CN103529412A - Experiment method based on pH value-sensitive magnetization transfer on 1.5T magnetic resonance imaging - Google Patents
Experiment method based on pH value-sensitive magnetization transfer on 1.5T magnetic resonance imaging Download PDFInfo
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Abstract
The invention discloses an experiment method based on pH value-sensitive magnetization transfer on 1.5T magnetic resonance imaging. The method includes the following steps that two groups of pH value test tube models are prepared, and an agarose-creatine model is arranged in each test tube; scanning is carried out on a clinical 1.5T magnetic resonance scanner, the coil adopted by scanning is an eight-channel transmitter/receiver coil, and the offset frequency of a radio-frequency pulse can be set as negative 121Hz, 121Hz and 224Hz by modifying sequential source codes; and at the offset frequency of 224Hz, the high-quality magnetization transfer imaging of the two groups of pH value test tube models can be obtained. By utilizing the magnetization transfer technology, optimizing sequential parameters and choosing offset frequency, the experiment method can obtain pH value-sensitive magnetization transfer imaging on the clinical 1.5T magnetic resonance scanner, provides an experimental basis for the clinical research of pH value-sensitive magnetization transfer imaging, and is significant in characterizing ischemic tissue-damaged regions and directing the treatment of strokes and the diagnosis of tumors.
Description
Technical field
The invention belongs to nuclear magnetic resonance technique field, relate in particular to that a kind of responsive magnetization is delivered in the experimental technique in 1.5T magnetic resonance imaging based on pH value.
Background technology
Magnetization effect phenomenon is common in muscle and brain tissue, its cardinal principle be utilize biasing RF pulse-to-pulse bring saturated large molecule or with hydrogen proton on hydrone that large molecule is combined, these protons can with the hydrogen proton generation chemical exchange of free water, thereby produce magnetization transmission effects, indirectly cause the decline of magnetic resonance water signal intensity;
In recent years, be based upon theoretic chemical exchange saturation transfer (the Chemical Exchange Saturation Transfer of magnetization Transfer Technology and chemical exchange, CEST) technology and amide proton shift (Amide Proton Transfer, APT) technology has become the focus that molecular image research is paid close attention to, , we know, the coindication the earliest of disease is that the potential of hydrogen in body changes, and some chemical exchange, as-OH ,-SH ,-NH
2, the chemical exchange of the hydrogen on amide group etc. and free water molecule is very responsive to the pH value of environment of living in, CEST technology can detect the interaction of these hydrogen protons and free water proton, thereby can assess the pH value of its environment of living in, APT technology is the chemical exchange directly occurring between the hydrogen proton for the amide proton on proteins and peptides and free water, this exchange depends on the potential of hydrogen of environment of living in, Zhou Deng seminar has specialized in the relation of amide group and pH value, this relation is shown by magnetic resonance imaging, they have successfully obtained the APT image that depends on pH value on clinical 3.0T, Preliminary Applications is in the magnetic resonance imaging of animal model and live body brain tissue, but they do not realize APT imaging on the magnetic resonance scanner of clinical 1.5T,
The existing method that realizes CEST imaging needs the presaturation pulse of a rapid lapse of time, adds subsequently fast imaging sequence, and wherein, presaturation pulse can be continuous wave, can be also pulsating wave; And fast imaging sequence can be EPI, GRE etc.,
This formation method has the deficiency of two aspects: 1, the acquisition time of CEST imaging is long; 2, dutycycle (Duty Cycle) is large, thereby causes specific absorption rate to increase, and this is higher to magnetic resonance hardware and software requirement, is difficult to popularize on clinical machine, and this has limited its clinical practice greatly, particularly the CEST imaging to human body.
Summary of the invention
The object of the present invention is to provide that a kind of responsive magnetization is delivered in the experimental technique in 1.5T magnetic resonance imaging based on pH value, the acquisition time that is intended to solve the CEST imaging that existing formation method exists is long, dutycycle is large, cause specific absorption rate to increase, higher to magnetic resonance hardware requirement, greatly limited the problem to the CEST imaging clinical practice of human body.
The present invention is achieved in that a kind of responsive magnetization is delivered in the experimental technique in 1.5T magnetic resonance imaging based on pH value, and experimental technique that should responsive magnetization is delivered in 1.5T magnetic resonance imaging based on pH value comprises the following steps:
The first step, prepares two groups of pH value test-tube models, and each is in vitro furnished with agarose-creatine model;
Second step, in the enterprising line scanning of magnetic resonance scanner of clinical 1.5T, it is 8 passage transmitting/receiving head coils that scanning adopts coil, radio-frequency pulse offset frequency is revised be set to-121Hz of sequence source code, 121Hz and 224Hz;
The 3rd step, transmits radio-frequency pulse offset frequency and has serious artifact when-121Hz and the 121Hz due to magnetization, at offset frequency, is 224Hz place, can obtain the MTI of the good two groups of pH value test-tube models of quality.
Further, in the first step, model production method is as follows: the phosphate buffer of the agarose that is first 3% with deionized water preparation containing massfraction, adopt microwave-oven-heating to forming Ago-Gel, when temperature drops to 46 ℃, add at once creatine, concentration is 50mmol/L, stir, then a part of gel being titrated to pH is 6.51, and minute install to the centrifuge tube of 7 identical 10ml, preservative film sealing, remaining gel is divided and install to 4 centrifuge tubes again, respectively pH value is titrated to 6.01, 6.30, 6.60 and 6.90, finally 7 test tubes are put into the beaker of a 200ml, other 4 test tubes such as are equipped with at the beaker that is put into another one 200ml together with the centrifuge tube of water gaging with 1.
Further, the mensuration of pH value adopts plum Teller-Tuo benefit pH meter.
Further, in second step, before each scanning, all carry out automatic shimming correction, scanning sequence is spin echo-magnetization translation sequence, before conventional spin-echo sequence, apply a presaturation radio-frequency pulse, radio-frequency pulse offset frequency can be by revising be set to-121Hz of sequence source code, 121Hz and 224Hz, the sweep parameter of magnetization Transfer Technology is set to: repetition time 400ms, echo time 9ms, bed thickness is 5mm, interlamellar spacing is 2mm, imaging array is 256 * 192, and visual field FOV is 16 * 16mm
2, the bandwidth of collection is 31.25KHz, acquisition time is 2 minutes and 37 seconds.
Further, saturated radio-frequency pulse is that pulse is transmitted in off resonance magnetization, and the waveform of pulse is Fermi's waveform.
It is provided by the invention that based on pH value, responsive magnetization is delivered in the experimental technique in 1.5T magnetic resonance imaging, by preparing the pH test-tube model of two groups of agarose-creatine gels, adopt amended spin echo-magnetization translation sequence to carry out MTI to this two group model, when offset frequency is 224Hz, the MTI signal intensity approximately equal of identical pH test-tube model, the MTI signal intensity of different pH test-tube models depends on pH value, pH value is higher, magnetic resonance signal intensity is larger, for the application clinically of the responsive MTI of pH value provides important experiment basis, the acquisition time that preferably resolves the CEST imaging that existing formation method exists is long, dutycycle is large, cause specific absorption rate to increase, higher to magnetic resonance hardware requirement, greatly limited the problem to the CEST imaging clinical practice of human body.The present invention is magnetized and is transmitted pulse and can successfully realize CEST imaging in conjunction with gradin-echo by routine, for the conversion universal and clinical practice of CEST imaging provides brand-new technical support.The successful imaging of the method on test-tube model, also utilizes CEST technology to carry out pH quantitative imaging to lay a good foundation for follow-up.In addition, the inventive method is simple, easy to operate, and the responsive MTI of pH value can be applied to the diagnoses and treatment of the diseases such as headstroke, brain tumor clinically.
Accompanying drawing explanation
Fig. 1 is the process flow diagram that the responsive magnetization based on pH value that the embodiment of the present invention provides is delivered in the experimental technique in 1.5T magnetic resonance imaging.
Embodiment
In order to make object of the present invention, technical scheme and advantage clearer, below in conjunction with embodiment, the present invention is further elaborated.Should be appreciated that specific embodiment described herein, only in order to explain the present invention, is not intended to limit the present invention.
The responsive magnetization based on pH value that Fig. 1 shows the embodiment of the present invention to be provided is delivered in the experimental technique flow process in 1.5T magnetic resonance imaging.For convenience of explanation, only show part related to the present invention.
The responsive magnetization based on pH value of the embodiment of the present invention is delivered in the experimental technique in 1.5T magnetic resonance imaging, is somebody's turn to do the experimental technique that responsive magnetization is delivered in 1.5T magnetic resonance imaging based on pH value and comprises the following steps:
The first step, prepares two groups of pH value test-tube models, and each is in vitro furnished with agarose-creatine model;
Second step, in the enterprising line scanning of magnetic resonance scanner of clinical 1.5T, it is 8 passage transmitting/receiving head coils that scanning adopts coil, radio-frequency pulse offset frequency is revised be set to-121Hz of sequence source code, 121Hz and 224Hz;
The 3rd step, transmits radio-frequency pulse offset frequency and has serious artifact when-121Hz and the 121Hz due to magnetization, at offset frequency, is 224Hz place, can obtain the MTI of the good two groups of pH value test-tube models of quality.
A prioritization scheme as the embodiment of the present invention, in the first step, model production method is as follows: the phosphate buffer of the agarose that is first 3% with deionized water preparation containing massfraction, adopt microwave-oven-heating to forming Ago-Gel, when temperature drops to 46 ℃, add at once creatine, concentration is 50mmol/L, stir, then a part of gel being titrated to pH is 6.51, and minute install to the centrifuge tube of 7 identical 10ml, preservative film sealing, remaining gel is divided and install to 4 centrifuge tubes again, respectively pH value is titrated to 6.01, 6.30, 6.60 and 6.90, finally 7 test tubes are put into the beaker of a 200ml, other 4 test tubes such as are equipped with at the beaker that is put into another one 200ml together with the centrifuge tube of water gaging with 1.
As a prioritization scheme of the embodiment of the present invention, the mensuration of pH value adopts plum Teller-Tuo benefit pH meter.
A prioritization scheme as the embodiment of the present invention, in second step, before each scanning, all carry out automatic shimming correction, scanning sequence is spin echo-magnetization translation sequence, before conventional spin-echo sequence, apply a presaturation radio-frequency pulse, radio-frequency pulse offset frequency can be by revising be set to-121Hz of sequence source code, 121Hz and 224Hz, the sweep parameter of magnetization Transfer Technology is set to: repetition time 400ms, echo time 9ms, bed thickness is 5mm, interlamellar spacing is 2mm, imaging array is 256 * 192, and visual field FOV is 16 * 16mm
2, the bandwidth of collection is 31.25KHz, acquisition time is 2 minutes and 37 seconds.
As a prioritization scheme of the embodiment of the present invention, saturated radio-frequency pulse is that pulse is transmitted in off resonance magnetization, and the waveform of pulse is Fermi's waveform.
Below in conjunction with drawings and the specific embodiments, application principle of the present invention is further described.
Do not have as shown in Figure 1 the experimental technique that responsive magnetization is delivered in 1.5T magnetic resonance imaging based on pH value of the embodiment of the present invention to comprise the following steps:
S101: prepare two groups of pH value test-tube models, each is in vitro furnished with agarose (Biowest supply)-creatine (Sigma Aldrich supply) model;
S102: adopting coil is 8 passage transmitting/receiving head coils, in the enterprising line scanning of magnetic resonance scanner (GE Signa HDX1.5T Scanner) of clinical 1.5T;
S103: radio-frequency pulse offset frequency can be by revising be set to-121Hz of sequence source code, 121Hz and 224Hz;
S104: be 224Hz place at offset frequency, can obtain the MTI of the good two groups of pH value test-tube models of quality.
Concrete steps of the present invention are:
The first step, prepare two groups of pH value test-tube models, each is in vitro furnished with agarose (Biowest supply)-creatine (Sigma Aldrich supply) model, model production method is as follows: the phosphate buffer of the agarose that is first 3% with deionized water preparation containing massfraction, adopt microwave-oven-heating to forming Ago-Gel, when temperature drops to 46 ℃, add at once creatine (concentration is 50mmol/L), stir, then a part of gel being titrated to pH is 6.51, and minute install to the centrifuge tube of 7 identical 10ml, preservative film sealing, remaining gel is divided and install to 4 centrifuge tubes again, respectively pH value is titrated to 6.01, 6.30, 6.60 and 6.90, the mensuration of pH value adopts plum Teller-Tuo benefit pH meter, finally 7 test tubes are put into the beaker of a 200ml, other 4 test tubes such as are equipped with at the beaker that is put into another one 200ml together with the centrifuge tube of water gaging with 1,
Second step, the enterprising line scanning of magnetic resonance scanner (GE Signa HDX1.5T Scanner) at clinical 1.5T, what scanning adopted coil is 8 passage transmitting/receiving head coils, before each scanning, all carry out automatic shimming correction, scanning sequence is spin echo-magnetization translation sequence, before conventional spin-echo sequence, apply a presaturation radio-frequency pulse, this pulse is that pulse is transmitted in off resonance magnetization, radio-frequency pulse offset frequency can be by revising be set to-121Hz of sequence source code, 121Hz and 224Hz, the waveform of pulse is Fermi's waveform, other parameter of magnetization Transfer Technology, as the intensity of radio-frequency pulse, duration, flip angles etc. all adopt the default value of clinical magnetic resonance instrument, what sweep parameter adopted is to choose according to the parameter optimization that repeatedly repeats experiment, be respectively: repetition time 400ms, echo time 9ms, bed thickness is that 5mm. interlamellar spacing is 2mm, imaging array is 256 * 192, visual field FOV is 16 * 16mm
2, the bandwidth of collection is 31.25KHz, acquisition time is 2 ' 37 ",
The 3rd step, because magnetization is transmitted radio-frequency pulse offset frequency and is had serious artifact when-121Hz and the 121Hz, cannot be by regulating imaging parameters to obtain significant MTI, and be 224Hz place at offset frequency, can obtain the MTI of the good two groups of pH value test-tube models of quality.
The present invention is described further by experiment:
1, the MTI that the centrifuge tube of 7 identical pH values (6.51) of first group is 224Hz in radio-frequency bias frequency, a test tube is owing to not shaking up and presenting inhomogeneous signal when model is prepared, we carry out the selection of region of interest to other 6 test tubes, then the Survey Software FuncTools carrying with magnetic resonance scanner measures the signal intensity of region of interest, that measures found that, the signal intensity of the MTI of the test tube that these 6 pH values are identical does not almost have any difference, can approximately equal in error range, the identical test-tube model of this explanation pH value, MTI signal intensity is identical,
2, 5 MTIs that centrifuge tube is 224Hz in radio-frequency bias frequency of second group, the parameter of imaging is consistent with the imaging parameters of first group of test tube, test tube e is the centrifuge tube that water gaging is housed etc., as location and purposes relatively, test tube a, b, c, d is agarose-creatine model, its pH value is respectively 6.01, 6.30, 6.60 with 6.90, the 3rd aspect 5 test tube imagings chosen region of interest, with FuncTools, carry out signal strength measurement, test tube a, b, c, the signal intensity of d and e is respectively 211.1 ± 1.9, 225.2 ± 2.0, 251.8 ± 1.5, 255.8 ± 3.1, 350.2 ± 2.2, result shows, at offset frequency, be that the MTI signal intensity at 224Hz place is relevant with pH value, pH value is higher, magnetic resonance signal intensity is larger,
In agarose-creatine jellium model that the present invention adopts, the chemical potential displacement of amido proton is 6.6ppm, the chemical exchange of itself and free water proton depends on the pH value of environment of living in, if use the radio-frequency bias frequency of 1.9ppm, be equivalent to the 121Hz on clinical 1.5T magnetic resonance scanner, just can reach best magnetic saturation transmission effects, the MTI obtaining can reflect the difference of different pH values better, but, in our preliminary experiment, the MTI of offset frequency 1.9ppm is vulnerable to serious artifact and disturbs and make image quality very low, therefore, it is the MTI that 224Hz obtains pH sensitivity that the present invention chooses offset frequency, choosing 224Hz is also the reason for following two aspects, on the one hand, in previous experiments, prepared pH value test-tube model study offset frequency from 200Hz to 400Hz between the MTI of (interval 50Hz), all there is artifact to a certain degree in MTI, and artifact can reduce along with the increase of offset frequency, but also find that the contrast difference between the MTI of test-tube model of different pH values reduces along with the increase of offset frequency simultaneously, on the other hand, according to translating at amide proton in picture, amide proton peak is to depart from water proton peak 3.5ppm, this is equivalent to the 224Hz under 1.5T, so on the magnetic resonance scanner of clinical 1.5T, obtain animal model and biological tissue (brain tumor, apoplexy etc.) MTI, the actual offset frequency arranging should be 224Hz, here it should be noted that, when radio-frequency bias frequency is 224Hz, although there is no the proton at complete saturated 1.9ppm place, but can partly reduce direct water saturation effect and artifact is reduced, so the MTI of offset frequency 224Hz just can slightly highlight the difference of different pH values, if want to obtain maximum contrast difference, must continue thinking deeply and how under the offset frequency of 1.9ppm, reduce as much as possible water saturation effect,
The offset frequency of the present invention's experiment is magnetized and is transmitted saturated sequence source code acquisition by modification, the offset frequency scope of the magnetization translation sequence that 1.5T magnetic resonance scanner carries is 400-1600Hz, and requirement of experiment is the offset frequency below 400Hz, therefore, the modification of source code is necessary, certainly, other imaging parameters of magnetization Transfer Technology, as the pulse strength of sequence, saturated duration and pulse flip angle etc., may also can affect the contrast difference of the MTI of different pH values, in follow-up research, these factors will be considered on the impact of imaging, the modification of source code also can be proceeded, object is to improve signal to noise ratio (S/N ratio) and the contrast of imaging,
The present invention utilizes magnetization Transfer Technology, by the optimization of sequential parameter and choosing of offset frequency, on clinical 1.5T magnetic resonance scanner, obtained the responsive MTI of pH value, the result of experimental study is consistent with the conclusion that the amide proton more than 3.0T translates into as acquisition at present, this provides experimental basis for the research of the responsive MTI of clinical pH value, characterizing ischemic tissue's damage district, instruct the treatment of apoplexy and the diagnosis aspect of tumour all to have great importance.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, all any modifications of doing within the spirit and principles in the present invention, be equal to and replace and improvement etc., within all should being included in protection scope of the present invention.
Claims (5)
1. based on pH value, responsive magnetization is delivered in the experimental technique in 1.5T magnetic resonance imaging, it is characterized in that, is somebody's turn to do the experimental technique that responsive magnetization is delivered in 1.5T magnetic resonance imaging based on pH value and comprises the following steps:
The first step, prepares two groups of pH value test-tube models, and each is in vitro furnished with agarose-creatine model;
Second step, in the enterprising line scanning of magnetic resonance scanner of clinical 1.5T, it is 8 passage transmitting/receiving head coils that scanning adopts coil, radio-frequency pulse offset frequency is revised be set to-121Hz of sequence source code, 121Hz and 224Hz;
The 3rd step, transmits radio-frequency pulse offset frequency and has serious artifact when-121Hz and the 121Hz due to magnetization, at offset frequency, is 224Hz place, can obtain the MTI of the good two groups of pH value test-tube models of quality.
It is 2. as claimed in claim 1 that based on pH value, responsive magnetization is delivered in the experimental technique in 1.5T magnetic resonance imaging, it is characterized in that, in the first step, model production method is as follows: the phosphate buffer of the agarose that is first 3% with deionized water preparation containing massfraction, adopt microwave-oven-heating to forming Ago-Gel, when temperature drops to 46 ℃, add at once creatine, concentration is 50mmol/L, stir, then a part of gel being titrated to pH is 6.51, and minute install to the centrifuge tube of 7 identical 10ml, preservative film sealing, remaining gel is divided and install to 4 centrifuge tubes again, respectively pH value is titrated to 6.01, 6.30, 6.60 and 6.90, finally 7 test tubes are put into the beaker of a 200ml, other 4 test tubes such as are equipped with at the beaker that is put into another one 200ml together with the centrifuge tube of water gaging with 1.
3. as claimed in claim 2 based on pH value, responsive magnetization is delivered in the experimental technique in 1.5T magnetic resonance imaging, it is characterized in that, the mensuration of pH value adopts plum Teller-Tuo benefit pH meter.
It is 4. as claimed in claim 1 that based on pH value, responsive magnetization is delivered in the experimental technique in 1.5T magnetic resonance imaging, it is characterized in that, in second step, before each scanning, all carry out automatic shimming correction, scanning sequence is spin echo-magnetization translation sequence, before conventional spin-echo sequence, apply a presaturation radio-frequency pulse, radio-frequency pulse offset frequency can be by revising be set to-121Hz of sequence source code, 121Hz and 224Hz, the sweep parameter of magnetization Transfer Technology is set to: repetition time 400ms, echo time 9ms, bed thickness is 5mm, interlamellar spacing is 2mm, imaging array is 256 * 192, visual field FOV is 16 * 16mm
2, the bandwidth of collection is 31.25KHz, acquisition time is 2 minutes and 37 seconds.
5. as claimed in claim 4 based on pH value, responsive magnetization is delivered in the experimental technique in 1.5T magnetic resonance imaging, it is characterized in that, saturated radio-frequency pulse is that pulse is transmitted in off resonance magnetization, and the waveform of pulse is Fermi's waveform.
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