CN103495251B - Human body hyperpolarized gas breathing equipment under a kind of non-narcotization - Google Patents
Human body hyperpolarized gas breathing equipment under a kind of non-narcotization Download PDFInfo
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- CN103495251B CN103495251B CN201310301919.XA CN201310301919A CN103495251B CN 103495251 B CN103495251 B CN 103495251B CN 201310301919 A CN201310301919 A CN 201310301919A CN 103495251 B CN103495251 B CN 103495251B
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Abstract
The invention discloses a kind of for human body hyperpolarized gas respiratory system device under non-narcotization, this device comprises control station (1), I/O interface (2), four electromagnetic valves (5,8,11,14), four solid-state relays (3,7,10,12), two logical Pneumatic valves (16), threeway break-in Pneumatic valve (20), three gas flowmeters (4,9,19), two nitrogen cylinders (13,15), hyperpolarized gas sampler bags (17), seals organic glass case (18) and oxygen cylinder (6).By control station by I/O Interface Controller solid-state relay power on/off magnet valve, electromagnetic valve switch Pneumatic valve controls human body and sucks the state with breath at every turn.Structure of the present invention is simple, and it is convenient to control, and human body can be made can accurately to suck under non-narcotization and the hyperpolarized gas of constant volume of breathing out, and can repeatedly breathe and repeated sampling.
Description
Technical field
The invention belongs to hyperpolarized gas nuclear magnetic resonance and spectrum, more specifically relate to a kind of hyperpolarized gas breathing equipment, also relate to respiratory and control, be applicable to NMR (Nuclear Magnetic Resonance)-imaging and the wave spectrum of hyperpolarized gas.
Background technology
NMR (Nuclear Magnetic Resonance)-imaging is as a kind of "dead", pathological changes etc. of being used for diagnosing the region of interest such as brain diseases, muscle injury without the imaging technique of intrusive mood within the hospital widely.But, what show in the diagnosis of pulmonary disease is very unable, because now commercial nuclear magnetic resonance imaging instrument is mainly detect core with proton, and the cavity structure that pulmonary is mainly made up of alveolar, the very low signal of nuclear magnetic resonance, NMR that causes of the density of proton is very low.Therefore, conventional NMR (Nuclear Magnetic Resonance)-imaging (taking proton as the nuclear magnetic resonance image observing core) can not obtain the nuclear magnetic resonance image of pulmonary.
In recent years, the mode utilizing the method for laser light pump and spin-exchange technology polarization inert gas to improve NMR signal obtains very big concern.Intensity (S) and the nuclear polarizability (P of NMR signal
0) relevant, proton nuclei in magnetic field by Boltzmann distribute determine thermal equilibrium polarization degree, and through noble gas nuclear polarization that the method for laser light pump and spin-exchange technology obtains, higher than the thermally equilibrated polarizability of proton nuclei more than 10000 times, and the proton density of pulmonary low three magnitude compared with the density of tissue, therefore, the NMR signal of the non-equilibrium nuclear spin polarization noble gas utilizing laser light pump and spin-exchange technology to produce can obtain the nuclear magnetic resonance of pulmonary as the mode of contrast agent.
At present, at the imaging major way of the hyperpolarized noble gas of human lung be: noble gas laser light pump polarizer being collected polarization is transferred in the sampler bag (Tedlar) of politef material, then gas in bag sucks in lung by human subject, holds one's breath and carry out imaging on magnetic resonance imager.Although this mode can obtain the image of pulmonary, can not ensure that each human body can suck the hyperpolarized noble gas of same volume, when can not ensure to sample, in human lung, the volume of gas is equal at every turn.Because which limit the application of hyperpolarized noble gas in human lung's imaging and quantitative analysis, particularly need repeatedly repeated sampling just can obtain the information of parameter, the quantitative analysis of the propagation measurement, pulmonary ventilation function (FractionalVentilation) etc. of such as pulmonary.
Relative to the pulmonary imaging of hyperpolarized noble gas at human body, pulmonary's imaging of animal can realize the hyperpolarized noble gas that repeatability sucks equivalent, can obtain compared to a higher-quality nuclear magnetic resonance of air-breathing, and the parameter such as the diffusion needing repeatedly suction gas to measure.This is because animal is generally narcotism when hyperpolarized noble gas imaging, controls the incoming call of animal and the gas flow of exhalation by intubation procedure and respirator and hold one's breath and sample, when realizing each sampling, sucking the hyperpolarized noble gas of equivalent.But, for the hyperpolarized noble gas nuclear magnetic resonance of human body, for the consideration of human-body safety and comfort level, be generally carry out autonomous respiration under waking state.Therefore, each more difficult control of gas volume sucking and breathe out.
Current existing respirator or respiratory system, (1) for animal, after usually needing anesthesia, by monitor pulmonary gas pressure or by the mode of Gas flow-limiting device high pressure to gas, the suction making it passive and breath; (2) the conventional respirator for human body, can realize the quantitative gas of human body and suck, but, be also generally the breathing making human body passive by the mode of pressure, but the breath of equivalent can not be realized.
In addition, in view of the particularity of hyperpolarized noble gas, during use, the suction gas needing human body quantitative on the one hand, needs the polarizability keeping noble gas on the other hand.
Summary of the invention
The object of the invention is to be the problems referred to above existed for prior art, human body hyperpolarized gas breathing equipment under a kind of non-narcotization is provided.This device comprises control station, I/O interface, four electromagnetic valves, four solid-state relays, two logical Pneumatic valves, threeway break-in Pneumatic valve, three gas flowmeters, two nitrogen cylinders, hyperpolarized gas sampler bags, seals organic glass case and oxygen cylinder.This apparatus structure is simple, it is convenient to control, human body can be made can accurately to suck under non-narcotization and the hyperpolarized gas of constant volume of breathing out, ensureing that the gas volume at every turn when sucking hyperpolarized gas in pulmonary is constant, can repeatedly breathe and repeated sampling.
To achieve these goals, the present invention is by the following technical solutions:
Human body hyperpolarized gas breathing equipment under a kind of non-narcotization, this device comprises control station, I/O interface, four electromagnetic valves, four solid-state relays, two logical Pneumatic valves, threeway break-in Pneumatic valve, three gas flowmeters, two nitrogen cylinders, hyperpolarized gas sampler bags, seals organic glass case and oxygen cylinder, the gas outlet of the first electromagnetic valve is communicated with by the air inlet of pipeline with the first gas flowmeter, first gas flowmeter is connected to gases exit line, the air inlet of the first electromagnetic valve is communicated with the gas outlet of the second electromagnetic valve with the interface A of threeway break-in Pneumatic valve respectively through three-way pipeline, the control end of the first electromagnetic valve is connected with the outfan of the first solid-state relay, the air inlet of the second electromagnetic valve is communicated with by the gas outlet of pipeline with the 3rd gas flowmeter, the import of the 3rd gas flowmeter is communicated with oxygen cylinder by pipeline, the control end of the second electromagnetic valve is connected with the outfan of the second solid-state relay, the air inlet of the 3rd electromagnetic valve is connected with the first nitrogen cylinder by pipeline, gas outlet is by the control gas orifice of pipeline and threeway break-in Pneumatic valve, the control end of the 3rd electromagnetic valve is connected with the outfan of the 3rd solid-state relay, the air inlet of the 4th electromagnetic valve is communicated with the second nitrogen cylinder by pipeline, gas outlet is connected with the control gas interface of two logical Pneumatic valves, the control end of the 4th electromagnetic valve is connected with the outfan of the 4th solid-state relay, hyperpolarized gas sampler bag is placed in sealing plexiglass box, hyperpolarized gas sampler bag is communicated with by the air inlet of pipeline with two logical Pneumatic valves, sealing plexiglass box is communicated with by the air inlet of pipeline with the second gas flowmeter, second gas flowmeter is connected to gases exit line, the gas outlet of two logical Pneumatic valves is communicated with by the interface B of pipeline with threeway break-in Pneumatic valve, threeway break-in Pneumatic valve is connected to corrugated hose, the input of I/O interface is connected with the outfan of control station, the outfan of I/O interface respectively with the first solid-state relay, second solid-state relay, 3rd solid-state relay and the 4th solid-state relay and the first gas flowmeter, second gas flowmeter is connected with the input of the 3rd gas flowmeter.
In above-mentioned hyperpolarized gas sampler bag, hyperpolarized gas is housed.
Above-mentioned hyperpolarized gas is xenon, helium or Krypton.
Above-mentioned hyperpolarized gas sampler bag, two logical Pneumatic valve, threeway break-in Pneumatic valve and pipelines all adopt polytetrafluoroethylmaterial material.
The present invention is used for the breath method of human body hyperpolarized gas under non-narcotization, the method includes the steps of:
Hyperpolarized gas adopts hyperpolarization xenon.
When apparatus of the present invention are started working, threeway break-in Pneumatic valve is communicated with hyperpolarized gas pipeline, corrugated hose, two logical Pneumatic valves are opened, human lung inhales the hyperpolarization xenon be stored in sampler bag, the minimizing being stored in the hyperpolarization xenon in sampler bag can cause the stereomutation of sampler bag, because whole lucite box is airtight, one end of second gas flowmeter is connected with the lucite box of sealing, the second gases exit line is passed through to air in one end, the two pressure is identical, the knots modification of the hyperpolarization xenon therefore in hyperpolarized gas sampler bag accurately can be measured by the second gas flowmeter, when the volume that gas flows through the second gas flowmeter is 500ml, control closedown two by control station and lead to Pneumatic valve, at this moment the hyperpolarization xenon be stored in sampler bag no longer flows out, human lung can not continue suction gas, enter the pattern of holding one's breath, now pulmonary gases constancy of volume, hyperpolarization xenon in human lung is sampled.
After sampling terminates, the break-in of threeway break-in Pneumatic valve is communicated with corrugated hose and oxygen corrugated hose, first electromagnetic valve is opened, human body is by corrugated hose active expiration, when gas reaches 500ml through the volume of the first gas flowmeter, control closedown first electromagnetic valve by control station, make the break-in of threeway break-in Pneumatic valve be communicated with hyperpolarized gas pipeline and corrugated hose simultaneously, human lung exhales end.
After expiration terminates, the break-in of threeway break-in Pneumatic valve is communicated with oxygen corrugated hose and pipeline, open the second electromagnetic valve, human lung initiatively sucks by corrugated hose, oxygen corrugated hose the oxygen provided by oxygen cylinder, when the oxygen volume through the 3rd gas flowmeter is 500ml, operating console cuts out the second electromagnetic valve, and make the break-in of threeway break-in Pneumatic valve be communicated with hyperpolarized gas pipeline and corrugated hose, human lung enters the screen oxygen stage simultaneously.
After screen oxygen terminates, threeway break-in Pneumatic valve break-in connecting pipe and oxygen corrugated hose, first electromagnetic valve is opened, human lung is exhaled by air tube, oxygen corrugated hose, when gas reaches 500ml through the volume of the first gas flowmeter, control closedown first electromagnetic valve by control station, make the break-in of threeway break-in Pneumatic valve be communicated with hyperpolarized gas pipeline and corrugated hose simultaneously, human lung exhales end.
The present invention compared with prior art, has the following advantages and effect:
1, human body accurately can suck the hyperpolarized gas of constant volume under non-narcotization, the gas of same volume of can breathing out, use existing respirator or respiratory system, human body can not at the gas of the suction of precise volumes under waking state and exhalation same volume;
2, human body is accurate under non-narcotization sucks the oxygen of constant volume and identical gas volume of breathing out, and can ensure that the gas volume at every turn when sucking hyperpolarized gas in pulmonary is constant.
3, respiratory system can realize A Single Intake by Inhalation hyperpolarized gas and carries out imaging, and the hyperpolarized gas that also can realize repeatedly repeating to suck equivalent carries out by the irrealizable diffusion tensor imaging of single air-breathing.
4, quantitatively oxygen uptake and quantitative expiration can ensure that the participant of imaging ensures blood oxygen level and physiological status when repeatedly inhaling hyperpolarized gas simultaneously.
Accompanying drawing explanation
Fig. 1 is human body hyperpolarized gas breathing equipment structural representation under a kind of non-narcotization.
In figure: 1-control station; 2-I/O interface; 3-first solid-state relay; 4-first gas flowmeter; 5-first electromagnetic valve; 6-oxygen cylinder; 7-second solid-state relay; 8-second electromagnetic valve; 9-the 3rd gas flowmeter; 10-the 3rd solid-state relay; 11-the 3rd electromagnetic valve; 12-the 4th solid-state relay; 13-first nitrogen cylinder; 14-the 4th electromagnetic valve; 15-second nitrogen cylinder; 16-two leads to Pneumatic valve; 17-hyperpolarized gas sampler bag; The lucite box of 18-sealing; 19-second gas flowmeter; 20-threeway break-in Pneumatic valve.
Fig. 2 is breath method flow chart the present invention being used for human body hyperpolarized gas under non-narcotization.
Detailed description of the invention
Below in conjunction with accompanying drawing, the present invention is further illustrated:
Human body hyperpolarized gas breathing equipment under a kind of non-narcotization, this device comprises control station 1, I/O interface 2, four electromagnetic valves 5,8,11,14, four solid-state relays 3,7,10,12, two logical Pneumatic valves 16, threeway break-in Pneumatic valve 20, three gas flowmeters 4,9,19, two nitrogen cylinders 13,15, hyperpolarized gas sampler bag 17, seals organic glass case 18 and oxygen cylinder 6, the gas outlet of the first electromagnetic valve 5 is communicated with by the air inlet of pipeline with the first gas flowmeter 4, first gas flowmeter 4 is connected to gases exit line, the air inlet of the first electromagnetic valve 5 is connected with the gas outlet of the second electromagnetic valve 8 with the interface A of threeway break-in Pneumatic valve 20 respectively through three-way pipeline, the control end of the first electromagnetic valve 5 is connected with the outfan of the first solid-state relay 3, the air inlet of the second electromagnetic valve 8 is connected by the gas outlet of pipeline with the 3rd gas flowmeter 9, the air inlet of the 3rd gas flowmeter 9 is communicated with oxygen cylinder 6 by pipeline, the control end of the second electromagnetic valve 8 is connected with the outfan of the second solid-state relay 7, the air inlet of the 3rd electromagnetic valve 11 is connected with the first nitrogen cylinder 13 by pipeline, gas outlet is connected with the control gas interface of threeway break-in Pneumatic valve 20 by pipeline, the control end of the 3rd electromagnetic valve 11 is connected with the outfan of the 3rd solid-state relay 10, the air inlet of the 4th electromagnetic valve 14 is communicated with the second nitrogen cylinder 15 by pipeline, gas outlet is connected with the control gas interface of two logical Pneumatic valves 16, the control end of the 4th electromagnetic valve 14 is connected with the outfan of the 4th solid-state relay 12, hyperpolarized gas sampler bag 17 is placed in sealing plexiglass box 18, hyperpolarized gas sampler bag 17 is communicated with two logical Pneumatic valves 16 by pipeline, sealing plexiglass box 18 is communicated with by the air inlet of pipeline with the second gas flowmeter 19, second gas flowmeter 19 is connected to gases exit line, the gas outlet of two logical Pneumatic valves 16 is connected by the interface B of pipeline with threeway break-in Pneumatic valve 20, threeway break-in Pneumatic valve 20 is connected to corrugated hose, the input of I/O interface 2 is connected with the outfan of control station 1, the outfan of I/O interface 2 respectively with the first solid-state relay 3, second solid-state relay 7, 3rd solid-state relay 10 and the 4th solid-state relay 12 and the first gas flowmeter 4, second gas flowmeter 19 is connected with the input of the 3rd gas flowmeter 9.
In above-mentioned hyperpolarized gas sampler bag 17, hyperpolarized gas is housed.
Above-mentioned hyperpolarized gas is xenon, helium or Krypton.
Above-mentioned hyperpolarized gas sampler bag 17, two logical Pneumatic valve 16, threeway break-in Pneumatic valve 20 and pipeline all adopt polytetrafluoroethylmaterial material.
The present invention is used for the breath method of human body hyperpolarized gas under non-narcotization, the method includes the steps of:
Step 1: control station 1 sends instruction to control I/O interface 2, be communicated with the 4th solid-state relay 12 and the 3rd solid-state relay 10 respectively, 4th electromagnetic valve 14 and the 3rd electromagnetic valve 11 are opened respectively, the high pressure nitrogen provided by the second nitrogen cylinder 15 and the first nitrogen cylinder 13 drives two logical Pneumatic valves 16 to open respectively and threeway break-in Pneumatic valve 20 is communicated with two logical pipelines between Pneumatic valve 16 and human body, human body initiatively sucks the hyperpolarized xenon gas be stored in sampler bag 17 by pipeline, when to monitor volume that the second gas flowmeter 19 flows through be 500ml to control station 1, sending instruction makes two logical Pneumatic valves 16 close by the 4th electromagnetic valve 14 that the 4th solid-state relay 12 controls, human body enters the stage of holding one's breath and carries out nuclear magnetic resonance sampling,
Step 2(exhalation process): control station 1 sends instruction to control I/O interface 2, be communicated with first respectively, 3rd solid-state relay 3, 10, control first, 3rd electromagnetic valve 5, 11 open respectively, the high pressure nitrogen driving threeway break-in Pneumatic valve 20 provided by the first nitrogen cylinder 13 is communicated with the pipeline between electromagnetic valve 5 and human body, human lung is by corrugated hose initiatively breath, when to monitor volume that the first gas flowmeter 4 flows through be 500ml to control station 1, send instruction and control the first electromagnetic valve 5 respectively by the first solid-state relay 3 and the 3rd solid-state relay 10 and the 3rd electromagnetic valve 11 cuts out, threeway break-in Pneumatic valve 20 is communicated with the pipeline between the outlet of two logical Pneumatic valves 16 and human body, human lung's end of exhaling prepares air-breathing next time,
Step 3(oxygen uptake process): control station 1 sends instruction to control I/O interface 2, be communicated with the second solid-state relay 7 and the 3rd solid-state relay 10 respectively, control the second electromagnetic valve 8 and the 3rd electromagnetic valve 11 is opened respectively, the high pressure nitrogen driving threeway break-in Pneumatic valve 20 provided by the first nitrogen cylinder 13 is communicated with the pipeline between electromagnetic valve 8 and human body, human lung initiatively sucks the oxygen provided by oxygen cylinder 6 by corrugated hose, when to monitor gas volume that the 3rd gas flowmeter 9 flows through be 500ml to control station 1, send instruction and control the second electromagnetic valve 8 respectively by the second solid-state relay 7 and the 3rd solid-state relay 10 and the 3rd electromagnetic valve 11 cuts out, threeway break-in Pneumatic valve 20 is communicated with hyperpolarized gas pipeline and corrugated hose, human lung's air-breathing terminates to prepare to exhale next time,
Step 4: repeat step 2 and exhale, then return step 1, carries out circulating until stop sampling.
Gas volume supposition set amount in above detailed description of the invention step is 500mL, experimentally can need adjustment in actual experiment.
Except hyperpolarized xenon (
131xe and
129xe), outside gas, hyperpolarized gas also comprises: hyperpolarization helium (
3he) gas, hyperpolarization krypton (
87kr) gas etc.
The work process of hyperpolarized gas breathing equipment is divided into four steps, that is: suck the oxygen-breath of hyperpolarization gas holding one's breath-breath-suction specified rate.Suck hyperpolarized gas to refer to human body under the control of hyperpolarization gas breathing system and initiatively suck quantitative hyperpolarized gas and hold one's breath and sample; After sampling terminates, the gas of human lung's active exhalation respiratory system given volume under the control of respiratory system; Then, in order to maintain the normal physiological status of human body, under the control of respiratory system, human lung sucks the oxygen volume of respiratory system setting; Then under the control of respiratory system, human lung breathe out respiratory system setting volume gas, then enter next gas circulation.The physiological status of experimental needs and human body can also select repeatedly respiratory oxygen, resorb hyperpolarization xenon, continuous several times also can be selected to suck hyperpolarization xenon, sample again, again respiratory oxygen maintain normal physiological status.
Claims (4)
1. human body hyperpolarized gas breathing equipment under a non-narcotization, it is characterized in that, this device comprises control station (1), I/O interface (2), four electromagnetic valves (5,8,11,14), four solid-state relays (3,7,10,12), two logical Pneumatic valves (16), threeway break-in Pneumatic valve (20), three gas flowmeters (4,9,19), two nitrogen cylinders (13,15), hyperpolarized gas sampler bags (17), seals organic glass case (18) and oxygen cylinder (6), the gas outlet of the first electromagnetic valve (5) is communicated with by the air inlet of pipeline with the first gas flowmeter (4), first gas flowmeter (4) is connected to gases exit line, the air inlet of the first electromagnetic valve (5) is communicated with the gas outlet of the second electromagnetic valve (8) with the interface A of threeway break-in Pneumatic valve (20) respectively through three-way pipeline, the control end of the first electromagnetic valve (5) is connected with the outfan of the first solid-state relay (3), the air inlet of the second electromagnetic valve (8) is communicated with by the gas outlet of pipeline with the 3rd gas flowmeter (9), the air inlet of the 3rd gas flowmeter (9) is communicated with oxygen cylinder (6) by pipeline, the control end of the second electromagnetic valve (8) is connected with the outfan of the second solid-state relay (7), the air inlet of the 3rd electromagnetic valve (11) is connected with the first nitrogen cylinder (13) by pipeline, gas outlet controls gas orifice by pipeline and threeway break-in Pneumatic valve (20), the control end of the 3rd electromagnetic valve (11) is connected with the outfan of the 3rd solid-state relay (10), the air inlet of the 4th electromagnetic valve (14) is communicated with the second nitrogen cylinder (15) by pipeline, gas outlet is connected with the control gas interface of two logical Pneumatic valves (16), the control end of the 4th electromagnetic valve (14) is connected with the outfan of the 4th solid-state relay (12), hyperpolarized gas sampler bag (17) is placed in sealing plexiglass box (18), hyperpolarized gas sampler bag (17) is communicated with by the air inlet of pipeline with two logical Pneumatic valves (16), sealing plexiglass box (18) is communicated with by the air inlet of pipeline with the second gas flowmeter (19), second gas flowmeter (19) is connected to gases exit line, the outlet of two logical Pneumatic valves (16) is communicated with by the interface B of pipeline with threeway break-in Pneumatic valve (20), threeway break-in Pneumatic valve (20) is connected to corrugated hose, the input of I/O interface (2) is connected with the outfan of control station (1), the outfan of I/O interface (2) respectively with the first solid-state relay (3), second solid-state relay (7), 3rd solid-state relay (10) and the 4th solid-state relay (12) and the first gas flowmeter (4), second gas flowmeter (19) is connected with the input of the 3rd gas flowmeter (9).
2. human body hyperpolarized gas breathing equipment under a kind of non-narcotization according to claim 1, is characterized in that: in described hyperpolarized gas sampler bag (17), hyperpolarized gas is housed.
3. human body hyperpolarized gas breathing equipment under a kind of non-narcotization according to claim 2, is characterized in that: described hyperpolarized gas is xenon, helium or Krypton.
4. human body hyperpolarized gas breathing equipment under a kind of non-narcotization according to claim 1, is characterized in that: described hyperpolarized gas sampler bag (17), two logical Pneumatic valve (16), threeway break-in Pneumatic valve and pipelines all adopt polytetrafluoroethylmaterial material.
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| CN104287731B (en) * | 2014-09-30 | 2016-08-17 | 中国科学院武汉物理与数学研究所 | The device that a kind of animal for pulmonary's hyperpolarized gas imaging is exhaled |
| CN104224401B (en) * | 2014-09-30 | 2016-03-23 | 中国科学院武汉物理与数学研究所 | A kind of animal autonomous respiration device for hyperpolarized gas MRI |
| CN106249183B (en) * | 2016-09-24 | 2018-10-12 | 中国科学院武汉物理与数学研究所 | One kind is based on spectrum as integrated hyperpolarization xenon magnetic resonance method |
| CN108553731A (en) * | 2018-05-03 | 2018-09-21 | 浙江氙科医疗器械有限公司 | A kind of portable xenon oxygen gas mixture suction apparatus |
| CN108578868A (en) * | 2018-05-03 | 2018-09-28 | 浙江氙科医疗器械有限公司 | Pipeline structure in portable xenon oxygen gas mixture suction apparatus |
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| US6085743A (en) * | 1997-05-30 | 2000-07-11 | The Regent Of The University Of Michigan | Polarized gas delivery system/method |
| CN1281345A (en) * | 1997-11-14 | 2001-01-24 | 诺伯特·韦勒 | Apparatus for fluid administration |
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Effective date of registration: 20180514 Address after: 430000 318 Friendship Avenue, Wuchang District, Wuhan, Hubei. Patentee after: Wuhan Zhongke polarization Medical Technology Co., Ltd. Address before: 430071 Wuchang Xiaohong Shanxi, Wuhan, Wuhan, Hubei Patentee before: Wuhan Inst. of Physics and Mathematics, Chinese Academy of Sciences |