CN103548813A - External protective set for vitrification refrigeration carrier - Google Patents
External protective set for vitrification refrigeration carrier Download PDFInfo
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- CN103548813A CN103548813A CN201310543204.5A CN201310543204A CN103548813A CN 103548813 A CN103548813 A CN 103548813A CN 201310543204 A CN201310543204 A CN 201310543204A CN 103548813 A CN103548813 A CN 103548813A
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- freezing
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Abstract
The invention relates to the field of biomedicines, and particularly relates to an external protective set for a vitrification refrigeration carrier. A sample is unlikely to drop out from the protective set, and can not be influenced by variation of a surrounding environment when being placed in a liquid nitrogen container. The external protective set for the vitrification refrigeration carrier comprises a refrigeration sleeve, a refrigeration cover pipe, an aluminum alloy refrigeration support and a fixed connecting line, wherein each of the refrigeration sleeve and the refrigeration cover pipe is in a cylinder structure with one opened end and the other closed end, and inner diameters are equal; the opened end of the refrigeration cover pipe is provided with an extending part, and the extending part is in a sheet structure with the arc-shaped cross section and is inserted into the refrigeration sleeve so as to connect with the refrigeration cover pipe with the refrigeration sleeve; the aluminum alloy refrigeration support is provided with a plurality of clamping grooves, the refrigeration cover pipe and the refrigeration sleeve are clamped on the aluminum alloy refrigeration support in an opening-to-opening manner, and the refrigeration cover pipe is capable of sliding on the aluminum alloy refrigeration support in a reciprocating manner; the aluminum alloy refrigeration support is provided with the fixed connecting line, one end of the fixed connecting line is connected with the aluminum alloy refrigeration support, and the other end of the fixed connecting line is a free end.
Description
Technical field
The present invention relates to biomedical sector, in particular to vitrified frozen vector outer protection, be set with.
Background technology
Vitrifying snap frozen is that high concentration cryoprotector and cell is fused; after certain hour balance; cell volume reduces 30-50% because of dehydration; afterwards dehydration cell is inserted in freezing equipment; again the freezing equipment that is loaded with dehydration cell is directly dropped into the cell moment vitrifying that makes to dewater in liquid nitrogen; without ice crystal, forming lower preservation, to reduce in cell, freezing and cause the injury to cell.
Can be not damaged in refrigerating process using the dehydration cell as sample in order to protect, and easily from liquid nitrogen container, take out, conventionally sample can be placed in special freezing equipment, then by freezing equipment be placed in liquid nitrogen container, carry out freezing.As shown in Figure 1, the freezing sleeve pipes 3 that the liquid nitrogen that existing freezing equipment is provided with a plurality of small openings by bottom carries 5, support 2 and two internal diameters equate form, two freezing sleeve pipes 3 dock setting mouth to mouth, and support 2 is stuck on the outer wall of two freezing sleeve pipes 3 as fixed support; Be fixed on freezing sleeve pipe 3 on freezing support and be arranged on liquid nitrogen and carry in 5, liquid nitrogen is carried 5 and is provided with for liquid nitrogen being carried to 5 handles that take out from liquid nitrogen container 1.When freezing, directly liquid nitrogen carried to 5 and be placed in liquid nitrogen container 1, a common liquid nitrogen is carried in 5 can place a plurality of supports 2.
The problem existing: although two freezing sleeve pipes that use in existing freezing equipment can be fixed therein sample well, sample is difficult for skidding off freezing sleeve pipe, but, the air entering together when entering part liquid nitrogen in the freezing sleeve pipe of two docking can not be discharged in time, the freezing sleeve pipe dropping in liquid nitrogen container can swim in liquid nitrogen surface again due to the reason of the exuberant air in inside, in the process of floating, the environmental temperature of sample can change so repeatedly, affects the quality of sample freezing.
Summary of the invention
The object of the present invention is to provide a kind of vitrified frozen vector outer protection suit, to solve the above problems.
The vitrified frozen vector outer protection suit providing in an embodiment of the present invention, comprising: freezing sleeve pipe, freezing lid pipe, the freezing support of aluminium alloy, be fixedly connected with line;
Described freezing sleeve pipe and described freezing lid pipe are the cylindrical structure of an end opening other end sealing, and internal diameter equates;
One end of described freezing lid tube opening is provided with extension, and described extension is that cross section is the laminated structure of arc, and described extension inserts described freezing sleeve pipe described freezing lid pipe is connected with described freezing sleeve pipe;
The freezing support of described aluminium alloy is provided with a plurality of draw-in grooves, and described freezing lid pipe and the setting of described freezing sleeve opening counterpart are connected on the freezing support of described aluminium alloy, and described freezing lid pipe can reciprocatingly slide on the freezing support of described aluminium alloy;
Described in the freezing support of described aluminium alloy is provided with, be fixedly connected with line, described in be fixedly connected with line one end be connected with the freezing support of described aluminium alloy, its other end is free end.
In vitrified frozen vector outer protection suit provided by the invention; use a freezing sleeve pipe and a freezing lid mouth of pipe counterpart to arrange; and in one end of freezing lid tube opening, be provided with the extension that cross section is the sheet of arc; extension inserts freezing sleeve pipe freezing lid pipe is connected with freezing sleeve pipe; and; freezing lid pipe after connection and freezing sleeve pipe are connected on the freezing support of aluminium alloy jointly; freezing lid pipe can reciprocatingly slide on the freezing support of aluminium alloy, and then is connected with freezing sleeve pipe or separated.On the freezing support of aluminium alloy, be provided with and be fixedly connected with line.
Sample is put into after freezing sleeve pipe, extension is inserted to freezing sleeve pipe freezing lid pipe is connected with freezing sleeve pipe, and then sample is fixed therein.
When the freezing support of the aluminium alloy that is fixed with sample is put into liquid nitrogen container, because there be the fixing of freezing lid pipe and freezing sleeve pipe, described sample can be easily from wherein not dropping out, simultaneously, because the extension that cross section is arc-shaped flaky is connected freezing lid pipe with freezing sleeve pipe, the interface that freezing lid pipe is connected with freezing sleeve pipe can leave certain space, and this space can make the air entering in freezing sleeve pipe and freezing lid pipe overflow, also just can avoid when sample is put into liquid nitrogen container, the possibility floating because be filled with air in freezing sleeve pipe, and then the impact of the variation of having avoided sample surrounding environment when putting into liquid nitrogen container on sample.
Because freezing lid pipe can reciprocatingly slide on the freezing support of aluminium alloy, so only freezing lid pipe need to be slidably reciprocated, can open or the opening of closed freezing lid pipe and freezing sleeve pipe.
For convenient, the freezing sleeve pipe and the freezing lid pipe that are loaded with sample are taken out from liquid nitrogen container, the present invention is for cost-saving, increase the quantity of putting into sample in liquid nitrogen container, removed liquid nitrogen and carried, saved the volume occupying in liquid nitrogen container, on the freezing support of aluminium alloy, be provided with and be fixedly connected with line simultaneously, the one end that is fixedly connected with line is fixed on the freezing support of aluminium alloy, its other end extends to outside liquid nitrogen container, and when taking, direct pull is fixedly connected with line and can be taken out like this.
Accompanying drawing explanation
Fig. 1 is the structural representation of the freezing equipment that uses in prior art;
Fig. 2 is the structural representation of vitrified frozen vector outer protection suit provided by the invention;
Fig. 3 is the end view of the freezing lid pipe in the vitrified frozen vector outer protection suit providing in the embodiment of the present invention 2;
Fig. 4 is the structural representation of the freezing support in the vitrified frozen vector outer protection suit providing in the embodiment of the present invention 2;
Fig. 5 is the end view of the freezing support in the vitrified frozen vector outer protection suit providing in the embodiment of the present invention 2;
1. liquid nitrogen container, 2. support, 3. freezing sleeve pipe, 4. sample, 5. liquid nitrogen is carried, 6. freezing lid pipe, 7. retainer ring, 8. fixed steelring, is 9. fixedly connected with line, 10. the freezing support of aluminium alloy.
Embodiment
Below by specific embodiment, also by reference to the accompanying drawings the present invention is described in further detail.
Embodiment 1: as Figure 2-Figure 5,
Vitrified frozen vector outer protection suit, comprising: freezing sleeve pipe 3, freezing lid pipe 6, the freezing support 10 of aluminium alloy, be fixedly connected with line 9;
Described freezing sleeve pipe 3 and described freezing lid pipe 6 are the cylindrical structure of an end opening other end sealing, and internal diameter equates;
One end that described freezing lid is managed 6 openings is provided with extension, and described extension is that cross section is the laminated structure of arc, and described extension inserts described freezing sleeve pipe 3 described freezing lid pipe 6 is connected with described freezing sleeve pipe 3;
The freezing support 10 of described aluminium alloy is provided with a plurality of draw-in grooves, and described freezing lid pipe 6 and described freezing sleeve pipe 3 arrange mouth to mouth and be connected on the freezing support 10 of described aluminium alloy, and described freezing lid pipe 6 can reciprocatingly slide on the freezing support 10 of described aluminium alloy;
Described in the freezing support 10 of described aluminium alloy is provided with, be fixedly connected with line 9, described in be fixedly connected with line 9 one end be connected with the freezing support 10 of described aluminium alloy, its other end is free end.
In vitrified frozen vector outer protection suit provided by the invention; use a freezing sleeve pipe 3 and a freezing lid pipe 6 to arrange mouth to mouth; and be provided with in one end that freezing lid is managed 6 openings the extension that cross section is the sheet of arc; extension inserts freezing sleeve pipe 3 freezing lid pipe 6 is connected with freezing sleeve pipe 3; and; freezing lid pipe 6 after connection and freezing sleeve pipe 3 are connected on the freezing support 10 of aluminium alloy jointly; freezing lid pipe 6 can reciprocatingly slide on aluminium alloy post, and then is connected with freezing sleeve pipe 3 or separated.On the freezing support 10 of aluminium alloy, be provided with and be fixedly connected with line 9.
When the freezing support 10 of the aluminium alloy that is fixed with sample 4 is put into liquid nitrogen container 1, because there be the fixing of freezing lid pipe 6 and freezing sleeve pipe 3, described sample can be easily from wherein not dropping out, simultaneously, because the extension that cross section is arc-shaped flaky is connected freezing lid pipe 6 with freezing sleeve pipe 3, freezing lid pipe 6 can leave certain space with the interface that freezing sleeve pipe 3 is connected, and this space can make liquid nitrogen enter rapidly, and can also make the air entering in freezing sleeve pipe 3 and freezing lid pipe 6 overflow, also just can avoid when sample is put into liquid nitrogen container 1, the possibility floating because be filled with air in freezing sleeve pipe 3, and then the impact of the variation of having avoided sample surrounding environment when putting into liquid nitrogen container 1 on sample.
Because freezing lid pipe 6 can reciprocatingly slide on the freezing support 10 of aluminium alloy, so only freezing lid pipe 6 need to be slidably reciprocated, can open or the opening of closed freezing lid pipe 6 and freezing sleeve pipe 3.
For convenient, the freezing sleeve pipe 3 and the freezing lid pipe 6 that are loaded with sample are taken out from liquid nitrogen container 1, the present invention is for cost-saving, increase the quantity of putting into sample in liquid nitrogen container 1, remove liquid nitrogen and carried 5, saved the volume occupying in liquid nitrogen container 1, on the freezing support 10 of aluminium alloy, be provided with and be fixedly connected with line 9 simultaneously, the one end that is fixedly connected with line 9 is fixed on the freezing support 10 of aluminium alloy, its other end extends to outside liquid nitrogen container 1, when taking, direct pull is fixedly connected with line 9 and can be taken out like this.
Embodiment 2:
Based on above-described embodiment, for vitrified frozen vector outer protection suit provided by the invention, further done following improvement:
The length of the freezing support 10 of described aluminium alloy is greater than or equal to the length sum of described freezing sleeve pipe 3 and described freezing lid pipe 6, is less than 1.1 times of length sum of described freezing sleeve pipe 3 and described freezing lid pipe 6.
In order to meet the slip of freezing lid pipe 6 on the freezing support 10 of aluminium alloy, the taking-up of convenience sample 4, the length that the freezing support 10 of aluminium alloy can be set is greater than or equal to the length sum of described freezing sleeve pipe 3 and described freezing lid pipe 6, but in order to save space in liquid nitrogen container 1, use, the length that the freezing support 10 of aluminium alloy can be set is less than 1.1 times of length sum of freezing sleeve pipe 3 and freezing lid pipe 6.
One end of the freezing support 10 of described aluminium alloy is provided with retainer plate, and the length place direction of the bearing of trend of the axis of described retainer plate and the freezing support 10 of described aluminium alloy is consistent.
In order further to improve freezing sleeve pipe 3 and the fixed stably solidity of freezing lid pipe 6 on the freezing support 10 of aluminium alloy, a retainer plate can be set in one end of the freezing support 10 of aluminium alloy, and the length place direction of the bearing of trend of the axis of retainer plate and the freezing support 10 of aluminium alloy is consistent.In use, retainer plate pad is in the bottom of freezing sleeve pipe 3, and freezing lid pipe 6 tips upside down on the top of freezing sleeve pipe 3, and this retainer plate can be held freezing sleeve pipe 3 better, has improved safety and firmness.
The inwall of the freezing support 10 of described aluminium alloy is provided with the fixing point of protrusion.
For can be by fixing more fastening of freezing sleeve pipe 3 and freezing lid pipe 6, the fixing point of protrusion can be set on the inwall of the freezing support 10 of aluminium alloy, when freezing sleeve pipe 3 and freezing lid pipe 6 are connected on the inwall of the freezing support 10 of aluminium alloy, this fixes tighter that point can be by its card.
Also comprise fixed steelring 8, described fixed steelring 8 comprises two annulus and a plurality of support bar, and a plurality of described support bars are located between two described annulus, and two described annulus are connected and composed to composite construction;
Described fixed steelring 8 is located at the outside of liquid nitrogen container 1, described in be fixedly connected with line 9 one end be fixed on described fixed steelring 8.
Described fixed steelring 8 is located at the outside of liquid nitrogen container 1, described in be fixedly connected with line 9 one end be fixed on described fixed steelring 8.
In order conveniently to extend the other end that is fixedly connected with line 9 fixing of liquid nitrogen container 1, and after easily find the correct line 9 that is fixedly connected with while needing to take, can be at fixed steelring 8 of outer setting of liquid nitrogen container 1, this fixed steelring 8 comprises two annulus and a plurality of support bar, a plurality of described support bars are located between two annulus, and two annulus are connected and composed to composite construction;
Fixed steelring 8 is located at the outside of liquid nitrogen container 1, and the one end that is fixedly connected with line 9 is fixed on the freezing support 10 of aluminium alloy, and its other end is fixed on fixed steelring 8.
The freezing support 10 of described aluminium alloy is provided with retainer ring 7, described in be fixedly connected with line 9 one end be fixed on described retainer ring 7, its other end is free end.
For convenient, the one end that is fixedly connected with line 9 is fixed on the freezing support 10 of aluminium alloy, can on the freezing support 10 of aluminium alloy, retainer ring 7 be set, while arranging, directly the one end that is fixedly connected with line 9 is tied up on retainer ring 7.
The described line 9 that is fixedly connected with is provided with and records label.
In order correctly to find rapidly required sample, can arrange and record label being fixedly connected with on line 9, this records on label can record different sample informations, helps the rapid identification of operator also to find different samples.And in existing scheme, need a plurality of samples to take out and identification finally need to spend the longer time and just can find required sample, and in the process of finding in identification, sample takes out from liquid nitrogen, and temperature rises, and can destroy like this integrality of sample.
The foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, for a person skilled in the art, the present invention can have various modifications and variations.Within the spirit and principles in the present invention all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (7)
1. vitrified frozen vector outer protection suit, is characterized in that, comprising: freezing sleeve pipe, freezing lid pipe, the freezing support of aluminium alloy, be fixedly connected with line;
Described freezing sleeve pipe and described freezing lid pipe are the cylindrical structure of an end opening other end sealing, and internal diameter equates;
One end of described freezing lid tube opening is provided with extension, and described extension is that cross section is the laminated structure of arc, and described extension inserts described freezing sleeve pipe described freezing lid pipe is connected with described freezing sleeve pipe;
The freezing support of described aluminium alloy is provided with a plurality of draw-in grooves, and described freezing lid pipe and the setting of described freezing sleeve opening counterpart are connected on the freezing support of described aluminium alloy, and described freezing lid pipe can reciprocatingly slide on the freezing support of described aluminium alloy;
Described in the freezing support of described aluminium alloy is provided with, be fixedly connected with line, described in be fixedly connected with line one end be connected with the freezing support of described aluminium alloy, its other end is free end.
2. vitrified frozen vector outer protection suit according to claim 1, is characterized in that,
The length of the freezing support of described aluminium alloy is greater than or equal to the length sum of described freezing sleeve pipe and described freezing lid pipe, is less than 1.1 times of length sum of described freezing sleeve pipe and described freezing lid pipe.
3. vitrified frozen vector outer protection suit according to claim 1, is characterized in that,
One end of the freezing support of described aluminium alloy is provided with retainer plate, and the length place direction of the bearing of trend of the axis of described retainer plate and the freezing support of described aluminium alloy is consistent.
4. vitrified frozen vector outer protection suit according to claim 1, is characterized in that,
The inwall of the freezing support of described aluminium alloy is provided with the fixing point of protrusion.
5. vitrified frozen vector outer protection suit according to claim 1, is characterized in that,
Also comprise fixed steelring, described fixed steelring comprises two annulus and a plurality of support bar, and a plurality of described support bars are located between two described annulus, and two described annulus are connected and composed to composite construction;
Described fixed steelring is located at the outside of liquid nitrogen container, described in be fixedly connected with line one end be fixed on the freezing support of described aluminium alloy, its other end is fixed on described fixed steelring.
6. vitrified frozen vector outer protection suit according to claim 1, is characterized in that,
The freezing support of described aluminium alloy is provided with retainer ring, described in be fixedly connected with line one end be fixed on described retainer ring, its other end is free end.
7. vitrified frozen vector outer protection suit according to claim 1, is characterized in that,
The described line that is fixedly connected with is provided with and records label.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310543204.5A CN103548813B (en) | 2013-11-05 | 2013-11-05 | External protective set for vitrification refrigeration carrier |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310543204.5A CN103548813B (en) | 2013-11-05 | 2013-11-05 | External protective set for vitrification refrigeration carrier |
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| Publication Number | Publication Date |
|---|---|
| CN103548813A true CN103548813A (en) | 2014-02-05 |
| CN103548813B CN103548813B (en) | 2015-05-20 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201310543204.5A Active CN103548813B (en) | 2013-11-05 | 2013-11-05 | External protective set for vitrification refrigeration carrier |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111700061A (en) * | 2020-06-12 | 2020-09-25 | 山东大学齐鲁医院 | Closed vitrification carrier and application thereof |
| WO2021129312A1 (en) * | 2019-12-24 | 2021-07-01 | 上海明悦医疗科技有限公司 | Carrier, vacuumizing device and tissue cryopreservation system |
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| WO2011070973A1 (en) * | 2009-12-08 | 2011-06-16 | 学校法人北里研究所 | Narrow tube for vitrification preservation of animal embryo or ovum |
| CN102204527A (en) * | 2011-04-15 | 2011-10-05 | 山东威高新生医疗器械有限公司 | Carrying tool for use in vitrification cryo-preservation of biomaterial |
| US20110275153A1 (en) * | 2010-05-06 | 2011-11-10 | Vance Products Inc., D/B/A Cook Urological Inc. | Cryogenic storage device |
| CN202095441U (en) * | 2011-04-25 | 2012-01-04 | 石家庄市第四医院 | Biological material vitrification freezing carrier |
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2013
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Patent Citations (5)
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| CN201379022Y (en) * | 2009-04-23 | 2010-01-13 | 北京微创介入医疗装备有限公司 | Carrier device for vitrification freezing of embryo and ovum in auxiliary reproductive technology |
| WO2011070973A1 (en) * | 2009-12-08 | 2011-06-16 | 学校法人北里研究所 | Narrow tube for vitrification preservation of animal embryo or ovum |
| US20110275153A1 (en) * | 2010-05-06 | 2011-11-10 | Vance Products Inc., D/B/A Cook Urological Inc. | Cryogenic storage device |
| CN102204527A (en) * | 2011-04-15 | 2011-10-05 | 山东威高新生医疗器械有限公司 | Carrying tool for use in vitrification cryo-preservation of biomaterial |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021129312A1 (en) * | 2019-12-24 | 2021-07-01 | 上海明悦医疗科技有限公司 | Carrier, vacuumizing device and tissue cryopreservation system |
| CN111700061A (en) * | 2020-06-12 | 2020-09-25 | 山东大学齐鲁医院 | Closed vitrification carrier and application thereof |
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| CN103548813B (en) | 2015-05-20 |
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