CN103547591A - 生长激素释放因子(grf)类似物及其用途 - Google Patents

生长激素释放因子(grf)类似物及其用途 Download PDF

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Publication number
CN103547591A
CN103547591A CN201280024235.3A CN201280024235A CN103547591A CN 103547591 A CN103547591 A CN 103547591A CN 201280024235 A CN201280024235 A CN 201280024235A CN 103547591 A CN103547591 A CN 103547591A
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CN
China
Prior art keywords
grf
seq
ala
analogue
analog
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201280024235.3A
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English (en)
Chinese (zh)
Inventor
K·G·佩里
A·哈比
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Theratechnologies Inc
Original Assignee
Theratechnologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theratechnologies Inc filed Critical Theratechnologies Inc
Publication of CN103547591A publication Critical patent/CN103547591A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/25—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN201280024235.3A 2011-04-21 2012-04-17 生长激素释放因子(grf)类似物及其用途 Pending CN103547591A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161477775P 2011-04-21 2011-04-21
US61/477,775 2011-04-21
PCT/CA2012/050242 WO2012142706A1 (en) 2011-04-21 2012-04-17 Growth hormone releasing factor (grf) analogs and uses thereof

Publications (1)

Publication Number Publication Date
CN103547591A true CN103547591A (zh) 2014-01-29

Family

ID=47021786

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280024235.3A Pending CN103547591A (zh) 2011-04-21 2012-04-17 生长激素释放因子(grf)类似物及其用途

Country Status (10)

Country Link
US (1) US8361964B2 (enExample)
EP (1) EP2699591A4 (enExample)
JP (1) JP6113144B2 (enExample)
KR (1) KR20140027284A (enExample)
CN (1) CN103547591A (enExample)
AR (1) AR087727A1 (enExample)
BR (1) BR112013027150A2 (enExample)
CA (1) CA2833434A1 (enExample)
MX (1) MX2013012259A (enExample)
WO (1) WO2012142706A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013190520A2 (en) 2012-06-22 2013-12-27 The General Hospital Corporation Gh-releasing agents in the treatment of vascular stenosis and associated conditions
PL3445778T3 (pl) 2016-04-19 2021-02-22 Griffon Pharmaceuticals International Sa Pegylowane bioaktywne peptydy i ich zastosowania
KR20230035600A (ko) * 2020-07-05 2023-03-14 쎄러테크놀로지스 인코포레이티드 Ghrh 유사체의 저-용량 약제학적 조성물 및 이들의 용도

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1032014A (zh) * 1987-09-18 1989-03-29 霍夫曼-拉罗奇有限公司 环形生长激素释放因子(grf)类似物及其制备方法
EP0454367A2 (en) * 1990-04-24 1991-10-30 Eli Lilly And Company Growth hormone releasing factor analogs
WO1997024369A1 (en) * 1995-12-28 1997-07-10 Pfizer Inc. Growth-hormone secretagogues
CN1514843A (zh) * 2001-06-08 2004-07-21 �о���Ӧ�ÿ�ѧЭ��ɷ����޹�˾ 生长激素释放抑制因子-多巴胺嵌合类似物

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4518586A (en) 1983-01-13 1985-05-21 The Salk Institute For Biological Studies GRF Analogs III
US4617149A (en) 1983-09-21 1986-10-14 Eli Lilly And Company Growth hormone release factor analogs
US4622312A (en) 1984-09-24 1986-11-11 Hoffmann-La Roche Inc. Growth hormone releasing factor analogs
US4734399A (en) * 1985-08-06 1988-03-29 Hoffmann-La Roche Inc. Growth hormone releasing factor analogs
US4801456A (en) 1987-07-09 1989-01-31 International Minerals & Chemical Corp. Growth hormone-releasing factor analogs
AU662731B2 (en) 1991-04-09 1995-09-14 F. Hoffmann-La Roche Ag Growth hormone releasing factor analogs
US5262519A (en) 1991-05-15 1993-11-16 The Salk Institute For Biological Studies GRF analogs XI
WO1996032126A1 (en) 1995-04-14 1996-10-17 The Administrators Of The Tulane Educational Fund Analogs of growth hormone-releasing factor
PT828758E (pt) 1995-05-26 2002-02-28 Theratechnologies Inc Analogos quimericos de corpo gordo-pro-grf com potencia biologica aumentada
EP0922446A1 (en) 1997-12-03 1999-06-16 Applied Research Systems Ars Holding N.V. Solution-phase site-specific preparation of GRF-PEG conjugates
US6057422A (en) 1998-11-25 2000-05-02 The Administrators Of The Tulane Educational Fund Antagonistic analogs of GH-RH inhibiting IGF-I and -II
IL155177A0 (en) 2000-10-05 2003-11-23 Ares Trading Sa Method for the preparation of grf-peg conjugate
CN101696240A (zh) 2001-02-02 2010-04-21 康久化学生物技术公司 长效生长激素释放因子衍生物
WO2004027064A2 (en) 2002-09-18 2004-04-01 Centre Hospitalier De L'universite De Montreal (Chum) Ghrh analogues
CA2527039C (en) 2003-05-29 2013-07-09 Theratechnologies Inc. Grf analog compositions and their use
TW200517400A (en) 2003-08-05 2005-06-01 Univ Tulane Antagonistic analogs of GH-RH (2003)
EP1675610A4 (en) 2003-10-20 2010-04-28 Theratechnologies Inc USE OF GROWTH HORMONE RELEASE FACTOR ANALOGUE IN THE TREATMENT OF PATIENTS WITH EXCEPTION
EP1812048A4 (en) 2004-10-20 2012-01-18 Theratechnologies Inc GH SECRETAGOGA AND ITS USE
US8021859B2 (en) 2005-03-15 2011-09-20 Allergan, Inc. Modified clostridial toxins with altered targeting capabilities for clostridial toxin target cells
WO2009009727A2 (en) 2007-07-12 2009-01-15 Akela Pharma Srl Ghrh analogs and therapeutic uses thereof
US20110021429A1 (en) 2007-10-01 2011-01-27 Pierrette Gaudreau Renoprotection by growth hormone-releasing hormone and agonists
US20100267636A1 (en) 2009-04-20 2010-10-21 Theratechnologies Inc. Use of cytochrome p450-metabolized drugs and grf molecules in combination therapy

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1032014A (zh) * 1987-09-18 1989-03-29 霍夫曼-拉罗奇有限公司 环形生长激素释放因子(grf)类似物及其制备方法
EP0454367A2 (en) * 1990-04-24 1991-10-30 Eli Lilly And Company Growth hormone releasing factor analogs
WO1997024369A1 (en) * 1995-12-28 1997-07-10 Pfizer Inc. Growth-hormone secretagogues
CN1514843A (zh) * 2001-06-08 2004-07-21 �о���Ӧ�ÿ�ѧЭ��ɷ����޹�˾ 生长激素释放抑制因子-多巴胺嵌合类似物

Also Published As

Publication number Publication date
CA2833434A1 (en) 2012-10-26
JP6113144B2 (ja) 2017-04-12
EP2699591A4 (en) 2014-05-07
WO2012142706A1 (en) 2012-10-26
BR112013027150A2 (pt) 2017-06-06
KR20140027284A (ko) 2014-03-06
AR087727A1 (es) 2014-04-16
MX2013012259A (es) 2013-11-22
JP2014515751A (ja) 2014-07-03
EP2699591A1 (en) 2014-02-26
US8361964B2 (en) 2013-01-29
US20120270784A1 (en) 2012-10-25

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Effective date of abandoning: 20180403