CN103505372A - Micro-capsule preparation production equipment high in yield and wide in application range - Google Patents
Micro-capsule preparation production equipment high in yield and wide in application range Download PDFInfo
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- CN103505372A CN103505372A CN201310494891.6A CN201310494891A CN103505372A CN 103505372 A CN103505372 A CN 103505372A CN 201310494891 A CN201310494891 A CN 201310494891A CN 103505372 A CN103505372 A CN 103505372A
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- aerator
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- 239000003094 microcapsule Substances 0.000 title claims abstract description 38
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 25
- 238000002360 preparation method Methods 0.000 title abstract description 7
- 238000001035 drying Methods 0.000 claims abstract description 58
- 239000000428 dust Substances 0.000 claims abstract description 37
- 239000012452 mother liquor Substances 0.000 claims abstract description 36
- 239000004744 fabric Substances 0.000 claims abstract description 35
- 239000000463 material Substances 0.000 claims description 128
- 238000005276 aerator Methods 0.000 claims description 41
- 239000000203 mixture Substances 0.000 claims description 30
- 238000009472 formulation Methods 0.000 claims description 28
- 238000007664 blowing Methods 0.000 claims description 23
- 238000006073 displacement reaction Methods 0.000 claims description 23
- 230000004083 survival effect Effects 0.000 abstract description 4
- 239000000047 product Substances 0.000 description 31
- 230000000975 bioactive effect Effects 0.000 description 16
- 239000000126 substance Substances 0.000 description 16
- 239000003814 drug Substances 0.000 description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 230000007423 decrease Effects 0.000 description 8
- 238000010586 diagram Methods 0.000 description 7
- 238000000034 method Methods 0.000 description 6
- 230000008859 change Effects 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 230000006872 improvement Effects 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 238000004140 cleaning Methods 0.000 description 4
- 238000001816 cooling Methods 0.000 description 4
- 239000010413 mother solution Substances 0.000 description 4
- 239000007921 spray Substances 0.000 description 4
- 101100480474 Rattus norvegicus Taar7b gene Proteins 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 238000007599 discharging Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000009688 liquid atomisation Methods 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 206010011732 Cyst Diseases 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 208000031513 cyst Diseases 0.000 description 1
- 239000003405 delayed action preparation Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 239000006041 probiotic Substances 0.000 description 1
- 230000000529 probiotic effect Effects 0.000 description 1
- 235000018291 probiotics Nutrition 0.000 description 1
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- Manufacturing Of Micro-Capsules (AREA)
Abstract
The invention discloses micro-capsule preparation production equipment high in yield and wide in application range. The micro-capsule preparation production equipment high in yield and wide in application range comprises a mother liquor tank, a plunger pump, drying devices, air blowers, an induced draft fan, air-stopping machines, a material-making tower, a material-collecting tower, a cloth bag pulse dust collector and an air compressor. The mother liquor tank is connected with the material-making tower through a connecting pipeline. The plunger pump is arranged between the mother liquor tank and the material-making tower. An air outlet of the first air blower is connected with the first drying device, and the first drying device is connected with the top of the material-making tower through a connecting pipeline. A pipeline set with holes is arranged in the material-making tower. An air outlet of the second air blower is connected with the second drying device, and the second drying device is connected with the pipeline set with the holes through a connecting pipeline. The bottom of the material-making tower is connected with the material-collecting tower through a connecting pipeline. The top of the material-collecting tower is connected with the cloth bag pulse dust collector through a connecting pipeline. The air compressor is connected with the cloth bag pulse dust collector through a connecting pipeline. The cloth bag pulse dust collector is connected with an air inlet of the induced draft fan through a connecting pipeline. The micro-capsule preparation production equipment high in yield and wide in application range improves the rate of finished products of the material-making tower and the survival rate of bioactivators in micro-capsule preparations.
Description
technical field
The present invention relates to oral microcapsule formulation process equipment field, particularly the high microcapsule formulation production equipment applied widely of a kind of productive rate.
Background technology
Microcapsule system utilizes natural or synthetic macromolecular material (being referred to as capsule material) as cyst membrane wall shell, the Drug Storage type microencapsulation that solid-state or liquid drug or bioactive substance or the strong material parcel of water solublity are become.Microcapsule can be covered bad smell and the taste of the material that medicine or bioactive substance or water solublity are strong; Can also improve the stability of the material that medicine or bioactive substance or water solublity are strong; And can reduce the stimulation of medicine to stomach; Solidify liquid drug, to facilitate its use; The compatibility that reduces compound medicine changes; Wherein maximum is to form sustained-release preparation and targeting preparation by microencapsulation method.
The oral microcapsule formulation production equipment that can use as shown in Figure 1 of producing of microcapsule formulation is produced, comprise blender 1, mother liquor tank 2, plunger displacement pump 4, nozzle 7, drying equipment 8, air filter 9, aerator, air-introduced machine, Blowing stopper, system material tower 12, material collection tower 13, cloth bag pulse dust collector 14 and air compressor machine 15, in described mother liquor tank 2, there is blender 1, described mother liquor tank has lower ball valve 3-1 for 2 times, described mother liquor tank 2 is connected with system material tower 12 by connecting pipe 5, between described mother liquor tank 2 and system material tower 12, there is plunger displacement pump 4, between described mother liquor tank 2 and plunger displacement pump 4, there is connection valve 3-2, between described plunger displacement pump 4 and system material tower 12, there is switch valve 6, described nozzle 7 is in system material tower 12, described nozzle 7 is arranged on connecting pipe 5 one end, described aerator has 2, described the first aerator 10-1 air inlet has air filter 9, described the first aerator 10-1 air outlet is connected with drying equipment 8, described drying equipment 8 is connected with system material Ta12 top by connecting pipe 5, described material tower processed 12 bottom discharge mouths have the first Blowing stopper 11-1, described material tower processed 12 bottoms have connecting pipe 5 to be connected with material collection tower 13, described collection tower 13 bottom discharge mouths have the second Blowing stopper 11-2, described collection Ta13 top is connected with cloth bag pulse dust collector 14 by connecting pipe 5, described air compressor machine 15 is connected with cloth bag pulse dust collector 14 by connecting pipe 5, described cloth bag pulse dust collector 14 bottom discharge mouths have the 3rd Blowing stopper 11-3, described cloth bag pulse dust collector 14 is connected with air-introduced machine 10-2 air inlet by connecting pipe 5, during this production equipment work, by blender 1, stir the interior mother solution of mother liquor tank 2, by plunger displacement pump 4, mother solution is transported to system material tower 12 again and passes through nozzle 7 by feed liquid atomization, meanwhile, air enters the first aerator 10-1 through air filter 9, after drying equipment 8 is dry, by connecting pipe 5, enter system material tower 12, droplet with through entering the hot blast of drying tower, in tower, mix, carry out flash heat transfer mass transfer, at extremely short time inner drying, become powder granular products, finished product falls by system material tower 12 discharge hole for discharge, remaining unfinished work is through material collection tower 13, part finished product finished product falls by system material tower 12 discharge hole for discharge, decline unfinished work is through cloth bag pulse dust collector 14, part finished product falls by cloth bag pulse dust collector 14 discharge hole for discharge, another part by air compressor machine 15 voltage supply again by after bag pulse dust collector 14 dedustings through air-introduced machine 10-2 air-out.
There are the following problems in production like this, first due to for fast cooling, therefore initial stage wind speed requires very fast, wind-force requires very large, therefore in initial stage material tower processed, yield rate is lower, and the end product quality in early stage is best after tested, although having increased again material collection tower and cloth bag pulse dust collector collects finished product, it is higher that but the more finished products in the place that wind passes through are retained on inwall probability, therefore still there are a lot of finished products to be retained on inwall, these dissolvent residuals can cause sticky wall, affecting subsequent product makes, secondly because the microcapsule formulation of bioactive substance or the strong material of water solublity can only be survived at a certain temperature, high temperature can only be survived the very short time, and this equipment hot blast persistent period is longer, therefore the material that bioactive substance or water solublity are strong is easily dead, once the material that bioactive substance or water solublity are strong is dead just without any drug effect.
Summary of the invention
For above problem, the present invention is the high microcapsule formulation production equipment applied widely of a kind of productive rate, this equipment arranges pipeline group with holes in system material tower, the dry gas that temperature is lower is sprayed by hole on pipeline group pipeline with holes, slowed down so on the one hand the decrease speed of initial stage material, improved the yield rate of system material tower, on the other hand, lower owing to entering gas temperature, after dry materials, can lower the temperature at once, and then greatly improved the survival rate of bioactive substance in microcapsule formulation, for reaching this object, the invention provides the high microcapsule formulation production equipment applied widely of a kind of productive rate, comprise blender, mother liquor tank, plunger displacement pump, nozzle, drying equipment, air filter, aerator, air-introduced machine, Blowing stopper, system material tower, material collection tower, cloth bag pulse dust collector and air compressor machine, in described mother liquor tank, there is blender, under described mother liquor tank, there is lower ball valve, described mother liquor tank is connected with system material tower by connecting pipe, between described mother liquor tank and system material tower, there is plunger displacement pump, between described mother liquor tank and plunger displacement pump, there is connection valve, between described plunger displacement pump and system material tower, there is switch valve, described nozzle is in system material tower, described nozzle is arranged on connecting pipe one end, described aerator has 3, described the first blower inlet has the first air filter, described the first blower outlet is connected with the first drying equipment, between described the first drying equipment and system material tower, there is the first temperature inductor, described the first drying equipment is connected with system material top of tower by connecting pipe, in described material tower processed, there is pipeline group with holes, described pipeline group with holes comprises pipe box and mesh duct, described mesh duct has 2-5 layer, described mesh duct is arranged in pipe box, described pipe box upper strata and interior survey wall are all porose, all porose on mesh duct transverse pipe and longitudinal pipe, described hole is opening up, described the second blower inlet has the second air filter, described the second blower outlet is connected with the second drying equipment, described the second drying equipment is connected with pipeline group with holes by connecting pipe, between described the second drying equipment and pipeline group with holes, there are the second temperature inductor and control valve, on described control valve, there is Pressure gauge, described material tower bottom discharging opening processed has the first Blowing stopper, described material tower bottom processed has connecting pipe to be connected with material collection tower, described collection tower bottom discharging opening has the second Blowing stopper, described collection top of tower is connected with cloth bag pulse dust collector by connecting pipe, described air compressor machine is connected with cloth bag pulse dust collector by connecting pipe, described cloth bag pulse dust collector bottom discharge mouth has the 3rd Blowing stopper, described cloth bag pulse dust collector is connected with fan inlet by connecting pipe.
As a further improvement on the present invention, on the canister aperture of described pipeline group with holes and mesh duct hole, there is fixed network, in described fixed network outer side edges, there is fixing hole, described fixed network is fixed on hole by fixture, because the application hole is The more the better, hole is the smaller the better, if but only very high at hole pipeline group cost, therefore hole can be first set, Zai installs fixed network on hole, if wrap up owing to producing the material that bioactive substance or water solublity are strong the Drug Storage type microencapsulation becoming, Kongzui is well very very little, if so only very high at pipeline group Shang Nong hole, hole cost, if use fixed network, hole just need not be very little, and fixed network can be fixed on hole by fixture, therefore can follow and change according to product difference.
As a further improvement on the present invention, described fixed network mesh size is 20 μ m---5 ㎜, according to product different material size, has obvious difference, and after mesh is less than material, material is just not easy to block mesh.
As a further improvement on the present invention, the inlet temperature of described the first aerator after the first drying equipment is processed is 80 degrees Celsius-160 degrees Celsius, the inlet temperature of described the second aerator after the second drying equipment is processed is 45 degrees Celsius-100 degrees Celsius, and the different inlet temperature of the present invention can be produced different product and be had operator and can select according to practical situation.
As a further improvement on the present invention, described have cover plate in system material tower one side, for pipeline group with holes is installed cleaning conveniently, can cover plate be set in system material tower one side.
As a further improvement on the present invention, described have threaded ends in system material one end, tower inner connection tube road, described nozzle is threaded connection mode and is arranged on connecting pipe one end, the application's nozzle can be installed to place by screw thread and be arranged on system material tower connecting pipe port, can to nozzle, change according to product difference like this.
The present invention is the high microcapsule formulation production equipment applied widely of a kind of productive rate, this equipment arranges pipeline group with holes in system material tower, the dry gas that temperature is lower is sprayed by hole on pipeline group pipeline with holes, owing to entering, the gas direction that gas first touches is different from it, therefore can slow down the decrease speed of initial stage material, material is just easily being made material tower formation finished product after declining slowly, and then the yield rate of deduction system material tower, in addition lower owing to entering gas temperature, decline gas is in contact with it early, therefore after dry materials, cooling rate significantly improves, temperature drops to bioactive substance in certain rear microcapsule formulation just can be dead, and then greatly improved the survival rate of bioactive substance in microcapsule formulation, owing to having pipeline group with holes in the application's material tower processed, gas sprays from hole, therefore solvent just can not remain on system material inner wall of tower at fast contact system material inner wall of tower, therefore not having sticky wall produces, although the application hole is The more the better, hole is the smaller the better, because hole is very very little, if only very high at pipeline group Shang Nong hole, hole cost, therefore hole can be first set, Zai installs fixed network on hole, two blower inlets of the application go out to be provided with temperature inductor, operator can carry out temperature adjusting according to the concrete condition of different pharmaceutical in microcapsule formulation or bioactive substance or the strong material of water solublity, the second blower inlet place is provided with control valve, on control valve, there is Pressure gauge, operator can regulate entering wind speed as required, the application's nozzle can be installed to place by screw thread and be arranged on system material tower connecting pipe port, can to nozzle, change according to product difference like this, in addition for pipeline group with holes, cleaning being installed facilitates the application's material tower one side processed that cover plate is set.
Accompanying drawing explanation
Fig. 1 is prior art schematic diagram of the present invention;
Fig. 2 is schematic diagram of the present invention;
Fig. 3 is a kind of embodiment top view of the present invention's pipeline group with holes;
Fig. 4 is the another kind of embodiment top view of the present invention's pipeline group with holes;
Fig. 5 is fixed network schematic diagram of the present invention;
Fig. 6 is material tower schematic diagram processed of the present invention;
Fig. 7 is nozzle schematic diagram of the present invention;
Member in figure is:
1, blender; 2, mother liquor tank; 3-1, lower ball valve;
3-2, connection valve; 4, plunger displacement pump; 5, connecting pipe;
5-1, threaded ends; 6, switch valve; 7, nozzle;
8, drying equipment; 8-1, the first drying equipment; 8-2, the second drying equipment;
9, air filter; 9-1, the first air filter; 9-2, the second air filter;
10-1, the first aerator; 10-2, air-introduced machine; 10-3, the second aerator;
11-1, the first Blowing stopper; 11-2, the second Blowing stopper; 11-3, the 3rd Blowing stopper;
12, system material tower; 13, material collection tower; 14, cloth bag pulse dust collector;
15, air compressor machine; 16, cover plate; 17-1, the first temperature inductor;
17-2, the second temperature inductor; 18, Pressure gauge; 19, control valve;
20, pipeline group with holes; 20-1, pipe box; 20-2, mesh duct;
20-3, hole; 21, fixed network; 21-1, fixing hole.
The specific embodiment
Below in conjunction with drawings and Examples, invention is described in detail:
The present invention is the high microcapsule formulation production equipment applied widely of a kind of productive rate, this equipment arranges pipeline group with holes in system material tower, the dry gas that temperature is lower is sprayed by hole on pipeline group pipeline with holes, slowed down so on the one hand the decrease speed of initial stage material, the yield rate that has improved system material tower is on the other hand, lower owing to entering gas temperature, after dry materials, can lower the temperature at once, and then greatly improve the survival rate of bioactive substance in microcapsule formulation.
As a kind of specific embodiment of the present invention, the invention provides the high microcapsule formulation production equipment applied widely of schematic diagram a kind of productive rate as shown in Figure 2, comprise blender 1, mother liquor tank 2, plunger displacement pump 4, nozzle 7, drying equipment, air filter, aerator, air-introduced machine, Blowing stopper, system material tower 12, material collection tower 13, cloth bag pulse dust collector 14 and air compressor machine 15, in described mother liquor tank 2, there is blender 1, described mother liquor tank has lower ball valve 3-1 for 2 times, described mother liquor tank 2 is connected with system material tower 12 by connecting pipe 5, between described mother liquor tank 2 and system material tower 12, there is plunger displacement pump 4, between described mother liquor tank 2 and plunger displacement pump 4, there is connection valve 3-2, between described plunger displacement pump 4 and system material tower 12, there is switch valve 6, described nozzle 7 is in system material tower 12, described nozzle 7 is arranged on connecting pipe 5 one end, described aerator has 3, described the first aerator 10-1 air inlet has the first air filter 9-1, described the first aerator 10-1 air outlet is connected with the first drying equipment 8-1, between described the first drying equipment 8-1 and system material tower 12, there is the first temperature inductor 17-1, described the first drying equipment 8-1 is connected with system material Ta12 top by connecting pipe 5, , the inlet temperature of described the first aerator 10-1 after the first drying equipment 8-1 processes is 80 degrees Celsius-160 degrees Celsius, the different inlet temperature of the present invention can be produced different product and be had operator and can select according to practical situation, in described material tower 12 processed, there is pipeline group 20 with holes, described pipeline group with holes 20 comprises pipe box 20-1 and mesh duct 20-2, described mesh duct 20-2 has 2-5 layer, described mesh duct 20-2 is arranged in pipe box 20-1, described pipe box 20-1 is the equal porose 20-3 of upper strata and interior survey wall as shown in Figure 3, equal porose 20-3 on mesh duct 20-2 transverse pipe and longitudinal pipe, described hole 20-3 is opening up, described the second aerator 10-3 air inlet has the second air filter 9-2, described the second aerator 10-3 air outlet is connected with the second drying equipment 8-2, the inlet temperature of described the second aerator 10-3 after the second drying equipment 8-2 processes is 45 degrees Celsius-100 degrees Celsius, the different inlet temperature of the present invention can be produced different product and be had operator and can select according to practical situation, described the second drying equipment 8-2 is connected with pipeline group 20 with holes by connecting pipe 5, between described the second drying equipment 8-2 and pipeline group with holes 20, there are the second temperature inductor 17-2 and control valve 19, on described control valve 19, there is Pressure gauge 18, described material tower processed 12 bottom discharge mouths have the first Blowing stopper 11-1, described material tower processed 12 bottoms have connecting pipe 5 to be connected with material collection tower 13, described collection tower 13 bottom discharge mouths have the second Blowing stopper 11-2, described collection Ta13 top is connected with cloth bag pulse dust collector 14 by connecting pipe 5, described air compressor machine 15 is connected with cloth bag pulse dust collector 14 by connecting pipe 5, described cloth bag pulse dust collector 14 bottom discharge mouths have the 3rd Blowing stopper 11-3, described cloth bag pulse dust collector 14 is connected with air-introduced machine 10-2 air inlet by connecting pipe 5.
As a kind of best specific embodiment of the present invention, the invention provides the high microcapsule formulation production equipment applied widely of schematic diagram a kind of productive rate as shown in Figure 2, comprise blender 1, mother liquor tank 2, plunger displacement pump 4, nozzle 7, drying equipment, air filter, aerator, air-introduced machine, Blowing stopper, system material tower 12, material collection tower 13, cloth bag pulse dust collector 14 and air compressor machine 15, in described mother liquor tank 2, there is blender 1, described mother liquor tank has lower ball valve 3-1 for 2 times, described mother liquor tank 2 is connected with system material tower 12 by connecting pipe 5, between described mother liquor tank 2 and system material tower 12, there is plunger displacement pump 4, between described mother liquor tank 2 and plunger displacement pump 4, there is connection valve 3-2, between described plunger displacement pump 4 and system material tower 12, there is switch valve 6, described nozzle 7 is in system material tower 12, described have threaded ends 5-1 in 5 one end, inner connection tube road as shown in Figure 7 at system material tower 12, described nozzle 7 is threaded connection mode and is arranged on connecting pipe 5 one end, the application's nozzle 7 can be installed to place by screw thread and be arranged on system material tower 12 connecting pipe 5 ports, can to nozzle, change according to product difference like this, described aerator has 3, described the first aerator 10-1 air inlet has the first air filter 9-1, described the first aerator 10-1 air outlet is connected with the first drying equipment 8-1, between described the first drying equipment 8-1 and system material tower 12, there is the first temperature inductor 17-1, described the first drying equipment 8-1 is connected with system material Ta12 top by connecting pipe 5, in described material tower 12 processed, there is pipeline group 20 with holes, described pipeline group with holes 20 comprises pipe box 20-1 and mesh duct 20-2, described mesh duct 20-2 has 2-5 layer, described mesh duct 20-2 is arranged in pipe box 20-1, described pipe box 20-1 upper strata and interior survey wall be porose 20-3 all, equal porose 20-3 on mesh duct 20-2 transverse pipe and longitudinal pipe, described hole 20-3 is opening up, on the pipe box 20-1 hole 20-3 of described pipeline group with holes 20 and mesh duct 20-2 hole 20-3, there is fixed network 21, in described fixed network 21 outer side edges, there is fixing hole 21-1, described fixed network 21 is fixed on the 20-3 of hole by fixture as shown in Figure 5, due to the application hole, 20-3 is The more the better, hole 20-3 is the smaller the better, if but only very high at hole pipeline group 20 costs, therefore hole can be first set, on the 20-3 of Zai hole, fixed network 21 is installed as shown in Figure 4, if wrap up owing to producing the material that bioactive substance or water solublity are strong the Drug Storage type microencapsulation becoming, hole 20-3 is preferably very very little, if so only very high at pipeline group 20Shang Nong hole, hole cost, if use fixed network 21, hole just need not be very little, and fixed network 21 can be fixed on hole by fixture, therefore can follow and change according to product difference, described fixed network 21 mesh sizes are 20 μ m---5 ㎜, according to product different material size, have obvious difference, after mesh is less than material, material is just not easy to block mesh, described have cover plate 16 at system material tower 12 as Fig. 6 mono-side, for 20 groups, pipeline with holes is installed cleaning conveniently, can cover plate 16 be set in system material tower 12 1 sides, described the second aerator 10-3 air inlet has the second air filter 9-2, described the second aerator 10-3 air outlet is connected with the second drying equipment 8-2, described the second drying equipment 8-2 is connected with pipeline group 20 with holes by connecting pipe 5, between described the second drying equipment 8-2 and pipeline group with holes 20, there are the second temperature inductor 17-2 and control valve 19, on described control valve 19, there is Pressure gauge 18, described material tower processed 12 bottom discharge mouths have the first Blowing stopper 11-1, described material tower processed 12 bottoms have connecting pipe 5 to be connected with material collection tower 13, described collection tower 13 bottom discharge mouths have the second Blowing stopper 11-2, described collection Ta13 top is connected with cloth bag pulse dust collector 14 by connecting pipe 5, described air compressor machine 15 is connected with cloth bag pulse dust collector 14 by connecting pipe 5, described cloth bag pulse dust collector 14 bottom discharge mouths have the 3rd Blowing stopper 11-3, described cloth bag pulse dust collector 14 is connected with air-introduced machine 10-2 air inlet by connecting pipe 5.
When the application works, by blender 1, stir the interior mother solution of mother liquor tank 2, by plunger displacement pump 4, mother solution is transported to system material tower 12 again and passes through nozzle 7 by feed liquid atomization, meanwhile, air enters the first aerator 10-1 through the first air filter 9-1, after the first drying equipment 8-1 is dry, by connecting pipe 5, enter system material tower 12, droplet with through entering the hot blast of drying tower, in tower, mix, carry out flash heat transfer mass transfer, at extremely short time inner drying, become powder granular products, in powder granular products dropping process, run into the gas cooling deceleration that pipeline group 20 with holes sprays, the gas that wherein pipeline group 20 with holes sprays is through the second air filter 9-2, to enter the second aerator 10-3 by air, after the second drying equipment 8-2 is dry, through the pipe box 20-1 of pipeline group 20 with holes and the hole 20-3 of mesh duct 20-2, spray, ejection gas temperature carries out temperature control by the second temperature inductor 17-2, speed is controlled by Pressure gauge 18 use control valves 19 by operator, because ejection gas temperature and gas temperature before exist the temperature difference, can carry out fast cooling to material, ejection gas direction is contrary with gas direction before, can greatly reduce material decrease speed, and then a large amount of finished products fall by system material tower 12 discharge hole for discharge, remaining unfinished work is through material collection tower 13, part finished product finished product falls by system material tower 12 discharge hole for discharge, decline unfinished work is through cloth bag pulse dust collector 14, part finished product falls by cloth bag pulse dust collector 14 discharge hole for discharge, another part by air compressor machine 15 voltage supply again by after bag pulse dust collector 14 dedustings through air-introduced machine 10-2 air-out.
Process preparation scope of the present invention is extremely wide, wherein produce the microcapsule formulation containing probiotic bacteria medicament, best fixed network mesh size should be 50-150 μ m, the inlet temperature of the first aerator after the first drying equipment is processed should be 80-100 ℃, the inlet temperature of described the second aerator after the second drying equipment is processed should be 45-60 ℃, adopts after tested the yield rate of above temperature mesh to reach as high as 92.3%.
Wherein produce the microcapsule formulation containing vitamin microorganism, best fixed network mesh size should be 100-300 μ m, the inlet temperature of the first aerator after the first drying equipment is processed should be 120-160 ℃, the inlet temperature of described the second aerator after the second drying equipment is processed should be 60-80 ℃, adopts after tested the yield rate of above temperature mesh to reach as high as 98.5%.
Wherein produce the microcapsule formulation of matters of containing biological activities bioactive substance, best fixed network mesh size should be, the inlet temperature of the first aerator after the first drying equipment is processed should be 100-120 ℃, the inlet temperature of described the second aerator after the second drying equipment is processed should be 60-80 ℃, adopts after tested the yield rate of above temperature mesh to reach as high as 98.6%.
The present invention is by significantly improving existing equipment, on the one hand owing in system material tower, pipeline group with holes being set, therefore greatly improved the output of finished product in system material tower, and the finished product through other equipment is not more owing to having, therefore greatly reduced the possibility that wall occurs to glue follow-up equipment, and because material just has a large amount of finished products to generate through system material tower, therefore high-quality finished product proportion is also relatively high, in addition because pipeline group with holes is jet, therefore can avoid material to be bonded on pipeline, and then reduced cleaning difficulty, on the other hand owing to there is the temperature difference in dry gas temperature and hole pipeline group pipeline, and by temperature inductor make both temperature all can people for controlling, therefore not only reduced material decrease speed, and for some, temperature is had to the medicine of requirement or kind and the scope that production product also can be produced and then greatly improved to bioactive substance, therefore the present invention both can manufacture common microcapsule for the very strong material of water solublity as vitamin, also can prepare the bioactive substance very high to temperature requirement, also can prepare the antibacterial microcapsule very high to temperature requirement, phage microcapsule.
The above, be only preferred embodiment of the present invention, is not the present invention to be done to the restriction of any other form, and according to any modification or equivalent variations that technical spirit of the present invention is done, still belongs to the present invention's scope required for protection.
Claims (8)
1. the high microcapsule formulation production equipment applied widely of a productive rate, comprise blender (1), mother liquor tank (2), plunger displacement pump (4), nozzle (7), drying equipment, air filter, aerator, air-introduced machine, Blowing stopper, system material tower (12), material collection tower (13), cloth bag pulse dust collector (14) and air compressor machine (15), it is characterized in that: in described mother liquor tank (2), have blender (1), under described mother liquor tank (2), there is lower ball valve (3-1), described mother liquor tank (2) is connected with system material tower (12) by connecting pipe (5), between described mother liquor tank (2) and system material tower (12), there is plunger displacement pump (4), between described mother liquor tank (2) and plunger displacement pump (4), there is connection valve (3-2), between described plunger displacement pump (4) and system material tower (12), there is switch valve (6), described nozzle (7) is in system material tower (12), described nozzle (7) is arranged on connecting pipe (5) one end, described aerator has 3, described the first aerator (10-1) air inlet has the first air filter (9-1), described the first aerator (10-1) air outlet is connected with the first drying equipment (8-1), between described the first drying equipment (8-1) and system material tower (12), there is the first temperature inductor (17-1), described the first drying equipment (8-1) is connected with system material tower (12) top by connecting pipe (5), in described material tower processed (12), there is pipeline group with holes (20), described pipeline group with holes (20) comprises pipe box (20-1) and mesh duct (20-2), described mesh duct (20-2) has 2-5 layer, described mesh duct (20-2) is arranged in pipe box (20-1), described pipe box (20-1) upper strata and interior survey wall be porose (20-3) all, on mesh duct (20-2) transverse pipe and longitudinal pipe all porose (20-3), (20-3) is opening up in described hole, described the second aerator (10-3) air inlet has the second air filter (9-2), described the second aerator (10-3) air outlet is connected with the second drying equipment (8-2), described the second drying equipment (8-2) is connected with pipeline group with holes (20) by connecting pipe (5), between described the second drying equipment (8-2) and pipeline group with holes (20), there are the second temperature inductor (17-2) and control valve (19), on described control valve (19), there is Pressure gauge (18), described material tower processed (12) bottom discharge mouth has the first Blowing stopper (11-1), described material tower processed (12) bottom has connecting pipe (5) to be connected with material collection tower (13), described collection tower (13) bottom discharge mouth has the second Blowing stopper (11-2), described collection tower (13) top is connected with cloth bag pulse dust collector (14) by connecting pipe (5), described air compressor machine (15) is connected with cloth bag pulse dust collector (14) by connecting pipe (5), described cloth bag pulse dust collector (14) bottom discharge mouth has the 3rd Blowing stopper (11-3), described cloth bag pulse dust collector (14) is connected with air-introduced machine (10-2) air inlet by connecting pipe (5).
2. the high microcapsule formulation production equipment applied widely of a kind of productive rate according to claim 1, is characterized in that: on pipe box (20-1) hole (20-3) of described pipeline group with holes (20) and mesh duct (20-2) hole (20-3), have fixed network (21).
3. the high microcapsule formulation production equipment applied widely of a kind of productive rate according to claim 2, is characterized in that: in described fixed network (21) outer side edges, have fixing hole (21-1), described fixed network (21) is fixed on hole (20-3) by fixture.
4. the high microcapsule formulation production equipment applied widely of a kind of productive rate according to claim 2, is characterized in that: described fixed network (21) mesh size is 20 μ m---5 ㎜.
5. the high microcapsule formulation production equipment applied widely of a kind of productive rate according to claim 2, is characterized in that: the inlet temperature of described the first aerator (10-1) after the first drying equipment (8-1) is processed is 80 degrees Celsius-160 degrees Celsius.
6. the high microcapsule formulation production equipment applied widely of a kind of productive rate according to claim 2, is characterized in that: the inlet temperature of described the second aerator (10-3) after the second drying equipment (8-2) is processed is 45 degrees Celsius-100 degrees Celsius.
7. the high microcapsule formulation production equipment applied widely of a kind of productive rate according to claim 1, is characterized in that: described have cover plate (16) in system material tower (12) one sides.
8. the high microcapsule formulation production equipment applied widely of a kind of productive rate according to claim 1, it is characterized in that: described have threaded ends (5-1) in system material one end, tower (12) inner connection tube road (5), and described nozzle (7) mode of being threaded connection is arranged on connecting pipe (5) one end.
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| CN108968146A (en) * | 2018-06-08 | 2018-12-11 | 云南中烟工业有限责任公司 | A kind of liquid storage capsule and its preparation method and application |
| CN113867152A (en) * | 2021-10-19 | 2021-12-31 | 金陵科技学院 | Modeling and control method for continuous freeze-drying process of single-hydration snoapril powder aerosol |
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| CN113867152A (en) * | 2021-10-19 | 2021-12-31 | 金陵科技学院 | Modeling and control method for continuous freeze-drying process of single-hydration snoapril powder aerosol |
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Effective date of registration: 20201224 Address after: 214500 south of mujinsi bridge, Jingcheng street, Jingjiang City, Taizhou City, Jiangsu Province Patentee after: Jiangsu HENGWEI protective equipment manufacturing Co.,Ltd. Address before: No. 99 Jiangning Road, Nanjing District hirokage 210000 cities in Jiangsu Province Patentee before: JINLING INSTITUTE OF TECHNOLOGY |
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