CN103517671B - Method and the device be associated of confirmed standardization illumination - Google Patents
Method and the device be associated of confirmed standardization illumination Download PDFInfo
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- CN103517671B CN103517671B CN201280018843.3A CN201280018843A CN103517671B CN 103517671 B CN103517671 B CN 103517671B CN 201280018843 A CN201280018843 A CN 201280018843A CN 103517671 B CN103517671 B CN 103517671B
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- skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
- A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0077—Devices for viewing the surface of the body, e.g. camera, magnifying lens
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medical Informatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Circuit Arrangement For Electric Light Sources In General (AREA)
Abstract
A kind of optimization illumination determining region human skin is to allow the method for its apparent condition of research, this skin area has raised areas, this illumination carrys out the device of self-contained one or more light source and produce shadow region near raised areas, the method comprises the following steps: to limit the first parameter P1 according to the contrast between the luminosity of inside, shadow region and the luminosity of outside, shadow region, uniformity according to luminosity limits the second parameter P2, cost function C is limited according to the first parameter P1 and/or the second parameter P2, find the maximum of cost function C.
Description
The present invention relates to and make it possible on skin area, provide high-quality and standardized illumination to allow the device of its apparent condition of research." high-quality illumination " refers to and allows to obtain the spatially uniform on the area-of-interest limited for the research in colorimetric simultaneously, and the illumination of the alignment features of the projection of permission display skin histology.
In beauty treatment and medical domain, the inspection of skin surface state is the key step that dennatological clinical checks.Among the different characteristic on this surface, the most information about its state is its projection, its color and its reflection.The display of these features will depend on used illumination.
Importantly can realize the interior observation of body of the type so that better close to the real conditions of live body.
FR2589242 describes the system showing skin projection based on impression.But this system is intended to the research of inert samples and does not allow to study in vivo the state of skin surface.
FR2826857 describes general skin illuminator.But the measurement of the protrusion features of skin histology is not the target of proposed device and does not clearly mention this measurement to the display of this feature at all.
Good illumination uniformity on area-of-interest is absolutely necessary for avoiding effect appraise.Two extreme lighting conditions can be considered.Isotropic illumination such as can provide the excellent homogeneity on the region of interest allowing correctly evaluate color, but can wipe projection by eliminating projection, thus causes the evaluation of this rear parameter to become impossible.Effective ways for manifesting projection comprise generation projection.The illumination of skimming over can maximize by making projection and therefore set off this projection by contrast, but can provide medium uniformity on studied region, thus causes the evaluation of color to become difficulty.It is suitable that produce the illumination of simultaneously combining these two features.
In addition, the reflectance signature of the tissue it is suitable that observed by consideration.Preferably avoid the visible direct reflection of light source to avoid interference evaluation.
Many skin areas can have benefited from the inspection with the type illumination.Can mention, exhaustive ground, the region of forearm, arm, buccal, lower limb, eyelet and eye pouch, the profile of eyes.From general angle, in some cases, any region of health can have the benefit with the illumination of such type observed (any dyskeratotic observation).
In order to contribute to observing, illuminator is placed on skin histology.Illumination constraint described above needed for optimal viewing is added to the constraint of the physical features about device, the size of device and weight should be low as much as possible not apply any impact to the state of skin histology.It is also important that dimension aspect is laid on whole human regions for the described device of permission.
The object of the invention is in conjunction with above-described all conditions, to be provided for studying the colorimetric aspect of the skin area on whole human body and the optimal illumination of projection.
According to the present invention, a kind of optimization illumination determining region human skin is to allow the method for its apparent condition of research, this skin area has raised areas, this illumination carrys out the device of self-contained one or more light source and produce shadow region near raised areas, it is characterized in that comprising the following steps:
-limit the first parameter P1 according to the contrast between the luminosity of inside, shadow region and the luminosity of outside, shadow region,
-limit the second parameter P2 according to the uniformity of luminosity,
-limit cost function C according to the first parameter P1 and/or the second parameter P2,
The maximum of-searching cost function C.
Described cost function can be restricted to the form of C=a*P1+b*P2, and wherein a and b is real number.
The maximum finding cost function C can comprise the step of the change wherein studying C according to the change of at least one following parameters: the type of light source, light source relative to the height (h) of skin, light source relative to the distance (e) of skin and each light source light angle (α) relative to considered skin area.
The present invention has also inquired into the device of illumination region human skin, and it has at least one following features that method according to the present invention is determined: light source relative to the height (h) of skin, light source relative to the distance (e) of skin and each light source light angle (α) relative to considered skin area.
Advantageously, at least one light source is point-like.
This device can comprise a window for observing.
This device can comprise the camera chain being fixed to its structure.
This device can be connected to and record and the system sent to remote subscriber photography.
This device can comprise makes the minimized plate leaned against on skin of the impact of this device on measured zone.
This plate can comprise allow this device around be fixed to skin outer member automatic centring to central module.
This device can comprise can the projection parts of light of emitting structural.
This device can comprise the measurement component measuring reflected light.
This device can comprise the optical character projection parts of auxiliary reorientation.
This device can comprise the sensor of the one or more physical attributes measuring skin.
Other features and advantages of the present invention become clear by the description below with reference to carry out preferred of accompanying drawing but without any the embodiment of limited features.In these figures:
Fig. 1 is perspective diagram, and the parts of skin according to the illuminated plane P of method of the present invention is shown,
Fig. 2 is the schematic diagram of the example of the light intensity distributions that point source is shown,
Fig. 3 is the schematic diagram that the example of linear block by having 3 point sources illustrates the enforcement according to method of the present invention,
Fig. 4 illustrates photodistributed schematic diagram, and described Light distribation produces the combination from 3 light sources changed with its spacing,
Fig. 5 is the cross section of the Fig. 4 for d=0,
Fig. 6 be for close to 40 the cross section of Fig. 4 of d,
Fig. 7 is the cross section of the Fig. 4 for d=100,
Fig. 8 is the view similar to Fig. 3 when having the special embodiment of 2 modules with 2 point sources,
Fig. 9 a with 9b illustrates the photodistributed schematic diagram obtained for 2 groups of different geometric parameters,
Figure 10 illustrates the schematic diagram by device display projection according to the present invention,
Figure 11 a and 11b illustrates contrast in order to show for 2 groups of different parameters and the schematic diagram of the example of the light stream obtained,
Figure 12 and 13 is the perspective views according to device of the present invention,
Figure 14 is the perspective view of the camera chain illustrated on the shell of the device being fixed on Figure 12 and 13,
Figure 15 is the view similar to Figure 14, illustrates the camera chain independent of shell,
Figure 16 has the view similar to Figure 12 throwing off part, illustrates the existence of area-of-interest edge high scale chi,
Figure 17 is the view similar to Figure 16, illustrates the existence of the color scale of fixing around area-of-interest,
Figure 18 is the view similar to Figure 16, illustrates the existence of the rotation disc of the color scale had for being carried out colorimetric evaluation by observer,
Figure 19 is the top view of the device of Figure 12, illustrates the existence of the amplifying device of area-of-interest,
Figure 20 is the view similar to Figure 12 with less ratio, illustrates the existence of reorientation auxiliary projection module, and
Figure 21 is in the perspective view according to device of the present invention when using reorientation accessory external module.
Consider that the plane of the skin histology studied can be positioned on datum plane P, feature of the present invention (comparison diagram 1) will be described based on this datum plane P.Area-of-interest can be any shape.In the embodiment provided in the publication, consider the rectangular region (comparison diagram 1) centered around an O.
Light is provided by one or more module.Each module by multiple can be point-like, light source that is linear or plane forms.These light sources can be incandescent lamp bulb, neon bulb, LED bulb or discharge bulb.The shape of module can be linear, circular, plane or any shape.
In this manual, consider that module is made up of point source.The enforcement of constraint described above is Light distribation by considering each light source and by determining that for area-of-interest the optimal geometrical parameter be oppositely arranged between light source and between the modules carries out.
The photodistributed example of light source shows on Fig. 2.The single light source of the type is used will obviously to produce uneven illumination.If the combination of Different Light its incorrect words are set also may provide light source heterogeneous.The present invention uses such light source: its interval, relative to study the height on surface and not only allowed uniform illumination relative to the light angle of studied normal to a surface but also allowed the display of projection.
In a special embodiment, light source is white.Not restrictive by the type of wavelength used in the present invention and can from ultra-violet (UV) band to ultrared.
In order to meet condition described above, first have studied the distribution of the combination of the Different Light produced in module.By the hypothesis based on 3 light sources, Fig. 3 shows an embodiment, these 3 light sources by position with on the parallel plane same straight line studied, there is the interval between each light source being labeled as d as represented in fig. 3, and each light source has the distribution of Gauss's luminosity, and the direction of its maximum intensity is schematically illustrated by dotted arrows.The illumination direction of each light source is supposition, is parallel in the present embodiment.This reasoning can be applied to the Light distribation of the whatsoever type of the illumination direction with any direction.Observe and throw light on the synthesis be labeled as on the straight line of L arranging line parallel of light source on Fig. 3.
Fig. 4 to 7 illustrates this synthesis illumination.Visible for little interval, the combination of 3 light sources produces the illumination of gaussian shape.The interval of light source allows to provide the distribution be crushed, until become best distribution around d=40, for d=40, it can be constant for throwing light on the horizontal segment of Breadth Maximum.Be greater than this optimal spacing, three Gaussian peaks corresponding to each light source will be recovered gradually.
Note, this distance d=40 is best for above-described special Light distribation.When different distributions, this value can change.
The present invention has arranged Different Light to obtain this optimum state.
Note, the application for the method described by a module can be popularized for several module.Therefore it is contemplated that the arranging of several modules around region to be studied can be distinguished or respectively place is bright.
In one particular embodiment, by the both sides of each 2 module installation be made up of 2 point sources in region as shown in Figure 8.This arranges and allows along privileged direction display projection.
In other possible configuration, arrange for 90 ° of 4 modules and allow along 2 privileged direction research projections.
Once be produced the uniformity of light by the module optimized, the setting of each module used is just optimised.The parameter studied is the height h of each module relative to reference surface P, the spacing e relative to an O and light angle α.By these parametric representations on Fig. 8.
The display of projection and the generation of Uniform Illumination are by arranging each module to carry out with height best for studied area-of-interest and angle of incidence.
The determination of the optimum of each parameter is by carrying out from the illumination uniformity of point of theory research area-of-interest and the display quality of projection.This research carry out by means of optical analog instrument and allow for each parameter simulation its on obtain the impact of final result of illumination.
Certainly, sample plot can be carried out by the enforcement of device and verify these notional results.
For determining that the methodology that the optimum of h, e and α uses can be repetition.Test from underlying parameter.By or study the impact of each parameter on result based on visual method or based on the designator (such as photodistributed interval type) representing uniformity.Carry out using the new test of the parameter through upgrading allowing to optimize illumination to wait until result is best.The optimized algorithm of simplex or Levenberg-Marquardt type can be used.
The observation of the method with experienced doctor combined, this doctor this time verifies with the clinical method of obtained result and instructs these parameters.Optimum power is a feature especially, and it cannot by means of only considering that the real observation of user is optimized.
For example Fig. 9 A and 9B of uniformity showing the light stream obtained for the special embodiment with 2 modules.In first situation of Fig. 9 A, notice low-quality illumination uniformity, there is the maximum luminosity point of central authorities.In the second situation that the wherein parameter of Fig. 9 B is optimised, notice the larger uniformity with lower diminuendo.
Once have adjusted uniformity, just adjustment parameter is so that the best image of projection.This display is undertaken by the contrast of research between the projection of the parallelepiped at measured zone center, as suggested by figure 10.Figure 11 A and 11B represents an example of obtained light stream.In shown example, can be observed the contrast of 0.67 in the first situation of Figure 11 A, and in the illumination of second configuration of Figure 11 B, in described special embodiment, produce the contrast of 0.63.
By using this contrast level parameter, repetition methods described above can be applied to the optimization of illumination.Herein, checking and optimization are also undertaken by measurement being combined with the observation of experienced clinician.
Can note, optimization can be passed through in succession to consider uniformity and contrast, or by considering 2 parameters to carry out simultaneously.
Structure of the present invention completely around area-of-interest, thus allow by this region and exterior lighting isolated.
Have in the embodiment that 2 covers throw light on relatively, described structure can be the shell of the parallelepiped shape had such as shown in Figure 12.
The support of shell on skin is realized by special plate.This plate can be a simple flat surface around area-of-interest, as represented in Figure 13, or also can be F-SP so as to allow around recline to skin special device to center.This special device can be such as with the ring used in the skin measurement of Laser Scanning Confocal Microscope.
Plate and shell also can have the inward flange of F-SP to adapt to the region that its form is not plane best.In the example of cheek region, the edge of introversion and plate allow abutment surface better to guarantee between area-of-interest with device continuous and contact.Deformable flex plate can also be adopted.
The observation of area-of-interest can be carried out in two ways.
In the first case, observation is direct and user sees area-of-interest, represented by Figure 12 by the window opened up on shell.
In the second situation, photographic attachment is positioned at above shell.Several solutions can be used in this case.
Can, by camera chain, according to first embodiment, be fixed on shell, as represented in Figure 14.In this case, the weight of system is born by the shell on the tissue regions around observed region.
In this second embodiment, camera chain is not fixed on shell.In this case, the external frame had around the support of shell allows to work, as represented in Figure 15 at the constant distance place of area-of-interest.
Photographic attachment can be photographing unit, compact photographic instrument or reflection photographic instrument.
If the device used is photographing unit, what so can be implemented in external screen is directly visual, has the probability directly using dimensional measurement instrument or colorimetric appraisal tool.
When using photographic attachment wherein, can be connected to allow record and distally user transmission photography external equipment.Transmission can be wired, also can be wireless.
In a still further embodiment, instrument can be arranged on enclosure to contribute to evaluating.
Can by rule, see Figure 16, be positioned in illumination plane with the size of evaluation Example as speckle or cicatrix.
On the edge that the fixing color scale through calibration can also be positioned at area-of-interest or inner, to carry out the colorimetric calibration of photographing, as in the embodiment represented by Figure 17.The scale of specifying may be used for carrying out especially white balance.
When the color evaluation undertaken by observer should be carried out, can be fixing onboard by the rotation disc circumferentially had at it corresponding to the color scale of desired tone, as in the embodiment represented by Figure 18.Therefore user can extract different tones to evaluate closest to that of region to be evaluated.
Before amplifying device can being placed in watch window, as the embodiment represented by Figure 19.
In a special embodiment, before color filter can being placed in light source and/or before watch window.These color filters may be used for filtering specific wavelength, light is polarized or particularly indicating characteristic.
In a special embodiment, can place the grenade instrumentation of structurized light on the region of interest in portion in the enclosure, described structurized light can be linear, grid or any pattern.The projection of structurized light allows to help user to evaluate the projection of institute's survey region, and if carried out the record of the projection of structurized light, so may be used for by means of the projection observed by computational algorithm reconstruct.
In a special embodiment, can place in inside and measure by the light stream of watch window perception or the device of reflectance.
For the ease of the device on studied area-of-interest different time between location and reorientation, can the module of projection light labelling be fixed on the shell of device, as in the embodiment represented by Figure 20.Reorientation also can realize by being fixed on the module be incident upon on skin in another structure and by labelling, thus allows to place this device as in embodiment represented on Figure 21.
In a special embodiment, can the one or more sensor and described plate that contact or do not measure contiguously the physical attribute of skin be carried out integrated to measure such as temperature or hydration.These sensors can be capacity type, resistance type or hot type.
The power supply of described device can be battery or set of cells, can be realized by the USB port of transformator or other power supplys such as computer.
This device allows to break away from outside optical condition.
Claims (13)
1. determine that the optimization illumination of region human skin is to allow the method for its apparent condition of research for one kind, this skin area has raised areas, this illumination carrys out the device of one or more light source self-contained and produce shadow region near raised areas, it is characterized in that comprising the following steps:
-limit the first parameter P1 according to the contrast between the luminosity of inside, shadow region and the luminosity of outside, shadow region,
-limit the second parameter P2 according to the uniformity of luminosity,
-limit cost function C according to the first parameter P1 and/or the second parameter P2,
The maximum of-searching cost function C,
The method finding the maximum of cost function C is repetition, first test is carried out from underlying parameter, by or based on visual method, or study the impact of each parameter on result based on the next self-metering designator representing uniformity, then with by using this device to upgrade and the parameter of verification experimental verification carries out new test, this allows to optimize illumination, this series of steps is re-started until result is best, the maximum wherein finding cost function C comprises the step of the change studying C according to the change of at least one following parameters: the type of light source, light source is relative to the height (h) of skin, light source is relative to the distance (e) of skin, and each light source is relative to the light angle (α) of considered skin area.
2. the method determining the optimization illumination of region human skin according to claim 1, it is characterized in that, described cost function is restricted to the form of C=a*P1+b*P2, and wherein a and b is real number.
3. the device of a region human skin of throwing light on, this skin area has raised areas, this device comprises one or more light source and produce shadow region near raised areas, and this device has method according to any one of claim 1 to 2 at least one following features determined: light source relative to the height (h) of skin, light source relative to the distance (e) of skin and each light source light angle (α) relative to considered skin area.
4. device according to claim 3, is characterized in that, at least one light source is point-like.
5. the device according to claim 3 or 4, is characterized in that comprising the window for observing.
6. the device according to claim 3 or 4, is characterized in that comprising the camera chain of the structure being fixed to this device.
7. the device according to claim 3 or 4, is characterized in that this device is connected to and allows to carry out recording and the device of long-distance transmissions to photography.
8. the device according to claim 3 or 4, is characterized in that comprising and makes the minimized plate leaned against on skin of the impact of this device on measured zone.
9. device according to claim 8, is characterized in that, described plate comprise allow this device around be fixed to skin outer member automatic centring to central module.
10. the device according to claim 3 or 4, it is characterized in that comprising can the projection parts of light of emitting structural.
11. devices according to claim 3 or 4, is characterized in that comprising the measurement component measuring reflected light.
12. devices according to claim 3 or 4, is characterized in that the optical character projection parts comprising auxiliary reorientation.
13. devices according to claim 3 or 4, is characterized in that one or more sensor comprising the physical attribute measuring skin.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1151757 | 2011-03-04 | ||
| FR1151757A FR2972109A1 (en) | 2011-03-04 | 2011-03-04 | METHOD FOR DETERMINING A STANDARDIZED LIGHTING FOR SURFACE CONDITION STUDY OF A SKIN AREA AND ASSOCIATED DEVICE |
| PCT/IB2012/050972 WO2012120413A1 (en) | 2011-03-04 | 2012-03-01 | Method for determining standardised lighting, and associated device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103517671A CN103517671A (en) | 2014-01-15 |
| CN103517671B true CN103517671B (en) | 2015-11-25 |
Family
ID=45833495
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280018843.3A Expired - Fee Related CN103517671B (en) | 2011-03-04 | 2012-03-01 | Method and the device be associated of confirmed standardization illumination |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP2680751A1 (en) |
| CN (1) | CN103517671B (en) |
| BR (1) | BR112013022128A2 (en) |
| FR (1) | FR2972109A1 (en) |
| WO (1) | WO2012120413A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105300665B (en) * | 2015-10-22 | 2018-04-27 | 浙江大学 | A kind of biological tissue's apprasial of lighting method based on aberration optimization |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101756696A (en) * | 2009-12-31 | 2010-06-30 | 中国人民解放军空军总医院 | Multiphoton skin lens image automatic analytical system and method for diagnosing malignant melanoma by using same system |
| EP2223650A1 (en) * | 2009-02-25 | 2010-09-01 | The Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth near Dublin | Method and apparatus for imaging tissue topography |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2589242B1 (en) | 1985-10-25 | 1988-11-25 | Oreal | PROCESS FOR EXAMINING THE SURFACE OF A SAMPLE AND APPARATUS FOR IMPLEMENTING SAME |
| WO1997029686A1 (en) * | 1996-02-16 | 1997-08-21 | L'oreal | Device for estimating in vivo skin wrinkling, and method therefor |
| US6993167B1 (en) * | 1999-11-12 | 2006-01-31 | Polartechnics Limited | System and method for examining, recording and analyzing dermatological conditions |
| JP3663598B2 (en) * | 2001-06-04 | 2005-06-22 | 岩雄 岡田 | Blood vessel detection device |
| FR2826857B1 (en) | 2001-07-09 | 2004-03-12 | Oreal | INSTRUMENT FOR OBSERVING SKIN OR HAIR |
| FR2831416B1 (en) * | 2001-10-29 | 2004-06-18 | Licorne Lab | APPARATUS FOR ANALYZING THE PHYSICO-CHEMICAL PROPERTIES OF A SKIN SURFACE |
-
2011
- 2011-03-04 FR FR1151757A patent/FR2972109A1/en not_active Withdrawn
-
2012
- 2012-03-01 EP EP12708960.5A patent/EP2680751A1/en not_active Withdrawn
- 2012-03-01 WO PCT/IB2012/050972 patent/WO2012120413A1/en unknown
- 2012-03-01 CN CN201280018843.3A patent/CN103517671B/en not_active Expired - Fee Related
- 2012-03-01 BR BR112013022128A patent/BR112013022128A2/en not_active IP Right Cessation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2223650A1 (en) * | 2009-02-25 | 2010-09-01 | The Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth near Dublin | Method and apparatus for imaging tissue topography |
| CN101756696A (en) * | 2009-12-31 | 2010-06-30 | 中国人民解放军空军总医院 | Multiphoton skin lens image automatic analytical system and method for diagnosing malignant melanoma by using same system |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012120413A1 (en) | 2012-09-13 |
| FR2972109A1 (en) | 2012-09-07 |
| CN103517671A (en) | 2014-01-15 |
| BR112013022128A2 (en) | 2016-12-06 |
| EP2680751A1 (en) | 2014-01-08 |
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