CN103505485A - Pharmaceutical composition for preventing birth defects and improving memory - Google Patents
Pharmaceutical composition for preventing birth defects and improving memory Download PDFInfo
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Abstract
A pharmaceutical composition for preventing birth defects and improving memory comprises Hippophae rhamnoides, Lycium barbarum fruit, processed Polygonum multiflorum, Herba Epimedii, Cuscuta chinensis seed, Ligustrum lucidum fruit, prepared Rehmannia glutinosa, Atractylodes macrocephala, vitamin A, beta-carotene, vitamin B complex, vitamin C, vitamin D, vitamin E, vitamin K, macroelements (calcium, potassium, and magnesium) and microelements (zinc, selenium, iron, chromium, copper, molybdenum, manganese, germanium, silicon and strontium). The pharmaceutical composition is mainly suitable for pre-pregnant women, pregnant women and nursing mothers, is effective in preventing birth defects and improving memory, has effects of promoting health and invigoration, and has no adverse effect even after long-term administration.
Description
Technical field: the present invention relates to Medicines and Health Product technical field; Pharmaceutical composition in particular for prevention birth defect and improvement memory.
Background technology: birth defect refers to fetus in parent and in the rear organ formative process of birth, embryo and paedomorphosis due to being interacted by the multiple environmental pathogenic factor in parent inside and outside and inherited genetic factors are disorderly, comprise that morphosis is abnormal, 4 types of physiological metabolism obstacle, congenital mental retardation and intrauterine growth retardations etc.; Various countries' Prevalence rate of birth defect is up to 5% left and right of birth sum, on population quality affect great ，Gei family, society causes white elephant, has become the common great public health problem of paying close attention in the current whole world.
The pathogenic factors of birth defect is very complicated, has inherited genetic factors, and environmental factors also has other multiple uncertain factor.Environmental factors comprises biological factor, physical factor, chemical factor; Embryo is subject to the injury of environment harmful factor and other multiple uncertain factor, birth defect sickness rate is increased, and eliminate these harmful factors, will make birth defect sickness rate lower.
Pharmaceutical composition of the present invention is the policy of following prenatal and postnatal care, by eliminating the birth defect factor that causes to embryo, the generation of prevention birth defect, reaches the object that lowers birth defect sickness rate, user is improved the effect of memory, favourable mothers and sons two generations's health simultaneously; Said composition comprises Fructus Hippophae, Fructus Lycii, Radix Polygoni Multiflori Preparata, Herba Epimedii, Semen Cuscutae, Fructus Ligustri Lucidi, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, vitamin A, beta-carotene, compound vitamin B, vitamin C, vitamin D, vitamin E, vitamin K and macroelement calcium, potassium, magnesium and trace element zinc, selenium, ferrum, chromium, copper, molybdenum, iodine, manganese, germanium, silicon, strontium.
Fructus Hippophae be a kind of be the natural Chinese medicine of food and medicine, have strengthening the spleen to promote digestion, expelling phlegm for arresting cough, the effect of blood circulation promoting and blood stasis dispelling; The clinical diseases such as insufficiency of the spleen lack of appetite, cough with copious phlegm, blood stasis amenorrhea, traumatic injury congestive edema that are used for the treatment of; Modern pharmacological research confirms that Fructus Hippophae has: 1, effect for reducing blood fat; 2, hepatoprotective effect; 3, antitumor action; 4, antioxidation, anti-aging effects; 5, hematopoietic cell is had to facilitation; 6, reduce blood viscosity, anticoagulation, anti thrombotic action; 7, strengthen immunologic function; 8, resist myocardial ischemia, anoxia, protection myocardial function; 9. antiulcer action; 10, the antiinflammatory effect of curing the wound; 11, anti-allergic effects; 12, anti-radiation function; 13, strong body antifatigue effect; Can make animal saliva, gastrointestinal glandular secretion increase, pepsin content raises, and gastrointestinal motility function is had to stimulation simultaneously, can make gastrointestinal rhythmicity contraction cycle extend, and amplitude increase etc. affects gastrointestinal function; 15, in addition can also arrhythmia, the ear poison reaction due to prevention and antagonism gentamycin.
Fructus Lycii be a kind of be the natural Chinese medicine of food and medicine, have liver and kidney tonifying, nourishing YIN and supplementing blood, replenishing vital essence to improve eyesight, the effect of nourishing the lung to arrest cough, is flat tonic thing simply; Ancient Chinese medicine is classified Fructus Lycii as on Chinese medicine product, wherein " book on Chinese herbal medicine converge with speech " to evaluation especially high, think that it has the advantage of tens kinds of Chinese medicines concurrently, claims it: " gas can be filled, and blood can be mended, Yang Kesheng, the moon can be grown, fire can fall, rheumatism can be gone "; Be mainly used in Liver and kidney two void, the soreness of the waist and knees of asthenia of essence and blood, has a dizzy spell, early whitening of beard and hair, visual deterioration, the diseases such as sexual hypofunction; Modern pharmacological research confirms that Fructus Lycii has: 1, strengthen immunity and reconcile immune effect; 2, anti-cancer and inhibiting tumor effect; 3, remove harmful free radical in body, fat-reducing liver-protecting effect; 4, hypoglycemic activity; 5, resisting fatigue and high temperature resistance effect; 6, strengthen the animal heart, cerebral tissue catalase, the activity of lactic acid dehydrogenase, can make superoxide dismutase activity in old human blood raise, and LPO reduces, can make hematopoietic stem cell strengthen, there is the effect of defying age and stimulating animal growth promoter; 7, promote intelligence and improve the function of remembering; 8, protection reproductive system effect; 9, antimutagenic effect etc.; Fructus Lycii nature and flavor are gentle, to promoting human physiological metabolism's function, have much useful value.
Radix Polygoni Multiflori Preparata is the class natural Chinese medicine of enriching blood through concocting, enriches blood, and the effect of benefit essence; On tcm clinical practice for blood deficiency insomnia, visual deterioration, spasm of muscles and vessels, the early whitening of beard and hair of damage of essence blood deficiency senilism, dizziness and blurred vision, the disease such as tinnitus is hard of hearing, weakness of the waist and knees; Modern study confirms: 1, Radix Polygoni Multiflori Preparata can reduce relevant enzyme---the monoamine oxidase, MAO (Type B) that causes brain aging in the different partitioned organizations of brain; 2, supplement composition---the lecithin that forms nervous tissue; 3, antioxidation, anti-aging effects; 4, protection thymus effect; 5, strengthen immunologic function; 6, promote hemopoietic function etc.
Herba Epimedii is a kind ofly can have kidney invigorating and YANG supporting as the natural Chinese medicine of health food, the effect of Eradicates wind dehumidifying; Clinical sterile for sexual impotence, cold womb is infertile, anemofrigid-damp arthralgia, the hemiplegia unsuccessful disease of waiting; Modern pharmacological research confirms that Herba Epimedii has: 1, strengthen gonad function, Herba Epimedii can strengthen hypothalamus-hypophysis-gonad axis function, to dog sperm, secretion has facilitation, can increase the weight of mice prostate, seminal vesicle, levator ani, showing has androgen-like action, Herba Epimedii extracting solution mouth is raised female rats, can improve hypophysis reactivity and the corpus luteum of corpus luteum generation releasing hormone are generated to plain reactivity, obviously increases normal rat antepituitary, ovary, uterus weight; 2, promote protein and nucleic acid synthetic, it is synthetic that Herba Epimedii extracting solution can affect " yang deficiency " model mice DNA, and promote the synthetic of protein, regulates cellular metabolism, obviously increase the weight of animals and resistance to freezing the time, can also significantly improve " deficiency of YIN " model mice DNA synthetic ratio; 3, strengthen immunologic function, Herba Epimedii all has facilitation to specificity and non-specific immunity; 4, osteoporosis, promotes bone tissue growth effect; 5, defying age, resisting oxygen lack; 6, heart tonifying, resist myocardial ischemia, blood pressure lowering, arrhythmia, the effects such as anticoagulant; 7, blood fat reducing, hypoglycemic activity; 8, antitussive, eliminate the phlegm, antiasthmatic effect; 9, to brain cell protective effect; 10, the effect such as antiinflammatory, antibiotic, antiviral.
Semen Cuscutae is a kind ofly can as the deficiency tonifying kind natural Chinese medicine of health food, have YANG invigorating tonifying YIN, controlling nocturnal emission with astringent drugs reducing urination, the effect of improving eyesight antidiarrheal.Be mainly used in soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, deficiency of the liver and kindey, poor vision, deficiency of spleen-YANG and kidneyYANG, have loose bowels in loose stool, frequent fetal movement, blood leaking in gestation etc.Doctor trained in Western medicine is examined as chronic nephritis, diabetes, aldosteronism, hypothyroidism, sexual neurasthenie, hypoadrenocorticism, the climacteric syndrome person that belongs to insufficiency of kidney-YANG, hypertension, interior Ménière belong to deficiency of the liver and kindey person, central serous chorioretinopathy, optic neuritis, vitreous opacity belong to deficiency of the liver and kindey, order eyeball loses and supports person, chronic gastroenteritis, gastric and duodenal ulcers belong to deficiency of spleen-YANG and kidneyYANG person, threatened abortion, habitual abortion belong to deficiency of the liver and kindey person; Modern pharmacological research confirms that Semen Cuscutae has: the activity of 1, obviously protecting hepatic injury; 2, increase the short luteal function of hypothalamic-pituitary-ovarian, improve hypophysis reactive effect to LH to LRH and ovary; 3, strengthen cardiac contractile force, preserved material, to anesthetized dog intravenous injection, can make its blood pressure drops; 4, Semen Cuscutae be a kind of take strengthen humoral immunization and phagocytic function is main immunostimulant; 5, there is antisterility effect; 6, mutation; 7, the effect such as antioxidation, defying age, anticancer, improving eyesight.
Fructus Ligustri Lucidi is a kind ofly can have the liver and the kidney tonifying as the nourishing YIN class natural Chinese medicine of health food, the effect that crow must improving eyesight; Clinical in soreness of the waist and knees, early whitening of beard and hair, hectic fever due to YIN-deficiency consumptive fever, night sweat seminal emission, the diseases such as dizzy order is dark, forgetful tinnitus.Modern pharmacological research confirms that Fructus Ligustri Lucidi has: 1, strengthen immunologic function; 2, mutation, suppresses allergy effect, and chromosome damage is had to protective effect; 3, blood sugar lowering, effect for reducing blood fat; 4, defying age, antioxidation; 5, function of increasing leukocyte; 6, increase the effect of coronary flow; 7, protect the liver in addition, the effect such as anticancer, antiinflammatory, antibiotic, diuresis, cough-relieving, cathartic, heart tonifying.
Radix Rehmanniae Preparata is nourishing YIN and supplementing blood class natural Chinese medicine, the effect that has the YIN nourishing of enriching blood, beneficial essence to fill out marrow.On tcm clinical practice for curing mainly blood deficiency and yellow complexion, menoxenia, metrostaxis, deficiency of kidney yin, soreness of the waist and knees, night sweat seminal emission, essence and blood two loses, have a dizzy spell, the diseases such as early whitening of beard and hair.Modern study confirms: 1, Radix Rehmanniae Preparata has the effect that promotes medulla hematopoietic system, also has the effect of hemostasis; 2, there is blood pressure lowering and protect myocardium effect; 3, obviously promote lymphocytic breeder reaction, significant reticuloendothelial system promotes active; The effects such as 4, blood lipid-reducing blood sugar-decreasing, antitumor, antioxidation, anoxia enduring, promotion liver glycogen be synthetic.
The Rhizoma Atractylodis Macrocephalae is a kind ofly can have invigorating the spleen and benefiting QI as the QI invigorating class natural Chinese medicine of health food, dampness diuretic, hidroschesis consolidating superficial resistance, and in antiabortive effect; Ancient Chinese medicine is classified the Rhizoma Atractylodis Macrocephalae as on Chinese medicine product, antiabortive monarch drug, the panacea of fetus nourishing; Modern clinic is used for cirrhotic ascites, diarrhoea, Mo Niai syndrome, edema spontaneous perspiration, frequent fetal movement etc.; Modern pharmacological research confirms: 1, Rhizoma Atractylodis Macrocephalae Wheat Protein, can alleviate lipid peroxidation, reduce the content of peroxide, avoid the destruction of harmful substance to cellularity and function, and be improved the active trend of SOD, the ability of enhancing body to free radical scavenging, thereby the damage of minimizing radical pair body; 2, the Rhizoma Atractylodis Macrocephalae has delaying senility function, Rhizoma Atractylodis Macrocephalae decoct can improve the erythrocytic superoxide dismutase of aged mouse (SOD) activity, suppresses brain activity of monoamine oxidase simultaneously, can also suppress erythrocytic autoxidation haemolysis, directly remove free radical, show anti-aging effects; 3, the Rhizoma Atractylodis Macrocephalae has enhancing immunization, and oral lymhocyte transformation rate and the serum IgG content of making of Rhizoma Atractylodis Macrocephalae decoct significantly rises, and shows that the Rhizoma Atractylodis Macrocephalae has immunostimulation, and can strengthen the vigor of macrophage, strengthens the phagocytic function of reticuloendothelial system; 4, anticancer tumor effect, Rhizoma Atractylodis Macrocephalae volatile oil has inhibitory action to murine sarcoma S180, and external have direct killing action to ehrlich ascites tumor cell, and in vitro Eca109 esophageal cancer cell is presented to inhibition, can make cell detachment, karyopycnosis, Chromatin condensation, cell does not divide or seldom division; 5, the Rhizoma Atractylodis Macrocephalae also has blood lipid-reducing blood sugar-decreasing effect, antibacterial action, and blood coagulation resisting function, promotes brood body weight to increase, physical potentiation, can make leukocyte count raise to the leukopenia by causing after chemotherapy or radiotherapy tumor; The compatibility Rhizoma Atractylodis Macrocephalae is to promote the absorption of medicament effective component in prescription for traditional Chinese medical science custom, and particularly compatibility gold, stone class medicine are to promote absorption and the utilization of mineral.
Vitamin A also claims retinol, is improved vision, prevents the effect of nyctalopia, has the anemia of pregnant woman of enhancing Abwehrkraft des Koepers function, can promote mucopolysaccharide synthetic, affects renewal, the growth of osseous tissue, and long bone is grown to both-end; If vitamin A deficiency is prone to premature labor or fetal congenital deformity.Beta-carotene can change vitamin A under the effect of enzyme in vivo, the effect of performance vitamin A.
Vitamin B group participates in body internal protein, fat and sugar metabolism, makes the excitement of brain cell and suppresses in poised state, and it comprises vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid etc., in vivo collaborative performance physiological action.Vitamin B
1there is the effect that maintains nervous system normal function, during shortage, occur the phenomenons such as carbohydrate metabolism is incomplete, and heat energy is under-supply, thereby cause hypomnesis, affect the normal function of brain, if vitamin B
1abundance, can effectively form the energy of brain cell activity necessity, can improve memory, concentration power and learning capacity, in addition vitamin B
1suppress in addition cholinesterase, improve the function of cholinergic nerve; Vitamin B
2having another name called riboflavin, is the ingredient of many important coenzyme in body, and it participates in the substance metabolism in body, promotes fetus and baby's growth promoter to play an important role, vitamin B to the activity that sustains life
2to maintain skin and the requisite vitamin of eye health, anemia of pregnant woman's vitamin B
2lack or can not cause or inspire pregnant early pregnancy vomiting completely, second trimester angular cheilitis, glossitis, cheilitis and premature infant's incidence rate increase; Nicotiamide claims again niacin amide or vitamin PP, and its physiological function is to participate in body intracellular metabolic, maintains normal neurological function, and synthesizing of assurance gonadal hormone etc., pellagra can occur during shortage, and main manifestations is dermatitis, diarrhoea, dull-witted three large symptoms; Pantothenic acid extensively exists in each organism, participates in metabolic activity widely, and known have 70 plurality of enzymes in catalysis body different kind organism chemical reaction, all to need pantothenic acid to participate in, otherwise just can Metabolic disorder; Biotin is also a kind of vitamin B group, coordinates to participate in the metabolism of human body matter and energy with other vitamin B group, and it is synthetic with nucleic acid, and the compositive relation of gonadal hormone is close, and it also has control poliosis, bareheaded effect; Vitamin B
6most important to maincenter neurodevelopment, if shortage can make nervus centralis hypoevolutism, intelligence declines, and it has assistance vitamin B
1effect, be the vitamin that can improve concentration power and stimulate desire learn; Vitamin B
12participate in nucleic acid in vivo, choline, amino acid whose synthetic and fatty and sugared metabolism, to hemopoietic function of bone marrow, gastrointestinal epithelial cells function, liver function and nervous system myelin function complete has certain effect, it is the necessary vitamin of intelligence of bringing into normal play, if lacked, not only cause dysnoesia, also there will be nutritional anemia, impact is to blood supply in brain; Folic acid participates in the synthetic of aminoacid and nucleic acid, and and vitamin B
12the common generation and maturation that promotes cell, during shortage, normal cell can not carry out mitosis, there will be neurological symptom, as: the loss of memory, depression and dementia etc.; Human body can be at vitamin B in addition
12under the effect of folic acid as cofactors, by the serine of taking in and the synthetic choline of methionine, choline is the key component of acetylcholine, and acetylcholine is important neurotransmitter in human body; There are again folic acid, vitamin B
6and vitamin B
12can work in coordination with the homotype cysteine of removing in human body, homotype cysteine is a kind of neurotoxin, can cause the self murder of brain; There are some researches show, homocysteine is a kind of potential teratogen of independently growing, and is related closely with congenital heart disease and neural tube defects; In addition homocysteine also can cause miscarriage, premature labor, the clinical disastrous effect such as preeclampsia.
Vitamin C claims again ascorbic acid, vitamin C and collagen in close relations, not only there is vessel softening effect, the effect purifying the blood in addition, prevent arteriosclerosis, can also promote the absorption of human body to ferrum in food, for hemopoietic provides essential raw material, meanwhile, vitamin C regaining one's strength, the aspect effect such as allaying tiredness, keeping tensions down emotion is obvious; Pregnancy duration, anemia of pregnant woman's hypovitaminosis C or deficiency there will be subcutaneous hemorrhage, swelling and aching of gum, the symptom such as bleed, fester, long-term lacking vitamin C easily has virus flu, and increases the danger of fetus teratogenesis, and famine can cause miscarriage.
Vitamin D is sterols derivant, and the subcutaneous dehydrocholesterol of human body produces vitamin D through ultraviolet radiation
3, ergosterol produces vitamin D after ultraviolet radiation
2, the two originates different, and function is consistent, and in human nutrition, the importance of vitamin D is to regulate the metabolism of calcium and phosphorus; Vitamin D promotes calcium at intestinal absorption, be deficient in vitamin D a large amount of calcium by feces, discharged, thereby cause human body calcium deficiency, can there is rickets in child, become the calcium phosphorus of storing in human body to exhaust and can cause osteomalacia, modal osteomalacia crowd is anemia of pregnant woman, wet nurse and old people.
Vitamin E is all general designations with the bioactive chromone derivative of alpha-tocopherol, and wherein the activity of alpha-tocopherol is the highest.There is the effect of eliminating free radical, slow down aging, prevention maxicell hemolytic anemia, medically often adopting vitamin E treatment male and female infertility and threatened abortion; Vitamin E deficiency or can not make anemia of pregnant woman's reproductive system suffer damage completely, there is irreversible variation in germinal epithelium, in addition, the phenomenons such as maxicell hemolytic anemia and shortening red blood cell life span also can occur.
The main Physiological Function of vitamin K is: 1, regulate the synthetic of clottable protein warmed, with synthesizing of thrombinogen and other thrombin in assurance liver, guarantee the operation of clotting mechanism, often there is intracranial hemorrhage in neonate, its pathogenesis relevant with pregnancy period parent vitamin K Deficiency of Intake at birth; 2, guarantee the health of osseous tissue, the synthetic participation that depends on vitamin K of three kinds of protein in osteoblast.
Calcium is the macroelement that body weight for humans is wanted, the effect of main Qi Liang aspect, the one, form Gu Chideng sclerous tissues, the 2nd, with protein bound or with the form of calcium ion, form the material that has specific function, form calcium in so-called miscible calcium pool and bone tooth and maintain dynamic equilibrium, in body, all cells all need its normal function of calcium competence exertion; Anemia of pregnant woman and wet nurse's calcium deficiency can affect the growth of its body constitution and fetus or infant, and calcium deficiency also can cause that endocrine dysfunction and cell cycle regulation are malfunctioning, and anemia of pregnant woman and wet nurse be due to physiological feature, the Deficiency of Intake of ubiquity calcium.
Potassium participates in the metabolic activity of cell, for the normal activity of some enzyme provides suitable condition, its outstanding effect is to maintain the normal irritability of myocardial cell, self-disciplining and conductivity, is regulating acid-base balance, maintains osmotic pressure and keeps water balance aspect to play an important role; Hypokalemia and hyperkalemia all can produce serious infringement to human body, and the lighter can cause tired, irritated, and severe one can cause arrhythmia, even dead.
Magnesium topmost function in human body is the generation of containment free radical, and free radical is short old and feeble factor, is also the factor that mainly causes birth defect; Another function of magnesium is to bring into play the effect of protection skeleton together with vitamin D with calcium, and osteoporosis easily occurs magnesium deficiency, easily fractures; In addition magnesium also has cardioprotection and prevents and treats the function etc. of diabetes.
Trace element zinc is merged in biomacromolecule ligand---in protein, nucleic acid, film (being mainly memebrane protein), generate stable metallic biomacromolecule complex---metalloprotein, metalloproteinase nucleic acid complex etc., at present, known these materials participate in the synthetic and degradation process of carbohydrate, lipid, protein and nucleic acid, have the existence of zinc enzyme in six large fermentoids; Zinc is also the essential element that strengthens immune vigor; Zinc can promote that proinsulin is converted into insulin by activating protaminase, and zinc deficiency makes insulin be obstructed in the activity of peripheral tissues, causes glucose tolerance curve abnormal; Anemia of pregnant woman's zinc deficiency, can affect the growth promoter of fetus to some extent, so that causes all deformities of fetus; Zinc deficiency can cause brain development bad, incomplete development of mind.
Trace element-selenium has obvious reduction serum total cholesterol, triglyceride and lipid peroxide, improves high density lipoprotein, the effect of superabundant fats metabolism in acceleration bodies; Selenium also has strong anti-oxidation function, and protection embryo is not subject to the injury of superoxides, prevention of cardiac; Anticancer by strengthening immune recognition system to remove cancerous cell; Remove and excretion heavy metal ion, hydrargyrum, methyl mercury, cadmium, lead etc. are had to Detoxication, and heavy metal pollution is mainly to cause birth defect factor; Scarce selenium can make human insulin secretion reduce, impaired glucose tolerance, and oxidation resistance declines and accelerates human senility and intelligence decline.
The main Physiological Function of trace elements iron is as hemoglobin, Myoglobin, and the ingredient of cytochrome etc. participates in transporting and Tissue respiration process of the interior oxygen of body; In the conveying of oxygen and electronics, play central role; In catalatic structure, contain ferrum, and hydrogen peroxide relies on catalatic degraded, hydrogen peroxide is free radical the most dangerous in human body; Iron deficiency is common in infant, anemia of pregnant woman and wet nurse, causes iron deficiency anemia, and its cardinal symptom is to have a delicate constitution, and memory weakens, and ability to work declines, and iron deficiency also can exert an influence to other system of human body; As nervous system iron deficiency, can affect the nerves conduction and make child occur that intelligence reduces and behavior disorder.
Trace element chromium is a kind of essential trace element, only has the trivalent chromium can be for the supplement of chromium, and it can strengthen and promote the physiological action of insulin, and its can prevention of arterial sclerosis, strengthens immunologic function, enhancing development; Scarce chromium can cause growth promoter to be stagnated, and accelerates old and feeble.
Trace copper in human body mainly the form with copper-containing metal enzyme play a role, participate in utilization, hemopoietic, phospholipid synthetic of ferrum, a series of metabolic processes such as collagenic connective tissue formation; The shortage of copper can cause collagen cross-linking obstacle in connective tissue, heart disease and anemia, leukopenia, and arterial wall elasticity weakens, albinism etc.
Trace element molybdenum is one of micro elements needed by human, it is the Constitution Elements of plurality of enzymes, participate in the utilization of ferrum, promote erythrocytic growth and maturation, can prevent anemia, and can help carbohydrate and fatty metabolism, it participates in removing the murder by poisoning of poisonous aldehydes in human body, eliminate human free radical, there is anticancer, defying age, enhancing immunity and anticariogenic function; Scarce molybdenum can bring out cardiovascular disease, cancer and dental caries.
Trace iodine is the main synthetic thyroid element that participates in human body, and thyroxinic physiological function is to regulate organism metabolism level, affects the generation of body heat energy, blood glucose and ketoboidies level, muscle and nervous, many-sided functions such as body weight, intelligence and sexual function; Adult's iodine deficiency can cause thyromegaly, and fetus and neonate iodine deficiency can cause deaf and dumb, dull-witted, of short and small stature, spastic paralysis, mental retardation, microcephaly in various degree.The serious disease such as low set ears.
Trace element manganese participates in the formation of some enzymes in human body, and it is the metabolism of involved in sugar and lipid not only, and all works in protein, DNA and RVA are synthetic.
Trace element germanium has and regulates immune function in human body, promotes growth, regulates physiological equilibrium, removes free radical, defying age, the function such as anticancer.
It is synthetic that trace element silicon participates in mucopolysaccharide in human body, promotes bone growth, maintains epithelial tissue and connective tissue intensity and elasticity, safeguards normal function and the permeability of blood vessel, prevents sclerosis.
Trace element strontium is the normal ingredient of skeleton and tooth, prophylaxis of hypertension, heart disease; Relevant with nerve and muscle excitement, stabilate cell membrane, promotes union of fracture, prevents senile osteoporosis.
Application contains Fructus Hippophae, Fructus Lycii, Radix Polygoni Multiflori Preparata, Herba Epimedii, Semen Cuscutae, Fructus Ligustri Lucidi, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, vitamin A, beta-carotene, vitamin B
1, vitamin B
2, vitamin B
6, nicotiamide, pantothenic acid, biotin, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E, vitamin K and macroelement calcium, potassium, magnesium and trace element zinc, selenium, ferrum, chromium, copper, molybdenum, iodine, manganese, germanium, silicon, strontium be known as the compositions of active component, but by Fructus Hippophae, Fructus Lycii, Radix Polygoni Multiflori Preparata, Herba Epimedii, Semen Cuscutae, Fructus Ligustri Lucidi, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E, vitamin K
1not yet report for the pharmaceutical composition that prevents birth defect and improvement to remember with macroelement calcium, potassium, magnesium and trace element zinc, selenium, ferrum, chromium, copper, molybdenum, iodine, manganese, germanium, silicon, strontium compatibility.
Current have multiplely for improving the medicine of memory or health food kind, but aims at there is not yet for improving medicine or the health food of memory of pregnant front women, anemia of pregnant woman, wet nurse's development; There is not yet for preventing the medicine label of birth defect rarely seen report that has folic acid supplementation for neural tube defects; But its target spot is few, link shortcoming, needs perfect.And will prevent birth defect and improve the effect of memory and there is not yet for same medicine person.
Summary of the invention: in order to overcome existing prevention birth defect and/or to improve the shortcoming and defect of remembering medicine, the object of this invention is to provide a kind of compositions, said composition is with Fructus Hippophae, vitamin B
6, vitamin B
12, folic acid is host, with Fructus Lycii, Radix Polygoni Multiflori Preparata, Herba Epimedii, Semen Cuscutae, Fructus Ligustri Lucidi, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin C, vitamin D, vitamin E, vitamin K and macroelement calcium, potassium, magnesium and trace element zinc, selenium, ferrum, chromium, copper, molybdenum, iodine, manganese, germanium, silicon, strontium be adjuvant; The collaborative vitamin B that increases of this host Fructus Hippophae
6, vitamin B
12, folic acid improves the effect of memory and prevention birth defect, passes through vitamin B simultaneously
6, vitamin B
12, folic acid supplements and strengthen the effect that Fructus Hippophae has strengthening the spleen to promote digestion, expelling phlegm for arresting cough, blood circulation promoting and blood stasis dispelling.Due to the result of broad research, the inventor has found Fructus Hippophae, vitamin B
6, vitamin B
12, folic acid is the basis of effect host for preventing birth defect and/or improving memory, is aided with or is aided with respectively Fructus Lycii, Radix Polygoni Multiflori Preparata, Herba Epimedii, Semen Cuscutae, Fructus Ligustri Lucidi, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin C, vitamin D, vitamin E, vitamin K and macroelement calcium, potassium, magnesium and trace element zinc, selenium, ferrum, chromium, copper, molybdenum, iodine, manganese, germanium, silicon, strontium play to prevention birth defect and/or the effect of improving memory the complementary effect that is added.And the effective ingredient of each component has health care benefiting action to human body, as the Fructus Hippophae of this compositions dosage used has the effect of strengthening the spleen to promote digestion, expelling phlegm for arresting cough, blood circulation promoting and blood stasis dispelling; Fructus Lycii has liver and kidney tonifying, nourishing YIN and supplementing blood, replenishing vital essence to improve eyesight, the effect of nourishing the lung to arrest cough; Radix Polygoni Multiflori Preparata has enriching blood and replenishing vital essence, antioxidation, antidotal effect; Herba Epimedii has kidney invigorating and YANG supporting, and expelling wind and removing dampness promotes the effect that protein and nucleic acid is synthetic, and osteoporosis promotes bone tissue growth effect; Semen Cuscutae has YANG invigorating tonifying YIN, controlling nocturnal emission with astringent drugs reducing urination, the effect of improving eyesight antidiarrheal; Fructus Ligustri Lucidi has the effect of the liver and the kidney tonifying, the improving eyesight of crow palpus; The effects such as Radix Rehmanniae Preparata has the effect that promotes medulla hematopoietic system, and blood lipid-reducing blood sugar-decreasing, antitumor, antioxidation, promotion liver glycogen are synthetic; The Rhizoma Atractylodis Macrocephalae has that fetus nourishing is antiabortive, the effect of defying age, enhancing immunity and physical strength reinforcing; Trace element zinc is the necessary material of zinc enzyme in the interior six large fermentoids of human body, is also the essential element that strengthens immune vigor; Trace element-selenium can acceleration bodies in the metabolism of superabundant fats, there is strong anti-oxidation function, prevention of cardiac function, anti-cancer function etc.; Trace elements iron participates in transporting and Tissue respiration process of the interior oxygen of body, is the only element that prevents iron deficiency anemia; Trace element chromium has prevention of arterial sclerosis, strengthens immunity, antidotal function; Trace copper participates in utilization, hemopoietic, phospholipid synthetic of ferrum; Trace element molybdenum has anticancer, defying age, enhancing immunity and anticariogenic function; Trace iodine can be prevented and treated the goiter that iodine deficiency causes, can prevent fetus and neonate iodine deficiency to cause the serious maldevelopment such as cretinism, mental retardation; Trace element manganese participates in the synthetic of protein, DNA and RNA; Trace element germanium has and regulates immune function in human body, promotes growth, regulates physiological equilibrium, removes free radical, defying age, the function such as anticancer; It is synthetic that trace element silicon participates in mucopolysaccharide in human body, promotes bone growth, maintains epithelial tissue and connective tissue intensity and elasticity, safeguards normal function and the permeability of blood vessel, prevents sclerosis; Trace element strontium is the normal ingredient of skeleton and tooth, prophylaxis of hypertension, heart disease; Relevant with nerve and muscle excitement, stabilate cell membrane, promotes union of fracture, prevents senile osteoporosis etc.; And for example vitamin A is improved vision, prevents the effect of nyctalopia etc.; Vitamin B
1can prevent and treat vitamin B1 deficiency, maintain the normal activity of nerve, digestion, muscle, blood circulation; Vitamin B
2to maintain skin and the requisite vitamin of eye health; Can there is pellagra in nicotinamide deficiency; Pantothenic acid shortage can cause Metabolic disorder; Biotin can be prevented and treated poliosis, alopecia; Vitamin B
6can eliminate intraepithelial neoplasia cells, strengthen immunologic function, protection blood vessel; Vitamin B
12for various megaloblastic anemias, and neural disease; Folic acid also has cardioprotection and antitumaous effect; Vitamin C has vessel softening, purifies the blood, and prevents arteriosclerotic effect; Vitamin E has the effect of removing free radical, slow down aging; Vitamin K regulates the synthetic of clottable protein warmed; Macroelement potassium maintains the normal irritability of myocardial cell, self-disciplining and conductivity; Macroelement calcium, magnesium and vitamin D are brought into play the effect of protection skeleton jointly; There is not incompatibility in this compositions, have no side effect, and cost is low, thereby forms the present invention.
The invention provides for preventing birth defect and improving the pharmaceutical composition of remembering, it comprises with Fructus Hippophae, vitamin B
6, vitamin B
12, folic acid is host, with Fructus Lycii, Radix Polygoni Multiflori Preparata, Herba Epimedii, Semen Cuscutae, Fructus Ligustri Lucidi, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin C, vitamin D, vitamin E, vitamin K and macroelement calcium, potassium, magnesium and trace element zinc, selenium, ferrum, chromium, copper, molybdenum, iodine, manganese, germanium, silicon, the strontium active princlple that is adjuvant.
Fructus Hippophae be Elaeangnaceae machaka or dungarunga Fructus Hippophae (Hippophae rhamnoides) dry fruit for; There are the kinds such as Fructus Hippophae thibetanae, subsp.neurocarpa, Jiangzi Fructus Hippophae, central asian sea buckthorn, mongolian seabuckthorn; Main product in the Inner Mongol, the ground such as Shanxi, Shaanxi, Qinghai; The present invention Fructus Hippophae used can be with its extract as raw material.
Fructus Lycii be Solanaceae machaka or dungarunga Fructus Lycii Lycium chinense Mill berry for; Ovalize spindle shape, dry finished product is slightly crushed, long 1.5-2cm, diameter 4-8mm, orange red to kermesinus, taste is slightly sweet; Kind is more, and large with lycium barbarum Lycium darbarum L. fruit, matter is good famous; Be distributed in east Asia and Europe, all have the ground cultivations such as wild ，Yi Ningxia, Gansu, Qinghai, the Inner Mongol, Shaanxi more all over China; The present invention's Fructus Lycii used can be with its extract as raw material.
Radix Polygoni Multiflori is the tuber of the perennial voluble herb Plant-Polygonum of Polygonaceae (Polygonum multiflorum Thunb).Main product in Henan, the ground such as Hubei, Guangxi.Two season of autumn and winter excavates when leaf is withered, cuts sheet dry, claims Radix Polygoni Multiflori; With decoction of black soybean, mix thoroughly, inside and outside steaming extremely, be sepia, dry, claim Radix Polygoni Multiflori Preparata, Radix Polygoni Multiflori Preparata temperature compensation is not dry, long-term taking safety; China's Ministry of Public Health is listed Radix Polygoni Multiflori Preparata in " article that can be used for health food " list; Radix Polygoni Multiflori Preparata of the present invention can be with its extract as raw material.
Herba Epimedii be Berberidaceae herbaceos perennial Herba Epimedii (Epimedium brevicornum) and other sibling species aerial parts for, main product in Shaanxi, the ground such as Shanxi, Sichuan, Hubei, Guangxi, be wild, the present invention's Herba Epimedii used can be with its extract as raw material.
Semen Cuscutae is the mature seed of convolvulus cuscuta plant Cuscuta chinensis Lam..All there is distribution most areas, the whole nation.Extract aerial parts during fruit maturation autumn, dries, and lays seed.Raw use, or boil to mash and be used as cake.Be divided into two kinds of semen cuscutae japonicae and Semen Cuscutae.Semen Cuscutae is main flow commodity.Semen cuscutae japonicae take that grain is full, pitchy evenly, free from admixture person is as good; Semen Cuscutae take that grain is full, matter is solid, taupe brown or yellowish-brown be as good.The present invention's Semen Cuscutae used can be with its extract as raw material.
Fructus Ligustri Lucidi is the ripe dry fruit of Oleaceae evergreen shrubs plant Fructus Ligustri Lucidi (Ligustrum lu-cidus), is Berry-like drupe, and Long Circle, is about 1cm, and diameter 3～4mm is black-and-blue, slightly curved.After pluck cleaning, dry or steam after dry.Mainly originate in the ground such as Zhejiang, Jiangsu, Hunan.The present invention's Fructus Ligustri Lucidi used can be with its extract as raw material.
Radix Rehmanniae Preparata is the tuber of scrophulariaceae rehmannia glutinosa plant (Rehmannia glutinosa Libosch), through processing, concocts and forms.By take wine, Fructus Amomi, Pericarpium Citri Reticulatae as adjuvant is through repeatedly steaming and shine, glossy to inside and outside darkish complexion, quality is soft glutinous greasy; Section use, or parch to black is used.Take surperficial corvinus, glossy, stickiness is large, soft glossy, the sweet person of taste of matter is as good; You Yi Henan product bosom celebrating Radix Rehmanniae is best, is one of four-Huai medicine; Processed with wine Radix Rehmanniae Preparata is mended and oiliness, is one of the most frequently used Chinese medicine; Radix Rehmanniae Preparata of the present invention can be with its extract as raw material.
The Rhizoma Atractylodis Macrocephalae is the rhizome of the Compositae herbaceos perennial Rhizoma Atractylodis Macrocephalae (Atractylodes macrocephala koidz).Main product in Zhejiang, the ground such as Hubei, Hunan.Gather winter, dries or dry, and gives birth to use or parching with earth, parched with bran use.The present invention's Rhizoma Atractylodis Macrocephalae used can be with its extract as raw material.
For vitamin B of the present invention
1(VitaminB
1), vitamin B
2(VitaminB
2), nicotiamide (Nicotinamide), pantothenic acid (Pantothenic Acid), biotin (Vitamin H), vitamin B
6(VitaminB
6), vitamin B
12(VitaminB
12), folic acid (Folic Acid), vitamin C (Vitamin C), are all water soluble vitamins, do not accumulate in vivo, vitamin A (Vitamin A), vitamin D (VitaminD), vitamin E (Vitamin E), vitamin K (Vitamin K), be fatsoluble vitamin, beta-carotene (Beta Carotene) is the precursor substance of vitamin A, useful and harmless by the present invention's dosage used, zinc (Zn), selenium (Se), ferrum (Fe), chromium (Cr), copper (Cu), molybdenum (Mo), iodine (I), manganese (Mn) are micro elements needed by human, germanium (Ge), silicon (Si), strontium (Sr) are human body possibility essential trace element, and calcium (Ca), potassium (K), magnesium (Mg) are the macroelements of needed by human, macroelement calcium in the present invention can be selected calcium gluconate, calcium acetate, calcium caseinate, calcium chloride, calcium citrate, calcium malate, calcium cirate malate, calcium hydrogen phosphate, dalcium biphosphate, calcium phosphate, calcium sulfate, calcium ascorbate, calcium glycerophosphate, calcium lactate, calcium carbonate etc., macroelement potassium can be selected potassium carbonate, potassium chloride, potassium citrate, dipotassium hydrogen phosphate, potassium gluconate, potassium sulfate, potassium glycerinophosphate, potassium lactate etc., macroelement magnesium can be selected magnesium chloride, magnesium gluconate, magnesium lactate, magnesium citrate, magnesium hydrogen phosphate, magnesium phosphate, magnesium glycerophosphate, magnesium carbonate etc., trace element zinc can be selected zinc citrate, zinc gluconate, zinc acetate, zinc carbonate, zinc oxide, zinc chloride, zinc lactate, zinc sulfate, single zinc methionine etc., trace element-selenium can be selected Selenomethionine, methoxybenzyl cyanic acid selenium, the two cyanic acid selenium of phenylene, sodium selenite, selenocarrageenan, selenocysteine, selenizing methionine, sodium selenate etc., trace elements iron can be selected Ferrous gluconate, ferrous lactate, ferric ammonium citrate, iron chloride, ferric citrate, ferrous carbonate, ferrous citrate, ferrous fumarate, heme iron, ferric phrophosphate, protohemin, ferrous succinate, ferrous sulfate etc., trace element chromium can be selected chromium trichloride, nicotinic acid chromium, chromium picolinate, chromium yeast etc., trace copper can be selected curpic carbonate, copper citrate, copper gluconate, copper sulfate etc., trace element molybdenum can be selected ammonium molybdate, sodium molybdate etc., trace iodine can be selected potassium iodate etc., and trace element manganese can be selected manganese sulfate, manganese gluconate, manganese glycerophosphate, manganese chloride, manganese citrate, trace element silicon can be selected Silicon chloride., and trace element germanium can be selected Carboxyethyl-germanium Sesquioxide, germanium-enriched yeast, trace element strontium can be selected strontium chloride Deng，Jun You professional production factory and supplier.
Compositions of the present invention is mainly applicable to women in pregnant early stage, anemia of pregnant woman and wet nurse, be subject to the impact of the factors such as geology, food chain, dietetic life custom and Time of Administration length, the effective dose that the crowd that benefits from benefits from this compositions each component has certain difference, by the present invention, the effective dose of Fructus Hippophae extract is counted 300-10000mg/ days with whole crude drug, the effective dose of Fructus Lycii extract is counted 300-10000mg/ days with whole crude drug, the effective dose of Radix Polygoni Multiflori Preparata extract is counted 200-8000mg/ days with whole crude drug, the effective dose of Herba Epimedii extract is counted 300-10000mg/ days with whole crude drug, the effective dose of Semen Cuscutae extract is counted 300-12000mg/ days with whole crude drug, the effective dose of Fructus Ligustri Lucidi extract is counted 300-10000mg/ days with whole crude drug, the effective dose of Radix Rehmanniae Preparata extract is counted 0-8000mg/ days with whole crude drug, the effective dose of Rhizoma Atractylodis Macrocephalae extract is counted 0-15000mg/ days with whole crude drug, vitamin B
1effective dose be 0.5-20mg/ days, vitamin B
2effective dose be 0.5-20mg/ days, the effective dose of nicotiamide is 5-50mg/ days, the effective dose of pantothenic acid is 2-20mg/ days, the effective dose of biotin is 0.01-0.1mg/ days, vitamin B
6effective dose be 0.5-10mg/ days, vitamin B
12effective dose be 0.001-0.025mg/ days, the effective dose of folic acid is 0.1-1mg/ days, ascorbic effective dose is 30-500mg/ days, and the effective dose of vitamin A and/or beta-carotene (take retinol equivalent) is 250-800 μ gRE/ days, the effective dose of vitamin D is 0.0015-0.01mg/ days, the effective dose of vitamin E (take alpha-tocopherol equivalent) is 5-150mg α-TE/ days, the effective dose of vitamin K is 0-0.12mg/ days, the effective dose of macroelement calcium is counted 100-1000mg/ days with element calcium, the effective dose of potassium is counted 0-1200mg/ days with Element Potassium, the effective dose of magnesium is counted 30-300mg/ days with element magnesium, the effective dose of trace element zinc is counted 5-20mg/ days with element zinc, the effective dose of selenium is counted 0.015-0.1mg/ days with elemental selenium, the effective dose of ferrum is counted 5-20mg/ days with elemental iron.The effective dose of chromium is counted 0.015-0.15mg/ days with elemental chromium, the effective dose of copper is counted 0.5-2mg/ days with elemental copper, the effective dose of molybdenum is counted 0.02-0.06mg/ days with molybdenum, the effective dose of iodine is counted 0-0.2mg/ days with elemental iodine, the effective dose of manganese is counted 1-3mg/ days with element manganese, the effective dose of germanium is counted 0-3.8mg/ days with elements germanium, and the effective dose of silicon is counted 0-50mg/ days with elemental silicon, and the effective dose of strontium is counted 0-2mg/ days with elements strontium.
Compositions of the present invention can or directly be taken by following pharmaceutical dosage forms dispenser, for example, oral formulations is (as granule, powder, capsule, ball, sheet, dry syrup, liquid formulation), or food is as food (as cookies), that the additive known with other mixes and prepare, this class additive is for example: carrier, disintegrating agent, slow releasing agent, excipient, filler, covering, binding agent, lubricant, antioxidant, coating agent, coloring agent, correctives, sweeting agent, sucrose succedaneum, nutrition enhancer, flavouring agent, surfactant, plasticizer, PH regulator, freshener, suspending agent, defoamer, antiseptic, thickening agent, solubilisation aids etc., by usual way be prepared or using them as functional component or additive add food.
By the present invention, Fructus Hippophae, Fructus Lycii, Radix Polygoni Multiflori Preparata, Herba Epimedii, Semen Cuscutae, Fructus Ligustri Lucidi, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, vitamin A, beta-carotene, compound vitamin B, vitamin C, vitamin D, vitamin E, vitamin K and macroelement calcium, potassium, magnesium and trace element zinc, selenium, ferrum, chromium, copper, molybdenum, iodine, manganese, germanium, silicon, strontium each component can be distinguished preparation, use or mix when different and use while using after the preparation of each component can being mixed.
Advantage of the present invention is that this compositions eliminates from too many levels, multisystem, many target spots the many factors that causes birth defect and cause hypomnesis, between each component, there is the effect of collaborative performance effect, prevention birth defect and improvement memory are had to significant effect, sufficient raw, cost is low, and in compositions, each component has no side effect, without incompatibility, except prevention birth defect and improvement memory, human body is still had to health care benefiting action.
Subordinate list 1: this compositions and Fructus Hippophae component and vitamin B
6, vitamin B
12, the comparison of the young rat/mouse labyrinth test effect of folic acid component and vitamin added elements component:
Subordinate list 2: this compositions and Fructus Hippophae component and vitamin B
6, vitamin B
12, folic acid component and the comparison of vitamin added elements component Aged Mice maze test effect:
Below with reference to embodiment and test implementation example effect comparison list, describe the present invention in detail.
Embodiment 1:
By the starch of said components and appropriate amount, polyvinyl pyrrolidone, light anhydrous silicic acid, Polyethylene Glycol and flavoring agent are evenly mixed and made into independent 9, every day 3 times, each 3.
Embodiment 2:
Said components is further mixed as aluminosilicate magnesium, poly-solvate 60 and propylene glycol equably with the additive of appropriate amount, gained mixture is inserted to capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 3:
Said components is further mixed as aluminosilicate magnesium, poly-solvate 60 and propylene glycol equably with the additive of appropriate amount, gained mixture is inserted to capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 4:
By the starch of said components and appropriate amount, polyvinyl pyrrolidone, light anhydrous silicic acid, Polyethylene Glycol and flavoring agent are evenly mixed and made into independent 9, every day 3 times, each 3.
Embodiment 5:
Above-mentioned component and appropriate amount flavoring agent, as after citric acid receives and evenly mix with high sweetener sucralose, then are sneaked in 100g flour, add after appropriate culture propagation, then add an egg bake to become bread, as the staple food of a staggering amount.
Embodiment 6:
Above-mentioned component is further mixed as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and flavoring agent equably with the additive of appropriate amount, then gained mixture is made to 3 bag shot-like particles.Take every day 3 times, each serving a bag.
Embodiment 7:
Above-mentioned component is further mixed as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and flavoring agent equably with the additive of appropriate amount, then gained mixture is made to 3 bag shot-like particles.Take every day 3 times, each serving a bag.
Embodiment 8:
Above-mentioned component is further mixed as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and flavoring agent equably with the additive of appropriate amount, then gained mixture is made to 3 bag shot-like particles.Take every day 3 times, each serving a bag.
Embodiment 9:
Above-mentioned component is further mixed as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and flavoring agent equably with the additive of appropriate amount, then gained mixture is made to 3 bag shot-like particles.Take every day 3 times, each serving a bag, serve on 7, withdraw at 7 days at 2 taking medicine twice a day.
Embodiment 10:
Above-mentioned component is further mixed as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and flavoring agent equably with the additive of appropriate amount, then gained mixture is made to 3 bag shot-like particles.Take every day 3 times, each serving a bag.
Through animal experiment proved compositions, belong to nontoxic level; Crowd takes and also has no toxicity.
Subordinate list 1: this compositions and Fructus Hippophae component and vitamin B
6, vitamin B
12, the comparison of the young rat/mouse labyrinth test effect of folic acid component and vitamin added elements component:
Subordinate list 2: this compositions and Fructus Hippophae component and vitamin B
6, vitamin B
12, folic acid component and the comparison of vitamin added elements component Aged Mice maze test effect:
Note: in subordinate list 1, subordinate list 2, each group is tested by dosage feed in table respectively for 60 days; In table, each component consumption converts by per kilogram of body weight respectively.
Select 120 of newly-married healthy womens, 28 years old mean age, 6 months from pregnant start to take continuously this compositions host, within 6 months, follow up a case by regular visits to none routine birth defect to baby due.Contrast with associated materials statistics, Fetal malformation account for newborn population sum 4-6% there were significant differences.
From table 1, table 2, can obviously find out, this compositions by rat/mouse labyrinth test with compositions in Fructus Hippophae component and vitamin B
6, vitamin B
12, the contrast of folic acid component and vitamin added elements component, the statistical result of mistake percentage rate, the function of this composition for improved memory is better than Fructus Hippophae component or vitamin B
6, vitamin B
12, folic acid component and vitamin added elements component; Relatively there is significant difference with blank group.
Claims (10)
1. for preventing birth defect and improving a pharmaceutical composition of remembering, it is characterized in that, it is made by weight ratio by following raw materials according:
2. the pharmaceutical composition for preventing birth defect and improvement to remember according to claim 1, is characterized in that, it is made by weight ratio by following raw materials according:
3. the pharmaceutical composition for preventing birth defect and improvement to remember according to claim 1, is characterized in that, it is made by weight ratio by following raw materials according:
4. the pharmaceutical composition for preventing birth defect and improvement to remember according to claim 1, is characterized in that, it is made by weight ratio by following raw materials according:
5. the pharmaceutical composition for preventing birth defect and improvement to remember according to claim 1, is characterized in that, it is made by weight ratio by following raw materials according:
6. the pharmaceutical composition for preventing birth defect and improvement to remember according to claim 1, is characterized in that, it is made by weight ratio by following raw materials according:
7. the pharmaceutical composition for preventing birth defect and improvement to remember according to claim 1, is characterized in that, it is made by weight ratio by following raw materials according:
8. the pharmaceutical composition for preventing birth defect and improvement to remember according to claim 1, is characterized in that, it is made by weight ratio by following raw materials according:
9. the pharmaceutical composition for preventing birth defect and improvement to remember according to claim 1, is characterized in that, it is made by weight ratio by following raw materials according:
10. the pharmaceutical composition for preventing birth defect and improvement to remember according to claim 1, is characterized in that, it is made by weight ratio by following raw materials according:
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| CN101366757A (en) * | 2008-09-26 | 2009-02-18 | 北京冠五洲生物科学研究院 | Pharmaceutical combination for preventing birth defect and improving anamnesis |
| CN101366765A (en) * | 2008-09-26 | 2009-02-18 | 北京冠五洲生物科学研究院 | Pharmaceutical combination for preventing birth defect and improving anamnesis |
| CN101366766A (en) * | 2008-09-26 | 2009-02-18 | 北京冠五洲生物科学研究院 | Pharmaceutical combination for preventing birth defect and improving anamnesis |
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| CN101366767A (en) * | 2008-09-26 | 2009-02-18 | 北京冠五洲生物科学研究院 | Pharmaceutical combination for preventing birth defect and improving anamnesis |
| CN101366764A (en) * | 2008-09-26 | 2009-02-18 | 北京冠五洲生物科学研究院 | Pharmaceutical combination for preventing birth defect and improving anamnesis |
| CN101366761A (en) * | 2008-09-26 | 2009-02-18 | 北京冠五洲生物科学研究院 | Pharmaceutical combination for preventing birth defect and improving anamnesis |
| CN101366762A (en) * | 2008-09-26 | 2009-02-18 | 北京冠五洲生物科学研究院 | Pharmaceutical combination for preventing birth defect and improving anamnesis |
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Application publication date: 20140115 |