CN103621503B - A kind of composition pesticide containing Spiromesifen and bishydrazide - Google Patents
A kind of composition pesticide containing Spiromesifen and bishydrazide Download PDFInfo
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- CN103621503B CN103621503B CN201210310713.9A CN201210310713A CN103621503B CN 103621503 B CN103621503 B CN 103621503B CN 201210310713 A CN201210310713 A CN 201210310713A CN 103621503 B CN103621503 B CN 103621503B
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Abstract
The invention discloses a kind of composition pesticide containing Spiromesifen and bishydrazide, composition pesticide containing active components A and active component B, active components A is selected from Spiromesifen, active component B is selected from any one compound following: worm hydrazides, methoxyfenozide, furan tebufenozide, ring worm hydrazides, chlorine worm hydrazides, and the weight ratio of active components A and active component B is 1 ︰ 60 ~ 80 ︰ 1.The various pests of the present composition to harm agricultural production has synergistic effect, and decrease pesticide usage amount, reduce the residual quantity of agricultural chemicals on crop, alleviate environmental pollution, to person poultry safety, Environmental compatibility is good, and insect not easily develops immunity to drugs.
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of application of composition pesticide on crop pests containing Spiromesifen and bishydrazide.
Background technology
Spiromesifen (Spiromesifen) molecular formula: C
23h
30o
4.The mechanism of action of Spiromesifen is the growth affecting aleyrodid and acarid, disturb the biosynthesis of its liposome, especially have good activity to larval stage, ovarian duct closure function can also be produced simultaneously, reduce the fertility of acarid and adult whitefly, greatly reduce quantity of laying eggs.
Worm hydrazides, methoxyfenozide, furan tebufenozide, ring worm hydrazides, chlorine worm hydrazides all belong to bishydrazide insect growth regulator, IGR.Bishydrazide insect growth regulator, IGR is that the class developed successively is in recent years efficient, selectivity is strong, environment amenable insect growth regulator, IGR, its action target is the same with insect moulting hormones (20E), be incorporated into the heterodimer of ecdysone receptor (EcR)-superfluous valve albumen (USP), transcribing of induction insect early gene, but due to the sustainable existence of bishydrazide compounds in insect bodies, under making 20E there is not situation, event can not be carried out, as DOP Adecarboxylase (DDC) isogenic expression is obstructed, do not synthesize chitin, eclosion hormo can not discharge, finally make larva precocity decortication and dead.
But in the real process of agricultural production, the problem that pest control the most easily produces is the generation of pest resistance to insecticide.Different cultivars composition carries out composite, is to prevent and treat the very common method of resistant insect.Heterogeneity is carried out composite, according to practical application effect, judge certain composite be synergy, add and or antagonism.In most cases, the composite effect of agricultural chemicals is all additive effect, really has synergy to lack, especially synergistic effect clearly, very high composite just less of co-toxicity coefficient.Study very much through the composite of inventor, find Spiromesifen and worm hydrazides, methoxyfenozide, furan tebufenozide, ring worm hydrazides, chlorine worm hydrazides is composite after can produce good synergistic effect, and not yet open about the relevant report that Spiromesifen and worm hydrazides, methoxyfenozide, furan tebufenozide, ring worm hydrazides, chlorine worm hydrazides are composite.
Summary of the invention
The object of the invention is to propose to have that synergistic function, use cost are low, preventive effect is good containing the composition pesticide of Spiromesifen and bishydrazide.
A kind of composition pesticide containing Spiromesifen and bishydrazide, containing active components A and active component B, it is characterized in that: the weight ratio of active components A and active component B is 1 ︰ 60 ~ 80 ︰ 1, described active components A is selected from Spiromesifen, active component B is selected from worm hydrazides, methoxyfenozide, furan tebufenozide, ring worm hydrazides, one in chlorine worm hydrazides, active components A and the preferred weight ratio of active component B are 1 ︰ 40 ~ 60 ︰ 1, the weight ratio being more preferably Spiromesifen and worm hydrazides is 1 ︰ 25 ~ 10 ︰ 1, the weight ratio of Spiromesifen and methoxyfenozide is 1 ︰ 15 ~ 30 ︰ 1, the weight ratio of Spiromesifen and furan tebufenozide is 1 ︰ 20 ~ 20 ︰ 1, the weight ratio of Spiromesifen and ring worm hydrazides is 1 ︰ 15 ~ 30 ︰ 1, the weight ratio of Spiromesifen and chlorine worm hydrazides is 1 ︰ 10 ~ 30 ︰ 1, the weight ratio most preferably being Spiromesifen and worm hydrazides is 1 ︰ 15 ~ 5 ︰ 1, the weight ratio of Spiromesifen and methoxyfenozide is 1 ︰ 5 ~ 10 ︰ 1, the weight ratio of Spiromesifen and furan tebufenozide is 1 ︰ 10 ~ 10 ︰ 1, the weight ratio of Spiromesifen and ring worm hydrazides is 1 ︰ 5 ~ 10 ︰ 1, and the weight ratio of Spiromesifen and chlorine worm hydrazides is 1 ︰ 5 ~ 15 ︰ 1.
The described composition pesticide containing Spiromesifen and bishydrazide is for preventing and treating the application of crop pests, and described crops comprise cereal crops, legume crop, fiber crop, sugar [yielding, melon crop, fruits crop, dry fruit crop, hobby crop, root crop, oil crop, flower crop, medicinal crop, crop, green manure pasture crop; Described insect comprises whitefly in bt cotton, Tetranychus urticae, two spotted spider mite, leaf roller, beet armyworm, prodenia litura, diamond-back moth, tea geometrid, corn borer, striped rice borer, armyworm, pine caterpillars, aphid, trialeurodes vaporariorum, peach fruit borer, cotton bollworm, cutworm, cabbage caterpillar.
The weight ratio of active components A, active component B is 1 ︰ 60 ~ 80 ︰ 1.In usual composition, the weight percentage of active component is 0.5% ~ 90% of gross weight, is preferably 5% ~ 80%.According to different preparation types, active component content scope is different.Usually, liquid preparation contains the active substance of by weight 1% ~ 70%, is preferably 5% ~ 50%; Solid pharmaceutical preparation contains the active substance of by weight 5% ~ 80%, is preferably 10% ~ 80%.
At least containing a kind of surfactant in composition pesticide of the present invention, the dispersion of active component in water when being beneficial to use.Surface-active contents is 5% ~ 30% of total formulation weight amount, and surplus is solid or liquid diluent.
Composition pesticide of the present invention can by user before use through diluting or directly using.Its preparation can be prepared by common processing method known in those skilled in the art, after mixing with liquid flux or solid carrier by active substance, then add surfactant as one or more in dispersant, stabilizing agent, wetting agent, binding agent, defoamer, disintegrant, antifreeze etc.
Composition pesticide of the present invention, can be processed into acceptable formulation on any agricultural chemicals on demand, wherein more excellent formulation is: wetting powder, water dispersible granules, suspending agent, aqueous emulsion, microemulsion, suspension emulsion, microcapsule suspending agent, microcapsule suspension-suspendinagent agent.
Composition comprises following component and content when making wetting powder: active components A 0.5% ~ 80%, active component B0.5% ~ 60%, dispersant 1% ~ 12%, wetting agent 1% ~ 8%, filler surplus.
Composition comprises following component and content when making water dispersible granules: active components A 0.5% ~ 80%, active component B0.5% ~ 60%, dispersant 1% ~ 12%, wetting agent 1% ~ 8%, disintegrant 1% ~ 10%, binding agent 0 ~ 8%, filler surplus.
Composition comprises following component and content when making suspending agent: active components A 0.5% ~ 50%, active component B0.5% ~ 50%, dispersant 1% ~ 10%, wetting agent 1% ~ 10%, defoamer 0.01% ~ 2%, thickener 0 ~ 2%, antifreeze 0 ~ 8%, deionized water add to 100%.
Composition comprises following component and content when making suspension emulsion: active components A 0.5% ~ 50%, active component B0.5% ~ 50%, emulsifier 1% ~ 10%, dispersant 1% ~ 10%, solvent 1% ~ 20%, defoamer 0.01% ~ 2%, thickener 0 ~ 2%, antifreeze 0 ~ 8%, deionized water add to 100%.
Composition comprises following component and content when making microemulsion: active components A 0.5% ~ 50%, active component B0.5% ~ 50%, emulsifier 3% ~ 25%, solvent 1% ~ 20%, antifreeze 0 ~ 8%, defoamer 0.01% ~ 2%, deionized water add to 100%.
Composition comprises following component and content when making aqueous emulsion: active components A 0.5% ~ 50%, active component B0.5% ~ 50%, solvent 1% ~ 20%, emulsifier 1% ~ 12%, antifreeze 0 ~ 8%, defoamer 0.01% ~ 2%, thickener 0 ~ 2%, deionized water add to 100%.
Composition comprises following component and content when making microcapsule suspending agent: active components A 0.5% ~ 50%, active component B0.5% ~ 50%, macromolecule cyst material 1% ~ 10%, dispersant 2% ~ 10%, solvent 1% ~ 10%, emulsifier 1% ~ 7%, pH adjusting agent 0.01% ~ 5%, defoamer 0.01% ~ 2%, deionized water add to 100%.
Composition comprises following component and content when making microcapsule suspension-suspendinagent agent: active components A 0.5% ~ 50%, active component B0.5% ~ 50%, macromolecule cyst material 1% ~ 12%, dispersant 1% ~ 12%, wetting agent 1% ~ 8%, solvent 1% ~ 15%, emulsifier 1% ~ 8%, defoamer 0.01% ~ 2%, thickener 0 ~ 2%, pH adjusting agent 0.01% ~ 5%, deionized water add to 100%.
Wetting powder the key technical indexes of the present invention:
Water dispersible granules the key technical indexes of the present invention:
Suspending agent the key technical indexes of the present invention:
Suspension emulsion the key technical indexes of the present invention:
Microemulsion the key technical indexes of the present invention:
Aqueous emulsion the key technical indexes of the present invention:
Microcapsule suspending agent the key technical indexes of the present invention:
Microcapsule suspension-suspendinagent agent the key technical indexes of the present invention:
The invention has the advantages that:
(1) Spiromesifen and worm hydrazides, methoxyfenozide, furan tebufenozide, ring worm hydrazides, chlorine worm hydrazides composite after, there is obvious synergy and lasting effect; (2) greater activity is all had to the whitefly in bt cotton on crops, Tetranychus urticae, two spotted spider mite, leaf roller, beet armyworm, prodenia litura, diamond-back moth, tea geometrid, corn borer, striped rice borer, armyworm, pine caterpillars, aphid, trialeurodes vaporariorum, peach fruit borer, cotton bollworm, cutworm, cabbage caterpillar etc.; (3) decrease pesticide usage amount, reduce the residual quantity of agricultural chemicals on crop, alleviate environmental pollution; (4) to person poultry safety, Environmental compatibility is good, and preparation adhesion strength strengthens, resistance of rainwater washing against.
Embodiment
Below in conjunction with embodiment to further instruction of the present invention, the percentage in embodiment is all weight percentage, but the present invention is not limited thereto.
Application Example one
Example 1 ~ 16 wetting powder
Spiromesifen, active component B, dispersant, wetting agent, filler are mixed in mixed cylinder, mixes again after airslide disintegrating mill is pulverized, wetting powder product of the present invention can be obtained, specifically in table 1.
The each component of table 1 embodiment 1 ~ 16 and content
Example 17 ~ 32 water dispersible granules
Spiromesifen, active component B, dispersant, wetting agent, disintegrant, filler etc. are obtained together the particle diameter needed through air-flow crushing, then add other auxiliary agents such as binding agent (can add and can not add), obtain granulation materials.Item is quantitatively sent in fluidized bed granulating dryer through granulating and after drying, water dispersible granules product of the present invention can being obtained, specifically in table 2.
The each component of table 2 embodiment 17 ~ 32 and content
Example 33 ~ 48 suspending agent
By dispersant, wetting agent, defoamer, thickener (can add and can not add), antifreeze (can add and can not add), mix through high speed shear, add Spiromesifen, active component B, ball milling 2 ~ 3 hours in ball mill, make diameter of particle all below 5 μm, surplus deionized water is supplied, and can obtain suspending agent product of the present invention, specifically in table 3.
The each component of table 3 embodiment 33 ~ 48 and content
Example 49 ~ 58 suspension emulsion
Dispersant, defoamer, thickener (can add and can not add), antifreeze (can add and can not add) are mixed through high speed shear, add Spiromesifen, ball milling 2 ~ 3 hours in ball mill, make diameter of particle all below 5 μm, obtained Spiromesifen suspending agent, then by active component B, emulsifier, solvent and the direct emulsification of various auxiliary agent high speed agitators in suspending agent, obtained suspension emulsion product of the present invention.Specifically in table 4,5.
Table 4 example 49 ~ 53 component and content
Table 5 example 54 ~ 58 component and content
Worm hydrazides, methoxyfenozide, furan tebufenozide, ring worm hydrazides, chlorine worm hydrazides in table 1 ~ 5 are exchanged, can novel formulation be obtained.
Embodiment 59 ~ 61 aqueous emulsion
Spiromesifen, active component B, solvent, emulsifier are added together, make to be dissolved into homogeneous oil phase; Deionized water, antifreeze (can add and can not add), thickener (can add and can not add), defoamer are mixed, becomes homogeneous aqueous phase.Under high velocity agitation, aqueous phase is added oil phase, obtained aqueous emulsion product of the present invention.Specifically in table 6.
The each component of table 6 embodiment 59 ~ 61 and content
Embodiment 62 ~ 64 microemulsion
Spiromesifen, active component B are dissolved in and are equipped with in the homogenizer of solvent, emulsifier, antifreeze (can add and can not add), defoamer are joined in the homogenizer that above-mentioned solution is housed, give strong mixing after supplying surplus by deionized water and homogenize, finally obtain the microemulsion product of the present invention that clear appearance is transparent.Specifically in table 7.
The each component of table 7 embodiment 62 ~ 64 and content
Embodiment 65 ~ 67 microcapsule suspending agent
By Spiromesifen, active component B, macromolecule cyst material, solvent, make to be dissolved into homogeneous oil phase, in a shear condition, oil phase is joined in the aqueous phase solution containing emulsifier, pH adjusting agent, dispersant, defoamer, surplus is supplied by deionized water, bi-material reacts at oil-water interfaces, forms macromolecule cyst wall, makes the finely disseminated microcapsule suspending agent product of the present composition.Specifically in table 8.
The each component of table 8 embodiment 65 ~ 67 and content
Embodiment 68 ~ 70 microcapsule suspension-suspendinagent agent
By active component B, macromolecule cyst material, solvent, make to be dissolved into homogeneous oil phase, oil phase is joined in a shear condition in the aqueous phase solution containing emulsifier, pH adjusting agent, make finely disseminated microcapsule suspending agent.Dispersant, wetting agent, defoamer, thickener (can add and can not add) are mixed through high speed shear, add Spiromesifen, ball milling 2 ~ 3 hours in ball mill, make diameter of particle all below 5 μm, obtained suspending agent, then join in the aqueous phase solution of micro-capsule suspension by suspending agent, deionized water supplies surplus, makes the finely disseminated microcapsule suspension-suspendinagent agent product of the present composition.Specifically in table 9.
The each component of table 9 embodiment 68 ~ 70 and content
The embodiment of the present invention is the method adopting Toxicity Determination and field trial to combine.First pass through Toxicity Determination, co-toxicity coefficient (CTC) after clear and definite two kinds of medicaments are composite by a certain percentage, CTC < 80 is antagonism, 80≤CTC≤120 are summation action, CTC > 120 is synergistic effect, on this basis, then carry out field trial.
Test method: respectively the mother liquor of each mixed agent is diluted to five series concentration during test, is placed in beaker respectively for subsequent use.Adopt the method connecing worm after first soaking leaf, take out after the blade of the same size not contacting any medicament is soaked 5s in the liquid configured, naturally dry, put into insect box, then connect for examination larva, raise under 25 DEG C of conditions, often process and repeat for 3 times, often repeating examination borer population used is 50, establishes blank simultaneously, checks dead borer population in 72h, calculate lethality and corrected mortality, try to achieve virulence regression equation and calculate LC
50value.If contrast lethality is greater than 10%, be then considered as invalid test.Computing formula is as follows:
Insect corrected mortality is converted into probit value (y), and concentration for the treatment of (μ g/ml) converts logarithm value to (x), draws virulence regression equation, and calculate the value of often kind of medicament thus with method of least squares.Co-toxicity coefficient CTC is calculated according to the abundant equation of Sun Yun.Computing formula following (take Spiromesifen as standard agent, its toxicity index is 100):
TI × the P of theoretical toxicity index (the TTI)=Spiromesifen of M
spiromesifentI × the P of+effective active composition B
effective active compositionb
In formula: M is the mixture of different ratio
P
effective active compositionb is the shared in the composition ratio of effective active composition B
P
spiromesifenfor the ratio that Spiromesifen is shared in the composition
B is selected from the one in worm hydrazides, methoxyfenozide, furan tebufenozide, ring worm hydrazides, chlorine worm hydrazides.
Application Example two:
For examination insect: Laphygma exigua Hubner
Test medicine provides by Shaanxi Meibang Pesticide Co., Ltd..
Experimental scheme: through effective lethal concentration scope of preliminary experiment determination Spiromesifen and the former medicine of worm hydrazides and the two different ratio mixture.
Toxicity test result
Table 10 Spiromesifen and the composite toxicity test analysis of results table to Laphygma exigua Hubner of worm hydrazides
| Reagent agent | Proportioning | LC 50(ug/mL) | Co-toxicity coefficient (CTC) |
| Spiromesifen | - | 1.89 | - |
| Worm hydrazides | - | 4.69 | - |
| Luo first Man Zhi ︰ worm hydrazides | 80：1 | 0.98 | 194.29 |
| Luo first Man Zhi ︰ worm hydrazides | 60：1 | 0.97 | 196.77 |
| Luo first Man Zhi ︰ worm hydrazides | 40：1 | 0.96 | 199.78 |
| Luo first Man Zhi ︰ worm hydrazides | 20：1 | 0.95 | 204.77 |
| Luo first Man Zhi ︰ worm hydrazides | 10：1 | 0.90 | 222.05 |
| Luo first Man Zhi ︰ worm hydrazides | 5：1 | 0.91 | 230.64 |
| Luo first Man Zhi ︰ worm hydrazides | 1：1 | 1.14 | 236.34 |
| Luo first Man Zhi ︰ worm hydrazides | 2：5 | 1.35 | 244.09 |
| Luo first Man Zhi ︰ worm hydrazides | 1：6 | 1.60 | 241.92 |
| Luo first Man Zhi ︰ worm hydrazides | 1：15 | 1.83 | 234.31 |
| Luo first Man Zhi ︰ worm hydrazides | 1：25 | 1.99 | 222.97 |
| Luo first Man Zhi ︰ worm hydrazides | 1：40 | 2.24 | 202.07 |
| Luo first Man Zhi ︰ worm hydrazides | 1：60 | 2.35 | 194.84 |
As shown in Table 10, the proportioning of Spiromesifen and the composite control Laphygma exigua Hubner of worm hydrazides is when 1 ︰ 60 ~ 80 ︰ 1, co-toxicity coefficient is all greater than 120, both explanations mixture in 1 ︰ 60 ~ 80 ︰ 1 scope all shows synergistic effect, when the proportioning of Spiromesifen and worm hydrazides is at 1 ︰ 25 ~ 10 ︰ 1, synergistic effect is more outstanding, co-toxicity coefficient is all greater than 220, testing through applicant the optimum ratio finding Spiromesifen and worm hydrazides is 10:1, 5:1, 4:1, 3:1, 2:1, 1:1, 1:2, 2:5, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, 1:11, 1:12, 1:13, 1:14, 1:15, 1:20, 1:25, wherein when Spiromesifen and worm hydrazides weight ratio are 2 ︰ 5, co-toxicity coefficient is maximum, synergistic effect is the most obvious.
Application Example three
For examination insect: rice-stem borer
Test medicine provides by Shaanxi Meibang Pesticide Co., Ltd..
Experimental scheme: through effective lethal concentration scope of preliminary experiment determination Spiromesifen and the former medicine of methoxyfenozide and the two different ratio mixture.
Table 11 Spiromesifen and the composite toxicity test analysis of results table to rice-stem borer of methoxyfenozide
| Reagent agent | Proportioning | LC 50(ug/mL) | Co-toxicity coefficient (CTC) |
| Spiromesifen | - | 1.65 | - |
| Methoxyfenozide | - | 0.83 | - |
| Luo first Man Zhi ︰ methoxyfenozide | 80：1 | 0.84 | 194.06 |
| Luo first Man Zhi ︰ methoxyfenozide | 60：1 | 0.81 | 200.46 |
| Luo first Man Zhi ︰ methoxyfenozide | 40：1 | 0.78 | 206.56 |
| Luo first Man Zhi ︰ methoxyfenozide | 30：1 | 0.73 | 219.05 |
| Luo first Man Zhi ︰ methoxyfenozide | 19：1 | 0.71 | 221.46 |
| Luo first Man Zhi ︰ methoxyfenozide | 14：1 | 0.69 | 224.35 |
| Luo first Man Zhi ︰ methoxyfenozide | 10：1 | 0.65 | 232.93 |
| Luo first Man Zhi ︰ methoxyfenozide | 6：1 | 0.60 | 240.99 |
| Luo first Man Zhi ︰ methoxyfenozide | 2：1 | 0.50 | 248.25 |
| Luo first Man Zhi ︰ methoxyfenozide | 1：1 | 0.45 | 245.43 |
| Luo first Man Zhi ︰ methoxyfenozide | 1：5 | 0.38 | 238.15 |
| Luo first Man Zhi ︰ methoxyfenozide | 1：9 | 0.39 | 223.95 |
| Luo first Man Zhi ︰ methoxyfenozide | 1：15 | 0.40 | 214.15 |
| Luo first Man Zhi ︰ methoxyfenozide | 1：25 | 0.42 | 201.47 |
| Luo first Man Zhi ︰ methoxyfenozide | 1：40 | 0.43 | 195.39 |
| Luo first Man Zhi ︰ methoxyfenozide | 1：60 | 0.44 | 190.19 |
As shown in Table 11, the proportioning of Spiromesifen and the composite water prevention chilo suppressalis of methoxyfenozide is when 1 ︰ 60 ~ 80 ︰ 1, co-toxicity coefficient is all greater than 120, both explanations mixture in 1 ︰ 60 ~ 80 ︰ 1 scope all shows synergistic effect, when the proportioning of Spiromesifen and methoxyfenozide is at 1 ︰ 15 ~ 30 ︰ 1, synergistic effect is more outstanding, co-toxicity coefficient is all greater than 210, testing through applicant the optimum ratio finding Spiromesifen and methoxyfenozide is 30:1, 25:1, 20:1, 15:1, 10:1, 9:1, 8:1, 7:1, 6:1, 5:1, 4:1, 3:1, 2:1, 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, 1:15, wherein when Spiromesifen and methoxyfenozide weight ratio are 2 ︰ 1, co-toxicity coefficient is maximum, synergistic effect is the most obvious.
Application Example four
For examination insect: brassicaceous vegetable diamond-back moth
Test medicine provides by Shaanxi Meibang Pesticide Co., Ltd..
Experimental scheme: through effective lethal concentration scope of preliminary experiment determination Spiromesifen and the former medicine of furan tebufenozide and the two different ratio mixture
Table 12 Spiromesifen and the composite toxicity test analysis of results table to brassicaceous vegetable diamond-back moth of furan tebufenozide
| Reagent agent | Proportioning | LC 50(ug/mL) | Co-toxicity coefficient (CTC) |
| Spiromesifen | - | 1.78 | - |
| Furan tebufenozide | - | 1.69 | - |
| Luo first Man Zhi ︰ furan tebufenozide | 80：1 | 0.96 | 185.29 |
| Luo first Man Zhi ︰ furan tebufenozide | 60：1 | 0.94 | 189.00 |
| Luo first Man Zhi ︰ furan tebufenozide | 40：1 | 0.92 | 193.23 |
| Luo first Man Zhi ︰ furan tebufenozide | 20：1 | 0.83 | 213.92 |
| Luo first Man Zhi ︰ furan tebufenozide | 10：1 | 0.81 | 218.69 |
| Luo first Man Zhi ︰ furan tebufenozide | 4：1 | 0.79 | 222.94 |
| Luo first Man Zhi ︰ furan tebufenozide | 1：1 | 0.75 | 231.18 |
| Luo first Man Zhi ︰ furan tebufenozide | 1：4 | 0.76 | 224.64 |
| Luo first Man Zhi ︰ furan tebufenozide | 1：10 | 0.77 | 220.49 |
| Luo first Man Zhi ︰ furan tebufenozide | 1：20 | 0.79 | 214.44 |
| Luo first Man Zhi ︰ furan tebufenozide | 1：40 | 0.88 | 192.28 |
| Luo first Man Zhi ︰ furan tebufenozide | 1：60 | 0.90 | 187.93 |
As shown in Table 12, Spiromesifen and the composite proportioning of preventing and treating brassicaceous vegetable diamond-back moth of furan tebufenozide are when 1 ︰ 60 ~ 80 ︰ 1, co-toxicity coefficient is all greater than 120, both explanations mixture in 1 ︰ 60 ~ 80 ︰ 1 scope all shows synergistic effect, when the proportioning of Spiromesifen and furan tebufenozide is at 1 ︰ 20 ~ 20 ︰ 1, synergistic effect is more outstanding, co-toxicity coefficient is all greater than 210, testing through applicant the optimum ratio finding Spiromesifen and furan tebufenozide is 20:1, 15:1, 10:1, 9:1, 8:1, 7:1, 6:1, 5:1, 4:1, 3:1, 2:1, 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, 1:15, 1:20, wherein when Spiromesifen and furan tebufenozide weight ratio are 1 ︰ 1, co-toxicity coefficient is maximum, synergistic effect is the most obvious.
Application Example five
For examination insect: apple peach fruit borer
Test medicine provides by Shaanxi Meibang Pesticide Co., Ltd..
Experimental scheme: through effective lethal concentration scope of preliminary experiment determination Spiromesifen and the former medicine of ring worm hydrazides and the two different ratio mixture.
Table 13 Spiromesifen and the composite toxicity test analysis of results table to apple peach fruit borer of ring worm hydrazides
| Reagent agent | Proportioning | LC 50(ug/mL) | Co-toxicity coefficient (CTC) |
| Spiromesifen | - | 1.91 | - |
| Ring worm hydrazides | - | 1.01 | - |
| Luo first Man Zhi ︰ ring worm hydrazides | 80：1 | 0.96 | 196.79 |
| Luo first Man Zhi ︰ ring worm hydrazides | 60：1 | 0.94 | 200.05 |
| Luo first Man Zhi ︰ ring worm hydrazides | 40：1 | 0.92 | 203.19 |
| Luo first Man Zhi ︰ ring worm hydrazides | 30：1 | 0.83 | 223.69 |
| Luo first Man Zhi ︰ ring worm hydrazides | 19：1 | 0.81 | 225.74 |
| Luo first Man Zhi ︰ ring worm hydrazides | 14：1 | 0.79 | 228.21 |
| Luo first Man Zhi ︰ ring worm hydrazides | 10：1 | 0.75 | 235.58 |
| Luo first Man Zhi ︰ ring worm hydrazides | 6：1 | 0.70 | 242.05 |
| Luo first Man Zhi ︰ ring worm hydrazides | 2：1 | 0.60 | 245.43 |
| Luo first Man Zhi ︰ ring worm hydrazides | 1：1 | 0.55 | 240.24 |
| Luo first Man Zhi ︰ ring worm hydrazides | 1：5 | 0.46 | 238.28 |
| Luo first Man Zhi ︰ ring worm hydrazides | 1：9 | 0.46 | 230.42 |
| Luo first Man Zhi ︰ ring worm hydrazides | 1：15 | 0.47 | 221.41 |
| Luo first Man Zhi ︰ ring worm hydrazides | 1：25 | 0.50 | 205.73 |
| Luo first Man Zhi ︰ ring worm hydrazides | 1：40 | 0.51 | 200.34 |
| Luo first Man Zhi ︰ ring worm hydrazides | 1：60 | 0.52 | 195.74 |
As shown in Table 13, the proportioning of Spiromesifen and ring worm hydrazides composite control apple peach fruit borer is when 1 ︰ 60 ~ 80 ︰ 1, co-toxicity coefficient is all greater than 120, both explanations mixture in 1 ︰ 60 ~ 80 ︰ 1 scope all shows synergistic effect, when the proportioning of Spiromesifen and ring worm hydrazides is at 1 ︰ 15 ~ 30 ︰ 1, synergistic effect is more outstanding, co-toxicity coefficient is all greater than 220, testing through applicant the optimum ratio finding Spiromesifen and ring worm hydrazides is 30:1, 25:1, 20:1, 15:1, 10:1, 9:1, 8:1, 7:1, 6:1, 5:1, 4:1, 3:1, 2:1, 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, 1:15, wherein when Spiromesifen and ring worm hydrazides weight ratio are 2 ︰ 1, co-toxicity coefficient is maximum, synergistic effect is the most obvious.
Application Example six
For examination insect: cotton cotton bollworm
Test medicine provides by Shaanxi Meibang Pesticide Co., Ltd..
Experimental scheme: through effective lethal concentration scope of preliminary experiment determination Spiromesifen and the former medicine of chlorine worm hydrazides and the two different ratio mixture
Table 14 Spiromesifen and the composite toxicity test analysis of results table to cotton cotton bollworm of chlorine worm hydrazides
| Reagent agent | Proportioning | LC 50(ug/mL) | Co-toxicity coefficient (CTC) |
| Spiromesifen | - | 1.79 | - |
| Chlorine worm hydrazides | - | 0.52 | - |
| Luo first Man Zhi ︰ chlorine worm hydrazides | 80：1 | 0.91 | 190.95 |
| Luo first Man Zhi ︰ chlorine worm hydrazides | 60：1 | 0.88 | 195.58 |
| Luo first Man Zhi ︰ chlorine worm hydrazides | 40：1 | 0.85 | 198.75 |
| Luo first Man Zhi ︰ chlorine worm hydrazides | 30：1 | 0.75 | 221.24 |
| Luo first Man Zhi ︰ chlorine worm hydrazides | 21：1 | 0.72 | 223.77 |
| Luo first Man Zhi ︰ chlorine worm hydrazides | 15：1 | 0.67 | 231.78 |
| Luo first Man Zhi ︰ chlorine worm hydrazides | 9：1 | 0.61 | 235.84 |
| Luo first Man Zhi ︰ chlorine worm hydrazides | 4：1 | 0.50 | 240.52 |
| Luo first Man Zhi ︰ chlorine worm hydrazides | 1：1 | 0.34 | 237.03 |
| Luo first Man Zhi ︰ chlorine worm hydrazides | 1：5 | 0.25 | 235.89 |
| Luo first Man Zhi ︰ chlorine worm hydrazides | 1：10 | 0.25 | 222.34 |
| Luo first Man Zhi ︰ chlorine worm hydrazides | 1：20 | 0.26 | 206.99 |
| Luo first Man Zhi ︰ chlorine worm hydrazides | 1：40 | 0.27 | 195.98 |
| Luo first Man Zhi ︰ chlorine worm hydrazides | 1：60 | 0.28 | 187.90 |
As shown in Table 14, Spiromesifen and the composite proportioning of preventing and treating cotton cotton bollworm of chlorine worm hydrazides are when 1 ︰ 60 ~ 80 ︰ 1, co-toxicity coefficient is all greater than 120, both explanations mixture in 1 ︰ 60 ~ 80 ︰ 1 scope all shows synergistic effect, when the proportioning of Spiromesifen and chlorine worm hydrazides is at 1 ︰ 10 ~ 30 ︰ 1, synergistic effect is more outstanding, co-toxicity coefficient is all greater than 220, testing through applicant the optimum ratio finding Spiromesifen and chlorine worm hydrazides is 30:1, 25:1, 20:1, 15:1, 14:1, 13:1, 12:1, 11:1, 10:1, 9:1, 8:1, 7:1, 6:1, 5:1, 4:1, 3:1, 2:1, 1:1, 1:2, 1:3, 1:4, 1:5, 1:10, wherein when Spiromesifen and chlorine worm hydrazides weight ratio are 4 ︰ 1, co-toxicity coefficient is maximum, synergistic effect is the most obvious.
Through test find: Spiromesifen and active component B composite after have obvious synergistic effect to the control of the whitefly in bt cotton in various crop, Tetranychus urticae, two spotted spider mite, leaf roller, beet armyworm, prodenia litura, diamond-back moth, tea geometrid, corn borer, striped rice borer, armyworm, pine caterpillars, aphid, trialeurodes vaporariorum, peach fruit borer, cotton bollworm, cutworm, cabbage caterpillar, co-toxicity coefficient is all more than 120.
Test of pesticide effectiveness part test medicament is researched and developed by Shaanxi Meibang Pesticide Co., Ltd., is provided, contrast medicament 24% Spiromesifen suspending agent (autogamy), 20% Tebufenozide suspending agent (commercial), 240g/L methoxyfenozide suspending agent (commercial), 10% furan tebufenozide suspending agent (autogamy), 5% ring Tebufenozide suspending agent (autogamy), 15% chlorine worm hydrazides granule (autogamy).
Application Example seven Spiromesifen and active component B and composite control Laphygma exigua Hubner thereof
The test of pesticide effectiveness
This test arrangement is at Xian District, Shanxi Province suburban area, and investigation Laphygma exigua Hubner insect pest index before medicine, in the dispenser of insect pest initial stage of origination, 3 days, 7 days, 15 days investigation insect pest indexes after dispenser also calculate preventive effect.Result of the test is as follows:
Table 15 Spiromesifen and active component B and the composite control Laphygma exigua Hubner test of pesticide effectiveness thereof
As can be seen from Table 15, Spiromesifen and active component B composite after effectively can prevent and treat Laphygma exigua Hubner, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long, and can prevent and treat wild cabbage diamond-back moth, cabbage caterpillar, prodenia litura, and preventive effect is all greater than 96%.In test scope of medication, target crop is had no adverse effects.
Application Example eight Spiromesifen and active component B and composite water prevention chilo suppressalis medicine thereof
Effect test
This test arrangement is at Shaanxi Province's Hanzhong City, and investigation rice-stem borer insect pest index before medicine, in the dispenser of insect pest initial stage of origination, 10 days, 20 days, 30 days investigation insect pest indexes after dispenser also calculate preventive effect.Result of the test is as follows:
Table 16 Spiromesifen and active component B and the composite water prevention chilo suppressalis test of pesticide effectiveness thereof
As can be seen from Table 16, Spiromesifen and active component B composite after can effective water prevention chilo suppressalis, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example nine Spiromesifen and active component B and composite control apple Tetranychus urticae thereof
The test of pesticide effectiveness
This test arrangement is in Xianyang, Shanxi province city, and investigation apple Tetranychus urticae insect pest index before medicine, in the dispenser of insect pest initial stage of origination, 7 days, 14 days, 20 days investigation insect pest indexes after dispenser also calculate preventive effect.Result of the test is as follows:
Table 17 Spiromesifen and active component B and the composite control apple Tetranychus urticae test of pesticide effectiveness thereof
As can be seen from Table 17, Spiromesifen and active component B composite after can effectively prevent and treat apple Tetranychus urticae, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long, and can prevent and treat European red mite, and preventive effect is all greater than 96%.In test scope of medication, target crop is had no adverse effects.
Application Example ten Spiromesifen and active component B and composite control cotton cotton bollworm medicine thereof
Effect test
This test arrangement is in Dali County, Shaanxi Province, and investigation cotton cotton bollworm insect pest index before medicine, in the dispenser of insect pest initial stage of origination, 3 days, 7 days, 15 days investigation insect pest indexes after dispenser also calculate preventive effect.Result of the test is as follows:
Table 18 Spiromesifen and active component B and the composite control cotton cotton bollworm test of pesticide effectiveness thereof
As can be seen from Table 18, Spiromesifen and active component B composite after can effectively prevent and treat cotton cotton bollworm, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long, and can prevent and treat cotton whitefly in bt cotton, two spotted spider mite, and preventive effect is all greater than 96%.In test scope of medication, target crop is had no adverse effects.
Application Example 11 Spiromesifen and active component B and composite control Cruciferae vegetables thereof
The dish cabbage caterpillar test of pesticide effectiveness
This test arrangement is at Xian District, Shanxi Province suburban area, and investigation brassicaceous vegetable cabbage caterpillar insect pest index before medicine, in the dispenser of insect pest initial stage of origination, 3 days, 7 days, 15 days investigation insect pest indexes after dispenser also calculate preventive effect.Result of the test is as follows:
Table 19 Spiromesifen and active component B and the composite control brassicaceous vegetable cabbage caterpillar test of pesticide effectiveness thereof
As can be seen from Table 19, Spiromesifen and active component B composite after can effectively prevent and treat brassicaceous vegetable cabbage caterpillar, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long, and apple brassicaceous vegetable beet armyworm, diamond-back moth, prodenia litura can be prevented and treated, and preventive effect is all greater than 96%.In test scope of medication, target crop is had no adverse effects.
Application Example 12 Spiromesifen and active component B and the little food of composite control apple peach thereof
The heart worm test of pesticide effectiveness
This test arrangement is at Shaanxi Province's Weinan City, and investigation apple peach fruit borer insect pest index before medicine, in the dispenser of insect pest initial stage of origination, 10 days, 20 days, 30 days investigation insect pest indexes after dispenser also calculate preventive effect.Result of the test is as follows:
Table 20 Spiromesifen and active component B and the composite control apple peach fruit borer test of pesticide effectiveness thereof
As can be seen from Table 20, Spiromesifen and active component B composite after can effectively prevent and treat apple peach fruit borer, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long, and can prevent and treat apple skin worm, and preventive effect is all greater than 96%.In test scope of medication, target crop is had no adverse effects.
Application Example 13 Spiromesifen and active component B and composite control tomato trialeurodes vaporariorum thereof
The test of pesticide effectiveness
This test arrangement is at Xian District, Shanxi Province suburban area, and investigation tomato trialeurodes vaporariorum insect pest index before medicine, in the dispenser of insect pest initial stage of origination, 3 days, 7 days, 15 days investigation insect pest indexes after dispenser also calculate preventive effect.Result of the test is as follows:
Table 21 Spiromesifen and active component B and the composite control tomato trialeurodes vaporariorum test of pesticide effectiveness thereof
As can be seen from Table 21, Spiromesifen and active component B composite after can effectively prevent and treat tomato trialeurodes vaporariorum, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long, and can prevent and treat tomato aphid, and preventive effect is all greater than 96%.In test scope of medication, target crop is had no adverse effects.
After draw through tests different local throughout the country, Spiromesifen and worm hydrazides, methoxyfenozide, furan tebufenozide, ring worm hydrazides, the composite rear preventive effect to common insect pests such as the whitefly in bt cotton in various crop, Tetranychus urticae, two spotted spider mite, leaf roller, beet armyworm, prodenia litura, diamond-back moth, tea geometrid, corn borer, striped rice borer, armyworm, pine caterpillars, aphid, trialeurodes vaporariorum, peach fruit borer, cotton bollworm, cutworm, cabbage caterpillars of chlorine worm hydrazides are all more than 95%, be better than single dose preventive effect, synergistic effect is obvious.
Claims (6)
1. one kind contains the composition pesticide of Spiromesifen and bishydrazide, active ingredient is active components A and active component B, it is characterized in that: the weight ratio of active components A and active component B is 1 ︰ 60 ~ 80 ︰ 1, described active components A is Spiromesifen, and active component B is selected from the one in worm hydrazides, methoxyfenozide.
2. the composition pesticide containing Spiromesifen and bishydrazide according to claim 1, is characterized in that: the weight ratio of active components A and active component B is 1 ︰ 40 ~ 60 ︰ 1.
3. the composition pesticide containing Spiromesifen and bishydrazide according to claim 2, is characterized in that:
The weight ratio of Spiromesifen and worm hydrazides is 1 ︰ 25 ~ 10 ︰ 1;
The weight ratio of Spiromesifen and methoxyfenozide is 1 ︰ 15 ~ 30 ︰ 1.
4. the composition pesticide containing Spiromesifen and bishydrazide according to any one of claim 1 to 3, is characterized in that: composition makes wetting powder, water dispersible granules, suspending agent, aqueous emulsion, microemulsion, suspension emulsion, microcapsule suspending agent, microcapsule suspension-suspendinagent agent.
5. the composition pesticide containing Spiromesifen and bishydrazide according to claim 4 is for preventing and treating the purposes of insect on crops.
6. purposes according to claim 5, is characterized in that: described insect comprises whitefly in bt cotton, two spotted spider mite, leaf roller, beet armyworm, prodenia litura, diamond-back moth, tea geometrid, corn borer, striped rice borer, armyworm, pine caterpillars, aphid, trialeurodes vaporariorum, peach fruit borer, cotton bollworm, cutworm, cabbage caterpillar.
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| CN201510681196.XA Expired - Fee Related CN105248421B (en) | 2012-08-29 | 2012-08-29 | A kind of composition pesticide containing Spiromesifen and bishydrazide |
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| CN1400864A (en) * | 2000-02-18 | 2003-03-05 | 拜尔公司 | Active substance combinations comprising insecticidal and acaricidal properties |
| CN101801196A (en) * | 2007-09-21 | 2010-08-11 | 拜尔农作物科学股份公司 | Active ingredient combinations having insecticidal and acaricidal properties |
| US20110229582A1 (en) * | 2010-01-22 | 2011-09-22 | Bayer Cropscience Ag | Acaricidal and/or insecticidal active ingredient combinations |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1400864A (en) * | 2000-02-18 | 2003-03-05 | 拜尔公司 | Active substance combinations comprising insecticidal and acaricidal properties |
| CN101801196A (en) * | 2007-09-21 | 2010-08-11 | 拜尔农作物科学股份公司 | Active ingredient combinations having insecticidal and acaricidal properties |
| US20110229582A1 (en) * | 2010-01-22 | 2011-09-22 | Bayer Cropscience Ag | Acaricidal and/or insecticidal active ingredient combinations |
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| CN103621503A (en) | 2014-03-12 |
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