0%;

(4) total mixed, the tabletting of granulate.

Character

This product is the faint yellow sheet to brown color; The sweet micro-hardship of taste.

Differentiate

(1) get 1 of this product, porphyrize, adds water 10ml and makes to dissolve, and filters, and gets filtrate 1ml, adds sodium nitrite solution (1 → 20) 0.3ml, adds aluminum nitrate solution (1 → 10) 0.3ml and sodium hydroxide (1 → 20) and makes to be alkalescence, aobvious red.

(2) get the filtrate 1ml under discriminating (1) item, add ferric chloride test solution, aobvious green.

(3) in the chromatogram of the record under (assay) item, in test sample chromatogram, should present the chromatographic peak consistent with chlorogenic acid and baicalin reference substance retention time.

Check

Except not checking disintegration, should meet every regulation relevant under tablet item (appendix I D of Chinese Pharmacopoeia version in 2010)

Assay

According to high performance liquid chromatography (appendix VI D of Chinese Pharmacopoeia version in 2010), measure.

Every of this product contains Flos Lonicerae extract in chlorogenic acid (C16H18O9), must not be less than 5.0mg; Contain Radix Scutellariae extract in baicalin (C21H18O11), must not be in 40.0mg.

Claims (2)

1. a silver yellow chewable tablet, is characterized in that what it was comprised of the raw material of following weight parts:

Flos Lonicerae extract 190-210, Radix Scutellariae extract 75-85, mannitol 280-320, sucrose 200-220, citric acid 4-6, magnesium stearate 80-100, silica 1 0-20, stevioside 10-20,95% appropriate amount of ethanol.

2. a preparation method for silver yellow chewable tablet as claimed in claim 1, is characterized in that comprising the following steps:

(1) by above-mentioned mannitol, sucrose, citric acid co-grinding, and cross 80-100 mesh sieve, mix with above-mentioned Flos Lonicerae extract, Radix Scutellariae extract, stevioside, join in wet granulator dry powder blend 10-12 minute;

(2) divide and add above-mentioned 95% ethanol for 2-5 time, running wet granulator, stirring at low speed 12-20 minute, then carries out making for 4-6 minute soft material with low speed pelletizing simultaneously again, then soft material is crossed to 24 order nylon mesh, can be made into wet grain;

(3) open the negative pressure system of boiling drier, wet granular is moved in ebullated dryer, in the process of transfer particle, tackle granule heats simultaneously, the baking temperature of wet grain should be set in 50-52 ℃, be controlled at 10-15 minute drying time, the moisture content of dry granule should be controlled between 1.5-2.0%;

(4) total mixed, the tabletting of granulate.