CN103554070A - Ascorbic acid bismuth oxide, preparation method and application of ascorbic acid bismuth oxide - Google Patents
Ascorbic acid bismuth oxide, preparation method and application of ascorbic acid bismuth oxide Download PDFInfo
- Publication number
- CN103554070A CN103554070A CN201310553725.9A CN201310553725A CN103554070A CN 103554070 A CN103554070 A CN 103554070A CN 201310553725 A CN201310553725 A CN 201310553725A CN 103554070 A CN103554070 A CN 103554070A
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- CN
- China
- Prior art keywords
- xitix
- oxygen bismuth
- preparation
- ascorbic acid
- bismuth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/62—Three oxygen atoms, e.g. ascorbic acid
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to a new substance of ascorbic acid bismuth oxide, a preparation method and the application of the ascorbic acid bismuth oxide. The preparation method is characterized by comprising the following steps: (1) weighing and inputting raw materials of bismuth hydroxide, ascorbic acid and water into a reaction kettle, wherein the bismuth hydroxide and the ascorbic acid are in the substance amount ratio of 1:1; (2) starting a machine for performing chemical reaction for half a hour; (3) stopping the machine for half a hour, and discharging the reaction product ascorbic acid bismuth oxide. The ascorbic acid bismuth oxide prepared by the preparation method can be applied to the field of medicine and food, for example, the ascorbic acid bismuth oxide can serve as a stomachic digestion Vc (vitamin C)-supplement antioxidant preservative, a stomachic digestion VC-supplement food additive, and a medicament for treating stomach illness, stomach cancer, bronchitis, pneumonia, hepatitis, liver cancer and hypertension.
Description
Technical field
The present invention relates to biochemical industry medicine food field, relate in particular to a kind of new material xitix oxygen bismuth, preparation method and application thereof altogether.
Background technology
On the outer biochemical industry medicine food of Now Domestic market, bismuthyl carbonate is the medicine of controlling stomach trouble, its English name: Bismuth Oxycarbonate, has another name called bismuth subcarbonate, Bismuth Subcarbonate, molecular formula: (BiO)
2cO
31/2H
2o, molecular weight: 518.97.But bismuthyl carbonate can only be used for the treatment of common stomach trouble, can not treat cancer of the stomach, and can not play the prophylactic effect of disease.Therefore, need to develop a kind of new material and can not only be applied to treat stomach trouble, and can also treat cancer of the stomach.
At present, although xitix has the effects such as preventing cancer, heart trouble, apoplexy, protection gum and gum, because its acidity is stronger, and be not suitable for the treatment of stomach trouble.
Summary of the invention
The object of the invention is for the deficiencies in the prior art, a kind of preparation method of xitix oxygen bismuth is provided, and the xitix oxygen bismuth preparing can be used as stomach strengthening and digestion promoting and mends Vc antioxidant fresh-keeping agent, stomach strengthening and digestion promoting benefit Vc foodstuff additive, controls stomach trouble, cancer of the stomach, bronchitis, pneumonia, hepatitis, liver cancer, hypertension agents.
In order to solve the problems of the technologies described above, the object of the invention is to be achieved through the following technical solutions:
The preparation method of xitix oxygen bismuth, is characterized in that, comprises the following steps:
(1) take feed hydrogen bismuth oxide, xitix and water and drop into reactor, wherein the ratio of the amount of substance of bismuth hydroxide and xitix is 1:1;
(2) start chemical reaction half an hour;
(3) shut down half an hour, emit reaction product xitix oxygen bismuth.Further, the chemical reaction of described (2) step is to carry out at normal temperatures.
Further, being undertaken by following reaction formula of the chemical reaction of described (2) step:
Bi(OH)
3+C
6H
8O
6=BiO(C
6H
7O
6)·2H
2O。
Further again, described (3) step also comprises that reaction is finished to material in rear reactor filters and carrying out washing treatment, obtains xitix oxygen bismuth crystal.
Further, the preparation method of described xitix oxygen bismuth, is characterized in that, also comprises (4) step: packaging final prod after drying and dewatering, chemical equation is as follows: BiO (C
6h
7o
6) 2H
2o=BiO (C
6h
7o
6)+2H
2o.
Another object of the present invention is to provide a kind of new material xitix oxygen bismuth, it is characterized in that, according to above-mentioned arbitrary described preparation method, obtains.
Another object of the present invention is the application of described xitix oxygen bismuth.
Further, xitix oxygen bismuth is in the application in medicine food field.
Further again, the application of xitix oxygen bismuth aspect treatment cancer.
Further, the application of xitix oxygen bismuth aspect treatment cancer of the stomach.
Compared with prior art, the preparation method of xitix oxygen bismuth of the present invention has following beneficial effect:
The xitix oxygen bismuth that the present invention prepares, English name is: Bismuth Oxyascorbate, has another name called Vc oxygen bismuth, inferior xitix bismuth, alkali formula xitix bismuth, molecular formula: BiO (C
6h
7o
6), molecular weight: 400.13, containing oxygen bismuth 56.23%, containing xitix 43.77%, purity is in more than 99% (medicine food level), and white or micro-yellow crystal powder, is slightly soluble in water.Because xitix (is called for short Vc; have another name called vitamins C) Main Function be to improve immunizing power; preventing cancer, heart trouble, apoplexy, protection gum and gum etc.; the reductibility that Vc has can be eliminated and causes the nitroso-group of canceration and cause old and feeble free radical; therefore there is the effect of anti-aging, anticancer, antioxygen, Vitamin C disease, antifatigue, anti-inflammatory, sterilization; it is the antioxidant fresh-keeping agent in good food, food, taste product, drink; Vc is the main antioxidant of organism, and its effect realizes by antioxygenation.The xitix oxygen bismuth that the present invention is prepared by xitix, owing to having accessed Vitamin C acid group, the advantage that possesses xitix, can be used as stomach strengthening and digestion promoting and mend Vc antioxidant fresh-keeping agent, stomach strengthening and digestion promoting benefit Vc foodstuff additive, and the elimination effect to nitrite by Vitamin C acid group, there is treatment stomach trouble, cancer of the stomach, bronchitis, pneumonia, hepatitis, liver cancer, hypertensive effect.
Accompanying drawing explanation
Fig. 1 is preparation method's schema of xitix oxygen bismuth of the present invention.
Embodiment
Below in conjunction with accompanying drawing, the preferred embodiments of the present invention are described, should be appreciated that preferred embodiment described herein, only for description and interpretation the present invention, is not intended to limit the present invention.
Embodiment 1
The preparation method of the present embodiment xitix oxygen bismuth, comprises the following steps:
(1) take bismuth hydroxide 260g, xitix 176.13g and water, raw material is dropped in reactor together;
(2) start chemical reaction half an hour, chemical equation is:
Bi (OH)
3+ C
6h
8o
6=BiO (C
6h
7o
6) 2H
2o, reaction conditions is normal temperature;
(3) shut down half an hour, emit xitix oxygen bismuth, filter and carrying out washing treatment, obtain xitix oxygen bismuth crystal.
(4) drying and dewatering, its chemical equation is: BiO (C
6h
7o
6) 2H
2o=BiO (C
6h
7o
6)+2H
2o, obtains xitix oxygen bismuth 400.13g, then packaging final prod.
Embodiment 2
The preparation method of the present embodiment xitix oxygen bismuth, comprises the following steps:
(1) take bismuth hydroxide 520g, xitix 352.26g and water, raw material is dropped in reactor together;
(2) start chemical reaction half an hour, chemical equation is:
Bi (OH)
3+ C
6h
8o
6=BiO (C
6h
7o
6) 2H
2o; , reaction conditions is normal temperature;
(3) shut down half an hour, emit xitix oxygen bismuth, filter and carrying out washing treatment, obtain xitix oxygen bismuth crystal.
(4) drying and dewatering, its chemical equation is: BiO (C
6h
7o
6) 2H
2o=BiO (C
6h
7o
6)+2H
2o, obtains xitix oxygen bismuth 800.26g, then packaging final prod.
Finally it should be noted that: these are only the preferred embodiments of the present invention; be not limited to the present invention; for a person skilled in the art; all any modifications of doing within the spirit and principles in the present invention, be equal to replacement, improvement etc., within protection scope of the present invention all should be included in.
Claims (10)
1. the preparation method of xitix oxygen bismuth, is characterized in that, comprises the following steps:
(1) take feed hydrogen bismuth oxide, xitix and water and drop into reactor, wherein the ratio of the amount of substance of bismuth hydroxide and xitix is 1:1;
(2) start chemical reaction half an hour;
(3) shut down half an hour, emit reaction product xitix oxygen bismuth.
2. the preparation method of xitix oxygen bismuth according to claim 1, is characterized in that, the chemical reaction of described (2) step is to carry out at normal temperatures.
3. the preparation method of xitix oxygen bismuth according to claim 1, is characterized in that, being undertaken by following reaction formula of the chemical reaction of described (2) step: Bi (OH)
3+ C
6h
8o
6=BiO (C
6h
7o
6) 2H
2o.
4. the preparation method of xitix oxygen bismuth according to claim 1, is characterized in that, described (3) step also comprises that reaction is finished to material in rear reactor filters and carrying out washing treatment, obtains xitix oxygen bismuth crystal.
5. the preparation method of xitix oxygen bismuth according to claim 4, is characterized in that, also comprises (4) step: packaging final prod after drying and dewatering, chemical equation is as follows: BiO (C
6h
7o
6) 2H
2o=BiO (C
6h
7o
6)+2H
2o.
6. xitix oxygen bismuth, is characterized in that, according to claim 1～5, arbitrary described preparation method obtains.
7. the application of xitix oxygen bismuth claimed in claim 6.
8. the application of xitix oxygen bismuth according to claim 7, is characterized in that, xitix oxygen bismuth is in the application in medicine food field.
9. the application of xitix oxygen bismuth according to claim 8, is characterized in that, the application of xitix oxygen bismuth aspect treatment cancer.
10. the application of xitix oxygen bismuth according to claim 9, is characterized in that, the application of xitix oxygen bismuth aspect treatment cancer of the stomach.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310553725.9A CN103554070A (en) | 2013-11-08 | 2013-11-08 | Ascorbic acid bismuth oxide, preparation method and application of ascorbic acid bismuth oxide |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310553725.9A CN103554070A (en) | 2013-11-08 | 2013-11-08 | Ascorbic acid bismuth oxide, preparation method and application of ascorbic acid bismuth oxide |
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| Publication Number | Publication Date |
|---|---|
| CN103554070A true CN103554070A (en) | 2014-02-05 |
Family
ID=50008473
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310553725.9A Pending CN103554070A (en) | 2013-11-08 | 2013-11-08 | Ascorbic acid bismuth oxide, preparation method and application of ascorbic acid bismuth oxide |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106632172A (en) * | 2016-12-28 | 2017-05-10 | 李玉成 | Bismuth potassium ascorbic acid citrate, as well as preparation method and application thereof |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3671549A (en) * | 1970-03-05 | 1972-06-20 | Merck & Co Inc | Process for preparing ascorbyl-3-phosphate and salts thereof |
| US4647672A (en) * | 1985-06-25 | 1987-03-03 | Kansas State University Research Foundation | Ascorbate 2-polyphosphate esters and method of making same |
| RO91766A2 (en) * | 1985-05-24 | 1987-05-15 | Institutul De Medicina Si Farmacie,Ro | METHOD OF TREATMENT OF ENTERBODY |
| WO1998030555A1 (en) * | 1997-01-14 | 1998-07-16 | Sakalosky George P | Treatment for cancer and compounds for use therewith |
| CN1208041A (en) * | 1995-11-28 | 1999-02-17 | 北京市潮白河新技术研究所 | Ascorbic acid derivative |
| US6127409A (en) * | 1997-04-30 | 2000-10-03 | Showa Denko Kabushiki Kaisha | Ascorbic acid derivative and vitamin C preparation containing the same |
| WO2002100395A1 (en) * | 2001-06-08 | 2002-12-19 | Genzyme Corporation | Bismuth salts of anti-oxidants and radical scavengers for prevention and treatment of mucous membrane ulcers |
| CN1658864A (en) * | 2002-04-12 | 2005-08-24 | 昭和电工株式会社 | Stabilized ascorbic acid derivatives |
| JP2007099670A (en) * | 2005-10-04 | 2007-04-19 | Madre X:Kk | External preparation for skin |
| CN103313720A (en) * | 2010-11-08 | 2013-09-18 | 辛索尼克斯公司 | Bismuth-containing compounds for modulating properties of biologically active agents |
-
2013
- 2013-11-08 CN CN201310553725.9A patent/CN103554070A/en active Pending
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3671549A (en) * | 1970-03-05 | 1972-06-20 | Merck & Co Inc | Process for preparing ascorbyl-3-phosphate and salts thereof |
| RO91766A2 (en) * | 1985-05-24 | 1987-05-15 | Institutul De Medicina Si Farmacie,Ro | METHOD OF TREATMENT OF ENTERBODY |
| US4647672A (en) * | 1985-06-25 | 1987-03-03 | Kansas State University Research Foundation | Ascorbate 2-polyphosphate esters and method of making same |
| CN1208041A (en) * | 1995-11-28 | 1999-02-17 | 北京市潮白河新技术研究所 | Ascorbic acid derivative |
| WO1998030555A1 (en) * | 1997-01-14 | 1998-07-16 | Sakalosky George P | Treatment for cancer and compounds for use therewith |
| US6127409A (en) * | 1997-04-30 | 2000-10-03 | Showa Denko Kabushiki Kaisha | Ascorbic acid derivative and vitamin C preparation containing the same |
| WO2002100395A1 (en) * | 2001-06-08 | 2002-12-19 | Genzyme Corporation | Bismuth salts of anti-oxidants and radical scavengers for prevention and treatment of mucous membrane ulcers |
| CN1658864A (en) * | 2002-04-12 | 2005-08-24 | 昭和电工株式会社 | Stabilized ascorbic acid derivatives |
| JP2007099670A (en) * | 2005-10-04 | 2007-04-19 | Madre X:Kk | External preparation for skin |
| CN103313720A (en) * | 2010-11-08 | 2013-09-18 | 辛索尼克斯公司 | Bismuth-containing compounds for modulating properties of biologically active agents |
Non-Patent Citations (4)
| Title |
|---|
| 张岭漪 等: "维生素C与胃癌", 《甘肃科技》, vol. 1, no. 6, 30 December 1999 (1999-12-30), pages 33 - 34 * |
| 李媛 等: "维生素Ｃ治疗肿瘤的研究进展", 《医药导报》, vol. 25, no. 4, 1 April 2006 (2006-04-01), pages 323 - 324 * |
| 王晓怀 等: "维生素C与胃癌及其它恶性肿瘤", 《国外医学(肿瘤学分册)》, no. 1, 30 June 1983 (1983-06-30), pages 173 - 176 * |
| 胡荣华 等: "维生素C预防胃癌研究", 《肿瘤》, vol. 5, no. 6, 27 December 1985 (1985-12-27), pages 261 - 263 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106632172A (en) * | 2016-12-28 | 2017-05-10 | 李玉成 | Bismuth potassium ascorbic acid citrate, as well as preparation method and application thereof |
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Application publication date: 20140205 |
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