CN103501690B - 通气量充足性的检测 - Google Patents
通气量充足性的检测 Download PDFInfo
- Publication number
- CN103501690B CN103501690B CN201280010487.0A CN201280010487A CN103501690B CN 103501690 B CN103501690 B CN 103501690B CN 201280010487 A CN201280010487 A CN 201280010487A CN 103501690 B CN103501690 B CN 103501690B
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- CN
- China
- Prior art keywords
- ventilation
- hypoventilation
- histogrammic
- rectangular histogram
- histogram
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/0051—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes with alarm devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Measuring devices for evaluating the respiratory organs
- A61B5/083—Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Measuring devices for evaluating the respiratory organs
- A61B5/087—Measuring breath flow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/0057—Pumps therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/0057—Pumps therefor
- A61M16/0066—Blowers or centrifugal pumps
- A61M16/0069—Blowers or centrifugal pumps the speed thereof being controlled by respiratory parameters, e.g. by inhalation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/021—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes operated by electrical means
- A61M16/022—Control means therefor
- A61M16/024—Control means therefor including calculation means, e.g. using a processor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7235—Details of waveform analysis
- A61B5/7264—Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/0027—Accessories therefor, e.g. sensors, vibrators, negative pressure pressure meter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/003—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter
- A61M2016/0033—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical
- A61M2016/0039—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical in the inspiratory circuit
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/15—Detection of leaks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/18—General characteristics of the apparatus with alarm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/35—Communication
- A61M2205/3546—Range
- A61M2205/3553—Range remote, e.g. between patient's home and doctor's office
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
- A61M2205/502—User interfaces, e.g. screens or keyboards
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/40—Respiratory characteristics
- A61M2230/43—Composition of exhalation
- A61M2230/435—Composition of exhalation partial O2 pressure (P-O2)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Animal Behavior & Ethology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Physiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Obesity (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161466560P | 2011-03-23 | 2011-03-23 | |
| US61/466,560 | 2011-03-23 | ||
| PCT/AU2012/000270 WO2012126041A1 (en) | 2011-03-23 | 2012-03-15 | Detection of ventilation sufficiency |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103501690A CN103501690A (zh) | 2014-01-08 |
| CN103501690B true CN103501690B (zh) | 2016-10-26 |
Family
ID=46878525
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280010487.0A Active CN103501690B (zh) | 2011-03-23 | 2012-03-15 | 通气量充足性的检测 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10342939B2 (enExample) |
| EP (1) | EP2688466B1 (enExample) |
| JP (1) | JP6002747B2 (enExample) |
| CN (1) | CN103501690B (enExample) |
| AU (1) | AU2012231762B2 (enExample) |
| WO (1) | WO2012126041A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9862892B2 (en) | 2012-02-21 | 2018-01-09 | Battelle Memorial Institute | Heavy fossil hydrocarbon conversion and upgrading using radio-frequency or microwave energy |
| ES2985195T3 (es) | 2012-04-05 | 2024-11-04 | Fisher & Paykel Healthcare Ltd | Aparato de asistencia respiratoria |
| BR112014026201A2 (pt) * | 2012-04-24 | 2017-06-27 | Koninklijke Philips Nv | sistema portátil de suporte de pressão configurado para fornecer um fluxo pressurizado de gás respirável às vias aéreas de um indivíduo; e método de fornecimento de um fluxo pressurizado de gás respirável às vias aéreas de um indivíduo com um sistema de suporte de pressão que inclui um alojamento |
| US9839756B2 (en) | 2012-11-27 | 2017-12-12 | Resmed Limited | Methods and apparatus for ionization therapy |
| JP6226523B2 (ja) * | 2012-12-28 | 2017-11-08 | キヤノン株式会社 | 被検体情報取得装置、表示方法、およびデータ処理装置 |
| WO2014203104A1 (en) * | 2013-06-19 | 2014-12-24 | Koninklijke Philips N.V. | Determining of subject zero flow using cluster analysis |
| SG10201810281TA (en) | 2014-05-27 | 2018-12-28 | Fisher & Paykel Healthcare Ltd | Gases mixing and measuring for a medical device |
| US9931483B2 (en) * | 2014-05-28 | 2018-04-03 | Devilbiss Healtcare Llc | Detection of periodic breathing during CPAP therapy |
| NZ717495A (en) * | 2014-06-10 | 2017-09-29 | Resmed Ltd | Method and apparatus for treatment of respiratory disorders |
| US10112022B2 (en) | 2014-09-18 | 2018-10-30 | Devilbiss Healthcare Llc | Method for detecting an inspiratory flow limitation during sleep-disordered breathing |
| US10786645B2 (en) | 2014-12-30 | 2020-09-29 | Koninklijke Philips N.V. | Capnometry system with supplemental oxygen detection and method of operation thereof |
| US10869614B2 (en) * | 2014-12-31 | 2020-12-22 | Koninklijke Philips N.V. | System for performing histogram analysis of the time-based capnography signals and method of operation thereof |
| US11497870B2 (en) * | 2015-02-24 | 2022-11-15 | Somnetics International, Inc. | Systems and methods for estimating flow in positive airway pressure therapy |
| US11247015B2 (en) | 2015-03-24 | 2022-02-15 | Ventec Life Systems, Inc. | Ventilator with integrated oxygen production |
| US10315002B2 (en) | 2015-03-24 | 2019-06-11 | Ventec Life Systems, Inc. | Ventilator with integrated oxygen production |
| KR101808691B1 (ko) * | 2015-06-25 | 2017-12-14 | 충북대학교 산학협력단 | 중환자 호흡 모니터링 시스템 및 방법 |
| EP3334339B1 (en) * | 2015-08-11 | 2019-09-11 | Koninklijke Philips N.V. | Capnography with decision support system architecture |
| US11266801B2 (en) * | 2015-10-09 | 2022-03-08 | University Of Utah Research Foundation | Ventilation devices and systems and methods of using same |
| US11247009B2 (en) * | 2015-10-19 | 2022-02-15 | Koninklijke Philips N.V. | Anomaly detection device and method for respiratory mechanics parameter estimation |
| EP4023277B1 (en) | 2015-12-02 | 2024-09-11 | Fisher & Paykel Healthcare Limited | Flow path sensing for flow therapy apparatus |
| CN105457135B (zh) * | 2015-12-28 | 2018-12-28 | 湖南明康中锦医疗科技发展有限公司 | 呼吸机压力调整方法、装置及呼吸机 |
| ITUB20160614A1 (it) * | 2016-02-10 | 2017-08-10 | Elbi Int Spa | Assieme di trasduttore di pressione e dispositivo antiallagamento per un apparecchio, ad esempio una macchina lavatrice. |
| JP7082064B2 (ja) * | 2016-04-29 | 2022-06-07 | フィッシャー アンド ペイケル ヘルスケア リミテッド | 気道開存性を決定するためのシステム |
| US10773049B2 (en) | 2016-06-21 | 2020-09-15 | Ventec Life Systems, Inc. | Cough-assist systems with humidifier bypass |
| US12239785B2 (en) * | 2016-10-07 | 2025-03-04 | University Of Utah Research Foundation | Ventilation devices and systems and methods of using same |
| EP3688770A1 (en) * | 2017-09-28 | 2020-08-05 | Koninklijke Philips N.V. | System and method for detecting stroke in patients during pressure support therapy |
| DE102017011625A1 (de) * | 2017-12-15 | 2019-07-18 | Drägerwerk AG & Co. KGaA | Verfahren, Computerprogramm, Vorrichtung und Beatmungssystem zur Detektion eines Lecks in einem Patientengasmodul |
| CN112218674A (zh) | 2018-05-13 | 2021-01-12 | 萨米尔·萨利赫·艾哈迈德 | 使用便携式氧气浓缩器的便携式医用呼吸机系统 |
| US10866006B2 (en) * | 2018-06-25 | 2020-12-15 | Dell Products L.P. | Systems and methods for fan typing and anomaly detection |
| DE102018126553A1 (de) * | 2018-10-24 | 2020-04-30 | Dürr Dental SE | Sensoreneinheit und Druckluftkompressorsystem mit einer solchen |
| JP2022546139A (ja) * | 2019-09-02 | 2022-11-02 | 株式会社マリ | 酸素および非侵襲的換気療法監視装置 |
| WO2021152526A1 (en) * | 2020-01-31 | 2021-08-05 | Resmed Sensor Technologies Limited | Systems and methods for detecting mouth leak |
| DE102021000317A1 (de) | 2020-02-14 | 2021-08-19 | Löwenstein Medical Technology S.A. | Überwachungssystem zur Erkennung von Leckagen während einer Beatmung und Verfahren |
| JP2024503250A (ja) | 2020-12-21 | 2024-01-25 | ベンテック ライフ システムズ, インコーポレイテッド | 一体化された酸素送達を有するベンチレータシステムおよび関連付けられたデバイスおよび方法 |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5335654A (en) * | 1992-05-07 | 1994-08-09 | New York University | Method and apparatus for continuous adjustment of positive airway pressure for treating obstructive sleep apnea |
| US5704345A (en) * | 1993-11-05 | 1998-01-06 | Resmed Limited | Detection of apnea and obstruction of the airway in the respiratory system |
| US6099481A (en) * | 1997-11-03 | 2000-08-08 | Ntc Technology, Inc. | Respiratory profile parameter determination method and apparatus |
| US6273088B1 (en) * | 1997-06-13 | 2001-08-14 | Sierra Biotechnology Company Lc | Ventilator biofeedback for weaning and assistance |
| WO2003030804A2 (en) * | 2001-10-12 | 2003-04-17 | Ric Investments, Inc. | Auto-titration pressure support system and method of using same |
| US20060070624A1 (en) * | 2004-10-01 | 2006-04-06 | Ric Investments, Llc | Method and apparatus for treating cheyne-stokes respiration |
| US20060282002A1 (en) * | 2005-06-10 | 2006-12-14 | Treatyou Medical Technology Co. | Respiratory testing system |
| US20070073181A1 (en) * | 2005-09-16 | 2007-03-29 | Yachuan Pu | Respiration monitoring using respiration rate variability |
| US20070084464A1 (en) * | 2000-08-29 | 2007-04-19 | Wickham Peter John D | Respiratory apparatus with improved flow-flattening detection |
| US20070129645A1 (en) * | 2005-12-01 | 2007-06-07 | Hartley Jesse W | Determining blood gas saturation based on measured parameter of respiration |
| CN101842128A (zh) * | 2007-05-11 | 2010-09-22 | 雷斯梅德有限公司 | 针对流量限制检测的自动控制 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10014427A1 (de) * | 2000-03-24 | 2001-10-04 | Weinmann G Geraete Med | Verfahren zur Steuerung eines Beatmungsgerätes sowie Vorrichtung zur Überwachung |
| DE10103973A1 (de) * | 2001-01-30 | 2002-08-01 | Peter L Kowallik | Verfahren und Vorrichtung zur Schlafüberwachung |
| US7938114B2 (en) * | 2001-10-12 | 2011-05-10 | Ric Investments Llc | Auto-titration bi-level pressure support system and method of using same |
| US6881192B1 (en) * | 2002-06-12 | 2005-04-19 | Pacesetter, Inc. | Measurement of sleep apnea duration and evaluation of response therapies using duration metrics |
| US7539537B2 (en) * | 2002-10-03 | 2009-05-26 | Scott Laboratories, Inc. | Systems and methods for providing sensor fusion |
| US8467876B2 (en) * | 2003-10-15 | 2013-06-18 | Rmx, Llc | Breathing disorder detection and therapy delivery device and method |
| JP5138936B2 (ja) * | 2003-11-26 | 2013-02-06 | レスメド・リミテッド | 呼吸不全の存在下での換気サポートの全身制御のための方法及び装置 |
| US20080269583A1 (en) * | 2005-02-07 | 2008-10-30 | Widemed Ltd. | Detection and Monitoring of Stress Events During Sleep |
| US7810497B2 (en) * | 2006-03-20 | 2010-10-12 | Ric Investments, Llc | Ventilatory control system |
-
2012
- 2012-03-15 JP JP2014500202A patent/JP6002747B2/ja active Active
- 2012-03-15 AU AU2012231762A patent/AU2012231762B2/en not_active Ceased
- 2012-03-15 EP EP12761355.2A patent/EP2688466B1/en active Active
- 2012-03-15 US US14/006,772 patent/US10342939B2/en active Active
- 2012-03-15 CN CN201280010487.0A patent/CN103501690B/zh active Active
- 2012-03-15 WO PCT/AU2012/000270 patent/WO2012126041A1/en not_active Ceased
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5335654A (en) * | 1992-05-07 | 1994-08-09 | New York University | Method and apparatus for continuous adjustment of positive airway pressure for treating obstructive sleep apnea |
| US5704345A (en) * | 1993-11-05 | 1998-01-06 | Resmed Limited | Detection of apnea and obstruction of the airway in the respiratory system |
| US6273088B1 (en) * | 1997-06-13 | 2001-08-14 | Sierra Biotechnology Company Lc | Ventilator biofeedback for weaning and assistance |
| US6099481A (en) * | 1997-11-03 | 2000-08-08 | Ntc Technology, Inc. | Respiratory profile parameter determination method and apparatus |
| US20070084464A1 (en) * | 2000-08-29 | 2007-04-19 | Wickham Peter John D | Respiratory apparatus with improved flow-flattening detection |
| WO2003030804A2 (en) * | 2001-10-12 | 2003-04-17 | Ric Investments, Inc. | Auto-titration pressure support system and method of using same |
| US20060070624A1 (en) * | 2004-10-01 | 2006-04-06 | Ric Investments, Llc | Method and apparatus for treating cheyne-stokes respiration |
| US20060282002A1 (en) * | 2005-06-10 | 2006-12-14 | Treatyou Medical Technology Co. | Respiratory testing system |
| US20070073181A1 (en) * | 2005-09-16 | 2007-03-29 | Yachuan Pu | Respiration monitoring using respiration rate variability |
| US20070129645A1 (en) * | 2005-12-01 | 2007-06-07 | Hartley Jesse W | Determining blood gas saturation based on measured parameter of respiration |
| CN101842128A (zh) * | 2007-05-11 | 2010-09-22 | 雷斯梅德有限公司 | 针对流量限制检测的自动控制 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2688466A1 (en) | 2014-01-29 |
| AU2012231762A1 (en) | 2013-07-04 |
| US20140007878A1 (en) | 2014-01-09 |
| AU2012231762B2 (en) | 2015-06-18 |
| JP6002747B2 (ja) | 2016-10-05 |
| EP2688466B1 (en) | 2021-11-17 |
| NZ612813A (en) | 2015-04-24 |
| US10342939B2 (en) | 2019-07-09 |
| JP2014519856A (ja) | 2014-08-21 |
| EP2688466A4 (en) | 2014-11-12 |
| WO2012126041A1 (en) | 2012-09-27 |
| CN103501690A (zh) | 2014-01-08 |
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|---|---|---|---|
| C06 | Publication | ||
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| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information |
Address after: New South Wales Australia Applicant after: RESMED LTD. Address before: New South Wales Australia Applicant before: Raysmedd Co., Ltd. |
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| COR | Change of bibliographic data | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CP01 | Change in the name or title of a patent holder | ||
| CP01 | Change in the name or title of a patent holder |
Address after: New South Wales Australia Patentee after: Reisman Private Limited Address before: New South Wales Australia Patentee before: RESMED LTD. |