CN103529032A - Detection method for measuring content of N-methylmorpholine - Google Patents
Detection method for measuring content of N-methylmorpholine Download PDFInfo
- Publication number
- CN103529032A CN103529032A CN201210233209.3A CN201210233209A CN103529032A CN 103529032 A CN103529032 A CN 103529032A CN 201210233209 A CN201210233209 A CN 201210233209A CN 103529032 A CN103529032 A CN 103529032A
- Authority
- CN
- China
- Prior art keywords
- titration
- methylmorpholine
- content
- perchloric acid
- conical flask
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- SJRJJKPEHAURKC-UHFFFAOYSA-N N-Methylmorpholine Chemical compound CN1CCOCC1 SJRJJKPEHAURKC-UHFFFAOYSA-N 0.000 title claims abstract description 179
- 238000001514 detection method Methods 0.000 title claims abstract description 28
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 claims abstract description 90
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 claims abstract description 88
- 238000004448 titration Methods 0.000 claims abstract description 81
- 239000007788 liquid Substances 0.000 claims abstract description 38
- 239000013078 crystal Substances 0.000 claims abstract description 17
- IWZKICVEHNUQTL-UHFFFAOYSA-M potassium hydrogen phthalate Chemical compound [K+].OC(=O)C1=CC=CC=C1C([O-])=O IWZKICVEHNUQTL-UHFFFAOYSA-M 0.000 claims description 17
- 238000003918 potentiometric titration Methods 0.000 claims description 9
- 239000002904 solvent Substances 0.000 abstract description 8
- 238000000034 method Methods 0.000 abstract description 4
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 28
- 239000000243 solution Substances 0.000 description 17
- 229960000583 acetic acid Drugs 0.000 description 14
- 239000012362 glacial acetic acid Substances 0.000 description 14
- 238000000954 titration curve Methods 0.000 description 4
- 239000013558 reference substance Substances 0.000 description 3
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 125000003368 amide group Chemical group 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
Images
Landscapes
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Abstract
The invention provides a detection method for measuring the content of N-methylmorpholine. The detection method comprises the following steps of quantitatively dissolving the N-methylmorpholine by taking acetic anhydride as a solvent, performing titration by perchloric acid titration liquid by taking crystal violet as an indicating agent, and measuring the content of the N-methylmorpholine by an indicating agent titration method. The method has the advantages of small using amount of samples, simplicity in operation, good repetitiveness and the like.
Description
Technical field
The present invention relates to a kind of detection method of measuring N-methylmorpholine content.
Background technology
N-methylmorpholine is a kind of important organic chemical industry's reagent, in order to control better the quality of N-methylmorpholine, applicant has carried out a large amount of research to the content assaying method of N-methylmorpholine in reagent, and a kind of detection method of measuring N-methylmorpholine content by non-aqueous titration is provided.
The relevant information of N-methylmorpholine described in the present invention is:
Chinese: N-methylmorpholine
Chinese another name: 4-methyl morpholine; N-methylmorpholine; 4-methylmorpholine; 4-methyl morpholine; Isosorbide-5-Nitrae-oxaza heptane; Methyl morpholine.
English name: N-methylmorpholine, is called for short: NMM.
Molecular formula: C5H11NO
Relative molecular mass: 101.15.
Summary of the invention
Technical matters to be solved by this invention is: a kind of detection method of measuring N-methylmorpholine content is provided; Described detection method is quick, accurate, highly sensitive, reproducible.
The detection method of mensuration N-methylmorpholine content of the present invention is such:
Measure a detection method for N-methylmorpholine content, adopt indicator titration method, step is as follows: take N-methylmorpholine sample, put in conical flask, add aceticanhydride and dissolve, add crystal violet indicator solution, to conical flask, dropwise drip perchloric acid titration liquid, limit edged jolting conical flask, observes the variation of color in conical flask, and the color in conical flask becomes green, and colour-fast in 30 seconds, arrive titration end-point, write down now registration, and the result of titration is proofreaied and correct with blank test.
Specifically, the detection method of described mensuration N-methylmorpholine content is: adopt indicator titration method, step is as follows: take N-methylmorpholine sample 0.2g, put in conical flask, adding aceticanhydride 20-50mL dissolves, adding crystal violet indicator solution 1-5 drips, control buret and dropwise drip to conical flask the perchloric acid titration liquid that concentration is 0.01-0.15mol/L, limit edged jolting conical flask, observe the variation of color in conical flask, color in conical flask becomes green, and colour-fast in 30 seconds, arrive titration end-point, write down now registration, and the result of titration is proofreaied and correct with blank test.
The content of N-methylmorpholine is calculated as follows:
Wherein: V
samplefor titration Potassium Hydrogen Phthalate, consume the volume number (ml) of perchloric acid liquid to terminal time; V
emptythe perchloric acid volume number (ml) consuming to terminal time for titration blank; C is the concentration (mol/L) of perchloric acid titration liquid; W is the Potassium Hydrogen Phthalate amount (mg) taking.
The detection method of aforesaid mensuration N-methylmorpholine content, the addition of described aceticanhydride is 30mL.
The detection method of aforesaid mensuration N-methylmorpholine content, the addition of described crystal violet indicator solution is 2.
The detection method of aforesaid mensuration N-methylmorpholine content, the concentration of described perchloric acid titration liquid is 0.1 mol/L.
The detection method of aforesaid mensuration N-methylmorpholine content, described in while taking N-methylmorpholine sample, should be accurate to 0.0001g
The detection method of aforesaid mensuration N-methylmorpholine content, the hop point of titration end-point color during with potentiometric titration is as the criterion.
The present invention is the chemical constitution in view of N-methylmorpholine itself, contains amido structure in its molecule, can react with perchloric acid, can be used for surveying its content.Reaction principle is:
Detection method of the present invention is the preferred plan obtaining through a large amount of shaker tests, and following experimental study is preferred process of the present invention:
experimental example 1.
One, the selection of solvent
Titration curve when investigating respectively mixed solution with glacial acetic acid, glacial acetic acid and aceticanhydride different proportion, aceticanhydride etc. and making solvent, result shows that, while making solvent with aceticanhydride, the scope of titration is large compared with other solvents, therefore selects aceticanhydride to make solvent, sees accompanying drawing 1.Wherein: 1. glacial acetic acid; 2. glacial acetic acid: aceticanhydride (25:5); 3. glacial acetic acid: aceticanhydride (20:10); 4. glacial acetic acid: aceticanhydride (15:15); 5. aceticanhydride.
Two, titration end-point determines
Take N-methylmorpholine sample 0.2g(and be accurate to 0.0001g), add 30ml aceticanhydride it is dissolved, add 2 of crystal violet indicator solutions, according to potentiometric titration, with 0.1mol/L perchloric acid titration liquid, carry out titration, use current potential directing terminal, when result shows terminal, solution is aobvious green.Draw titration curve and titration curve first order derivative figure, in Table 1, accompanying drawing 2 and accompanying drawing 3.
Table 1 potentiometric titration result
| Consume perchloric acid liquid long-pending (ml) | Voltage (mV) | dV(ml) | dE(mV) | dE/dV(mV/ml) |
| 0.000 | 101 | ? | ? | ? |
| 0.250 | 126 | 0.250 | 25 | 100 |
| 1.000 | 168 | 0.750 | 42 | 56 |
| 1.500 | 187 | 0.500 | 19 | 38 |
| 2.000 | 201 | 0.500 | 14 | 28 |
| 2.500 | 213 | 0.500 | 12 | 24 |
| 3.000 | 222 | 0.500 | 9 | 18 |
| 3.500 | 231 | 0.500 | 9 | 18 |
| 4.000 | 239 | 0.500 | 8 | 16 |
| 4.500 | 247 | 0.500 | 8 | 16 |
| 5.000 | 253 | 0.500 | 6 | 12 |
| 5.500 | 259 | 0.500 | 6 | 12 |
| 6.000 | 265 | 0.500 | 6 | 12 |
| 6.500 | 270 | 0.500 | 5 | 10 |
| 7.000 | 275 | 0.500 | 5 | 10 |
| 7.525 | 279 | 0.525 | 4 | 8 |
| 8.000 | 283 | 0.475 | 4 | 8 |
| 8.500 | 287 | 0.500 | 4 | 8 |
| 9.000 | 291 | 0.500 | 4 | 8 |
| 9.500 | 296 | 0.500 | 5 | 10 |
| 10.000 | 300 | 0.500 | 4 | 8 |
| 10.500 | 303 | 0.500 | 3 | 6 |
| 11.000 | 307 | 0.500 | 4 | 8 |
| 11.500 | 311 | 0.500 | 4 | 8 |
| 12.000 | 315 | 0.500 | 4 | 8 |
| 12.500 | 319 | 0.500 | 4 | 8 |
| 13.000 | 323 | 0.500 | 4 | 8 |
| 13.500 | 327 | 0.500 | 4 | 8 |
| 14.000 | 332 | 0.500 | 5 | 10 |
| 14.500 | 336 | 0.500 | 4 | 8 |
| 15.000 | 341 | 0.500 | 5 | 10 |
| 15.500 | 345 | 0.500 | 4 | 8 |
| 16.000 | 350 | 0.500 | 5 | 10 |
| 16.500 | 356 | 0.500 | 6 | 12 |
| 17.000 | 363 | 0.500 | 7 | 14 |
| 17.100 | 364 | 0.100 | 1 | 10 |
| 17.200 | 365 | 0.100 | 1 | 10 |
| 17.300 | 367 | 0.100 | 2 | 20 |
| 17.400 | 368 | 0.100 | 1 | 10 |
| 17.500 | 370 | 0.100 | 2 | 20 |
| 17.600 | 372 | 0.100 | 2 | 20 |
| 17.700 | 373 | 0.100 | 1 | 10 |
| 17.800 | 376 | 0.100 | 3 | 30 |
| 17.900 | 378 | 0.100 | 2 | 20 |
| 18.000 | 380 | 0.100 | 2 | 20 |
| 18.100 | 382 | 0.100 | 2 | 20 |
| 18.200 | 385 | 0.100 | 3 | 30 |
| 18.300 | 387 | 0.100 | 2 | 20 |
| 18.400 | 390 | 0.100 | 3 | 30 |
| 18.500 | 393 | 0.100 | 3 | 30 |
| 18.600 | 397 | 0.100 | 4 | 40 |
| 18.700 | 402 | 0.100 | 5 | 50 |
| 18.800 | 406 | 0.100 | 4 | 40 |
| 18.900 | 413 | 0.100 | 7 | 70 |
| 19.000 | 421 | 0.100 | 8 | 80 |
| 19.050 | 428 | 0.050 | 7 | 140 |
| 19.100 | 435 | 0.050 | 7 | 140 |
| 19.150 | 440 | 0.050 | 5 | 100 |
| 19.200 | 461 | 0.050 | 21 | 420 |
| 19.250 | 501 | 0.050 | 40 | 800 |
| 19.275 | 551 | 0.025 | 50 | 2000 |
| 19.300 | 667 | 0.025 | 116 | 4640 |
| 19.313 | 682 | 0.012 | 15 | 1200 |
| 19.325 | 696 | 0.012 | 14 | 1120 |
| 19.338 | 704 | 0.013 | 8 | 640 |
| 19.350 | 711 | 0.012 | 7 | 560 |
| 19.363 | 715 | 0.012 | 4 | 320 |
| 19.375 | 720 | 0.012 | 5 | 400 |
| 19.388 | 724 | 0.012 | 4 | 320 |
| 19.400 | 727 | 0.013 | 3 | 240 |
| 19.450 | 738 | 0.150 | 71 | 473 |
| 19.500 | 744 | 0.050 | 6 | 120 |
| 19.550 | 751 | 0.050 | 7 | 140 |
| 19.600 | 755 | 0.050 | 4 | 80 |
| 19.650 | 761 | 0.050 | 6 | 120 |
| 19.700 | 764 | 0.050 | 3 | 60 |
| 19.800 | 770 | 0.100 | 6 | 60 |
| 19.900 | 774 | 0.100 | 4 | 40 |
| 20.000 | 777 | 0.100 | 3 | 30 |
Three, the preparation of 0.1mol/L perchloric acid titration liquid: get anhydrous glacial acetic acid and (calculate by water cut, every 1g water adds aceticanhydride 5.22ml) 750ml, add perchloric acid (70%～72%) 8.5ml, shake up, at room temperature slowly drip aceticanhydride 24ml, limit edged shakes, and after adding, jolting is even again, lets cool, add anhydrous glacial acetic acid and make in right amount 1000ml, shake up, place 24 hours, standby.
Four, the demarcation of perchloric acid titration liquid: be taken at 105 ℃ of about 0.16g of benchmark Potassium Hydrogen Phthalate that are dried to constant weight, accurately weighed, adding anhydrous glacial acetic acid 20ml makes to dissolve, add 1 of crystal violet indicator solution (5g/L), with this liquid, be slowly titrated to blueness, and the result of titration is proofreaied and correct with blank test.The perchloric acid titration liquid (0.1mol/L) of every 1ml is equivalent to the Potassium Hydrogen Phthalate of 20.42mg.According to the amount of taking of the consumption of this liquid and Potassium Hydrogen Phthalate, calculate the concentration of this liquid, obtain.
Wherein: V
samplefor titration Potassium Hydrogen Phthalate, consume the volume number (ml) of perchloric acid liquid to terminal time; V
emptythe perchloric acid volume number (ml) consuming to terminal time for titration blank; C is the concentration (mol/L) of perchloric acid titration liquid; W is the Potassium Hydrogen Phthalate amount (mg) taking.
Because the expansion coefficient of glacial acetic acid is larger, so if when titration sample and the temperature difference while demarcating perchloric acid titration liquid surpass 10 ℃, re-start demarcation, if while not surpassing 10 ℃, reply temperature causes that the change of volume proofreaies and correct.
Five, sample replica test
Take N-methylmorpholine sample (lot number 090420) 0.2g(and be accurate to 0.0001g), adding aceticanhydride 30mL dissolves, add 2 of crystal violet indicator solutions, with perchloric acid titration liquid (0.1 mol/L), be titrated to solution aobvious green, and the result of titration is proofreaied and correct with blank test.With 6 parts, this law replicate determination sample, the results are shown in Table 2.
Table 2 sample replica test result
Six, reference substance replica test
Take N-methylmorpholine reference substance 0.2g(and be accurate to 0.0001g), add aceticanhydride 30mL and dissolve, add 2 of crystal violet indicator solutions, with perchloric acid titration liquid (0.1 mol/L), be titrated to solution aobvious green, and the result of titration is proofreaied and correct with blank test.With 6 parts, this law replicate determination sample, the results are shown in Table 3.
Table 3 reference substance replica test result
Seven, sample size is measured
Take respectively N-methylmorpholine sample 0.2g(and be accurate to 0.0001g), add aceticanhydride 30mL and dissolve, add 2 of crystal violet indicator solutions, with perchloric acid titration liquid (0.1 mol/L), be titrated to solution aobvious green, and the result of titration is proofreaied and correct with blank test.3 parts of every batch sample replicate determinations, the results are shown in Table 4.
Table 4 sample size measurement result
Eight, middle precision test
Take N-methylmorpholine sample (lot number: 090420) 0.2g(is accurate to 0.0001g), adding aceticanhydride 30mL dissolves, add 2 of crystal violet indicator solutions, with perchloric acid titration liquid (0.1 mol/L), be titrated to solution aobvious green, and the result of titration is proofreaied and correct with blank test.The results are shown in Table 5.
Precision test result in the middle of table 5
Beneficial effect of the present invention is: the present invention be take aceticanhydride as solvent, quantitatively dissolve N-methylmorpholine, take crystal violet as indicator, with perchloric acid titration liquid, carry out titration, adopt indicator titration method to measure the content of N-methylmorpholine, the results show, described detection method is quick, accurate, highly sensitive, reproducible, can effectively control the quality of N-methylmorpholine, and the method amount of samples is little, simple to operate.Reached goal of the invention.
accompanying drawing explanation:
Fig. 1 is the titration curve figure that solvent is selected; Wherein: 1. glacial acetic acid; 2. glacial acetic acid: aceticanhydride (25:5); 3. glacial acetic acid: aceticanhydride (20:10); 4. glacial acetic acid: aceticanhydride (15:15); 5. aceticanhydride;
Fig. 2 is potentiometric titration curve figure;
Fig. 3 is a differential curve figure of potentiometric titration curve.
Embodiment
Embodiment 1.
The detection method of described mensuration N-methylmorpholine content is: adopt indicator titration method, step is as follows: take N-methylmorpholine sample 0.2g(and be accurate to 0.0001g), put in conical flask, adding aceticanhydride 30mL dissolves, add 2 of crystal violet indicator solutions, control buret and dropwise drip to conical flask the perchloric acid titration liquid that concentration is 0.1mol/L, limit edged jolting conical flask, observe the variation of color in conical flask, color in conical flask becomes green, and colour-fast in 30 seconds, arrive titration end-point, the hop point of titration end-point color during with potentiometric titration is as the criterion, write down now registration, and the result of titration is proofreaied and correct with blank test, the content of N-methylmorpholine is calculated as follows:
Wherein: V
samplefor titration Potassium Hydrogen Phthalate, consume the volume number (ml) of perchloric acid liquid to terminal time; V
emptythe perchloric acid volume number (ml) consuming to terminal time for titration blank; C is the concentration (mol/L) of perchloric acid titration liquid; W is the Potassium Hydrogen Phthalate amount (mg) taking.
The detection method of described mensuration N-methylmorpholine content is: adopt indicator titration method, step is as follows: take N-methylmorpholine sample 0.2g(and be accurate to 0.0001g), put in conical flask, adding aceticanhydride 50mL dissolves, add 5 of crystal violet indicator solutions, control buret and dropwise drip to conical flask the perchloric acid titration liquid that concentration is 0.15mol/L, limit edged jolting conical flask, observe the variation of color in conical flask, color in conical flask becomes green, and colour-fast in 30 seconds, arrive titration end-point, the hop point of titration end-point color during with potentiometric titration is as the criterion, write down now registration, and the result of titration is proofreaied and correct with blank test, the content of N-methylmorpholine is calculated as follows:
Wherein: V
samplefor titration Potassium Hydrogen Phthalate, consume the volume number (ml) of perchloric acid liquid to terminal time; V
emptythe perchloric acid volume number (ml) consuming to terminal time for titration blank; C is the concentration (mol/L) of perchloric acid titration liquid; W is the Potassium Hydrogen Phthalate amount (mg) taking.
Embodiment 3.
The detection method of described mensuration N-methylmorpholine content is: adopt indicator titration method, step is as follows: take N-methylmorpholine sample 0.2g(and be accurate to 0.0001g), put in conical flask, adding aceticanhydride 20mL dissolves, add 1 of crystal violet indicator solution, control buret and dropwise drip to conical flask the perchloric acid titration liquid that concentration is 0.01mol/L, limit edged jolting conical flask, observe the variation of color in conical flask, color in conical flask becomes green, and colour-fast in 30 seconds, arrive titration end-point, the hop point of titration end-point color during with potentiometric titration is as the criterion, write down now registration, and the result of titration is proofreaied and correct with blank test, the content of N-methylmorpholine is calculated as follows:
Wherein: V
samplefor titration Potassium Hydrogen Phthalate, consume the volume number (ml) of perchloric acid liquid to terminal time; V
emptythe perchloric acid volume number (ml) consuming to terminal time for titration blank; C is the concentration (mol/L) of perchloric acid titration liquid; W is the Potassium Hydrogen Phthalate amount (mg) taking.
Claims (7)
1. a detection method of measuring N-methylmorpholine content, is characterized in that: adopt indicator titration method, step is as follows: take N-methylmorpholine sample, put in conical flask, add aceticanhydride and dissolve, add crystal violet indicator solution, to conical flask, dropwise drip perchloric acid titration liquid, limit edged jolting conical flask, observes the variation of color in conical flask, and the color in conical flask becomes green, and colour-fast in 30 seconds, arrive titration end-point, write down now registration, and the result of titration is tested to correction by blank; Then be calculated as follows the content of N-methylmorpholine content:
Wherein: V
samplethe volume that consumes perchloric acid liquid to terminal time for titration Potassium Hydrogen Phthalate is counted ml; V
emptythe perchloric acid volume consuming to terminal time for titration blank is counted ml; C is the concentration mol/L of perchloric acid titration liquid; W is the Potassium Hydrogen Phthalate amount mg taking.
2. measure as claimed in claim 1 the detection method of N-methylmorpholine content, it is characterized in that: adopt indicator titration method, step is as follows: take N-methylmorpholine sample 0.2g, put in conical flask, adding aceticanhydride 20-50mL dissolves, adding crystal violet indicator solution 1-5 drips, control buret and dropwise drip to conical flask the perchloric acid titration liquid that concentration is 0.01-0.15mol/L, limit edged jolting conical flask, observe the variation of color in conical flask, color in conical flask becomes green, and colour-fast in 30 seconds, arrive titration end-point, write down now registration, and the result of titration is proofreaied and correct with blank test, then be calculated as follows the content of N-methylmorpholine content:
Wherein: V
samplethe volume that consumes perchloric acid liquid to terminal time for titration Potassium Hydrogen Phthalate is counted ml; V
emptythe perchloric acid volume consuming to terminal time for titration blank is counted ml; C is the concentration mol/L of perchloric acid titration liquid; W is the Potassium Hydrogen Phthalate amount mg taking.
3. measure as claimed in claim 2 the detection method of N-methylmorpholine content, it is characterized in that: the addition of described aceticanhydride is 30mL.
4. measure as claimed in claim 2 the detection method of N-methylmorpholine content, it is characterized in that: the addition of described crystal violet indicator solution is 2.
5. measure as claimed in claim 2 the detection method of N-methylmorpholine content, it is characterized in that: the concentration of described perchloric acid titration liquid is 0.1 mol/L.
6. measure as claimed in claim 1 or 2 the detection method of N-methylmorpholine content, it is characterized in that: described in while taking N-methylmorpholine sample, should be accurate to 0.0001g.
7. measure as claimed in claim 1 or 2 the detection method of N-methylmorpholine content, it is characterized in that: the hop point of titration end-point color during with potentiometric titration is as the criterion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210233209.3A CN103529032A (en) | 2012-07-06 | 2012-07-06 | Detection method for measuring content of N-methylmorpholine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210233209.3A CN103529032A (en) | 2012-07-06 | 2012-07-06 | Detection method for measuring content of N-methylmorpholine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103529032A true CN103529032A (en) | 2014-01-22 |
Family
ID=49931219
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210233209.3A Pending CN103529032A (en) | 2012-07-06 | 2012-07-06 | Detection method for measuring content of N-methylmorpholine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103529032A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114152605A (en) * | 2021-11-23 | 2022-03-08 | 镇江威特药业有限责任公司 | Method for detecting content of amino acid in feed |
-
2012
- 2012-07-06 CN CN201210233209.3A patent/CN103529032A/en active Pending
Non-Patent Citations (2)
| Title |
|---|
| JAMES E. RUCH ET AL: "Determination of SmaH Amounts of Tertiary Amines in the Presence of Primary and Secondary Amines", 《ANALYTICAL CHEMISTRY》 * |
| 杨速兵等: "非水滴定法测定叔胺和季胺盐含量", 《广东化工》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114152605A (en) * | 2021-11-23 | 2022-03-08 | 镇江威特药业有限责任公司 | Method for detecting content of amino acid in feed |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Maccà | Response time of ion-selective electrodes: Current usage versus IUPAC recommendations | |
| CN102095716B (en) | Method for detecting DEHP (Di 2-Ethyl Hexyl Phthalate) by using laser Raman spectrum | |
| CN106153498A (en) | A kind of new method detecting solute concentration in solution and device thereof | |
| CN103424443B (en) | A kind of ion selecting electrode determining method of Oil repellent in grain, Vegetables and fruits | |
| CN109030538A (en) | A kind of method of nuclear magnetic resonance hydrogen spectruming determining nitroglycerine moisture content | |
| CN105806915B (en) | A kind of nutrient solution potassium, Na ion concentration detector and detection method | |
| CN110031557A (en) | The detection method of 5- isoquinolin methylmesylate, 5- isoquinolin sulfonic acid in a kind of Fasudic hydrochloride | |
| CN102654476A (en) | Lead-ion-selective electrode with self-repairing function and preparation method thereof | |
| CN106324185A (en) | Measuring method for acid value of unsaturated polyester resin emulsion | |
| KR20130076700A (en) | Method for measuring hf content in lithium secondary battery electrolyte and analytical reagent composition used in the same | |
| CN110161133A (en) | A kind of method that external standard method tests and analyzes component in lithium ion function electrolyte | |
| CN104849335A (en) | Method for detecting ionic calcium content of blood sample | |
| CN103529032A (en) | Detection method for measuring content of N-methylmorpholine | |
| CN105319303A (en) | Determination method of content of fusel in ethylene carbonate | |
| CN107991403B (en) | The analysis method of genotoxicity impurity 6,8- dicloro caprylate ethyl ester in a kind of lipoic acid | |
| CN105842437A (en) | Kit for detecting D-3-hydroxybutyric acid and preparation method of kit | |
| CN109030537A (en) | A kind of method of nuclear magnetic resonance hydrogen spectruming determining butanetriol trinitrate and nitroglycerine naked nitric acid ester moisture content | |
| CN102901765A (en) | Potentiometric titration method for measuring content of Hg<2+> in solution | |
| CN107449772A (en) | Pregnant solution type lead acid accumulator electrolyte method for detecting impurities | |
| KR20180044040A (en) | Ion sensors for sensing multiple ions in blood | |
| CN102901764A (en) | Method for testing trace moisture in dimethyl sulfoxide | |
| CN107621497A (en) | A kind of analysis method for detecting mosquito repellent ester content | |
| CN109030540A (en) | A kind of method of nuclear magnetic resonance hydrogen spectruming determining diethylent glycol dinitrate and nitroglycerine naked nitric acid ester moisture content | |
| CN109030535A (en) | A kind of method of nuclear magnetic resonance hydrogen spectruming determining diethylent glycol dinitrate moisture content | |
| CN109030536A (en) | A kind of method of nuclear magnetic resonance hydrogen spectruming determining triethylene glycol dinitrate and nitroglycerine naked nitric acid ester moisture content |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20140122 |
|
| RJ01 | Rejection of invention patent application after publication |