CN103540627A - Production method of methionine - Google Patents
Production method of methionine Download PDFInfo
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- CN103540627A CN103540627A CN201210239216.4A CN201210239216A CN103540627A CN 103540627 A CN103540627 A CN 103540627A CN 201210239216 A CN201210239216 A CN 201210239216A CN 103540627 A CN103540627 A CN 103540627A
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Abstract
The invention discloses a production method of methionine, and the product belongs to the field of feed additives. A finished product is prepared by utilizing casein, hydrolase, sodium hydroxide and water as raw materials and utilizing a reaction kettle, a crystallization kettle, a centrifuge and a vacuum drying machine as equipment through such procedures as hydrolysis, rectification, centrifugal separation, drying, and the like, the production method is simple in process, free of three-waste emission, free of high temperature or high pressure reaction, convenient to operate, good in product quality and capable of producing high-quality methionine in batches, and universal equipment is adopted. The methionine is mainly used for resisting hepatocirrhosis, protecting cardiac muscle, resisting depression, reducing blood pressure, preventing and removing poison and reinforcing human body metabolism on medicine; and when being applied on livestock, the methionine has the effects of treating maldevelopment, weight reduction, liver and kidney function abate, sweeny and fur metamorphism.
Description
Technical field
The invention belongs to amino acid and manufacture field, relate in particular to a kind of production method of methionine(Met).
Background technology
Methionine(Met) claims again methionine(Met), 2-amino-4-first sulfydryl butyric acid, and molecular formula is C5H11NO2S, and molecular weight is 149.21, outward appearance is the crystallization of white flakes shape or crystalline powder, has special odor, and taste is micro-sweet, fusing point: 280～281 ℃, the pH value 5.6-6.1 of 10% aqueous solution, to heat and air-stable, unstable to strong acid, water-soluble, diluted acid and diluted alkaline, be soluble in 95% ethanol, the utmost point is insoluble in dehydrated alcohol, is dissolved in hardly ether.Methionine(Met) is a kind of nonpolar alpha amino acid of sulfur-bearing, a kind of in 20 seed amino acids of constitutive protein matter, methionine(Met) is one of indispensable amino acid forming human body, participate in protein synthesis, because it can not self generate in vivo, so must be obtained by outside, if methionine deficiency will cause body internal protein biosynthesis block, cause body damage.Methionine(Met) is a kind of composition of protein, a lot of in Protalbinic acid and casein, and natural what obtain is L-type, and L-type D type is all effective, is present in Protalbinic acid and casein.Available casein obtains through being hydrolyzed, refining; Also can through building-up reactions, be prepared by thiomethyl alcohol and propenal.Methionine(Met) is mainly used in anti-liver cirrhosis, fatty liver and various acute, chronic, viral, jaundice liver aspect medical; Myocardial preservation, the cardiac damage especially Keshan disease being caused is particularly useful; Depression, in patients with depression blood, methionine(Met) concentration significantly reduces, and supplemented with exogenous methionine(Met) has therapeutic action to dysthymia disorders; Hypotensive, methionine(Met) generates taurine by transsulfuration obvious hypotensive effect; Gas defence Eradicates poison; Strengthen body metabolism, methylate and in biosynthesis and metabolism, play an important role in vivo; Methionine(Met) and glycine have antagonistic action, and livestock lacks that methionine(Met) can cause dysplasia, loses weight, the hypodynamia of liver kidney, amyotrophy, fur are rotten etc.It is raw material that casein, lytic enzyme, sodium hydroxide, water are take in the present invention, take reactor, crystallization kettle, whizzer, Vacuumdrier is equipment, by operations such as hydrolysis, refining, centrifugation, oven dry, make finished product, this production method technique is simple, use general-purpose equipment, three-waste free discharge, without high-temperature high-voltage reaction, easy to operate, good product quality, can be mass out high-quality methionine(Met).
Summary of the invention
The problem that the present invention mainly solves is to provide a kind of production method of methionine(Met), it is raw material that the method be take casein, lytic enzyme, sodium hydroxide, water, hydrochloric acid, take reactor, crystallization kettle, whizzer, Vacuumdrier is equipment, by operations such as hydrolysis, refining, centrifugation, oven dry, make finished product, have technique simple, use the advantages such as general-purpose equipment, easy to operate, good product quality.The proportioning raw materials of producing this product use is: casein 15%-16%, lytic enzyme 2%, water 80%-81%, sodium hydroxide 2%, aqueous sodium hydroxide solution and hydrochloric acid are appropriate.
The present invention can be achieved through the following technical solutions:
A production method for methionine(Met), is characterized in that consisting of following steps:
(1) water of formula ratio is sent in reactor, add while stirring the sodium hydroxide of formula ratio, and keep temperature-resistant after being warming up to 50 ℃-55 ℃, add while stirring casein and the lytic enzyme of formula ratio, stirring reaction 4-5 hour, stops stirring after hydrolysis finishes.
(2) material in reactor is sent into crystallization kettle, with hydrochloric acid and aqueous sodium hydroxide solution, adjusting at normal temperatures the pH value of liquid in still is 5.74, and standing 10 hours, methionine(Met) crystallization was complete.
(3) liquid in crystallization kettle is discharged, methionine(Met) xln is sent into whizzer to carry out separated to remove a small amount of moisture, then the methionine(Met) after separation being sent into Vacuumdrier is dried, dry 9-11 hour at 65 ℃-75 ℃, after being dried, can fragmentation sieve, then packing obtains methionine(Met) finished product.
Temperature of reaction in step (1) reactor is 52 ℃.
Drying temperature in step (3) in drying machine is 70 ℃, and be 10 hours time of drying.
The invention has the beneficial effects as follows: a kind of method of producing methionine(Met) is provided, this production method have technique simple, use general-purpose equipment, three-waste free discharge, without high-temperature high-voltage reaction, be easy to the series of advantages such as production operation, good product quality, can be mass out high-quality methionine(Met).
Embodiment
Below in conjunction with specific embodiment, the present invention is described in further detail.
Embodiment 1
By accounting for total amount, be that 80% water is sent in reactor, add while stirring that to account for total amount be 2% sodium hydroxide, and keep temperature-resistant after being warming up to 50 ℃-55 ℃, add while stirring that to account for total amount be 16% casein and to account for total amount be 2% lytic enzyme, stirring reaction 4-5 hour, stops stirring after hydrolysis finishes; Material in reactor is sent into crystallization kettle, and with appropriate hydrochloric acid and aqueous sodium hydroxide solution, adjusting at normal temperatures the pH value of liquid in still is 5.74, and standing 10 hours, methionine(Met) crystallization was complete; Liquid in crystallization kettle is discharged, methionine(Met) xln is sent into whizzer to carry out separated to remove a small amount of moisture, then the methionine(Met) after separation being sent into Vacuumdrier is dried, dry 9-11 hour at 65 ℃-75 ℃, after being dried, can fragmentation sieve, then packing obtains methionine(Met) finished product.
Embodiment 2
By accounting for total amount, be that 80.5% water is sent in reactor, add while stirring that to account for total amount be 2% sodium hydroxide, and keep temperature-resistant after being warming up to 50 ℃-55 ℃, add while stirring that to account for total amount be 15.5% casein and to account for total amount be 2% lytic enzyme, stirring reaction 4-5 hour, stops stirring after hydrolysis finishes; Material in reactor is sent into crystallization kettle, and with appropriate hydrochloric acid and aqueous sodium hydroxide solution, adjusting at normal temperatures the pH value of liquid in still is 5.74, and standing 10 hours, methionine(Met) crystallization was complete; Liquid in crystallization kettle is discharged, methionine(Met) xln is sent into whizzer to carry out separated to remove a small amount of moisture, then the methionine(Met) after separation being sent into Vacuumdrier is dried, dry 9-11 hour at 65 ℃-75 ℃, after being dried, can fragmentation sieve, then packing obtains methionine(Met) finished product.
Embodiment 3
By accounting for total amount, be that 81% water is sent in reactor, add while stirring that to account for total amount be 2% sodium hydroxide, and keep temperature-resistant after being warming up to 50 ℃-55 ℃, add while stirring that to account for total amount be 15% casein and to account for total amount be 2% lytic enzyme, stirring reaction 4-5 hour, stops stirring after hydrolysis finishes; Material in reactor is sent into crystallization kettle, and with appropriate hydrochloric acid and aqueous sodium hydroxide solution, adjusting at normal temperatures the pH value of liquid in still is 5.74, and standing 10 hours, methionine(Met) crystallization was complete; Liquid in crystallization kettle is discharged, methionine(Met) xln is sent into whizzer to carry out separated to remove a small amount of moisture, then the methionine(Met) after separation being sent into Vacuumdrier is dried, dry 9-11 hour at 65 ℃-75 ℃, after being dried, can fragmentation sieve, then packing obtains methionine(Met) finished product.
Claims (3)
1. a production method for methionine(Met), the proportioning raw materials of use is: casein 15%-16%, lytic enzyme 2%, water 80%-81%, sodium hydroxide 2%, aqueous sodium hydroxide solution and hydrochloric acid are appropriate; It is characterized in that: step (1) is sent into the water of formula ratio in reactor, add while stirring the sodium hydroxide of formula ratio, and keep temperature-resistant after being warming up to 50 ℃-55 ℃, add while stirring casein and the lytic enzyme of formula ratio, stirring reaction 4-5 hour, stops stirring after hydrolysis finishes; Step (2) is sent the material in reactor into crystallization kettle, and with hydrochloric acid and aqueous sodium hydroxide solution, adjusting at normal temperatures the pH value of liquid in still is 5.74, and standing 10 hours, methionine(Met) crystallization was complete; Step (3) is discharged the liquid in crystallization kettle, methionine(Met) xln is sent into whizzer to carry out separated to remove a small amount of moisture, then the methionine(Met) after separation being sent into Vacuumdrier is dried, dry 9-11 hour at 65 ℃-75 ℃, after being dried, can fragmentation sieve, then packing obtains methionine(Met) finished product.
2. the production method of a kind of methionine(Met) according to claim 1, the feature of its step (1) is: the hydrolysis temperature in described reactor is 52 ℃.
3. the production method of a kind of methionine(Met) according to claim 1, the feature of its step (3) is: the drying temperature in described drying machine is 70 ℃, be 10 hours time of drying.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210239216.4A CN103540627A (en) | 2012-07-12 | 2012-07-12 | Production method of methionine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210239216.4A CN103540627A (en) | 2012-07-12 | 2012-07-12 | Production method of methionine |
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| CN103540627A true CN103540627A (en) | 2014-01-29 |
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| CN201210239216.4A Pending CN103540627A (en) | 2012-07-12 | 2012-07-12 | Production method of methionine |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11349357B2 (en) | 2017-07-06 | 2022-05-31 | Siemens Aktiengesellschaft | Stator-housing unit for an electric machine |
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2012
- 2012-07-12 CN CN201210239216.4A patent/CN103540627A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11349357B2 (en) | 2017-07-06 | 2022-05-31 | Siemens Aktiengesellschaft | Stator-housing unit for an electric machine |
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Application publication date: 20140129 |