CN103505405B - Hydrogel constituent and the application being formed by it - Google Patents
Hydrogel constituent and the application being formed by it Download PDFInfo
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- CN103505405B CN103505405B CN201210226348.3A CN201210226348A CN103505405B CN 103505405 B CN103505405 B CN 103505405B CN 201210226348 A CN201210226348 A CN 201210226348A CN 103505405 B CN103505405 B CN 103505405B
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Abstract
The application that the present invention relates to hydrogel constituent and formed by it. A kind of hydrogel constituent, the polyacrylate that it comprises 5 % by weight～10 % by weight; The polyalcohol of 15 % by weight～41 % by weight; The pure water of 47 % by weight～76 % by weight; And the function reagent of 0.01 % by weight～9 % by weight, and the weight ratio scope of this pure water and polyalcohol is 1.1～5. When this hydrogel constituent or application are used for human skin, can make rapidly human skin lower the temperature more than 5 DEG C, and the temperature that can make rapidly human skin is down to the temperature range (more than 15 DEG C) that skin can bear, and can not make again the temperature of skin continue to reduce, cause skin frostbite. Moreover this hydrogel constituent and application when because of the impaired position of burn and scald, can make temperature be down to the temperature range that skin can bear, and have obvious help for wound healing in the future.
Description
Technical field
The present invention relates to a kind of application, particularly a kind of application of hydrogel constituent.
Background technology
Processing the most key step of burn and scald is cooling damaged part, and consults periodicalBurn, the content that 2000,28,173-176 discloses, can understand cooling damaged partThe good cold water that uses 8 DEG C～25 DEG C, and rinse time of damaged part and be about 15 pointsClock～20 minute, comparatively ideal temperature, about 15 DEG C, just can not cause damaged part to freezeWound, thus the problem that damaged part heals difficult in the future occurs. Have on the market at present and permittedHow can reduce the commodity of shell temperature, for example iced bag, ice pillow, heat radiation subsides etc.,Being applied to the position impaired because of burn and scald, there is inconvenient problem with use in described commodity,So still need the development while processing for burn and scald, can bring into play cooling damaged part effectApplication.
Application formula Design in general patch is mainly towards alleviating muscle or joint is sent outThe direction of scorching pain improves, so that active ingredient can be effectively released, andEasily absorbed by the skin of human body, and performance anti-inflammatory or analgesic effect.
TWI227145 discloses the application that a kind of hydrophily absorbs through skin. This application hasThe effect of anti-inflammatory analgesic the Sodium Polyacrylate (poly that comprises 1 % by weight～10 % by weightSodiumacrylate), the gelatin of 1 % by weight～10 % by weight (gelatin), 1 % by weight～The polyvinyl alcohol (polyvinylalcohol) of 10 % by weight, 1 % by weight～10 % by weightThe polyalcohol (glycol) of kaolin (kaolin), 5 % by weight～30 % by weight, 0.1 weightThe copolymer (copolymer) of %～10 % by weight, the carboxylic first of 0.5 % by weight～10 % by weightBase sodium cellulosate (sodiumcarboxymethylcellulose), and 10 % by weight～The pure water of 80 % by weight, and, menthol also added. But above-mentioned application is in systemStandby and use and still have problems, for example this sodium carboxymethylcellulose need be present inPH more than 7～9 just can stablize, but the application of meta-alkalescence has wound to human skinEvil. Moreover when this sodium carboxymethylcellulose and gelatin exist, it is heavy easily to form simultaneouslyShallow lake thing, causes application unstable, and this application cannot be used for the damaged part of burn and scaldOn.
In order to reach desirable burn and scald application condition, can be quick during with processing burn and scaldGround reaches the object of cooling damaged part, still needs to develop one and has iced effect and heightThe application of biocompatibility, to protect the damaged part of burn and scald.
Summary of the invention
The first object of the present invention is to provide a kind of hydrogel group with iced effectBecome thing.
Hydrogel constituent of the present invention, comprises:
The polyacrylate of 5 % by weight～10 % by weight;
The polyalcohol of 15 % by weight～41 % by weight;
The pure water of 47 % by weight～76 % by weight; And
The function reagent of 0.01 % by weight～9 % by weight,
And the weight ratio scope of this pure water and polyalcohol is 1.1～5.
Hydrogel constituent of the present invention, the weight ratio scope of described pure water and polyalcoholBe 3～5.
Hydrogel constituent of the present invention, taking the total amount of described hydrogel constituent as 100% by weight meter, the content range of described pure water is 67 % by weight～76 % by weight.
Hydrogel constituent of the present invention, taking the total amount of described hydrogel constituent as 100% by weight meter, the content range of described polyalcohol is 15 % by weight～22 % by weight.
Hydrogel constituent of the present invention, it also comprises polyvinyl alcohol, and with described water-settingThe total amount of glue constituent is 100 weight portion meters, and the content range of described polyvinyl alcohol is0.5 weight portion～5.5 weight portion.
Hydrogel constituent of the present invention, it also comprises soda acid adjusting agent, and with described waterThe total amount of gel composition is 100 weight portion meters, the content range of described soda acid adjusting agentIt is 0.6 weight portion～3 weight portion.
Hydrogel constituent of the present invention, it comprises: poly-third of 8 % by weight～9.5 % by weightThe glycerine of olefin(e) acid salt, 15 % by weight～39 % by weight, 50 % by weight～73 % by weight pureWater; The menthol of 0.3 % by weight～0.4 % by weight, the carboxylic of 0.3 % by weight～1.5 % by weightThe cetyl isopropyl propionate, 0.3 of base ethene polymers, 0.9 % by weight～1 % by weightThe sorbitol ester based compound of % by weight～0.4 % by weight, and 1 % by weight～1.5 weightThe Sodium Benzoate of %, and taking the total amount of described hydrogel constituent as 100 weight portions,The content range of described polyvinyl alcohol is 0.5 weight portion～3.2 weight portion, described soda acidThe content range of adjusting agent is 0.6 weight portion～0.7 weight portion.
Hydrogel constituent of the present invention, it comprises: poly-third of 5 % by weight～5.5 % by weightThe glycerine of olefin(e) acid salt, 15 % by weight～22 % by weight, 67 % by weight～76 % by weight pureThe polyacrylic acid of water, 0.3 % by weight～0.45 % by weight, 0.3 % by weight～0.4 % by weightMenthol, the Myrj 45 of 0.3 % by weight～0.4 % by weight, 0.01 weightThe titanium dioxide of amount %～0.1 % by weight, the kaolin of 0.01 % by weight～0.1 % by weight,And the gelatin of 2.5 % by weight～4.5 % by weight, and with the total amount of described hydrogel constituentBe 100 weight portion meters, the content range of described polyvinyl alcohol is 3.19 weight portion～5.5Weight portion, the content range of described soda acid adjusting agent is 2 weight portion～3 weight portions.
The second object of the present invention is to provide a kind of application with iced effect.
Application of the present invention, comprises: hydrogel constituent as above.
Beneficial effect of the present invention is: by the weight ratio of this pure water and polyalcoholRegulation and control, make this hydrogel constituent or application after iced, for human skin,Can bring into play rapidly iced effect and allow human epidermal skin lower the temperature more than 5 DEG C, and can be fastMake the temperature of human epidermal skin be down to temperature range that skin can bear (approximately fastlyMore than 15 DEG C), and can not make again the temperature of skin continue to reduce, cause skin frostbite.Moreover this hydrogel constituent and application, can when because of the impaired position of burn and scaldPromptly cooling this damaged part, significantly reduces the pain that damaged part brings and burnsHotness, and cool the temperature to the temperature range that skin can bear, for wound in the future moreClose obvious help.
Brief description of the drawings
Fig. 1 is curve map, and the iced effect of the embodiment of the present invention 8 is described;
Fig. 2 is curve map, and the iced effect of ice pack is described; And
Fig. 3 is curve map, and the iced effect of the embodiment of the present invention 1 and 2 is described.
Detailed description of the invention
The polyacrylic acid that hydrogel constituent of the present invention comprises 5 % by weight～10 % by weightSalt; The polyalcohol of 15 % by weight～41 % by weight; The pure water of 47 % by weight～76 % by weight;And the function reagent of 0.01 % by weight～9 % by weight, and the weight of this pure water and polyalcoholRatio range is 1.1～5. Preferably, the weight ratio scope of this pure water and polyalcoholBe 3～5.
Preferably, taking the total amount of this hydrogel constituent as 100 % by weight, this pure waterContent range be 67 % by weight～76 % by weight.
Preferably, this polyalcohol is selected from glycerine, D-sorbite (sorbitol), or theyCombination. Preferably, taking the total amount of this hydrogel constituent as 100 % by weight, shouldThe content range of polyalcohol is 15 % by weight～22 % by weight.
By the part by weight regulation and control of polyalcohol and pure water, can delay pure water volatilization looseThe speed of ease, makes this iced effect can be more lasting. And this hydrogel constituent orApplication, after iced, for human skin, can be brought into play rapidly iced effect and allowsHuman epidermal skin is lowered the temperature more than 5 DEG C, meanwhile, and can make rapidly human epidermal skinTemperature be down to the temperature range (more than approximately 15 DEG C) that skin can bear, and can not make againThe temperature of skin continues to reduce, and causes skin frostbite. Moreover, this hydrogel constituentAnd application is when because of the impaired position of burn and scald, promptly cooling this damaged part,Significantly reduce pain and burning heat sensation that damaged part brings, and temperature is down to skinThe temperature range that can bear, has obvious help for wound healing in the future. The present inventionHydrogel constituent also can be applicable to the acute position of wounding, spraining or dampening, doFor the application of best ice compress type.
This polyacrylate can be used alone or as a mixture, and this polyacrylate comprise butBe not limited to Sodium Polyacrylate, polyacrylic acid potassium, ammonium polyacrylate, polyacrylic acid list secondAlcohol ammonium, polyacrylic acid diethanol ammonium, or polyacrylic acid triethanol ammonium etc. Preferably,This polyacrylate is Sodium Polyacrylate.
This function reagent can be used alone or as a mixture, and this function regent pack contains but do not limitIn solvent (solvent), emulsifying agent (emulsifier), suspending agent (suspendingagent),Dispersant (dispersant), surfactant (surfactant), binding agent (bindingAgent), excipient (excipient), stabilizing agent (stabilizingagent), chelating agent(chelatingagent), diluent (diluent), freshener, anticorrisive agent(preservative), thickener (viscosity-increasingagent), filler(filler), gelling agent (gellingagent) or lubricant (lubricant) etc. This solvent bagContain but be not limited to isopropyl alcohol. This emulsifying agent is including but not limited to Myrj 45(polyoxyethylenestearate), carboxyl ethylene polymer (carboxyvinylPolymer), alkyl acid isopropyl ester, or sorbitol ester based compound (sorbitanEster-basedcompounds) etc. This anticorrisive agent including but not limited to Sodium Benzoate,Methyl p-hydroxybenzoate, ethyl-para-hydroxybenzoate, or propylparabenDeng. This filler is including but not limited to kaolin or titanium dioxide etc. This freshener bagContain but be not limited to menthol or borneol etc. This thickener is including but not limited to polyacrylic acid.
Preferably, this Myrj 45 is as shown in the formula shown in (I):
In formula (I), n represents 2～150 integer.
Preferably, this carboxyl ethylene polymer is molecular weight 300～115,000 poly-thirdOlefin(e) acid polymer. This carboxyl ethylene polymer can be used alone or as a mixture, and this carboxylEthene polymers including but not limited to carbomer910 (molecular weight 3,000～7,000),Carbomer934 (molecular weight 30,500～39,400), carbomer934P (molecular weight29,400～39,400), carbomer940 (molecular weight 40,000～60,000),Carbomer941 (molecular weight 4,000～11,000), or carbomer1342 (molecular weight9,500～26,500). In embodiments of the invention, this carboxyl ethylene polymer concreteFor example carbomer934 (molecular weight 30,500～39,400).
Preferably, this alkyl acid isopropyl ester is selected from cetyl isopropyl propionate (isopropylPalmitate), myristyl isopropyl propionate (isopropylmyristate), or theyCombination. In embodiments of the invention, this alkyl acid isopropyl ester is cetyl acid isopropylEster.
Preferably, this sorbitol ester based compound is selected from polyoxyethylene sorbitol acid anhydrideMonolaurate (polyoxyethylenesorbitanmonolaurate), polyoxyethylene mountainPears sugar alcohol acid anhydride monopalmitate (polyoxyethylenesorbitanmonopalmitate),Tween-60 (polyoxyethylenesorbitanMonostearate), Tween-65(polyoxyethylenesorbitantristearate), polyoxyethylene sorbitol acid anhydride list oilAcid esters (polyoxyethylenesorbitanmonooleate), polyoxyethylene sorbitolAcid anhydride trioleate (polyoxyethylenesorbitantrioleate), sorbitan listLaurate (sorbitanmonolaurate), sorbitan monopalmitate(sorbitanmonopalmitate), sorbitan monostearate (sorbitanMonostearate), sorbitan tristearate (sorbitantristearate), mountainPears sugar alcohol acid anhydride monoleate (sorbitanmonooleate), sorbitan trioleate, or their combination (sorbitantrioleate). In embodiments of the invention, this mountainPears sugar alcohol ester based compound is Tween-81, model:Tween80, and taking the total amount of this hydrogel constituent as 100 % by weight, this sorbThe content range of sugar alcohol ester based compound is 0.3 % by weight.
Preferably, this hydrogel constituent also comprises polyvinyl alcohol, and with this hydrogelThe total amount of constituent is 100 weight portion meters, and the content range of this polyvinyl alcohol is 0.5 weightAmount part～5.5 weight portions.
Preferably, this hydrogel constituent also comprises soda acid adjusting agent, and with this water-settingThe total amount of glue constituent is 100 weight portion meters, and the content range of this soda acid adjusting agent is0.6 weight portion～3 weight portion. The kind of this soda acid adjusting agent is not particularly limited,As long as can make this hydrogel constituent there is skin-friendly. This soda acid adjusting agent can be singleOnly or mixing is used, and this soda acid adjusting agent is including but not limited to tartaric acid or hydroxideSodium etc. Preferably, by this soda acid adjusting agent by hydrogel constituent of the present inventionPH regulates and controls 4.5～7, can have good skin-friendly.
In an embodiment of the present invention, this hydrogel constituent comprises 8 % by weight～9.5The polyacrylate of % by weight, the glycerine of 15 % by weight～39 % by weight, 50 % by weight～The pure water of 73 % by weight; The menthol of 0.3 % by weight～0.4 % by weight, 0.3 % by weight～The carboxyl ethylene polymer of 1.5 % by weight, the cetyl acid of 0.9 % by weight～1 % by weightThe sorbitol ester based compound of isopropyl ester, 0.3 % by weight～0.4 % by weight, and 1 weightThe Sodium Benzoate of amount %～1.5 % by weight, and taking the total amount of this hydrogel constituent as 100Weight portion meter, the content range of this polyvinyl alcohol is 0.5 weight portion～3.2 weight portion,The content range of this soda acid adjusting agent is 0.6 weight portion～0.7 weight portion.
In an embodiment of the present invention, this hydrogel constituent comprises 5 % by weight～5.5The polyacrylate of % by weight, the glycerine of 15 % by weight～22 % by weight, 67 % by weight～The pure water of 76 % by weight, the polyacrylic acid of 0.3 % by weight～0.45 % by weight, 0.3 weightThe menthol of %～0.4 % by weight, the polyoxyethylene stearyl of 0.3 % by weight～0.4 % by weightThe titanium dioxide of acid esters, 0.01 % by weight～0.1 % by weight, 0.01 % by weight～0.1 weightThe kaolin of %, and the gelatin of 2.5 % by weight～4.5 % by weight, and with this hydrogel groupBecoming the total amount of thing is 100 weight portion meters, and the content range of this polyvinyl alcohol is 3.19 weightPart～5.5 weight portions, the content range of this soda acid adjusting agent is 2 weight portion～3 weightPart.
This hydrogel constituent can adopt general hybrid mode by polyacrylate, manyUnit's alcohol, pure water and function reagent, and optionally add polyvinyl alcohol or soda acid adjustmentAgent evenly mixes, and can obtain hydrogel constituent of the present invention.
Application of the present invention comprises hydrogel constituent as above. This application can be,But be not limited to: emulsion (emulsion), gel (gel), ointment (ointment), breast frost(cream), paster (patch), liniment (embrocation), aerosol (aerosol), sprayMist (spray), emulsion (lotion), serum (serum), paste (paste), foam (foam)And drops (drop). The preparation of this application can adopt method for making in the past, so no longerRepeat in detail.
In embodiments of the invention, this application is paster, and this paster is by water of the present inventionGel composition is formed on base material. The preparation method of this paster can be according to general preparationMode, so repeat no more. This base material is not particularly limited, and its comprise butBe not limited to adhesive-bonded fabric. This paster has preferably docile property and can not stick damaged part,And there is preferably fissility, when avoiding paster to tear off damaged part, cause and be subject toDamage the advantages such as position secondary injury.
<embodiment>
[embodiment 1～12] hydrogel constituent and application
Polyacrylate is evenly mixed with glycerine, form the first component; By pure water,Soda acid adjusting agent and function reagent evenly mix, and form second component; Then, shouldThe first component and second component evenly mix, and can make hydrogel constituent. This is formerKind and the use amount thereof of material are as shown in table 1.
Hydrogel constituent described above is formed at respectively on base material, treats maturationForm paster.
[assessment item]
1. iced effect: by the paster of embodiment 1,2,8,9 and 12 be placed in 4 DEG C coldIn the cabinet of Tibetan, more than 8 hours, after taking-up, be placed in rapidly testee's the nearly elbow of both hands forearm place,Test with infra red thermograph (model: NECG100W2) again, within every 10 seconds, get 1Individual picture (frame), tests 15 minutes, totally 90 pictures Output rusults.
2. fissility: will on the paster of embodiment 1～12, cover respectively one deck glassine paper,Treat that glassine paper removes, on sight glasses paper, whether have hydrogel constituent residual.
3. adherence: the paster of embodiment 1～12 is placed in respectively at 24 DEG C～27 DEG C,According to the ball experimental test of continent pharmacopeia, its range of viscosities is No. 9 steel ball～No. 20 steel ballsFor good, be more preferably No. 13 steel balls.
From the result of Fig. 1 and Fig. 3, when the weight ratio scope of this pure water and glycerineBe 1.15～4.95 o'clock, this hydrogel constituent, for human skin, can make rapidlyHuman skin is lowered the temperature more than 5 DEG C, and can effectively maintain more than 15 minutes, and reaches icedEffect, and can make the temperature of human skin be down to (15 DEG C of the temperature ranges that skin can bearAbove).
From the result of Fig. 2, though use ice pack ice compress can make rapidly human skinCooling is more than 21 DEG C, but it can make the temperature of human skin to reducing by 12 DEG C, likelyCan make human skin top layer frostbite, and cause the more serious injury of damaged part.
In sum, the regulation and control of the weight ratio by this pure water and polyalcohol, this waterGel composition or application, after iced, for human skin, can make people rapidlyBody skin is lowered the temperature more than 5 DEG C, and reaches iced effect, and can make the temperature of human skinBe down to the temperature range (more than 15 DEG C) that skin can bear, and can not make again the temperature of skinDegree continues to reduce, and causes skin frostbite. Moreover this hydrogel constituent and application are usedWhen because of the impaired position of burn and scald, promptly cooling this damaged part, significantly fallsThe pain that low damaged part brings and burning heat sensation, and temperature is down to skin and can be bornTemperature range, have obvious help for wound healing in the future, so really can reachBecome object of the present invention.
Claims (2)
1. a hydrogel constituent, is characterized in that, it is by following composition instituteComposition: the polyacrylate of 8 % by weight～9.5 % by weight, 15 % by weight～39 % by weightGlycerine, the pure water of 50 % by weight～73 % by weight; 0.3 % by weight～0.4 % by weightThe carboxyl ethylene polymer of menthol, 0.3 % by weight～1.5 % by weight, 0.9 % by weight～The cetyl isopropyl propionate of 1 % by weight, the D-sorbite of 0.3 % by weight～0.4 % by weightEster based compound, and the Sodium Benzoate of 1 % by weight～1.5 % by weight, and polyvinyl alcoholAnd soda acid adjusting agent, and taking the total amount of described hydrogel constituent as 100 weight portions,The content range of described polyvinyl alcohol is 0.5 weight portion～3.2 weight portion, described soda acidThe content range of adjusting agent is 0.6 weight portion～0.7 weight portion, all the components contentSummation is 100 % by weight.
2. a hydrogel constituent, is characterized in that, it is by following composition instituteComposition: the polyacrylate of 5 % by weight～5.5 % by weight, 15 % by weight～22 % by weightPure water, 0.3 % by weight～0.45 % by weight of glycerine, 67 % by weight～76 % by weightThe menthol of polyacrylic acid, 0.3 % by weight～0.4 % by weight, 0.3 % by weight～0.4 weightThe titanium dioxide of Myrj 45,0.01 % by weight～0.1 % by weight of amount %,The kaolin of 0.01 % by weight～0.1 % by weight, and 2.5 % by weight～4.5 % by weight is brightGlue, and polyvinyl alcohol and soda acid adjusting agent, and total with described hydrogel constituentAmount is 100 weight portion meters, the content range of described polyvinyl alcohol be 3.19 weight portions～5.5 weight portions, the content range of described soda acid adjusting agent is 2 weight portion～3 weight portions,The summation of all the components content is 100 % by weight.
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| CN102144989A (en) * | 2011-04-28 | 2011-08-10 | 天津瑞德药业有限公司 | Preparation method of hydrogel cataplasm and prepared cataplasm with effect of relieving swelling and pains |
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| CN102144989A (en) * | 2011-04-28 | 2011-08-10 | 天津瑞德药业有限公司 | Preparation method of hydrogel cataplasm and prepared cataplasm with effect of relieving swelling and pains |
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