CN103610801B - A kind of Chinese medicine composition being used for the treatment of typhoid fever cold limbs due to intense heat in the interior disease - Google Patents
A kind of Chinese medicine composition being used for the treatment of typhoid fever cold limbs due to intense heat in the interior disease Download PDFInfo
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- CN103610801B CN103610801B CN201310582551.9A CN201310582551A CN103610801B CN 103610801 B CN103610801 B CN 103610801B CN 201310582551 A CN201310582551 A CN 201310582551A CN 103610801 B CN103610801 B CN 103610801B
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Abstract
Be used for the treatment of a Chinese medicine composition for typhoid fever cold limbs due to intense heat in the interior disease, relate to field of Chinese herbal medicine technology, be made up of the crude drug of following weight, Radix Bupleuri 10-20g, Radix Paeoniae Alba 10-20g, Fructus Aurantii Immaturus 5-15g, Radix Scutellariae 8-14g, Caulis Akebiae 5-15g, Flos Carthami 1-10g, Radix Glycyrrhizae 5-15g.The present invention draws materials easily, makes the features such as simple, with low cost, compatibility is reasonable, and taking dose is little, and Harmful ingredient content is low, has no side effect, evident in efficacy.
Description
Technical field
The present invention relates to field of Chinese herbal medicine technology, be specifically related to a kind of Chinese medicine composition being used for the treatment of typhoid fever cold limbs due to intense heat in the interior disease.
Background technology
Eight comas cards in treatise on Febrile Diseases, comprise cold limbs, cold limbs due to intense heat in the interior, water fainted, syncope due to accumulation of phlegm, lose consciousness, syncope due to excessive bleeding, the ascariasis of biliary tract, visceral shock due to extreme YIN-cold etc.Card of fainting is outer time, and its pathogenesis is that Yinyang is mutually along connecing.
Cold limbs due to intense heat in the interior is that yang-energy is solely high, and pathogenic heat is deep, and causes yang-energy pent-up, can not be sensible caused by the extremity.Treatise on Febrile Diseases is said: " typhoid fever rolling pulse with coldness on the extremities person, heat in the interior, Baihu Tang master it." this i.e. volt in pathogenic heat, heat is fainted the also dark meaning deeply.Golden Mirror of Medicine is thought: " rolling pulse with coldness on the extremities, sliding is YANG pulse, and interior-heat is known, be cold limbs due to intense heat in the interior also." You Zaijing proposition, faint pulse with coldness on the extremites is YIN pathogen damaging the spleen and stomach, trembles with fear inner; Rolling pulse with coldness on the extremities, YANG pathogen hindered, heat in the interior.From clinical practice, though cold limbs due to intense heat in the interior extremity are cold, and the hands that burns that breast abdomen is laid one's hand on, or see to wave one's hand and throw foot, aversion to cold is thirsty, and agitation is not peaceful, even unconsciousness and delirium; hot urination, order closes and blood vessel fills with eyeball, and deep-rolling pulse is really done one's bit inside; yellowish fur on the tongue tongue is dry; or scorching tongue is black very plays the diseases such as thorn, therefore reaches heat with Baihu Tang and go out to show, and makes it heat and goes to faint back.
But it should be noted that and occur cold limbs due to intense heat in the interior clinically, belong to that sick dark with the passing of time because lying prostrate in pathogenic heat, also visible abdominal distention tenderness, does not defecate and wait excess syndrome caused by interior-heat card, then when capturing internal organs in fact with holding gas, removing burning wood away under the boiler, expels the heat-evil to control and faints more.Therefore the established practice that can not stick to Baihu Tang.In a word, the heat of cold limbs due to intense heat in the interior is this, and fainting is mark, and heat is the starting point of pathogenesis, and fainting is outer time illusion, is namely real heat with pseudo-cold, should carefully distinguishes.In addition, also must be pointed out, clinically infantile hyperpyrexia, though disease soon, also can occur the syndrome of coldness on the extremities caused by blockage of excessive heat of " rolling pulse with coldness on the extremities ", as infantile pneumonia, pathogenic heat gathers lung, roughly pants, but brothers faint cold, and fingerprint is livid purple and stagnant, also belong to card of fainting, control when the suitable lung of heat clearing away, reach heat and go out, its runback of fainting.As acute infectious diseases such as acute bacillary dysentery, epidemic encephalitis type B, epidemic cerebrospinal meningitis, all can there is cold limbs due to intense heat in the interior in him, when clearly dialectical, because card treats.
Summary of the invention
It is high that technical problem to be solved by this invention is to provide a kind of cure rate, the safe and reliable Chinese medicine composition being used for the treatment of typhoid fever cold limbs due to intense heat in the interior disease.
Technical problem to be solved by this invention realizes by the following technical solutions:
Be used for the treatment of a Chinese medicine composition for typhoid fever cold limbs due to intense heat in the interior disease, the medicament be made up of the crude drug of following weight,
Radix Bupleuri 10-20g, Radix Paeoniae Alba 10-20g, Fructus Aurantii Immaturus 5-15g, Radix Scutellariae 8-14g, Caulis Akebiae 5-15g, Flos Carthami 1-10g, Radix Glycyrrhizae 5-15g.
The preferred weight of each component is:
Radix Bupleuri 15g, Radix Paeoniae Alba 15g, Fructus Aurantii Immaturus 10g, Radix Scutellariae 12g, Caulis Akebiae 10g, Flos Carthami 5g, Radix Glycyrrhizae 10g.
The preferred ingredient of each component is:
Soft Radix Bupleuri 15g, Radix Paeoniae Alba 15g, Fructus Aurantii Immaturus (parched) 10g, Radix Scutellariae 12g, Chinese Caulis Akebiae 10g, Flos Carthami 5g, Radix Glycyrrhizae 10g.
Crude drug used by the present invention can be bought from common Chinese shop and obtain, and its specification meets national Chinese crude drug standard.
Chinese medicine composition of the present invention can add various adjuvants required when preparing different dosage form, such as disintegrating agent, lubricant, adhesive etc., the conventional oral formulations of any one is prepared into the method for Chinese medicinal of routine, wherein, described oral formulations can be decoction, pill, capsule or tablet.
Another object of the present invention is to provide a kind of method preparing the present composition, comprises the steps,
1) each crude drug is taken by following weight number: soft Radix Bupleuri 15g, Radix Paeoniae Alba 15g, Fructus Aurantii Immaturus (parched) 10g, Radix Scutellariae 12g, Chinese Caulis Akebiae 10g, Flos Carthami 5g, Radix Glycyrrhizae 10g.
2) above-mentioned each taste material medicine is mixed being placed in marmite adds water did not have powder, soak after 20 ~ 40 minutes, with slow fire boiling, renew after boiling and decoct 30 minutes, decoct three times altogether, merges three decocting liquids filtrations, obtain decoction.
Usage and consumption:
The dosage of medicine of the present invention depends on concrete dosage form, and the factor such as the age of patient, body weight, health status.Instruction: decoction, every day 1 dose, decocting, point morning, noon and afternoon clothes, know for 1 dose, and 2 doses light, and 3 doses of work, rest 3, as usual and fully recover from an illness.
By Cheng Wuji day: " faint if all and begin to obtain it, brothers just faint and warm person, are that yin channel is subject to heresy, YANG QI deficiency, available decoction for Resuscitation, if brothers' self-heating and the temperature that arrives, from the inverse and person of fainting that arrives, the heresy of transmission from one channel to another also, Sini San master it." this cold limbs due to intense heat in the interior disease, therefore in side Radix Bupleuri to dredge its wood strongly fragrant, Radix Paeoniae leads to its constipation of YIN type, the fire of clear three Jiao of Radix Scutellariae, and Fructus Aurantii Immaturus is let out its painful abdominal mass and trembled with fear, and gas during Radix Glycyrrhizae is in harmonious proportion, adds Caulis Akebiae and declare its latent heat, and Flos Carthami promoting the circulation of blood feeling pulse becomes silted up, and interior relieving the exterior syndrome reaches, and blood vessels pass unimpeded, and yang-energy is happy, and cold limbs due to intense heat in the interior spontaneous recovery.
Medicated diet prepared by the present invention has carried out a large amount of clinical trials of a large amount of animal acute toxicity tests, long-term toxicity test for animals and disease therapy, drops into the use link of disease therapy provide science and objective foundation to this medicine.Its test method and result of the test are distinguished as follows:
1. the medicated diet that couple the present invention boils carries out animal acute toxicity test:
Medicine: the decoction boiled by prescription of the present invention, saves backup in refrigerator, is provided by The First Affiliated Hospital of Anhui College of Traditional Chinese Medicine.
Experimental animal: white mice, body weight is at 30-50g, and male and female Stochastic choice, is provided by Medical University Of Anhui.
Method and result: get white mice 50, be divided into 5 groups, often organize 10, hungry 15 hours, fill with medicine feed thing by every only each 5ml, in 24 hours, fill with medicine feed thing respectively 1,2,3,4,5 times for the 1st, 2,3,4,5 group, observe 5 days, white mice is movable normal, non-toxic reaction, without dead.Wherein white mice dosage is by kg body weight medicine calculation, shows that oral liquid is without acute toxicity, clinical medicine dose safety.
2. the decoction that couple the present invention boils carries out long-term toxicity test for animals:
Experimental animal: rat, body weight, at 120-130g, all selects male white rat, is provided by Medical University Of Anhui.
Method and result: get rat 50, be divided into 5 groups, often organize 10, wherein the 1st, 2, 3, 4 groups as administration group, often organize and fill with medicine feed thing 4ml respectively, 6ml, 8ml, 10ml, 5th group of diet as a control group, once a day, continuous irrigation is fed 90 days, survey body weight, 24 hours sacrificed by decapitation after last administration, survey blood, routine urinalysis, liver function, renal function, core, the internal organs such as kidney, the change of tissues observed form, observe the effect of dosage, observe diet, movable change, experiment proves that administration group compares without significant change with matched group, visible by the dosage equal non-toxic reaction of kg body weight calculating relative to clinical 50-200 times, a kind of safe drugs.
3. in order to verify clinical efficacy, this prescription Jieshou City institute of traditional Chinese medicine tries out, and by random selecting wherein 50 routine patients, the course for the treatment of is the shortest 1 day, and the longest is 5 days.
4. Therapeutic Method
According to drug ratios of the present invention, take raw material (dose), obtain medicinal liquid according to the method for usually boiling medicine, every day potion, the morning, noon and afternoon service once.
5. efficacy determination: adopt grade III Standard;
Effective 40 examples (subjective symptoms all disappears), effective 8 examples (subjective symptoms is obviously improved); Invalid 2 examples (subjective symptoms is without improvement); Total effective rate 96%.
The invention has the beneficial effects as follows: the present invention draws materials easily, makes the features such as simple, with low cost, compatibility is reasonable, and taking dose is little, and Harmful ingredient content is low, has no side effect, evident in efficacy.
Detailed description of the invention
The technological means realized to make the present invention, creation characteristic, reaching object and effect is easy to understand, below in conjunction with specific embodiment, setting forth the present invention further.
Embodiment 1
Each crude drug is taken: Radix Bupleuri 15g, Radix Paeoniae Alba 15g, Fructus Aurantii Immaturus 10g, Radix Scutellariae 12g, Caulis Akebiae 10g, Flos Carthami 5g, Radix Glycyrrhizae 10g by following weight number.
Above-mentioned each taste material medicine is mixed being placed in marmite adds water did not have powder, soak after 20 ~ 40 minutes, with slow fire boiling, renew after boiling and decoct 30 minutes, decoct three times altogether, merges three decocting liquids filtrations, obtain decoction.Instruction: decoction, gets a pair and takes herb liquid, three times on the one, and morning, noon and afternoon sub-service, serve on 3 days.
Embodiment 2
Each crude drug is taken: Radix Bupleuri 16g, Radix Paeoniae Alba 16g, Fructus Aurantii Immaturus 11g, Radix Scutellariae 13g, Caulis Akebiae 11g, Flos Carthami 6g, Radix Glycyrrhizae 11g by following weight number.
Above-mentioned each taste material medicine is mixed being placed in marmite adds water did not have powder, soak after 20 ~ 40 minutes, with slow fire boiling, renew after boiling and decoct 30 minutes, decoct three times altogether, merges three decocting liquids filtrations, obtain decoction.Instruction: decoction, gets a pair and takes herb liquid, three times on the one, and morning, noon and afternoon sub-service, serve on 3 days.
Embodiment 3
Each crude drug is taken: Radix Bupleuri 14g, Radix Paeoniae Alba 14g, Fructus Aurantii Immaturus 9g, Radix Scutellariae 11g, Caulis Akebiae 9g, Flos Carthami 4g, Radix Glycyrrhizae 9g by following weight number.
Above-mentioned each taste material medicine is mixed being placed in marmite adds water did not have powder, soak after 20 ~ 40 minutes, with slow fire boiling, renew after boiling and decoct 30 minutes, decoct three times altogether, merges three decocting liquids filtrations, obtain decoction.Instruction: decoction, gets a pair and takes herb liquid, three times on the one, and morning, noon and afternoon sub-service, serve on 3 days.
Embodiment 4
Each crude drug is taken: Radix Bupleuri 10g, Radix Paeoniae Alba 10g, Fructus Aurantii Immaturus 5g, Radix Scutellariae 8g, Caulis Akebiae 5g, Flos Carthami 1g, Radix Glycyrrhizae 5g by following weight number.
Above-mentioned each taste material medicine is mixed being placed in marmite adds water did not have powder, soak after 20 ~ 40 minutes, with slow fire boiling, renew after boiling and decoct 30 minutes, decoct three times altogether, merges three decocting liquids filtrations, obtain decoction.Instruction: decoction, gets a pair and takes herb liquid, three times on the one, and morning, noon and afternoon sub-service, serve on 3 days.
Model case
Case 1
Chen, man, is past sixty years of age, people from Jieshou City, Anhui Province.Just go to a doctor on July 11st, 2012, patient have latent heat, and excessively, the acid of sense body, aversion to cold, is intended to sweating from taking Herba Alii fistulosi ginger decoction and exempts from medicine, then send out headache to evening in work in midsummer.Front doctor's mistaken diagnosis doctor anemopyretic cold, heavy lapidation cream, the Radix Rehmanniae, Radix Ophiopogonis and so on, more disease on the three is counter exacerbates, and deadly cold hand and foot is uncomfortable in chest, syncope, if ear is without news, hundred lips are all white, only henna work, and tongue fur is deep yellow, all volts about arteries and veins and strong.Card belongs to critical, and front doctor wrongly takes the solidifying product of sweet Han Yin, holds back Re Guer.Plan is examined: typhoid fever syndrome of coldness on the extremities caused by blockage of excessive heat.Fa Dangda is strongly fragrant to activate yang, and expel the heat-evil a surname's painful abdominal mass.Take the embodiment of the present invention 1 water decoction, within 3 days, cure.
Case 2
Weigh certain, man, 35, people from Jieshou City, Anhui Province.The acid of patient's conscious body, aversion to cold, is intended to sweating from taking Herba Alii fistulosi ginger decoction and exempts from medicine, then send out headache to evening.Diagnosis: if ear is without news, hundred lips are all white, only henna work, and tongue fur is deep yellow, all volts about arteries and veins and strong.Card belongs to critical, intends examining: typhoid fever syndrome of coldness on the extremities caused by blockage of excessive heat.Fa Dangda is strongly fragrant to activate yang, and expel the heat-evil a surname's painful abdominal mass.Take the embodiment of the present invention 1 water decoction, within 3 days, cure.
Case 3
Lee, female, 55, people from Jieshou City, Anhui Province.The conscious body acid of patient, aversion to cold; Diagnosis: if ear is without news, hundred lips are all white, only henna work, and tongue fur is deep yellow, all volts about arteries and veins and strong.Card belongs to critical, intends examining: typhoid fever syndrome of coldness on the extremities caused by blockage of excessive heat.Fa Dangda is strongly fragrant to activate yang, and expel the heat-evil a surname's painful abdominal mass.Take the embodiment of the present invention 1 water decoction, within 3 days, cure.
More than show and describe ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; what describe in above-described embodiment and description just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.Application claims protection domain is defined by appending claims and equivalent thereof.
Claims (2)
1. be used for the treatment of a Chinese medicine composition for typhoid fever cold limbs due to intense heat in the interior disease, it is characterized in that, be made up of the crude drug of following weight: Radix Bupleuri 10-20g, Radix Paeoniae Alba 10-20g, Fructus Aurantii Immaturus 5-15g, Radix Scutellariae 8-14g, Caulis Akebiae 5-15g, Flos Carthami 1-10g, Radix Glycyrrhizae 5-15g.
2. a kind of Chinese medicine composition being used for the treatment of typhoid fever cold limbs due to intense heat in the interior disease according to claim 1, is characterized in that, be made up of the crude drug of following weight: Radix Bupleuri 15g, Radix Paeoniae Alba 15g, Fructus Aurantii Immaturus 10g, Radix Scutellariae 12g, Caulis Akebiae 10g, Flos Carthami 5g, Radix Glycyrrhizae 10g.
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| CN105434616A (en) * | 2014-09-19 | 2016-03-30 | 李玉兰 | Traditional Chinese medicine composition treating typhoid |
| CN104771628A (en) * | 2015-04-07 | 2015-07-15 | 陆开云 | Traditional Chinese medicine preparation for treating typhoid fever and heat syncope |
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| CN100348228C (en) * | 2002-11-27 | 2007-11-14 | 北京中医药大学 | New use of powder for regulating liver and spleen and its active part |
| CN1250255C (en) * | 2003-01-28 | 2006-04-12 | 南京师范大学 | Chinese herbal medicine combination for treating disease of disorder of bowels's function and its product |
| CA2687492C (en) * | 2007-08-02 | 2013-08-20 | Xiaolin Tong | A herbal composition, method for preparing the same and use thereof for treating diabetes mellitus |
| CN101623366B (en) * | 2009-07-18 | 2012-09-05 | 南京师范大学 | Composition for curing gastrointestinal functional disorders, preparation method thereof and application thereof in preparing drugs for curing gastrointestinal functional disorders |
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