CN103550409B - Pharmaceutical composition of a kind of fat-reducing and preparation method thereof - Google Patents
Pharmaceutical composition of a kind of fat-reducing and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to pharmaceutical composition of a kind of fat-reducing and preparation method thereof, comprise Flos Rosae Rugosae 40-100 part, Radix Persicae 40-100 part, Flos Camelliae Japonicae 40-100 part, white turnip 30-50 part, Margarita powder 60-110 part, Oleum Camelliae 70-110 part, olive oil 80-150 part, Mel 30-50 part, salt 60-110 part, white vinegar 30-50 part, fry through fire, pulverize, alcohol extraction process is made, there is the fat that disappears deoil, promoting blood circulation to remove obstruction in the collateral, refrigerant antiinflammatory, effect of whitening and softening skin, its total obvious effective rate 96.7% of losing weight, healing person is after end treatment, keep normal dietary habit, without rebound phenomena, a kind of safety, instant effect, curative effect is short, the pure traditional Chinese medicine capable of reducing weight medicine not easily recurred.
Description
Technical field
The present invention relates to field of medicine invention, be specifically related to pharmaceutical composition of a kind of fat-reducing and preparation method thereof.
Background technology
Obesity (adiposity) is one group of common, ancient metabolism disease group.When human body feed heat is more than consumption of calorie, waste heat is with storage as fat in body, and its amount exceedes normal physiological requirement, and then develops into obesity when reaching certain value.Because the increase of body fat makes be above standard body weight 20% or Body Mass Index [BMI=body weight (k)/height (m) 2] of body weight be greater than 24 and be called obesity.As can be the person of seeking claimed simple obesity without the obvious cause of disease; There is clear and definite cause of disease person and be called secondary obesity.
It is attractive in appearance that obesity not only affects human body, the more important thing is and affect health, as obesity can cause [2] such as hypertension (overweight people's sickness rate is 25 ~ 55%), diabetes (overweight people's sickness rate is 14 ~ 20%), coronary heart disease (overweight people's sickness rate is 10 ~ 15%), hyperlipemia (overweight people's sickness rate is 35 ~ 53%), sleep apnea (overweight people's sickness rate is 10 ~ 20%), depressions (in overweight people, sickness rate is 70 ~ 90%), other also comprises tumor, infertility, calculus etc. and life-span and the direct unforgettable relevant disease of a few inferior quality of living.Acute disease is when particularly obesity reaches morbid obesity (BMI is more than 40), and its mortality rate can sharply increase.Fat and relevant disease is more and more registered attention, along with science and technology impact is progressive, is fatly subject to not diagnosis and treatment to have large development.
The medicine for the treatment of of obesity conventional at present mainly contains two classes: a kind of is the appetite suppressant acting on maincenter: this type of medicine is also known as anorexic medicine, it is the activity by the mediator that affects the nerves, reduce five hydroxytryptamine and norepinephrine reuptake, thus minimizing food intake dose, appetite-suppressing and raising basal metabolic rate carry out loss of weight, as sibutramine.Also having a kind of is the lipase inhibitor acting on periphery: reach fat-reducing object by the absorption blocking partial fat in diet, as orlistat, suppresses gastric lipase and pancreas at GI tract, thus reduces the absorption about 30% of fat.The patient B MI of Drug therapy is needed to be greater than 30kg/m
2and without complication, or be greater than 28kg/m
2have other complication, but this type of drug side effect is obvious, and easily rebounds.Take surgical operation therapy to reach the object of fat-reducing in addition in addition, but surgery cost is high and there is certain operation risk.
Therefore, provide one safely and effectively appetrol become urgent problem.
Inventor, in order to overcome the above problems, outside research and development externally-applied liniment, have developed a series of endo-medicine.
Summary of the invention
The object of this invention is to provide a kind of pharmaceutical composition for slimming.
Another object of the present invention is to the preparation method that a kind of pharmaceutical composition for slimming is provided.
The invention provides a kind of pharmaceutical composition of fat-reducing, comprise the medicine of following weight portion:
Flos Rosae Rugosae 40-100 part, Radix Persicae 40-100 part, Flos Camelliae Japonicae 40-100 part, white turnip 30-50 part, Margarita powder 60-110 part, Oleum Camelliae 70-110 part, olive oil 80-150 part, Mel 30-50 part, salt 60-110 part, white vinegar 30-50 part.
The invention provides a kind of pharmaceutical composition of fat-reducing, preferably include the medicine of following weight portion: Flos Rosae Rugosae 50-90 part, Radix Persicae 50-90 part, Flos Camelliae Japonicae 50-90 part, white turnip 35-45 part, Margarita powder 70-100 part, Oleum Camelliae 80-100 part, olive oil 90-140 part, Mel 35-45 part, salt 70-100 part, white vinegar 35-45 part.
Aforesaid pharmaceutical composition is solid preparation or liquid preparation.
Aforesaid pharmaceutical composition solid preparation is tablet, capsule, granule or pill.
Aforesaid pharmaceutical composition liquid preparation is oral liquid or injection.
Aforesaid pharmaceutical composition is made up of following steps:
1) each medicine is taken by formula;
2) clean, drain;
3) fritter white turnip being cut into 4-6cm long adds the fiery fried dry of white vinegar, smashs to pieces, for subsequent use;
4) Radix Persicae is added the ethanol extraction three times of 2-5 times amount 50-75%, each 1-3 hour, merge extractive liquid, extracting solution is condensed into thick paste, is ground into fine powder, for subsequent use;
5) after step 4) being extracted, Radix Persicae is cut into the long segment of 4-7cm, immerses in salt and takes out after 11-20 days, dry, smash to pieces, mix with the fine powder of step 4), for subsequent use;
6) by Flos Rosae Rugosae, Flos Camelliae Japonicae powder is broken into fine powder and immerses 6-9 days in Mel, for subsequent use;
7) by Margarita powder and step 3), 5), 6) standby mix, for subsequent use;
8) by Oleum Camelliae and mixed with olive oil, miscella is obtained, for subsequent use;
9) standby in step 7) is added in the miscella in step 8) and soak 35-50 days, stir evenly;
10) add adjuvant, technique makes required dosage form routinely.
Aforesaid pharmaceutical composition is preferably made up of following steps:
1) each medicine is taken by formula;
2) clean, drain;
3) fritter white turnip being cut into 5cm long adds the fiery fried dry of white vinegar, smashs to pieces, for subsequent use;
4) Radix Persicae is added the ethanol extraction three times of 3 times amount 65%, each 2 hours, merge extractive liquid, extracting solution is condensed into thick paste, is ground into fine powder, for subsequent use;
5) after step 4) being extracted, Radix Persicae is cut into the long segment of 5cm, immerses in salt and takes out after 15 days, dry, smash to pieces, mix with the fine powder of step 4), for subsequent use;
6) by Flos Rosae Rugosae, Flos Camelliae Japonicae powder is broken into fine powder and immerses in Mel 8 days, for subsequent use;
7) by Margarita powder and step 3), 5), 6) standby mix, for subsequent use;
8) by Oleum Camelliae and mixed with olive oil, miscella is obtained, for subsequent use;
9) standby in step 7) is added in the miscella in step 8) and soak 40 days, stir evenly;
10) add adjuvant, technique makes required dosage form routinely.
Aforesaid medicinal composition soft capsule is made up of following steps:
1) each medicine is taken by formula;
2) clean, drain;
3) fritter white turnip being cut into 5cm long adds the fiery fried dry of white vinegar, smashs to pieces, for subsequent use;
4) Radix Persicae is added the ethanol extraction three times of 3 times amount 65%, each 2 hours, merge extractive liquid, extracting solution is condensed into thick paste, is ground into fine powder, for subsequent use;
5) after step 4) being extracted, Radix Persicae is cut into the long segment of 5cm, immerses in salt and takes out after 15 days, dry, smash to pieces, mix with the fine powder of step 4), for subsequent use;
6) by Flos Rosae Rugosae, Flos Camelliae Japonicae powder is broken into fine powder and immerses in Mel 8 days, for subsequent use;
7) by Margarita powder and step 3), 5), 6) standby mix, for subsequent use;
8) by Oleum Camelliae and mixed with olive oil, miscella is obtained, for subsequent use;
9) standby in step 7) is added in the miscella in step 8) and soak 40 days, stir evenly;
10) make softgel shell glue with gelatin, adopt die pressing to make soft capsule.
Aforesaid medicament composition dropping pills agent is made up of following steps:
1) each medicine is taken by formula;
2) clean, drain;
3) fritter white turnip being cut into 5cm long adds the fiery fried dry of white vinegar, smashs to pieces, for subsequent use;
4) Radix Persicae is added the ethanol extraction three times of 3 times amount 65%, each 2 hours, merge extractive liquid, extracting solution is condensed into thick paste, is ground into fine powder, for subsequent use;
5) after step 4) being extracted, Radix Persicae is cut into the long segment of 5cm, immerses in salt and takes out after 15 days, dry, smash to pieces, mix with the fine powder of step 4), for subsequent use;
6) by Flos Rosae Rugosae, Flos Camelliae Japonicae powder is broken into fine powder and immerses in Mel 8 days, for subsequent use;
7) by Margarita powder and step 3), 5), 6) standby mix, for subsequent use;
8) by Oleum Camelliae and mixed with olive oil, miscella is obtained, for subsequent use;
9) standby in step 7) is added in the miscella in step 8) and soak 40 days, stir evenly;
10) add 20-100ml water, stir and carry out emulsifying in 30 minutes, add in rubber cement by emulsion under constantly stirring, stir and carry out emulsifying in 3 hours, by dosing pump pill dripping machine dripping, 13-15 DEG C of liquid Paraffin makes condensed fluid, constant pressure and dry, obtained drop pill.
Aforesaid medicinal composition tablets, capsule, granule are made up of following steps:
1) each medicine is taken by formula;
2) clean, drain;
3) fritter white turnip being cut into 5cm long adds the fiery fried dry of white vinegar, smashs to pieces, for subsequent use;
4) Radix Persicae is added the ethanol extraction three times of 3 times amount 65%, each 2 hours, merge extractive liquid, extracting solution is condensed into thick paste, is ground into fine powder, for subsequent use;
5) after step 4) being extracted, Radix Persicae is cut into the long segment of 5cm, immerses in salt and takes out after 15 days, dry, smash to pieces, mix with the fine powder of step 4), for subsequent use;
6) by Flos Rosae Rugosae, Flos Camelliae Japonicae powder is broken into fine powder and immerses in Mel 8 days, for subsequent use;
7) by Margarita powder and step 3), 5), 6) standby mix, for subsequent use;
8) by Oleum Camelliae and mixed with olive oil, miscella is obtained, for subsequent use;
9) standby in step 7) is added in the miscella in step 8) and soak 40 days, stir evenly;
10) add starch, conveniently technique makes tablet, capsule, granule.
Described adjuvant is selected from one or more in filler, binding agent, disintegrating agent, lubricant, surfactant or correctives, wherein:
Described filler is selected from starch, sucrose, lactose, mannitol, sorbitol, xylitol, microcrystalline Cellulose or glucose etc.
Described binding agent is selected from cellulose derivative, alginate, gelatin or polyvinylpyrrolidone etc.
Described disintegrating agent is selected from microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose or cross-linking sodium carboxymethyl cellulose.
Described lubricant is selected from stearic acid, Polyethylene Glycol, calcium carbonate, sodium bicarbonate, micropowder silica gel, Pulvis Talci or magnesium stearate.
Described surfactant is selected from the smooth or Polysorbate (tween) of dodecylbenzene sodium sulfonate, stearic acid, Pluronic F68, fatty acid Pyrusussuriensis.
Described correctives is selected from aspartame, Sucralose or saccharin sodium.
Described diluent is selected from water, edible oil.
Slimming medicine provided by the invention has the following advantages:
1, compared with prior art:
Employing Western medicine of the prior art or operative treatment are to reach the object of fat-reducing, but Western medicine side effect is large, and easily rebound; There is certain risk in operative treatment, costly.
2, the medicine of fat-reducing provided by the invention has the fat that disappears and deoils, promoting blood circulation to remove obstruction in the collateral, refrigerant antiinflammatory, effect of whitening and softening skin, its total obvious effective rate 96.7% of losing weight, and healing person is after end treatment, keeps normal dietary habit, without rebound phenomena, it is the short Chinese medicine composition of a kind of safety, instant effect, curative effect.
3, the present invention is the endo-medicine of inventor's research and development further on the basis of the appetrol liniment of research and development, short treating period.
Detailed description of the invention
Following examples for illustration of the present invention, but are not used for limiting the scope of the invention.
Embodiment 1:
Composition: Flos Rosae Rugosae 10g, Radix Persicae 10g, Flos Camelliae Japonicae 10g, white turnip 10g, Margarita powder 20g, Oleum Camelliae 30g, olive oil 60g, Mel 10g, salt 20g, white vinegar 10g.
Preparation method:
1) each medicine is taken by formula;
2) clean, drain;
3) fritter white turnip being cut into 5cm long adds the fiery fried dry of white vinegar, smashs to pieces, for subsequent use;
4) Radix Persicae is added the ethanol extraction three times of 3 times amount 65%, each 2 hours, merge extractive liquid, extracting solution is condensed into thick paste, is ground into fine powder, for subsequent use;
5) after step 4) being extracted, Radix Persicae is cut into the long segment of 5cm, immerses in salt and takes out after 15 days, dry, smash to pieces, mix with the fine powder of step 4), for subsequent use;
6) by Flos Rosae Rugosae, Flos Camelliae Japonicae powder is broken into fine powder and immerses in Mel 8 days, for subsequent use;
7) by Margarita powder and step 3), 5), 6) standby mix, for subsequent use;
8) by Oleum Camelliae and mixed with olive oil, miscella is obtained, for subsequent use;
9) standby in step 7) is added in the miscella in step 8) and soak 40 days, stir evenly;
10) make softgel shell glue with gelatin, adopt die pressing to make soft capsule.
Embodiment 2
Composition: Flos Rosae Rugosae 40g, Radix Persicae 40g, Flos Camelliae Japonicae 40g, white turnip 30g, Margarita powder 60g, Oleum Camelliae 70g, olive oil 80g, Mel 30g, salt 60g, white vinegar 30g.
Preparation method:
1) each medicine is taken by formula;
2) clean, drain;
3) fritter white turnip being cut into 5cm long adds the fiery fried dry of white vinegar, smashs to pieces, for subsequent use;
4) Radix Persicae is added the ethanol extraction three times of 3 times amount 65%, each 2 hours, merge extractive liquid, extracting solution is condensed into thick paste, is ground into fine powder, for subsequent use;
5) after step 4) being extracted, Radix Persicae is cut into the long segment of 5cm, immerses in salt and takes out after 15 days, dry, smash to pieces, mix with the fine powder of step 4), for subsequent use;
6) by Flos Rosae Rugosae, Flos Camelliae Japonicae powder is broken into fine powder and immerses in Mel 8 days, for subsequent use;
7) by Margarita powder and step 3), 5), 6) standby mix, for subsequent use;
8) by Oleum Camelliae and mixed with olive oil, miscella is obtained, for subsequent use;
9) standby in step 7) is added in the miscella in step 8) and soak 40 days, stir evenly;
10) add 20-100ml water, stir and carry out emulsifying in 30 minutes, add in rubber cement by emulsion under constantly stirring, stir and carry out emulsifying in 3 hours, by dosing pump pill dripping machine dripping, 13-15 DEG C of liquid Paraffin makes condensed fluid, constant pressure and dry, obtained drop pill.
Embodiment 3:
Composition: Flos Rosae Rugosae 100g, Radix Persicae 100g, Flos Camelliae Japonicae 100g, white turnip 50g, Margarita powder 110g, Oleum Camelliae 110g, olive oil 150g, Mel 50g, salt 110g, white vinegar 50g.
Preparation method:
1) each medicine is taken by formula;
2) clean, drain;
3) fritter white turnip being cut into 5cm long adds the fiery fried dry of white vinegar, smashs to pieces, for subsequent use;
4) Radix Persicae is added the ethanol extraction three times of 3 times amount 65%, each 2 hours, merge extractive liquid, extracting solution is condensed into thick paste, is ground into fine powder, for subsequent use;
5) after step 4) being extracted, Radix Persicae is cut into the long segment of 5cm, immerses in salt and takes out after 15 days, dry, smash to pieces, mix with the fine powder of step 4), for subsequent use;
6) by Flos Rosae Rugosae, Flos Camelliae Japonicae powder is broken into fine powder and immerses in Mel 8 days, for subsequent use;
7) by Margarita powder and step 3), 5), 6) standby mix, for subsequent use;
8) by Oleum Camelliae and mixed with olive oil, miscella is obtained, for subsequent use;
9) standby in step 7) is added in the miscella in step 8) and soak 40 days, stir evenly;
10) add starch, conveniently technique makes tablet.
Embodiment 4
Composition: Flos Rosae Rugosae 50g, Radix Persicae 50g, Flos Camelliae Japonicae 50g, white turnip 35g, Margarita powder 70g part, Oleum Camelliae 80g, olive oil 90g part, Mel 35g, salt 70g, white vinegar 35g.
Preparation method:
1) each medicine is taken by formula;
2) clean, drain;
3) fritter white turnip being cut into 5cm long adds the fiery fried dry of white vinegar, smashs to pieces, for subsequent use;
4) Radix Persicae is added the ethanol extraction three times of 3 times amount 65%, each 2 hours, merge extractive liquid, extracting solution is condensed into thick paste, is ground into fine powder, for subsequent use;
5) after step 4) being extracted, Radix Persicae is cut into the long segment of 5cm, immerses in salt and takes out after 15 days, dry, smash to pieces, mix with the fine powder of step 4), for subsequent use;
6) by Flos Rosae Rugosae, Flos Camelliae Japonicae powder is broken into fine powder and immerses in Mel 8 days, for subsequent use;
7) by Margarita powder and step 3), 5), 6) standby mix, for subsequent use;
8) by Oleum Camelliae and mixed with olive oil, miscella is obtained, for subsequent use;
9) standby in step 7) is added in the miscella in step 8) and soak 40 days, stir evenly;
10) add starch, conveniently technique makes granule.
Embodiment 5
Composition: Flos Rosae Rugosae 90g, Radix Persicae 90g, Flos Camelliae Japonicae 90g, white turnip 45g, Margarita powder 100g, Oleum Camelliae 100g, olive oil 140g, Mel 45g, salt 100g, white vinegar 45g.
Preparation method:
1) each medicine is taken by formula;
2) clean, drain;
3) fritter white turnip being cut into 5cm long adds the fiery fried dry of white vinegar, smashs to pieces, for subsequent use;
4) Radix Persicae is added the ethanol extraction three times of 3 times amount 65%, each 2 hours, merge extractive liquid, extracting solution is condensed into thick paste, is ground into fine powder, for subsequent use;
5) after step 4) being extracted, Radix Persicae is cut into the long segment of 5cm, immerses in salt and takes out after 15 days, dry, smash to pieces, mix with the fine powder of step 4), for subsequent use;
6) by Flos Rosae Rugosae, Flos Camelliae Japonicae powder is broken into fine powder and immerses in Mel 8 days, for subsequent use;
7) by Margarita powder and step 3), 5), 6) standby mix, for subsequent use;
8) by Oleum Camelliae and mixed with olive oil, miscella is obtained, for subsequent use;
9) standby in step 7) is added in the miscella in step 8) and soak 40 days, stir evenly;
10) add starch, conveniently technique makes capsule.
Experimental example 1
The medicine of Medications Example 1 of the present invention, effect of weight reducing human feeding trial is observed.
1. materials and methods
1.1 samples: the product of embodiment 1 prepared by the present inventor.
1.2 study subjects: Simple Obesity, through health check-up, without dysfunctions such as the obvious heart, liver, gallbladder, kidneys.
1.3.1. experimenter's choice criteria: the diagnosis index with reference to the Simple Obesity that Chinese Association of the Integration of Traditional Chinese Medicine and Western Medicine obesity research academic conference is formulated: be above standard body weight.
1.3.2. standard body weight: adult's standard body weight (kg)=[height (cm)-100] × 0.9
1.4. test-meal method
30 routine Simple Obesity experimenters, daily this product 2 times, each 2, continuous 28 days.Not dietary restriction when taking.
1.5. instrument and reagent: RG2-120 type scale, Wuxi City weighing apparatus factory produces.Sebum thickness measurer is Scientific Inst., State Physical Culture and Sports Commission's development.Bioelectrical impedance analysis instrument, U.S.'s biodynamics Company.F-820 type blood counting instrument, urinate ten analysers (German Bao Ling Man produces) AMS semi-automatic biochemical analyzer (Italy produces), biochemical reagents box is all provided by Zhong Sheng company.
2. observation index:
Observe 4 weeks, indices in test-meal experiment start and at the end of each test once, test-meal the 15th day, adds and surveys body weight and inquiry symptom once.
2.1. body weight and height: emptying defecation before measuring, treatment forebody-afterbody of taking off one's shoes timing of resurveying all is worn same clothes and is measured in same doctor's type scale.
2.2. bioelectrical impedance analysis: measure human body body fat rate, body fat weight, body fluid rate, body fluid weight.
2.3. measurements of the chest, waist and hips measure:
2.3.1. chest measurement: with the thorax perimeters of two breast root levels
2.3.2. waistline: the abdomen girth of flat umbilicus.
2.3.3. hip circumference: with the girth of both sides greater trochanter of femur level.
2.4. stratum corneum lipids measures: measurement site:
2.4.1. right triceps brachii belly of muscle mid point.
2.4.2. right angulus inferior scapulae.
2.4.3. the other 2cm of right umbilicus.
2.4.4. right anterior superior iliac spine.
2.5. blood fat (T-CHOL TC, triglyceride TG, HDL-C HDL-C) detects.
2.6. safety observations:
2.6.1. Blood routine examination
Red blood cell count(RBC), hemoglobin, numeration of leukocyte.
2.6.2. Biochemical Indexes:
The white egg ALB of serum, total protein TB, darling renal function (glutamic oxaloacetic transaminase, GOT AST, glutamate pyruvate transaminase ALT, blood urea nitrogen BUN, inosine Cre), uric acid (UA).
2.6.3. Abdominal B type ultrasonography, electrocardiogram, x-ray fluoroscopy of chest.
3. effect criterion: formulate with reference to " the new guideline of clinical investigations of Chinese medicine ".
3.1. the body weight of obesity, body fat rate efficacy criteria, with reference to the academic conference of national combination of Chinese and Western medicine obesity, is revised in conjunction with this research department's research practice result.
3.1.1. effective: weight loss >=3.5kg or body fat decline 2kg.
3.1.2. effective: weight loss >=2kg or body fat decline 1kg.
3.1.3. invalid: weight loss < 2kg.
4. result:
4.1. physical data:
Observe female subjects 30 example altogether, minimum 18 years old of age, the oldest 65 years old, average 38.6 ± 13.19 years old.Wherein workman 8 example, cadre 21 example, individual 1 example.The fat course of disease is the longest 34 years, the shortest 1 year, average 8.87 ± 8.14 years.
4.2. result statistics:
4.2.1. weight loss situation:
Weight loss situation is added up
| Index | Before test-meal | In test-meal | Difference | After test-meal | Difference |
| Body weight (kg) | 70.83±10.13 | 69.67±10.11 | 1.20±0.69*** | 68.65±10.27 | 2.22±0.87*** |
***P＜0.001
4.2.2. the every Testing index change in tested front and back
4.2.2.1. bioelectrical impedance analysis before and after test-meal:
| Project | Before test-meal | After test-meal | Difference |
| Body fat (%) | 37.77±4.35 | 34.22±4.02 | 3.55±2.73*** |
| Body fluid (%) | 43.86±2.34 | 46.52±2.13 | -2.66±2.06*** |
| Body fat weight (kg) | 26.84±5.86 | 23.72±5.21 | 3.11±2.24*** |
| Body fluid weight (kg) | 30.79±3.49 | 31.73±3.81 | -0.94±1.42** |
**P＜0.01 ***P＜0.001
4.2.2.2. measurements of the chest, waist and hips and sebum change before and after test-meal:
Measurements of the chest, waist and hips and stratum corneum lipids change statistics (n=30) before and after test-meal
***P＜0.001
4.2.3. effective percentage of losing weight is added up:
Fat-reducing effective percentage statistics
| Effective | Effectively | Invalid | Effective percentage | |
| Number of cases | 9 | 20 | 1 | 96.7% |
4.2.4 tested front and back Blood Lipid:
Tested front and back Blood Lipid statistics
| Project | Number of cases | Before tested | After tested | Difference |
| TC(mmol/L) | 30 | 4.83±1.07 | 4.22±0.84 | 0.61±1.0** |
| TG(mmol/L) | 30 | 1.23±0.58 | 1.10±0.63 | 0.13±0.59 |
| HDL-C(mmol/L) | 30 | 1.55±0.59 | 1.45±0.79 | 0.11±0.98 |
**P＜0.01
4.2.5. safety indices detects:
Safety indices detects
| Project | Number of cases | Before test-meal | After test-meal |
| TP(g/L) | 30 | 78.91±5.17 | 74.74±3.46 |
| ALB(g/L) | 30 | 51.36±2.60 | 52.30±2.87 |
| ALT(u/L) | 30 | 25.00±17.95 | 29.57±0.50 |
| AST(u/L) | 30 | 29.60±13.76 | 37.83±12.30 |
| GLU(mmol/L) | 30 | 4.35±0.66 | 4.47±0.84 |
| BUN(mmol/L) | 30 | 5.38±1.88 | 5.17±1.51 |
| CRE(mmol/L) | 30 | 70.35±9.09 | 80.93±12.19 |
| UA(umol/L) | 30 | 190.17±42.34 | 190.60±36.37 |
| HGB(g/L) | 30 | 143.07±10.85 | 141.70±10.25 |
| RBC(×10 12/L) | 30 | 4.89±0.44 | 5.37±0.46 |
| WBC(×10 9/L) | 30 | 6.57±1.91 | 6.13±1.48 |
Indices before and after test-meal all in normal range.
5. conclusion
5.1.30 routine experimenter, after observation requirement product of the present invention, its weight average reduces by 2.22 ± 0.87Kg, effective percentage reaches 96.7%, especially show as and reduce body fat weight and body fat rate, increase body fluid, body fat on average declines 3.11 ± 2.24Kg, body fluid weight average increases by 0.94 ± 1.42Kg, illustrates that this product fat-reducing effect is definite.
5.2. fat-reducing after, all can obviously reduce for measurements of the chest, waist and hips (chest measurement, waistline, hip circumference), especially for waistline and hip circumference more remarkable, be conducive to stature fitness.
Under upper arm, omoplate 5.3., stomach wall and ilium sour jujube stratum corneum lipids, all obviously reduce after fat-reducing, the other and ilium sour jujube sebum of umbilicus reduces the most remarkable, illustrates that this product can reduce subcutaneous fat, especially minimizing abdominal part and bung fat.
5.4. this product has the effect reducing serum total cholesterol.
5.5. blood glucose before and after this mouthful of test-meal, hemoglobin, total serum protein, albumin, all in normal range, and without significant difference, urine ketoboidies is negative, and maximal oxygen consumption, without significant change, illustrates that this product is harmless to body health.
5.6. the side effect such as allergy, edema is not observed.
Although above with general explanation, detailed description of the invention and test, the present invention is described in detail, and on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (9)
1. the pharmaceutical composition of a fat-reducing, it is characterized in that being made up of the medicine of following weight portion: Flos Rosae Rugosae 40-100 part, Radix Persicae 40-100 part, Flos Camelliae Japonicae 40-100 part, white turnip 30-50 part, Margarita powder 60-110 part, Oleum Camelliae 70-110 part, olive oil 80-150 part, Mel 30-50 part, salt 60-110 part, white vinegar 30-50 part.
2. pharmaceutical composition according to claim 1, it is characterized in that being made up of the medicine of following weight portion: Flos Rosae Rugosae 50-90 part, Radix Persicae 50-90 part, Flos Camelliae Japonicae 50-90 part, white turnip 35-45 part, Margarita powder 70-100 part, Oleum Camelliae 80-100 part, olive oil 90-140 part, Mel 35-45 part, salt 70-100 part, white vinegar 35-45 part.
3. pharmaceutical composition according to claim 1, is characterized in that, described pharmaceutical composition is solid preparation or liquid preparation.
4. pharmaceutical composition according to claim 3, is characterized in that, described solid preparation is tablet, capsule, granule or pill.
5. the pharmaceutical composition according to any one of claim 1-4, is characterized in that described pharmaceutical composition is made up of following steps:
1) each medicine is taken by formula;
2) clean, drain;
3) fritter white turnip being cut into 4-6cm long adds the fiery fried dry of white vinegar, smashs to pieces, for subsequent use;
4) Radix Persicae is added the ethanol extraction three times of 2-5 times amount 50-75%, each 1-3 hour, merge extractive liquid, extracting solution is condensed into thick paste, is ground into fine powder, for subsequent use;
5) by step 4) extract after Radix Persicae be cut into the long segment of 4-7cm and immerse in salt and take out after 11-20 days, dry, smash to pieces, with step 4) fine powder mix, for subsequent use;
6) by Flos Rosae Rugosae, Flos Camelliae Japonicae powder is broken into fine powder and immerses 6-9 days in Mel, for subsequent use;
7) by Margarita powder and step 3), 5), 6) standby mix, for subsequent use;
8) by Oleum Camelliae and mixed with olive oil, miscella is obtained, for subsequent use;
9) by step 7) in standby add step 8) in miscella in soak 35-50 days, stir evenly;
10) add adjuvant, technique makes required dosage form routinely.
6. pharmaceutical composition according to claim 5, is characterized in that described pharmaceutical composition is made up of following steps:
1) each medicine is taken by formula;
2) clean, drain;
3) fritter white turnip being cut into 5cm long adds the fiery fried dry of white vinegar, smashs to pieces, for subsequent use;
4) Radix Persicae is added the ethanol extraction three times of 3 times amount 65%, each 2 hours, merge extractive liquid, extracting solution is condensed into thick paste, is ground into fine powder, for subsequent use;
5) by step 4) extract after Radix Persicae be cut into the long segment of 5cm, immerse in salt and take out after 15 days, dry, smash to pieces, with step 4) fine powder mix, for subsequent use;
6) by Flos Rosae Rugosae, Flos Camelliae Japonicae powder is broken into fine powder and immerses in Mel 8 days, for subsequent use;
7) by Margarita powder and step 3), 5), 6) standby mix, for subsequent use;
8) by Oleum Camelliae and mixed with olive oil, miscella is obtained, for subsequent use;
9) by step 7) in standby add step 8) in miscella in soak 40 days, stir evenly;
10) add adjuvant, technique makes required dosage form routinely.
7. pharmaceutical composition according to claim 6, is characterized in that described pharmaceutical composition is made up of following steps:
1) each medicine is taken by formula;
2) clean, drain;
3) fritter 3) white turnip being cut into 5cm long adds the fiery fried dry of white vinegar, smashs to pieces, for subsequent use;
4) Radix Persicae is added the ethanol extraction three times of 3 times amount 65%, each 2 hours, merge extractive liquid, extracting solution is condensed into thick paste, is ground into fine powder, for subsequent use;
5) by step 4) extract after Radix Persicae be cut into the long segment of 5cm, immerse in salt and take out after 15 days, dry, smash to pieces, with step 4) fine powder mix, for subsequent use;
6) by Flos Rosae Rugosae, Flos Camelliae Japonicae powder is broken into fine powder and immerses in Mel 8 days, for subsequent use;
7) by Margarita powder and step 3), 5), 6) standby mix, for subsequent use;
8) by Oleum Camelliae and mixed with olive oil, miscella is obtained, for subsequent use;
9) by step 7) in standby add step 8) in miscella in soak 40 days, stir evenly;
10) make softgel shell glue with gelatin, adopt die pressing to make soft capsule.
8. pharmaceutical composition according to claim 6, is characterized in that described pharmaceutical composition is made up of following steps:
1) each medicine is taken by formula;
2) clean, drain;
3) fritter white turnip being cut into 5cm long adds the fiery fried dry of white vinegar, smashs to pieces, for subsequent use;
4) Radix Persicae is added the ethanol extraction three times of 3 times amount 65%, each 2 hours, merge extractive liquid, extracting solution is condensed into thick paste, is ground into fine powder, for subsequent use;
5) by step 4) extract after Radix Persicae be cut into the long segment of 5cm, immerse in salt and take out after 15 days, dry, smash to pieces, with step 4) fine powder mix, for subsequent use;
6) by Flos Rosae Rugosae, Flos Camelliae Japonicae powder is broken into fine powder and immerses in Mel 8 days, for subsequent use;
7) by Margarita powder and step 3), 5), 6) standby mix, for subsequent use;
8) by Oleum Camelliae and mixed with olive oil, miscella is obtained, for subsequent use;
9) by step 7) in standby add step 8) in miscella in soak 40 days, stir evenly;
10) add 20-100ml water, stir and carry out emulsifying in 30 minutes, add in rubber cement by emulsion under constantly stirring, stir and carry out emulsifying in 3 hours, by dosing pump pill dripping machine dripping, 13-15 DEG C of liquid Paraffin makes condensed fluid, constant pressure and dry, obtained drop pill.
9. pharmaceutical composition according to claim 6, is characterized in that described pharmaceutical composition is made up of following steps:
1) each medicine is taken by formula;
2) clean, drain;
3) fritter white turnip being cut into 5cm long adds the fiery fried dry of white vinegar, smashs to pieces, for subsequent use;
4) Radix Persicae is added the ethanol extraction three times of 3 times amount 65%, each 2 hours, merge extractive liquid, extracting solution is condensed into thick paste, is ground into fine powder, for subsequent use;
5) by step 4) extract after Radix Persicae be cut into the long segment of 5cm, immerse in salt and take out after 15 days, dry, smash to pieces, with step 4) fine powder mix, for subsequent use;
6) by Flos Rosae Rugosae, Flos Camelliae Japonicae powder is broken into fine powder and immerses in Mel 8 days, for subsequent use;
7) by Margarita powder and step 3), 5), 6) standby mix, for subsequent use;
8) by Oleum Camelliae and mixed with olive oil, miscella is obtained, for subsequent use;
9) by step 7) in standby add step 8) in miscella in soak 40 days, stir evenly;
10) add starch, conveniently technique makes tablet, capsule, granule.
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