CN103536377B - It is a kind of that the heart biology valve for replacing leaflet is repeated by Minimally Invasive Surgery - Google Patents
It is a kind of that the heart biology valve for replacing leaflet is repeated by Minimally Invasive Surgery Download PDFInfo
- Publication number
- CN103536377B CN103536377B CN201210247085.4A CN201210247085A CN103536377B CN 103536377 B CN103536377 B CN 103536377B CN 201210247085 A CN201210247085 A CN 201210247085A CN 103536377 B CN103536377 B CN 103536377B
- Authority
- CN
- China
- Prior art keywords
- valve
- leaflet
- frame
- valve frame
- heart biology
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Abstract
The embodiment of the invention discloses a kind of heart biology valve that replacement leaflet is repeated by Minimally Invasive Surgery, including for the valve frame with tissue apposition（1）With replaceable leaflet（2）, its mesopetalum frame（1）With replaceable leaflet（2）Pass through the card slot on valve frame（3）And seal groove（4）Realize close connection.When patient is implanted into the heart biology valve by open chest surgery, when there is functional deterioration and need to replace biovalve again in leaflet, Minimally Invasive Surgery can be passed through, by the conveying device equipped with new valve leaflet under visualization device guiding, the leaflet to break down is removed into device by the leaflet of conveying device and is removed, while opens new valve leaflet, by leaflet on valve frame, the replacement of leaflet is completed, and loads conveying device after the leaflet to break down is compressed and withdraws from vitro, completes cardiac valve replacement.Because service life reason causes to open the risk that chest replaces valve and bring huge wound to patient again after implanting present invention reduces biovalve.
Description
Technical field
The present invention relates to the field of medical instrument technology, and replacement is repeated by Minimally Invasive Surgery more specifically to one kind
The heart biology valve of leaflet.
Background technology
Valvulopathy is one of most common heart disease in China, and current most effective treatment method is to pass through surgical operation
Valve replacement is carried out, common displacement apparatus there are two kinds：Mechanical valve prosthesis and biovalve.Replacement operation is needed in cardiac arrest,
Carried out under the mode of extracorporal circulatory system, operating time length, loses blood more, while the damage to patient is larger.In recent years, it is external for height
The huge wound that age patient is difficult to bear to perform the operation have developed the intervention heart biology valve by apex of the heart puncture or femoral artery puncture
Film, obtains the SAPIEN balloon-expandables aortic valves and Medtronic that have Edwards of CE certifications at present
CoreValve self-expanding aortic valves, there is the operation dosage of tens thousand of.
The above-mentioned each have their own advantage and disadvantage of three classes cardiac valves：Mechanical valve prosthesis durability is good, it is not necessary to replaces, but is implanted into patient
After in vivo, thrombus is easily formed, so anticoagulant need to be taken throughout one's life, thrombus and bleeding etc. caused by anticoagulation improper use are concurrent
Disease carrys out many security risks to the health care belt of patient.The valve of biovalve haemodynamics and people itself is similar, and effect is preferable,
And without using anticoagulation, but the durability of biovalve is poor compared with mechanical valve prosthesis, and valve can calcification after being typically implanted internal 10 years
Cause disabler, it is necessary to re-replace cardiac valves, the huge wound of open chest surgery is difficult to bear to many patients again.It is situated between
Entering the replacement operation of heart biology valve without being carried out under cardiac arrest and the mode of extracorporal circulatory system, operating time is short, loses blood few,
Damage to patient is smaller, but intervene valve structure in itself result in valve service life it is short, haemodynamics is not opened
The biovalve of chest is good, while intervenes that valve application time is short, and long-term validity also needs further clinical observation, at present only
Suitable for high-risk patient.
CN 101601611A disclose the assembled artificial heart biovalve treatment replaced repeatedly under a kind of Minimally Invasive Surgery
Device, valve frame and leaflet split-type design, are implanted biovalve by open chest surgery, can be passed through after valvular function failure
Minimally Invasive Surgery carries out valve replacement, reduces the difficulty performed the operation again, reduces operation risk.But the solution party of the disclosure of the invention
The tie point of case, valve frame and leaflet is protruded inwardly from the bottom of valve frame, when blood passes through valve, prominent position meeting
Change the state of haemodynamics, while can cause the rupture of haemocyte during haemocyte contact and haemolysis occurs.The vertex of leaflet
With valve frame without effective fixing point, causing leaflet, leaflet shape distortion, accelerates the infringement of leaflet, shadow in long-term operation
Ring its service life.
The content of the invention
In view of this, the technical problem to be solved in the present invention is to provide a kind of repeated by Minimally Invasive Surgery to replace leaflet
Heart biology valve, mainly by the improvement on valve frame and leaflet structure, with the excellent hemodynamic of biovalve
Learn, biocompatibility and service life, at the same have the advantages that again Minimally Invasive Surgery replacement valve wound is small, operating time is short.
To achieve the above object, the present invention provides following technical solution：
It is a kind of that the heart biology valve for replacing leaflet is repeated by Minimally Invasive Surgery, including for the valve frame with tissue apposition
With replaceable leaflet, its mesopetalum frame and leaflet are two independent components, can assemble, dismantle.
Wherein described valve frame includes card slot, seal groove and suture ring.Card slot has three, outstanding, respectively positioned at valve frame
Three vertex, on valve frame in 120 degree be distributed；Seal groove is " u "-shaped, positioned at the outside of valve frame, is connected two-by-two, and outside
Highly it is less than the height of inner side；Suture ring is outstanding, positioned at the outer side bottom surface of valve frame, the suture for being used for and organizing.
The framework material of the valve frame can be one kind of cochrome, stainless steel, Nitinol or macromolecule PEEK.Institute
The material for stating the outer layer covers of valve frame is the preferable woven dacron of biocompatibility.
Wherein described leaflet includes bayonet, valve frame and valve.The bayonet includes activity template, fixinig plate and spring, this
Three component combinations together, apply certain power at one end, can open the other end, and the other end can be realized again after releasing power
Clamp.The valve frame by a nitinol alloy wire by being in three " u "-shapeds after sizing, two free ends by laser welding or
The ring for being joined together to form closing is mechanically fixed, the arc of valve frame is consistent with the arc of seal groove.The fixation of the bayonet
Piece and valve frame are fixed together.The outer layer covers of the valve frame have woven dacron or PTFE material.
The valve can be one kind of bovine pericardium, Pigs Hearts bag, horse pericardium or Pigs Hearts valve, be sewn on valve frame.It is above-mentioned
Material is all the common material of biovalve, has long-term Clinical practice history.
The leaflet is realized by the card slot on valve frame and seal groove and is closely connected with valve frame, while the leaflet can pass through
Bayonet is operated to realize and the separation with valve frame.
When patient is implanted into the heart biology valve by open chest surgery, functional deterioration, which occurs, in leaflet need to replace bioprosthetic valves again
During film, by the conveying device equipped with new valve leaflet under the guiding of DSA equipment, the leaflet to break down can be passed through defeated by Minimally Invasive Surgery
Send the leaflet of device to remove device to remove, while open new valve leaflet, by leaflet on valve frame, complete the replacement of leaflet, and will
Load conveying device after the leaflet compression to break down to withdraw from vitro, complete cardiac valve replacement.
It can be seen from the above technical scheme that the present invention's has the following advantages：
1st, compared with mechanical valve prosthesis, the present invention avoids thrombus caused by anticoagulation improper use without using anticoagulation
Carry out security risk to the health care belt of patient with complication such as bleedings；
2nd, compared with biovalve, the present invention maintains biovalve excellent haemodynamics and service life, at the same time
In view of the minimally invasive permutation function after valve failure, the huge wound that open chest surgery is brought to patient again is avoided, and this hair
Bright offer repeats the design for replacing leaflet by Minimally Invasive Surgery, solves the problems, such as the Long Service Life of biovalve；
3rd, compared with intervening valve, the present invention have Minimally Invasive Surgery without under cardiac arrest and the mode of extracorporal circulatory system into
OK, operating time is short, loses blood less, the less advantage of the damage to patient, while avoids valve after intervention valve implants
The risk of haemodynamics and service life is reduced caused by shape distortion.Intervention valve is only applicable to elderly patient at present, its
Because the reasons such as service life cannot use, the present invention solves the problems, such as the age limit of minimally invasive replacement valve by his patient.
Brief description of the drawings
In order to illustrate more clearly about the embodiment of the present invention or technical scheme of the prior art, below will be to embodiment or existing
There is attached drawing needed in technology description to be briefly described, it should be apparent that, drawings in the following description are only this
Some embodiments of invention, for those of ordinary skill in the art, without creative efforts, can be with
Other attached drawings are obtained according to these attached drawings.
Fig. 1 is heart biology valve schematic diagram of the embodiment of the present invention.
Fig. 2 is heart biology valve assembling schematic diagram of the embodiment of the present invention.
Fig. 3 is heart biology valve valve frame schematic diagram of the embodiment of the present invention.
Fig. 4 is heart biology valve valve frame card slot diagrammatic cross-section of the embodiment of the present invention.
Fig. 5 is heart biology valve valve frame seal groove diagrammatic cross-section of the embodiment of the present invention.
Fig. 6 is heart biology valve leaflets schematic diagram of the embodiment of the present invention.
Fig. 7 is heart biology valve leaflets bayonet schematic diagram of the embodiment of the present invention.
Fig. 8 is the leaflet frame schematic diagram of heart biology valve leaflets of the embodiment of the present invention.
Figure label explanation：
1st, valve frame；2nd, leaflet；3rd, card slot；4th, seal groove；5th, suture ring；6th, bayonet；7th, leaflet frame；8th, valve；9th, it is movable
Piece；10th, fixinig plate；11st, spring.
Embodiment
The invention discloses a kind of heart biology valve that replacement leaflet is repeated by Minimally Invasive Surgery, biovalve is solved
Because service life reason causes to open the risk that chest replaces valve and bring huge wound to patient again after implanting.
Below in conjunction with the attached drawing in the embodiment of the present invention, the technical solution in the embodiment of the present invention is carried out clear, complete
Site preparation describes, it is clear that described embodiment is only part of the embodiment of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, those of ordinary skill in the art are obtained every other without making creative work
Embodiment, belongs to the scope of protection of the invention.
Fig. 1 is heart biology valve schematic diagram of the embodiment of the present invention, including valve frame 1 and leaflet 2, Fig. 2 are present invention implementation
Example heart biology valve assembling schematic diagram, valve frame 1 and leaflet 2 are two independent components, can assemble, dismantle.
Fig. 3 is heart biology valve valve frame schematic diagram of the embodiment of the present invention, and valve frame 1 includes card slot 3, seal groove 4 and suture
Ring 5.Fig. 4 is heart biology valve valve frame card slot diagrammatic cross-section of the embodiment of the present invention, and card slot 3 has three, outstanding, difference
Positioned at three vertex of valve frame, in 120 degree of distributions on valve frame.Fig. 5 seals for heart biology valve valve of embodiment of the present invention frame
Grooved profile schematic diagram.Seal groove 4 is " u "-shaped, positioned at the outside of valve frame 1, is connected two-by-two, and the height in outside is less than the height of inner side
Degree.Suture ring 5 is outstanding, positioned at the outer side bottom surface of valve frame 1, the suture for being used for and organizing.The framework material of valve frame 1 can be
Cochrome, stainless steel, one kind of Nitinol or macromolecule PEEK, the material of outer layer covers are preferably washed for biocompatibility
Synthetic fibre cloth.
Fig. 6 is heart biology valve leaflets schematic diagram of the embodiment of the present invention, and leaflet 2 includes bayonet 6, valve frame 7 and valve
8.Fig. 7 is heart biology valve leaflets bayonet schematic diagram of the embodiment of the present invention, and bayonet 6 includes activity template 9, fixinig plate 10 and spring
11 three parts, these three component combinations together, apply certain power, can open the other end at one end, another after releasing power
One end can realize clamping again.Fig. 8 is the leaflet frame schematic diagram of heart biology valve leaflets of the embodiment of the present invention, and valve frame 7 is by one
By being in three " u "-shapeds after sizing, two free ends are linked together root nitinol alloy wire by laser welding or be mechanically fixed
The ring of closing is formed, the arc of valve frame 7 is consistent with the arc of seal groove 4.The fixinig plate 10 of three bayonets respectively with valve frame 7
Three vertex linked together by laser welding or be mechanically fixed, after one end of bayonet 6 applies certain power, can make
The other end of activity template 9 expands outwardly, and fixinig plate 10 does not have relative motion with respect to leaflet frame 7.The outer layer covers of leaflet frame 7 have
Woven dacron or PTFE material, can improve the blood compatibility of leaflet frame 7, while opposite slip when preventing from suturing with valve 8.
Valve 8 can be one kind of bovine pericardium, Pigs Hearts bag, horse pericardium or Pigs Hearts valve, be sewn on leaflet frame 7.Above-mentioned material is all raw
The common material of thing valve, has long-term Clinical practice history.
When leaflet 2 and valve frame 1 are installed, using leaflet erecting device, by three pawls of leaflet erecting device and leaflet 2 three
One end connection of bayonet 6, while applying certain power makes the other end of bayonet 6 open certain angle, while by the three of leaflet
A bayonet 6 is directed at three card slots 3 of valve frame, depresses leaflet 2 after alignment, the leaflet frame 7 of leaflet 2 is loaded the sealing of valve frame 1
In groove 4, the erecting device of three bayonets 6 is unclamped, bayonet 6 and card slot 3 is realized and is fixed, completes the installation of leaflet 2 and valve frame 1.
Heart biology valve is installed, device is removed, it can be achieved that the separation of valve frame 1 and leaflet 2 using leaflet.Leaflet is moved
Except one end of three bayonets 6 of three pawls and leaflet of device is connected, while applying certain power makes the other end of bayonet 6 open one
Fixed angle, fixed lobes frame 1, leaflet removal device is carried upwards, leaflet 2 is departed from valve frame 1, completes point of leaflet 2 and valve frame 1
From.
The process that implantation to heart biology valve below and Minimally Invasive Surgery replace leaflet is briefly described.
The program for routinely opening chest cardiac valve replacement carries out cardiac arrest and extracorporal circulatory system, by the valve frame and valve of the present invention
Leaflet is installed on valve frame by ring tissue apposition, valve frame after suturing by leaflet erecting device, completes heart biology valve
Implantation.
After patient is implanted into the heart biology valve of the present invention for a period of time, functional deterioration, which occurs, in leaflet need to replace life again
During thing valve, there are a variety of methods to replace leaflet.
Method one, can carry out cardiac arrest and extracorporal circulatory system by the program of conventional Thoracotomy in Management cardiac valve replacement, look at straight
Under, the leaflet of the present invention is removed into device by leaflet and removes the leaflet to break down, and uses leaflet erecting device by new valve leaflet
On valve frame, the replacement of leaflet is completed.Need to remove cardiac valves because the operation eliminates conventional replacement valve, then seam
Close valvular program so that operating time greatly shortens, and reduces amount of bleeding and operating difficulty, makes patient is postoperative can be extensive as early as possible
It is multiple.
Method two, can open a small notch, while puncture the blood of aortic arch by Minimally Invasive Surgery in the chest of patient
Pipe, under visualization device guiding, new valve leaflet is compressed in the conveying device supporting with the operation method, and inverse blood flow enters master
Artery valve site, removes device by the leaflet in conveying device and removes the leaflet to break down, while by conveying device
Leaflet erecting device new valve leaflet is installed on valve frame, complete the replacement of leaflet, and load after the leaflet to break down is compressed defeated
Device is sent to withdraw from the replacement in vitro, completing leaflet.Chest cardiac arrest need to be opened and follow in vitro by saving conventional valve replacement because of the operation
The program of ring, makes patient's bleeding few, and wound is small, it is postoperative can rehabilitation as early as possible.
Method three, can open a small notch, while puncture the portion in the heart of left ventricle by Minimally Invasive Surgery in the chest of patient
Position, under visualization device guiding, new valve leaflet is compressed in the conveying device supporting with the operation method, antegrade blood flow enters master
Artery valve site, removes device by the leaflet in conveying device and removes the leaflet to break down, while by conveying device
Leaflet erecting device new valve leaflet is installed on valve frame, complete the replacement of leaflet, and load after the leaflet to break down is compressed defeated
Device is sent to withdraw from the replacement in vitro, completing leaflet.Chest cardiac arrest need to be opened and follow in vitro by saving conventional valve replacement because of the operation
The program of ring, makes patient's bleeding few, and wound is small, it is postoperative can rehabilitation as early as possible.
Method four, in the thigh root row Femoral artery puncture of patient, can be guided by Minimally Invasive Surgery in visualization device
Under, new valve leaflet is compressed in the conveying device supporting with the operation method, inverse blood flow enters aortic valve site, by defeated
Send leaflet in device to remove device to remove the leaflet to break down, while by the leaflet erecting device in conveying device by new valve
Leaf is installed on valve frame, completes the replacement of leaflet, and is loaded conveying device after the leaflet to break down is compressed and withdrawn from vitro, completes valve
The replacement of leaf.Chest cardiac arrest and the program of extracorporal circulatory system need to be opened by saving conventional valve replacement because of the operation, make patient's bleeding few,
Wound is small, it is postoperative can rehabilitation as early as possible.
What each embodiment stressed is the difference with other embodiment in this specification, each embodiment it
Between identical similar portion mutually referring to.
The foregoing description of the disclosed embodiments, enables professional and technical personnel in the field to realize or use the present invention.
A variety of modifications to these embodiments will be apparent for those skilled in the art, as defined herein
General Principle can be realized in other embodiments without departing from the spirit or scope of the present invention.Therefore, it is of the invention
The embodiments shown herein is not intended to be limited to, and is to fit to and the principles and novel features disclosed herein phase one
The most wide scope caused.
Claims (10)
1. a kind of repeat the heart biology valve for replacing leaflet by Minimally Invasive Surgery, it is characterised in that including being used for and organizing
The valve frame of suture and replaceable leaflet, its mesopetalum frame and leaflet are two independent components, can assemble, dismantle；
The valve frame includes card slot, seal groove and suture ring, and the card slot is located at valve frame vertex, and the seal groove is " u "-shaped, position
In the outside of valve frame, the suture ring is outstanding, positioned at the outer side bottom surface of valve frame, the suture for being used for and organizing；
The leaflet includes bayonet, valve frame and valve, and the bayonet includes activity template, fixinig plate and spring, the bayonet
Fixinig plate and valve frame are fixed together, and apply one in the one end for the bayonet arrangement that the activity template, fixinig plate and spring are formed
Fixed power, can open the other end, and the other end can realize clamping again after releasing power, and the valve frame contains and the seal groove
The "u"-shaped to match, the fixinig plate and valve frame of the bayonet are fixed together, and the valve is sewn on leaflet frame；
Achievable leaflet is engaged with the bayonet in the leaflet, valve frame by the card slot on the valve frame and seal groove respectively
Close with valve frame is connected, while can realize the separation of leaflet and valve frame by operating bayonet；
When patient is implanted into the heart biology valve by open chest surgery, functional deterioration, which occurs, in leaflet need to replace biovalve again
When, by Minimally Invasive Surgery, by the conveying device equipped with new valve leaflet under visualization device guiding, the leaflet to break down is passed through into conveying
The leaflet of device removes device and removes, while opens new valve leaflet, by leaflet on valve frame, completes the replacement of leaflet, and will be bad
Load conveying device after the leaflet compression fallen to withdraw from vitro, complete cardiac valve replacement.
2. the heart biology valve as described in claim 1, it is characterised in that the height on the outside of the seal groove is less than inner side
Height.
3. the heart biology valve as described in claim 1, it is characterised in that the valve is bovine pericardium, Pigs Hearts bag, Ma Xin
One kind of bag or Pigs Hearts valve.
4. the heart biology valve as described in claim 1, it is characterised in that the framework material of the valve frame be cochrome,
One kind in stainless steel, Nitinol or macromolecule PEEK.
5. the heart biology valve as described in claim 1, it is characterised in that the material of the outer layer covers of the valve frame is made a living
The preferable woven dacron of thing compatibility.
6. the heart biology valve as described in claim 1, it is characterised in that the outer layer covers of the valve frame have woven dacron
Or PTFE materials.
7. the heart biology valve as described in claim 1, it is characterised in that the card slot is three, outstanding, respectively
Positioned at three vertex of valve frame, in 120 degree of distributions on valve frame.
8. the heart biology valve as described in claim 1, it is characterised in that the seal groove has three, is connected two-by-two.
9. heart biology valve as claimed in claim 7, it is characterised in that the valve frame is passed through by a nitinol alloy wire
It is in three " u "-shapeds after sizing, two free ends are joined together to form the ring of closing, valve by laser welding or be mechanically fixed
The arc of frame is consistent with the arc of seal groove.
10. the heart biology valve as described in claim 1, it is characterised in that card slot has three, outstanding,
It is located at three vertex of valve frame respectively, is distributed on valve frame in 120 degree, seal groove is " u "-shaped, positioned at the outside of valve frame,
It is connected two-by-two, and the height in outside is less than the height of inner side, valve frame is by a nitinol alloy wire by being in three " U " after sizing
Shape, two free ends are joined together to form the ring of closing, the arc of valve frame and sealing by laser welding or be mechanically fixed
The arc of groove is consistent, and three vertex of the fixinig plates of three bayonets respectively with valve frame by laser welding or are mechanically fixed connection
Together, it after one end of bayonet applies certain power, can expand outwardly the other end of activity template, and fixinig plate is with respect to valve
Leaf frame does not have relative motion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210247085.4A CN103536377B (en) | 2012-07-17 | 2012-07-17 | It is a kind of that the heart biology valve for replacing leaflet is repeated by Minimally Invasive Surgery |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210247085.4A CN103536377B (en) | 2012-07-17 | 2012-07-17 | It is a kind of that the heart biology valve for replacing leaflet is repeated by Minimally Invasive Surgery |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103536377A CN103536377A (en) | 2014-01-29 |
| CN103536377B true CN103536377B (en) | 2018-05-04 |
Family
ID=49960501
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210247085.4A Active CN103536377B (en) | 2012-07-17 | 2012-07-17 | It is a kind of that the heart biology valve for replacing leaflet is repeated by Minimally Invasive Surgery |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103536377B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109431656B (en) * | 2018-12-17 | 2020-10-23 | 山东省千佛山医院 | Aortic valve upper forming and fixing device |
| CN111265332B (en) * | 2020-02-27 | 2022-03-25 | 上海理工大学 | Artificial heart prosthesis valve |
| CN111249036B (en) * | 2020-02-27 | 2022-03-25 | 上海理工大学 | Artificial heart prosthesis valve with movable support |
| CN112773567A (en) * | 2021-02-26 | 2021-05-11 | 复旦大学 | Heart valve test fixture and use method thereof |
| CN115462934B (en) * | 2022-10-08 | 2023-07-14 | 浙江归创医疗科技有限公司 | Detachable venous valve |
| CN117503430A (en) * | 2023-12-12 | 2024-02-06 | 苏州心岭迈德医疗科技有限公司 | Valve prosthesis |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7758640B2 (en) * | 2004-12-16 | 2010-07-20 | Valvexchange Inc. | Cardiovascular valve assembly |
| US7776084B2 (en) * | 2005-07-13 | 2010-08-17 | Edwards Lifesciences Corporation | Prosthetic mitral heart valve having a contoured sewing ring |
| EP2076215A4 (en) * | 2006-10-23 | 2014-07-23 | Valvexchange Inc | Cardiovascular valve and assembly |
| US8092523B2 (en) * | 2007-03-12 | 2012-01-10 | St. Jude Medical, Inc. | Prosthetic heart valves with flexible leaflets |
| CN101601611B (en) * | 2009-04-03 | 2012-02-01 | 中国人民解放军第二军医大学 | Therapeutic device for repeatedly replacing assembled artificial heart biovalve in mini-invasive surgery |
-
2012
- 2012-07-17 CN CN201210247085.4A patent/CN103536377B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN103536377A (en) | 2014-01-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103536377B (en) | It is a kind of that the heart biology valve for replacing leaflet is repeated by Minimally Invasive Surgery | |
| RU2666591C2 (en) | Valve prosthesis installed by catheter and related method | |
| CN107106297B (en) | Heart valve prosthesis | |
| JP5788409B2 (en) | Minimally invasive heart valve | |
| WO2018145365A1 (en) | Device for treatment of valve regurgitation | |
| AU2011312517B2 (en) | Prosthetic heart valve frame with flexible commissures | |
| KR101617052B1 (en) | Stented heart valve devices | |
| CN105658179B (en) | For the device and method of mitral regurgitation method | |
| US8764818B2 (en) | Heart valve replacement | |
| JP2018047242A5 (en) | ||
| KR20120004677A (en) | Using two kinds of tissue heart valve prostheses and manufacturing methods | |
| WO2018131043A1 (en) | Multi-level cardiac implant | |
| CN107920898A (en) | Including the seal member organized the formation of by the extracellular matrix with change through conduit valve prosthesis | |
| EP3668455B1 (en) | Heart valve frame design with non-uniform struts | |
| CA2900655A1 (en) | Rapidly deployable surgical heart valves | |
| JP2005527283A5 (en) | ||
| JP2009509604A (en) | Ascending aortic segment prosthesis and surgical treatment of aortic valve leak | |
| CN111388147A (en) | Artificial heart valve | |
| US10660748B2 (en) | Bioprosthetic tissue for use in a prosthetic valve | |
| RU2664189C1 (en) | Method of prosthetic repair of all structures of the root of aorta | |
| CN214549745U (en) | Valve prosthesis device for implantation in the heart | |
| WO2022173692A1 (en) | Prosthetic valve systems, components, and methods | |
| CN103536376B (en) | It is a kind of that the intervention biovalve for replacing leaflet is repeated by Minimally Invasive Surgery | |
| CN112438826A (en) | Valve prosthesis device for implanting into heart | |
| CN214632504U (en) | Artificial heart valve |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| EXSB | Decision made by sipo to initiate substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |