CN103536352A - Balloon expanding renal artery sympathetic nerve ablation catheter - Google Patents
Balloon expanding renal artery sympathetic nerve ablation catheter Download PDFInfo
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- CN103536352A CN103536352A CN201210234388.2A CN201210234388A CN103536352A CN 103536352 A CN103536352 A CN 103536352A CN 201210234388 A CN201210234388 A CN 201210234388A CN 103536352 A CN103536352 A CN 103536352A
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Abstract
A balloon expanding renal artery sympathetic nerve ablation catheter comprises spiral electrodes, a balloon, an outer catheter and a functional handle, wherein the spiral electrodes are a pair of electrodes in parallel and are fixed on the outer surface of the balloon, the electrodes can be tightly attached to the blood vessel wall after the balloon is full to carry out double-electrode ablation on the sympathetic nerves on the blood vessel, a plurality of temperature sensors are connected below the electrodes, and the temperature of an ablation area can be monitored in the ablation process in real time. Micropores are formed in the balloon, and cool saline filling cooling can be carried out on the blood vessel tissue outside the ablation area in the ablation process to avoid excessive ablation. One end of the outer catheter can be bent freely, and thus operation and control in the blood vessel can be carried out conveniently. The functional handle can control the bending of the outer catheter, the moving of the balloon relative to the outer catheter and is connected with an external ablation device. According to the balloon expanding renal artery sympathetic nerve ablation catheter, the double-electrode ablation is carried out, ablation points are connected in a spiral mode, and all the sympathetic nerves of the renal artery are isolated effectively. Meanwhile, the ablation temperature is controllable, and due to the fact that the contact between the electrodes and the blood is isolated by the balloon, the purpose of ablating the sympathetic nerves of the renal artery can be achieved with low energy.
Description
Technical field
The present invention relates to medical instruments field, be specifically related to a kind of renal artery sympathetic nerve ablation catheter for hypertension interventional therapy.
Background technology
Intractable hypertension, refers to that the Drug therapy (comprising 3 kinds of depressor therapeutic alliances of diuretic) at maximum tolerated dose still cannot reach target pressure value.These patients are High risk groups of major cardiovascular events.
In April, 2009, Krum etc. have reported the new technique of percutaneous catheter kidney sympathetic nerve radiofrequency ablation intractable hypertension.The method is cut off kidney sympathetic nerve by radio-frequency (RF) ablation, and does not affect other abdominal paries, pelvis or lower limb nerve domination, has reached the object of avoiding severe complication in blood pressure lowering.In November, 2010, one relates to perspective, the randomized controlled trial that carry out 24 medical centers, and " Symplicity HTN-2 research " is published in lancet." Symplicity HTN-2 research " result shows, refractory hypertension patient is carried out, through conduit TSD, can obtaining remarkable and lasting efficacy of antihypertensive treatment.106 routine refractory hypertension patients are included in this test altogether in, and test group patient all adheres to carrying out multiple medicines associating antihypertensive therapy after carrying out RSD, and matched group patient only carries out multiple medicines therapeutic alliance.Test group patient's blood pressure in the time of 6th month 32/12mmHg that on average declined, matched group patient blood pressure is all without changing.And complication or the adverse events that operation is relevant do not found in research, and operation in patients metanephros function status is good.
As a new technology, the apparatus matching also relatively lacks, at present for clinical product, also there are problems, the more product of use is the Symplicity ablation system of Medtronic company clinically, because only having an electrode ablation, cause operation more complicated, the problems such as radio-frequency (RF) ablation time length.
CN102274074A discloses a kind of Multi-electrode open-type radio frequency ablation catheter, one end of conduit is Open architecture, what the problem that easy generation can not fit tightly with blood vessel when renal artery goes sympathetic nerve to melt and causing melted failure may, ablation points is discontinuous simultaneously, be prone to the problems such as sympathetic nerve melts not exclusively, and ablation effect is poor.CN201469401U discloses a kind of helical form renal artery sympathetic nerve frequency ablation electrode catheter, and electrode is helical structure, and simplicity of design is difficult to operation, has equally can not fit tightly the problem of blood vessel and cause melting the risk of failure.
Summary of the invention
The object of this invention is to provide a kind of simple to operate, effectively isolate all sympathetic nerve of renal artery, and with less radio-frequency (RF) energy, realize the ablation catheter of the vascular tissue of melting object and the non-zone of ablation of protection.
For achieving the above object, the invention provides a kind of balloon-expandable renal artery sympathetic nerve ablation catheter, comprise screw electrode, sacculus, outer tube and function handle, described screw electrode is parallel a pair of, continuously but not on a circumference and the axis projection annulus that is sealing; Sacculus is non-compliant balloon, and screw electrode is fixed on the outer surface of described sacculus; Described outer tube one end is fixed on the crooked control piece of function handle, and the other end can be realized free bend by crooked control piece; On described function handle, be provided with crooked control piece, sacculus extension and contraction control part, ablation apparatus interface, sacculus interface.
Described screw electrode is flexible conductive wire, and described conductive wire is preferably: copper wire, platinumiridio silk, platinum wire, gold silk, can be folded and expanded and do not affect serviceability by sacculus.
Preferably, under described screw electrode, be connected with a plurality of temperature sensors, by wire, be connected with the ablation apparatus interface of function handle, in ablation procedure, temperature detection by radio-frequency (RF) ablation instrument can Real Time Observation zone of ablation variations in temperature, once discovery temperature anomaly can end to melt, and avoids excessively melting the angiostenosis risk of bringing.
The diameter of described sacculus is 3～10mm, 3～8mm preferably, before melting, by sacculus interface, sacculus is full, the electrode of sacculus outer surface is fully contacted with blood vessel wall, make electrode and blood isolation simultaneously, the ablation energy loss of avoiding blood flow to cause, thereby compare with conventional ablation catheter, available lower ability reaches the same object that melts.
The straight section length of described sacculus is 10～30mm, preferably 15～20mm.
Preferably, have a plurality of micropores on the straight section of described sacculus, these micropores are distributed in the outside of electrode pair, in ablation procedure, by sacculus interface, cold brine perfusion are organized coolingly to ，Dui Fei zone of ablation, non-zone of ablation, protect the tissue of non-zone of ablation.
Described outer tube adopts medical macromolecular materials to make, and is double cavity structure, and a tube chamber is balloon cavity, and another tube chamber is traction fiber chamber.
Preferably, the braiding webmaster that described outer tube diameter is 2～4mm, material is the macromolecular materials such as fluorine class, polyesters, polyurethanes.
Preferably, described outer tube adopts the macromolecular material braiding of different hardness to form, to improve the handling of outer tube.
The balloon cavity of described outer tube makes sacculus turnover cavity by the sacculus extension and contraction control part of function handle.
The pipeline that the traction fiber chamber of described outer tube is traction fiber, described traction fiber one end is fixed on described outer tube one end, and the other end is fixed on the traction fiber fixture of described function handle, can realize the free bend of outer tube one end by the operation of traction fiber fixture.
Balloon-expandable renal artery sympathetic nerve ablation catheter provided by the invention, simple to operate, disposable bipolar ablation, ablation points spiral is continuous, melts temperature controlled, can effectively isolate all sympathetic nerve of renal artery.Meanwhile, because sacculus has completely cut off contacting of electrode and blood, available lower energy reaches and melts the orthosympathetic object of renal artery.
Accompanying drawing explanation
Fig. 1 is the structural representation of balloon-expandable renal artery sympathetic nerve ablation catheter.
Fig. 2 is balloon-expandable renal artery sympathetic nerve ablation catheter use procedure schematic diagram.
The explanation of Reference numeral
1, sacculus; 2, screw electrode; 3, sacculus bar; 4, developing ring; 5, sacculus micropore; 6, outer tube; 7, function handle; 8, crooked control piece; 9, traction fiber fixture; 10, sacculus extension and contraction control part; 11, ablation apparatus interface; 12, thread eye; 13, seal wire outlet; 14, sacculus interface; 15, seal wire; 16, aorta; 17, renal artery; 18, kidney; RS: renal artery sympathetic nerve.
The specific embodiment
Below in conjunction with drawings and Examples, the specific embodiment of the invention is described further, following examples are only for technical scheme of the present invention is more clearly described, and can not limit the scope of the invention with this.
Figure 1 shows that the structural representation of balloon-expandable renal artery sympathetic nerve ablation catheter of the present invention.Described balloon-expandable renal artery sympathetic nerve ablation catheter, comprise screw electrode 2, sacculus 1, outer tube 6 and function handle 7, screw electrode 2 is parallel a pair of, continuously but not on a circumference and the axis projection annulus that is sealing, while melting, be that electrode pair discharges ablation energy, vascular tissue between electrode pair is melted, and because zone of ablation can isolate the sympathetic nerve of renal artery blood vessel continuously completely, the zone of ablation narrow risk in long term can not avoided in zone of ablation on a circumference simultaneously; Sacculus 1 is non-compliant balloon, and screw electrode 2 is fixed on the outer surface of described sacculus 1; Described outer tube 6 one end are fixed on the crooked control piece 8 of function handle 7, and the other end can be realized free bend by crooked control piece 8, can make the sacculus 1 renal artery blood vessel 15 of entering smoothly; On described function handle 7, be provided with crooked control piece 8, sacculus extension and contraction control part 10, ablation apparatus interface 11, sacculus interface 14 etc.
Described screw electrode 2 is flexible conductive wire, can be copper wire, platinumiridio silk, platinum wire, gold silk, can be by sacculus 1 folding and expansion and do not affect serviceability.
Described screw electrode is connected with a plurality of temperature sensors 2 times, by wire, be connected with the ablation apparatus interface 11 of function handle 7, in ablation procedure, temperature detection by radio-frequency (RF) ablation instrument can Real Time Observation zone of ablation variations in temperature, once discovery temperature anomaly can end to melt, and avoids excessively melting the angiostenosis risk of bringing.
The diameter of described sacculus 1 is 3～10mm, 3～8mm preferably, the straight section length of sacculus 1 is 10～30mm, 15～20mm preferably, on sacculus bar 3, be fixed with the developing ring 4 of metal, material can be platinumiridio, gold, rustless steel etc., and described developing ring 4 is corresponding with the straight section two ends of sacculus 1, can observe the position of sacculus in blood vessel by X ray in use.Before melting, by sacculus interface 14, sacculus 1 is full, the electrode 2 of sacculus 1 outer surface is fully contacted with renal artery 17 blood vessel wall, make electrode 2 and blood isolation simultaneously, the ablation energy loss of avoiding blood flow to cause, thereby compare with conventional ablation catheter, available lower ability reaches the same object that melts.On the straight section of described sacculus 1, can there be a plurality of sacculus micropores 5 simultaneously; these micropores 5 are distributed in the outside of electrode 2, in ablation procedure, by sacculus interface 14, cold brine perfusion are arrived to non-zone of ablation; non-zone of ablation is organized cooling, protect the tissue of non-zone of ablation.
Described outer tube 6 adopts medical macromolecular materials to make, and is double cavity structure, and a tube chamber is balloon cavity, and another tube chamber is traction fiber chamber.Described outer tube diameter is the braiding webmaster of 2～4mm, and material is the macromolecular materials such as fluorine class, polyesters, polyurethanes.Described outer tube 6 adopts the macromolecular material braiding of different hardness to form, to improve the handling of outer tube.
The balloon cavity of outer tube 6 makes sacculus 1 turnover cavity by the sacculus extension and contraction control part 10 of function handle 7.The pipeline that the traction fiber chamber of outer tube 6 is traction fiber, described traction fiber one end is fixed on described outer tube one end, and the other end is fixed on the traction fiber fixture 9 of described function handle 7, can realize the free bend of outer tube 1 one end by the operation of traction fiber fixture 9.
Figure 2 shows that the use procedure schematic diagram of balloon-expandable renal artery sympathetic nerve ablation catheter of the present invention.First, by femoral artery, seal wire 15 is entered to renal artery 17 through aorta 16 under X ray guiding, described balloon-expandable renal artery sympathetic nerve ablation catheter is drawn in sacculus 1 in outer tube 6 by sacculus extension and contraction control part 10 in vitro, seal wire 15 penetrates from thread eye, from seal wire outlet 13, pass, ablation catheter enters renal artery 17 entrances of aorta 16 along seal wire, the crooked control piece 8 of manipulation function handle 7, make outer tube 6 one end crooked, aim at renal artery 17 entrances, the sacculus extension and contraction control part 10 of while manipulation function handle 7, make sacculus 1 enter renal artery 17, under X guiding, adjust the position of developing ring 4 in renal artery 17, as position suitable, sacculus 1 is full by sacculus interface 14, make screw electrode fit tightly the blood vessel wall of renal artery 17, adjust the ablation parameter of radiofrequency melting instrument simultaneously, renal artery 17 is melted, Real-Time Monitoring temperature change value in ablation procedure, as occur abnormal, emergent stopping, avoid excessively melting, guarantee safely and effectively arteriorenal sympathetic nerve to be melted.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, do not departing under the early stage of the technology of the present invention principle; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (10)
1. a balloon-expandable renal artery sympathetic nerve ablation catheter, comprises screw electrode, sacculus, outer tube and function handle, it is characterized in that:
Described screw electrode is parallel a pair of, continuously but not on a circumference;
Described sacculus is non-compliant balloon, and screw electrode is fixed on the outer surface of described sacculus;
Described outer tube one end is fixed on the crooked control piece of function handle, and the other end can be realized free bend by crooked control piece;
On described function handle, be provided with crooked control piece, sacculus extension and contraction control part, ablation apparatus interface, sacculus interface.
2. balloon-expandable renal artery sympathetic nerve ablation catheter as claimed in claim 1, its feature is flexible conductive wire at described screw electrode, can be folded and be expanded by sacculus.
3. balloon-expandable renal artery sympathetic nerve ablation catheter as claimed in claim 1, is characterized in that described screw electrode axis projection is for the annulus of sealing.
4. balloon-expandable renal artery sympathetic nerve ablation catheter as claimed in claim 2, is characterized in that being connected with a plurality of temperature sensors under described screw electrode, and described electrode is connected with the ablation apparatus interface of function handle by wire with temperature sensor.
5. balloon-expandable renal artery sympathetic nerve ablation catheter as claimed in claim 1, the diameter that it is characterized in that described sacculus is 3～10mm.
6. balloon-expandable renal artery sympathetic nerve ablation catheter as claimed in claim 1, the straight section length that it is characterized in that described sacculus is 10～30mm.
7. balloon-expandable renal artery sympathetic nerve ablation catheter as claimed in claim 1, is characterized in that there are a plurality of micropores on the straight section of described sacculus.
8. balloon-expandable renal artery sympathetic nerve ablation catheter as claimed in claim 1, is characterized in that described outer tube is double cavity structure, and a tube chamber is balloon cavity, and another tube chamber is traction fiber chamber.
9. balloon-expandable renal artery sympathetic nerve ablation catheter as claimed in claim 8, the balloon cavity that it is characterized in that described outer tube makes sacculus turnover cavity by the sacculus extension and contraction control part of function handle.
10. balloon-expandable renal artery sympathetic nerve ablation catheter as claimed in claim 8, the pipeline that the traction fiber chamber that it is characterized in that described outer tube is traction fiber, described traction fiber one end is fixed on described outer tube one end, and the other end is fixed on the traction fiber fixture of described function handle.
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104739504A (en) * | 2015-02-28 | 2015-07-01 | 上海凯利泰医疗科技股份有限公司 | Radiofrequency ablation device for spinal neoplasms operation |
| CN106725838A (en) * | 2016-02-11 | 2017-05-31 | 上海魅丽纬叶医疗科技有限公司 | Have the conduit and its ablation method of balloon expandable and RF ablation function concurrently |
| CN108882961A (en) * | 2016-04-08 | 2018-11-23 | 百多力公司 | For transmitting energy and/or measuring the device of electrical activity |
| CN110559022A (en) * | 2019-04-30 | 2019-12-13 | 上海科赐医疗技术有限公司 | Medical asymmetric balloon catheter with manipulator |
| CN110575251A (en) * | 2018-06-08 | 2019-12-17 | 赛诺微医疗科技（浙江）有限公司 | Balloon-type flexible microwave ablation catheter and ablation system and method adopting same |
| CN111419387A (en) * | 2020-03-27 | 2020-07-17 | 上海健康医学院 | Method for preparing balloon surface ablation electrode in piezoelectric spraying mode |
| WO2022000178A1 (en) * | 2020-06-29 | 2022-01-06 | 乐普（北京）医疗器械股份有限公司 | Electrode catheter system |
| CN115444541A (en) * | 2022-10-21 | 2022-12-09 | 复旦大学附属中山医院 | Sympathetic nerve ablation catheter and system |
| CN116942292A (en) * | 2023-09-18 | 2023-10-27 | 迈得诺医疗科技集团有限公司 | Ablation catheter, ablation device and ablation method thereof |
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Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104739504B (en) * | 2015-02-28 | 2017-03-22 | 上海凯利泰医疗科技股份有限公司 | Radiofrequency ablation device for spinal neoplasms operation |
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| CN106725838A (en) * | 2016-02-11 | 2017-05-31 | 上海魅丽纬叶医疗科技有限公司 | Have the conduit and its ablation method of balloon expandable and RF ablation function concurrently |
| CN106725838B (en) * | 2016-02-11 | 2024-03-29 | 上海魅丽纬叶医疗科技有限公司 | Catheter with balloon dilation and radio frequency ablation functions and ablation method thereof |
| CN108882961A (en) * | 2016-04-08 | 2018-11-23 | 百多力公司 | For transmitting energy and/or measuring the device of electrical activity |
| CN110575251A (en) * | 2018-06-08 | 2019-12-17 | 赛诺微医疗科技（浙江）有限公司 | Balloon-type flexible microwave ablation catheter and ablation system and method adopting same |
| CN110575251B (en) * | 2018-06-08 | 2022-02-18 | 赛诺微医疗科技（浙江）有限公司 | Balloon-type flexible microwave ablation catheter and ablation system and method adopting same |
| CN110559022B (en) * | 2019-04-30 | 2023-11-24 | 上海科赐医疗技术有限公司 | Medical asymmetric balloon catheter with manipulator |
| CN110559022A (en) * | 2019-04-30 | 2019-12-13 | 上海科赐医疗技术有限公司 | Medical asymmetric balloon catheter with manipulator |
| CN111419387A (en) * | 2020-03-27 | 2020-07-17 | 上海健康医学院 | Method for preparing balloon surface ablation electrode in piezoelectric spraying mode |
| WO2022000178A1 (en) * | 2020-06-29 | 2022-01-06 | 乐普（北京）医疗器械股份有限公司 | Electrode catheter system |
| CN115444541A (en) * | 2022-10-21 | 2022-12-09 | 复旦大学附属中山医院 | Sympathetic nerve ablation catheter and system |
| CN115444541B (en) * | 2022-10-21 | 2024-07-16 | 复旦大学附属中山医院 | Sympatholytic ablation catheter and system |
| CN116942292A (en) * | 2023-09-18 | 2023-10-27 | 迈得诺医疗科技集团有限公司 | Ablation catheter, ablation device and ablation method thereof |
| CN116942292B (en) * | 2023-09-18 | 2024-01-16 | 迈得诺医疗科技集团有限公司 | Ablation catheter, ablation device and ablation method thereof |
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Application publication date: 20140129 |