CN103599333B - 一种治疗宫颈柱状上皮异位的中药外敷剂 - Google Patents
一种治疗宫颈柱状上皮异位的中药外敷剂 Download PDFInfo
- Publication number
- CN103599333B CN103599333B CN201310585471.9A CN201310585471A CN103599333B CN 103599333 B CN103599333 B CN 103599333B CN 201310585471 A CN201310585471 A CN 201310585471A CN 103599333 B CN103599333 B CN 103599333B
- Authority
- CN
- China
- Prior art keywords
- parts
- herba
- radix
- cervix uteri
- aristolochiae
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 210000003679 cervix uteri Anatomy 0.000 title claims abstract description 18
- 210000000981 epithelium Anatomy 0.000 title claims abstract description 11
- 238000011282 treatment Methods 0.000 title abstract description 18
- 239000003814 drug Substances 0.000 claims abstract description 17
- 241001617284 Pedicularis rex Species 0.000 claims abstract description 9
- 239000008280 blood Substances 0.000 abstract description 10
- 210000004369 blood Anatomy 0.000 abstract description 10
- 210000000952 spleen Anatomy 0.000 abstract description 9
- 231100000614 poison Toxicity 0.000 abstract description 8
- 239000000843 powder Substances 0.000 abstract description 7
- 239000003440 toxic substance Substances 0.000 abstract description 6
- 201000010099 disease Diseases 0.000 abstract description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 4
- 238000002560 therapeutic procedure Methods 0.000 abstract description 4
- 230000000202 analgesic effect Effects 0.000 abstract description 3
- 206010067125 Liver injury Diseases 0.000 abstract description 2
- 230000035568 catharsis Effects 0.000 abstract description 2
- 230000006735 deficit Effects 0.000 abstract description 2
- 230000004064 dysfunction Effects 0.000 abstract description 2
- 230000008451 emotion Effects 0.000 abstract description 2
- 230000001717 pathogenic effect Effects 0.000 abstract description 2
- 239000002574 poison Substances 0.000 abstract description 2
- 230000009466 transformation Effects 0.000 abstract description 2
- 210000004291 uterus Anatomy 0.000 abstract description 2
- 240000008042 Zea mays Species 0.000 description 12
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 12
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 12
- 235000005822 corn Nutrition 0.000 description 12
- 208000002193 Pain Diseases 0.000 description 7
- 208000024891 symptom Diseases 0.000 description 7
- 229920000742 Cotton Polymers 0.000 description 4
- 230000003628 erosive effect Effects 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 210000001215 vagina Anatomy 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 206010013990 dysuria Diseases 0.000 description 2
- 230000005906 menstruation Effects 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 208000001387 Causalgia Diseases 0.000 description 1
- 208000023890 Complex Regional Pain Syndromes Diseases 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 206010048222 Xerosis Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000001741 anti-phlogistic effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 208000014439 complex regional pain syndrome type 2 Diseases 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 210000005224 forefinger Anatomy 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 208000021267 infertility disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000002175 menstrual effect Effects 0.000 description 1
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 1
- 229960000282 metronidazole Drugs 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 208000037920 primary disease Diseases 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 229910001961 silver nitrate Inorganic materials 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 229940126702 topical medication Drugs 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种治疗宫颈柱状上皮异位的中药外敷剂。中医学认为，宫颈柱状上皮异位是因七情过极，郁久化火，损伤肝脾，湿瘀互结，损害胞宫，阴部胞脉受损，外感邪毒使疏泄运化失常，气滞血瘀而成。本发明选择具有补脾益气，升阳利湿、清热解毒，化瘀定痛的中药还阳草根、刺老鸦、牛奶柴、铃兰、青香藤、粉苞苣、鼻血雷、鬼灯笼根、管南香、紫背天葵草、垂丝卫矛、青箭，共研细末备用，经临床试验，总有效率达到96.7％，明显优于对照组，而且副作用小，复发率低。
Description
技术领域
本发明涉及一种中药组合物，尤其涉及一种治疗宫颈柱状上皮异位的中药外敷剂。
背景技术
宫颈柱状上皮异位属正常生理现象，没有什么特殊的临床表现。但对于有症状的宫颈柱状上皮异位，需要进行治疗。主要症状表现为白带增多、外阴瘁痛、下腹及腰骶部疼痛、尿频或排尿困难甚至不孕。西医治疗该病采用口服药与阴道用药联合使用治疗，但是使用这些药物往往无法彻底治好中、重度糜烂，易复发。由于药物对于已糜烂的组织作用有限，需要长期、反复治疗，耗时长不说，且药物用久了身体就会产生抗药性，最终导致只能缓解症状，无法彻底的清除糜烂组织并消除炎症，不利于日后彻底治愈。中医重视整体观念，可根据不同病人的不同临床表现，从多方面进行治疗，局部施药更具优势，药物直达病所疗效更高，而且副作用小，简单经济，疗效显著。
发明内容
本发明的目的是提供一种治疗宫颈柱状上皮异位的中药外敷剂。中医学认为，宫颈柱状上皮异位是因七情过极，郁久化火，损伤肝脾，湿瘀互结，损害胞宫，阴部胞脉受损，外感邪毒使疏泄运化失常，气滞血瘀而成。中医治疗本病应以补脾益气，升阳利湿、清热解毒，化瘀定痛为原则。
本发明的目的是通过以下技术方案实现的，该治疗宫颈柱状上皮异位的中药外敷剂由以下重量份的中药制成：还阳草根25-30份、刺老鸦15-25份、牛奶柴30-60份、铃兰3-9份、青香藤6-9份、粉苞苣18-20份、鼻血雷3-6份、鬼灯笼根9-15份、管南香1-3份、紫背天葵草9-15份、垂丝卫矛15-25份、青箭3-9份。
优选的：还阳草根27份、刺老鸦20份、牛奶柴45份、铃兰6份、青香藤7份、粉苞苣19份、鼻血雷4份、鬼灯笼根12份、管南香2份、紫背天葵草12份、垂丝卫矛20份、青箭6份。
制备方法上述中药共研细末备用。
方中：还阳草根补益气血、健脾利湿；刺老鸦补气安神、强精补肾、祛风活络；牛奶柴补中益气；铃兰温阳利水、活血祛风；青香藤行气止痛、健脾；粉苞苣清热解毒、止痛消炎；鼻血雷清热解毒、止痛；鬼灯笼根清热解毒、止痛凉血；管南香清热解毒、祛瘀生肌、理气止痛；紫背天葵草、垂丝卫矛祛瘀活血，调经；青箭祛瘀调经、消肿止痛。
临床资料
1.一般资料本组60例均为门诊患者，按随机数字表，将病例随机平均分为治疗组和对照组。治疗组中I度糜烂15例，II度8例，III度糜烂7例，年龄26-51岁，平均35.5岁；对照组中I度糜烂12例，II度10例，III度糜烂8例，年龄27-55岁，平均37.1岁；两组患者在年龄、病程、病情方面比较，差异无显著性意义(P＞0.05)，具有可比性。
2.诊断标准按照宫颈糜烂面积大小将糜烂分为3度。I度：糜烂面积小于整个宫颈面积的1/3；II度：糜烂面积占到整个宫颈面积的1/3-2/3；III度：糜烂面积达到整个宫颈面积的2/3以上。
3.治疗方法对照组按照说明书口服甲硝唑片及宫颈局部上药，硝酸银溶液(浓度10％～20％)涂于宫颈的宫颈口和糜烂面，涂药后用棉签沾生理盐水涂抹，避免灼伤局部粘膜，每周1次，连续4周。治疗组使用本发明所述的中药外敷剂，称取还阳草根27g、刺老鸦20g、牛奶柴45g、铃兰6g、青香藤7g、粉苞苣19g、鼻血雷4g、鬼灯笼根12g、管南香2g、紫背天葵草12g、垂丝卫矛20g、青箭6g，上药共研细末，睡前将药棉放入药瓶轻摇，待沾满药粉后取出；将指套戴在食指上，然后将药棉推入阴道深处，24时后轻拉药棉细线取出；每天使用一次，每5次一个疗程，孕妇、哺乳期妇女、月经期妇女禁用，使用期间不能进行房事。
4.疗效标准治愈：糜烂面消失，宫颈光滑，白带清洁度转为正常。显效：临床症状消失，糜烂面缩小＞50％。有效：临床症状好转，糜烂面缩小＜50％。无效：宫颈糜烂、白带清洁度及临床症状均无变化。
5.治疗效果两组患者治疗1个月后疗效比较，治疗组30例，其中治愈20例(66.7％)；显效6例(20％)；有效3例(10％)，无效1例(3.3％)，总有效率96.7％；对照组30例，其中治愈10例(33.3％)；显效8例(26.7％)；有效7例(23.3％)，无效5例(16.7％)，总有效率83.3％。两组比较，治疗组治愈率、总有效率明显优于对照组，具有可比性。P＜0.05。治疗过程中治疗组没有明显不良反应，对照组3例患者有肠胃道症状，如恶心、厌食、呕吐、腹泻、便秘，1例患者出现皮肤过敏，5例患者出现阴道或外阴干燥、发热，灼痛，1例出现排尿困难，停药后症状减轻直至消失。治疗后随访半年，治疗组仅有2例(6.7％)复发，对照组9例(30％)复发。
具体实施方式
实施例一：称取还阳草根27g、刺老鸦20g、牛奶柴45g、铃兰6g、青香藤7g、粉苞苣19g、鼻血雷4g、鬼灯笼根12g、管南香2g、紫背天葵草12g、垂丝卫矛20g、青箭6g，上述中药共研细末备用。
实施例二：称取还阳草根25g、刺老鸦15g、牛奶柴60g、铃兰3g、青香藤9g、粉苞苣20g、鼻血雷6g、鬼灯笼根9g、管南香3g、紫背天葵草9g、垂丝卫矛25g、青箭3g，上述中药共研细末备用。
实施例三：称取还阳草根30g、刺老鸦25g、牛奶柴30g、铃兰9g、青香藤6g、粉苞苣18g、鼻血雷3g、鬼灯笼根15g、管南香1g、紫背天葵草15g、垂丝卫矛15g、青箭9g，上述中药共研细末备用。
Claims (1)
1.一种治疗宫颈柱状上皮异位的中药外敷剂，其特征在于该中药外敷剂由以下重量份的中药制成：还阳草根27份、刺老鸦20份、牛奶柴45份、铃兰6份、青香藤7份、粉苞苣19份、鼻血雷4份、鬼灯笼根12份、管南香2份、紫背天葵草12份、垂丝卫矛20份、青箭6份。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310585471.9A CN103599333B (zh) | 2013-11-14 | 2013-11-14 | 一种治疗宫颈柱状上皮异位的中药外敷剂 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310585471.9A CN103599333B (zh) | 2013-11-14 | 2013-11-14 | 一种治疗宫颈柱状上皮异位的中药外敷剂 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103599333A CN103599333A (zh) | 2014-02-26 |
| CN103599333B true CN103599333B (zh) | 2016-01-27 |
Family
ID=50117639
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310585471.9A Active CN103599333B (zh) | 2013-11-14 | 2013-11-14 | 一种治疗宫颈柱状上皮异位的中药外敷剂 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103599333B (zh) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102335394A (zh) * | 2011-10-11 | 2012-02-01 | 陕西东泰制药有限公司 | 一种用于治疗宫颈糜烂的中药组合物及其制备方法 |
| CN102688448A (zh) * | 2012-05-23 | 2012-09-26 | 刘开敏 | 治疗宫颈柱状上皮异位的中药 |
-
2013
- 2013-11-14 CN CN201310585471.9A patent/CN103599333B/zh active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102335394A (zh) * | 2011-10-11 | 2012-02-01 | 陕西东泰制药有限公司 | 一种用于治疗宫颈糜烂的中药组合物及其制备方法 |
| CN102688448A (zh) * | 2012-05-23 | 2012-09-26 | 刘开敏 | 治疗宫颈柱状上皮异位的中药 |
Non-Patent Citations (1)
| Title |
|---|
| 宫颈炎康栓联合抗宫炎软胶囊治疗宫颈柱状上皮异位疗效观察;王萍;《赣南医学院学报》;20111231;第31卷(第6期);796 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103599333A (zh) | 2014-02-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102247581B (zh) | 一种治疗子宫肌瘤的药物 | |
| CN104523865A (zh) | 一种治疗乳腺疾病的药物 | |
| CN103405698A (zh) | 一种治疗痤疮的中药搽剂及制备方法 | |
| CN101983644A (zh) | 一种治疗中风后遗症的药剂 | |
| CN104587206A (zh) | 治疗褥疮的药物及制备方法 | |
| CN104547093A (zh) | 一种治疗腱鞘炎的中药组合物 | |
| CN103599333B (zh) | 一种治疗宫颈柱状上皮异位的中药外敷剂 | |
| CN103705632A (zh) | 乳癖消片在制备治疗阴茎硬结症药物中的应用 | |
| CN103142794A (zh) | 拔毒祛疮膏 | |
| CN103585273B (zh) | 一种用于治疗局部肿胀、疼痛的中药组合物 | |
| CN102824470A (zh) | 一种治疗腰椎间盘突出、坐骨神经痛和腿痛的药酒 | |
| CN103272195B (zh) | 一种治疗疼痛的中药膏 | |
| CN103417788B (zh) | 一种治疗骨折内服中药 | |
| CN102949467A (zh) | 一种治疗湿热瘀阻所致慢性盆腔炎的药物组合物 | |
| CN103341100A (zh) | 一种活血止痛抗炎消肿的药酒 | |
| CN103816381A (zh) | 一种治疗跌打损伤的药物及其制备方法 | |
| CN113244363B (zh) | 一种骨科中药药饼灸及其制备方法与应用 | |
| CN102579772A (zh) | 一种治疗痰浊壅塞型臁疮的中药洗剂制备方法 | |
| CN102579867B (zh) | 一种治疗呕吐型臁疮的中药洗剂制备方法 | |
| CN101543562B (zh) | 一种治疗腰椎间盘突出症的中药 | |
| CN101596297B (zh) | 癣愈丸 | |
| CN104997930A (zh) | 一种筋骨贴膏 | |
| CN104666653A (zh) | 一种治疗膝盖骨关节炎的中药膏剂及其制备方法 | |
| CN104491327A (zh) | 一种用于治疗褥疮的喷雾药剂 | |
| CN104491703A (zh) | 一种口服治疗膝关节创伤性滑膜炎的中药组合物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| CB03 | Change of inventor or designer information |
Inventor after: Gao Yuliang Inventor after: Lian Hui Inventor after: Jiang Yanyan Inventor after: Qu Xiaoli Inventor before: Bao Sanju |
|
| COR | Change of bibliographic data | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20151217 Address after: 266300 Jiaozhou Central Hospital, Xuzhou Road, Qingdao, Shandong, No. 29,, China Applicant after: Gao Yuliang Address before: 276300 Yinan County People's Hospital of Yinan, Shandong Province, Lishan Road, No. 50, Linyi Applicant before: Bao Sanju |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CB03 | Change of inventor or designer information | ||
| CB03 | Change of inventor or designer information |
Inventor after: Mo Xiaojun Inventor before: Gao Yuliang Inventor before: Lian Hui Inventor before: Jiang Yanyan Inventor before: Qu Xiaoli |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20170424 Address after: 518109 Guangdong Province, Longhua New District, Qing Xiang Road on the 1st treasure science and Technology Park Po Chuang building, block C, floor 6, Patentee after: Shenzhen doctor Biotechnology Co., Ltd. Address before: 266300 Jiaozhou Central Hospital, Xuzhou Road, Qingdao, Shandong, No. 29,, China Patentee before: Gao Yuliang |