CN103611035A - Traditional Chinese medicine composition for treating phlegm-dampness stagnation type fatty liver - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for treating phlegm-dampness stagnation type fatty liver. Fatty liver equivalently belongs to the category of 'accumulation', 'phlegm', 'hypochondriac pain' and the like in traditional Chinese medicine. The pathogenesis of the fatty liver can be summarized as follows: liver dysfunction, liver blood stasis, dysfunction of the spleen in transport, non-dispelling of damp evil, internal phlegm turbidity, dysfunction of kidney for activation of Qi and phlegm stagnation. The phlegm-dampness stagnation type fatty liver is caused by qi stagnation and blood stasis due to long-time phlegm-damp accumulation. The traditional Chinese medicines which include cremanthodium, ligularia sibirica, fomitopsis officinalis ames, saltliving wormwood leaves, beautiful galangal fruit, phellandrium, trema cannabina, water spinach root, triptophenolide and flos rosae rugosae and have the effects of eliminating phlegm and dispelling dampness as well as soothing the liver and regulating qi-flowing for strengthening the spleen are selected; the traditional Chinese medicines are decocted with water into a decoction by a preparation room. Clinical tests show that the total effective rate reaches 97.5% and is obviously better than 78.9% of a control group, and the traditional Chinese medicine composition is worth of clinical popularization and application.

Description

A kind of Chinese medicine composition for the treatment of phlegm resistance type fatty liver

Technical field

The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine composition for the treatment of phlegm resistance type fatty liver.

Background technology

Fatty liver refers to the common clinical picture of athero in the hepatocyte being caused by a variety of causes.Most fatty livers is due to the accumulation of triglyceride (TG).Be more common in obesity, heavy drinking and other Disease.The western medical treatment of fatty liver, without specific treatment, generally be take causal treatment and supporting treatment as main, as alleviating alcohol addiction, lose weight, remove the cause of disease and inducement, as stopped using liver cytotoxic drug and avoid contacting hepatotoxicant matter, correction enteric flora disturbance etc.Treatment protopathy, the lighter can carry out diet control and take suitable exercise therapy, dispels risk factor, has symptom can adopt medicine auxiliary treatment.The medicine of the fatty liver of modern medicine treatment at present mainly contains degrease hepatic and lipid lowering agent, as the cruel class of chlorine shellfish fourth; Choline, methionine; Nicotinic acid class; Unsaturated fatty acid and phospholipid; The general egg nitronic acid of two knee joints; Ursodesoxycholic acid etc., but these medicines still lack definite curative effect, and there is untoward reaction in various degree.Chinese medicine has own uniqueness and abundant method aspect determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, a lot of advantage.Therefore, Chinese traditional treatment fatty liver is safe and reliable, evident in efficacy, can obviously improve patient's comprehensive quality of life.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine composition for the treatment of phlegm resistance type fatty liver.The categories such as fatty liver is equivalent to that motherland's medical science " is gathered ", " expectorant is turbid ", " hypochondriac pain ".The traditional Chinese medical science is thought: it is dirty in liver spleen kidney three that the generation of fatty liver is mainly blamed.Its pathogenesis can be summarized as: the liver failing to maintain the normal flow of QI, and the liver blood stasis of blood is stagnant; Dysfunction of the spleen in transportation, damp is not changed, the turbid interior life of expectorant; Kidney flatus, the expectorant stasis of blood is detained.Therefore answer this disease of dialectical treatment, phlegm resistance type fatty liver is with the passing of time caused by energy stagnation and blood stasis of stagnation of phlegm-damp.Therapeutic Principle is dispelling phlegm and eliminating dampness, is aided with depressed liver-energy dispersing and QI regulating spleen invigorating.

The object of the invention is to be achieved through the following technical solutions, the Chinese medicine composition of this treatment phlegm resistance type fatty liver is made by the Chinese medicine of following weight portion: Herba Cremanthodii plantaginei 6-12 part, Radix Ligulariae Dentatae 10-15 part, Fructificatio Fomitopsis Officinalis 3-4 part, Folium et Cacumen Artemisiae Halodendri 1-3 part, Fructus Alpinia Japanicae 6-9 part, Herba Limnophilae rugosae 6-15 part, Cortex Trematis Cannabinae Radicis 20-30 part, Radix ipomoeae aquaticae 50-60 part, Herba Begoniae Yunnanensis 13-16 part, Flos Rosae Rugosae 3-6 part.

Preferred: 8 parts of Herba Cremanthodii plantagineis, 13 parts of Radix Ligulariae Dentataes, 3.5 parts of Fructificatio Fomitopsis Officinalis, 2 parts of Folium et Cacumen Artemisiae Halodendris, 7 parts of Fructus Alpinia Japanicae, 10 parts of Herba Limnophilae rugosaes, 25 parts of Cortex Trematis Cannabinae Radiciss, 55 parts of Radix ipomoeae aquaticaes, 14 parts of Herba Begoniae Yunnanensis, 5 parts of Flos Rosae Rugosaes.

Preparation method is made decoction by above-mentioned Chinese medicine decocting.

In side: Herba Cremanthodii plantaginei expelling phlegm for arresting cough, the chest stuffiness relieving promoting the circulation of QI; Radix Ligulariae Dentatae phlegm-eliminiating and qi-regulating, hemostasis are invigorated blood circulation; Fructificatio Fomitopsis Officinalis reduce phlegm detumescence, expelling wind and removing dampness; Folium et Cacumen Artemisiae Halodendri eliminating phlegm and relieving asthma, the damp eliminating of inducing sweat; Fructus Alpinia Japanicae dampness cold relieving, the preventing the attack (or recurrence) of malaria that eliminates the phlegm, spleen invigorating warming the stomach; Herba Limnophilae rugosae invigorating spleen to remove dampness, activating QI to eliminate phlegm; Cortex Trematis Cannabinae Radicis invigorating spleen for diuresis, blood stasis dispersing and fresh blood promoting; Radix ipomoeae aquaticae inducing diuresis to remove edema and spleen circulation of qi promoting; Herba Begoniae Yunnanensis regulating QI to relieve pain, blood circulation promoting and blood stasis dispelling; Flos Rosae Rugosae regulate the flow of vital energy resolving depression, promoting blood circulation to remove blood stasis.

Clinical data

1. the selected object of physical data is my Out-patient Department and accepts patient for medical treatment, and all cases is all made a definite diagnosis through B ultrasonic and lab testing.Treatment group 40 examples, male 29 examples, female's 11 examples, 28～69 years old age, 50.6 years old mean age; Matched group 38 examples, male 25 examples, female's 13 examples, at 27～67 years old age, 49.1 years old mean age, treatment group and matched group case clinical data are learned processing by statistics, and no significant difference (P > 0.05), has comparability.

2. diagnostic criteria (1) is without history of drinking history or drink and amount to amount of alcohol male 140 grams weekly, 70 grams of women; (2) get rid of the specified disease that viral hepatitis, drug-induced liver disease, total parenteral nutrition, hepatolenticular degeneration etc. can cause fatty liver.(3), except primary disease clinical manifestation, there are nonspecific symptom and the signs such as weak, dyspepsia, dull pain in liver, hepatosplenomegaly.(4) can there be the metabolism syndromes such as overweight Abdominal obesity, fasting glucose increase, blood fat disorder, hypertension.(5) serum transaminase and glutamyl transpeptidase level can be by mild to moderate increasing (being less than 5 times of Upper Limit of Normal Values), and the alanine aminotransferase (" GPT " that be commonly called as in the past) of conventionally take raises as main.(6) tcm diagnosis standard: right flank distending pain, the lower mass in the abdomen of the side of body, abdominal distention is uncomfortable, the tending to vomit of feeling sick, anorexia is greasy, fat asthenia, greasy fur on tongue, rolling pulse.

3. two groups of patients of Therapeutic Method are all under the prerequisite of ban on opium-smoking and the opium trade alcohol prohibition, under instructing, nutritionist gives low fat diet, and give exercise therapy: trot row 70-80 step/min, 20min/ left and right, 2 times/d, quantity of motion is slightly perspired after being controlled at motion, breathe fast a little, uncomfortable without anterior pectorial region, slight tired after motion, rest fatigue half an hour can be alleviated.Treatment group on the basis of the above, add and use Chinese medicine preparation of the present invention, take Herba Cremanthodii plantaginei 8g, Radix Ligulariae Dentatae 13g, Fructificatio Fomitopsis Officinalis 3.5g, Folium et Cacumen Artemisiae Halodendri 2g, Fructus Alpinia Japanicae 7g, Herba Limnophilae rugosae 10g, Cortex Trematis Cannabinae Radicis 25g, Radix ipomoeae aquaticae 55g, Herba Begoniae Yunnanensis 14g, Flos Rosae Rugosae 5g, decocting is made decoction, 1 day 1 dose, each 200ml, every day 2 times, take half an hour after meal, be 3 months the course for the treatment of.

4. criterion of therapeutical effect (1) clinical cure: B ultrasonic shows that liver form recovers normal, and alanine aminotransferase is normal, rate and blood-lipid decreased or normal.(2) effective: ultrasound diagnosis shows intensive being clearly better of liver luminous point, and its rear echo attenuation obviously alleviates, and alanine aminotransferase is normal, rate and blood-lipid decreased.(3) effective: ultrasound diagnosis shows that liver fat sample degree of lightening improves, rate and blood-lipid decreased.(4) invalid: not reach effective standard.

5. therapeutic effect treatment was carried out effect assessment, treatment group 40 examples, clinical cure 19 examples (47.5%), effective 12 examples (30%), effective 9 examples (22.5%), invalid 1 example (2.5%), total effective rate 97.5% after 3 months.Matched group 38 examples, clinical cure 7 examples (18.4%), effective 10 examples (26.3%), effective 13 examples (34.2%), invalid 8 examples (21.1%), total effective rate 78.9%.Two groups of comparisons, treatment group cure rate, total effective rate are obviously better than matched group, have comparability (P < 0.05).

The specific embodiment

Embodiment mono-: take Herba Cremanthodii plantaginei 8g, Radix Ligulariae Dentatae 13g, Fructificatio Fomitopsis Officinalis 3.5g, Folium et Cacumen Artemisiae Halodendri 2g, Fructus Alpinia Japanicae 7g, Herba Limnophilae rugosae 10g, Cortex Trematis Cannabinae Radicis 25g, Radix ipomoeae aquaticae 55g, Herba Begoniae Yunnanensis 14g, Flos Rosae Rugosae 5g, above-mentioned Chinese medicine decocting is become to decoction.

Embodiment bis-: take Herba Cremanthodii plantaginei 12g, Radix Ligulariae Dentatae 15g, Fructificatio Fomitopsis Officinalis 4g, Folium et Cacumen Artemisiae Halodendri 1g, Fructus Alpinia Japanicae 9g, Herba Limnophilae rugosae 6g, Cortex Trematis Cannabinae Radicis 30g, Radix ipomoeae aquaticae 50g, Herba Begoniae Yunnanensis 16g, Flos Rosae Rugosae 3g, above-mentioned Chinese medicine decocting is become to decoction.

Embodiment tri-: take Herba Cremanthodii plantaginei 6g, Radix Ligulariae Dentatae 10g, Fructificatio Fomitopsis Officinalis 3g, Folium et Cacumen Artemisiae Halodendri 3g, Fructus Alpinia Japanicae 6g, Herba Limnophilae rugosae 15g, Cortex Trematis Cannabinae Radicis 20g, Radix ipomoeae aquaticae 60g, Herba Begoniae Yunnanensis 13g, Flos Rosae Rugosae 6g, above-mentioned Chinese medicine decocting is become to decoction.

Claims (2)

1. treat a Chinese medicine composition for phlegm resistance type fatty liver, it is characterized in that this Chinese medicine composition made by the Chinese medicine of following weight portion: Herba Cremanthodii plantaginei 6-12 part, Radix Ligulariae Dentatae 10-15 part, Fructificatio Fomitopsis Officinalis 3-4 part, Folium et Cacumen Artemisiae Halodendri 1-3 part, Fructus Alpinia Japanicae 6-9 part, Herba Limnophilae rugosae 6-15 part, Cortex Trematis Cannabinae Radicis 20-30 part, Radix ipomoeae aquaticae 50-60 part, Herba Begoniae Yunnanensis 13-16 part, Flos Rosae Rugosae 3-6 part.

2. a kind of Chinese medicine composition for the treatment of phlegm resistance type fatty liver according to claim 1, is characterized in that this Chinese medicine composition made by the Chinese medicine of following weight portion: 8 parts of Herba Cremanthodii plantagineis, 13 parts of Radix Ligulariae Dentataes, 3.5 parts of Fructificatio Fomitopsis Officinalis, 2 parts of Folium et Cacumen Artemisiae Halodendris, 7 parts of Fructus Alpinia Japanicae, 10 parts of Herba Limnophilae rugosaes, 25 parts of Cortex Trematis Cannabinae Radiciss, 55 parts of Radix ipomoeae aquaticaes, 14 parts of Herba Begoniae Yunnanensis, 5 parts of Flos Rosae Rugosaes.