CN103576314B - 阵列光学器件 - Google Patents

阵列光学器件 Download PDF

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Publication number
CN103576314B
CN103576314B CN201310331511.7A CN201310331511A CN103576314B CN 103576314 B CN103576314 B CN 103576314B CN 201310331511 A CN201310331511 A CN 201310331511A CN 103576314 B CN103576314 B CN 103576314B
Authority
CN
China
Prior art keywords
lens array
field lens
light source
pupil
field
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201310331511.7A
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English (en)
Chinese (zh)
Other versions
CN103576314A (zh
Inventor
A.弗兰
J.维特佐雷克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CN103576314A publication Critical patent/CN103576314A/zh
Application granted granted Critical
Publication of CN103576314B publication Critical patent/CN103576314B/zh
Active legal-status Critical Current
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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G01N21/6454—Individual samples arranged in a regular 2D-array, e.g. multiwell plates using an integrated detector array
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0096—Microscopes with photometer devices
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B3/00—Simple or compound lenses
    • G02B3/0006—Arrays
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B3/00—Simple or compound lenses
    • G02B3/0006—Arrays
    • G02B3/0037—Arrays characterized by the distribution or form of lenses
    • G02B3/0056—Arrays characterized by the distribution or form of lenses arranged along two different directions in a plane, e.g. honeycomb arrangement of lenses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G01N2021/6478—Special lenses
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B2207/00—Coding scheme for general features or characteristics of optical elements and systems of subclass G02B, but not including elements and systems which would be classified in G02B6/00 and subgroups
    • G02B2207/113—Fluorescence
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B3/00—Simple or compound lenses
    • G02B3/0006—Arrays
    • G02B3/0037—Arrays characterized by the distribution or form of lenses
    • G02B3/0062—Stacked lens arrays, i.e. refractive surfaces arranged in at least two planes, without structurally separate optical elements in-between
    • G02B3/0068—Stacked lens arrays, i.e. refractive surfaces arranged in at least two planes, without structurally separate optical elements in-between arranged in a single integral body or plate, e.g. laminates or hybrid structures with other optical elements

Landscapes

  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Lenses (AREA)
CN201310331511.7A 2012-08-02 2013-08-01 阵列光学器件 Active CN103576314B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12178956 2012-08-02
EP12178956.4 2012-08-02

Publications (2)

Publication Number Publication Date
CN103576314A CN103576314A (zh) 2014-02-12
CN103576314B true CN103576314B (zh) 2018-01-12

Family

ID=46754302

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201310331511.7A Active CN103576314B (zh) 2012-08-02 2013-08-01 阵列光学器件

Country Status (4)

Country Link
US (1) US9506865B2 (https=)
EP (1) EP2693252B1 (https=)
JP (1) JP6189666B2 (https=)
CN (1) CN103576314B (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6449591B2 (ja) 2013-09-02 2019-01-09 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 生物学的液体の光測定装置
CN105092544A (zh) * 2014-05-12 2015-11-25 绍兴安尼特微电子科技有限公司 一种荧光定量pcr检测仪光学激发和检测系统
CN105092543A (zh) * 2014-05-12 2015-11-25 绍兴安尼特微电子科技有限公司 一种便携式荧光定量pcr检测仪
KR101830372B1 (ko) * 2015-09-01 2018-02-20 삼성전자주식회사 냉장고
EP3312593A1 (de) 2016-10-20 2018-04-25 Hain Lifescience GmbH Verfahren und vorrichtung zur optischen anregung einer mehrzahl von analyten in einem array von reaktionsgefässen und zur erfassung von fluoreszenzlicht aus dem analyten
ES2895071T3 (es) * 2018-05-30 2022-02-17 Depixus Dispositivo de formación de imágenes de primer plano multicanal
CN114846706A (zh) * 2020-01-20 2022-08-02 索尼半导体解决方案公司 发光装置及其制造方法
EP4575467A1 (en) * 2023-12-22 2025-06-25 F. Hoffmann-La Roche AG Techniques for illumination and detection in analytical analyzers
DE102024114418A1 (de) * 2024-05-23 2025-11-27 Bmg Labtech Gmbh Beleuchtungssystem, Mikroplatten-Lesegerät und Verfahren zur Erzeugung zumindest eines Bildes von biologischen oder chemischen Proben mit einem Mikroplatten-Lesegerät

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8901077A (nl) * 1989-04-28 1990-11-16 Koninkl Philips Electronics Nv Optische belichtingsstelsel en projectie-apparaat voorzien van een dergelijk stelsel.
US5499138A (en) 1992-05-26 1996-03-12 Olympus Optical Co., Ltd. Image display apparatus
DE19748211A1 (de) * 1997-10-31 1999-05-06 Zeiss Carl Fa Optisches Array-System und Reader für Mikrotiterplatten
DE19846928A1 (de) 1998-10-12 2000-04-13 Zeiss Carl Fa Abbildungssystem mit einem Zylinderlinsenarray
DE19919092A1 (de) * 1999-04-27 2000-11-02 Zeiss Carl Jena Gmbh Anordnung zur optischen Auswertung eines Gegenstandsarrays
EP1305656A4 (en) * 2000-07-31 2006-03-08 Rochester Photonics Corp STRUCTURED UMBRELLAS FOR REGULATED DIFFUSION OF LIGHT
US7068432B2 (en) * 2004-07-27 2006-06-27 Micron Technology, Inc. Controlling lens shape in a microlens array
US7692783B2 (en) * 2006-02-13 2010-04-06 Pacific Biosciences Of California Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
EP2075615B1 (en) * 2006-10-19 2016-07-20 Olympus Corporation Microscope
EP2065752A1 (en) * 2007-11-23 2009-06-03 Koninklijke Philips Electronics N.V. Optical illumination apparatus for illuminating a sample with a line beam
EP2148187A1 (de) * 2008-07-25 2010-01-27 Roche Diagnostics GmbH Anregungs- und Abbildungsoptik für die Fluoreszenzdetektion

Also Published As

Publication number Publication date
EP2693252B1 (en) 2016-05-18
US9506865B2 (en) 2016-11-29
CN103576314A (zh) 2014-02-12
JP2014032192A (ja) 2014-02-20
US20140038190A1 (en) 2014-02-06
JP6189666B2 (ja) 2017-08-30
EP2693252A1 (en) 2014-02-05

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