CN103495251A - Hyperpolarization gas breathing device for human body under non-narcosis state - Google Patents
Hyperpolarization gas breathing device for human body under non-narcosis state Download PDFInfo
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- CN103495251A CN103495251A CN201310301919.XA CN201310301919A CN103495251A CN 103495251 A CN103495251 A CN 103495251A CN 201310301919 A CN201310301919 A CN 201310301919A CN 103495251 A CN103495251 A CN 103495251A
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Abstract
The invention discloses a hyperpolarization gas breathing device for a human body under a non-narcosis state. The device comprises a console (1), an I/O port (2), four electromagnetic valves (5, 8, 11 and 14), four solid-state relays (3, 7, 10 and 12), a two-way air control valve (16), a three-way direction-changing air control valve (20), three gas flow meters (4,9 and 19), two nitrogen cylinders (13 and 15), a hyperpolarization gas sampling bag (17), a sealed organic glass box (18) and an oxygen bottle (6). The console controls the solid-state relays to turn on or turn off the electromagnetic valves through the I/O port, and the electromagnetic valves turn on or turn off the air control valves to control the state of the human body each time air is breathed in and breathed out. The device is simple in structure, convenient to control and capable of enabling the human body to accurately breathing in and breathing out hyperpolarization gas in a constant size under the non-narcosis state, the human body can breathe multiple times and sampling can be carried out repeatedly.
Description
Technical field
The invention belongs to hyperpolarized gas nuclear magnetic resonance and spectrum, more specifically relate to a kind of hyperpolarized gas breathing equipment, also relate to respiratory and control, be applicable to NMR (Nuclear Magnetic Resonance)-imaging and the wave spectrum of hyperpolarized gas.
Background technology
NMR (Nuclear Magnetic Resonance)-imaging as a kind of "dead", be used for widely pathological changes of diagnosing the region of interest such as brain diseases, muscle injury etc. without the imaging technique of intrusive mood in hospital.But, what aspect the diagnosis of pulmonary disease, show is very unable, because commercial nuclear magnetic resonance imaging instrument is mainly to take proton as detecting core now, and the cavity structure that pulmonary mainly is comprised of alveolar, the very low signal of nuclear magnetic resonance, NMR that causes of the density of proton is very low.Therefore, conventional NMR (Nuclear Magnetic Resonance)-imaging (take proton as observing the nuclear magnetic resonance image of core) can not obtain the nuclear magnetic resonance image of pulmonary.
In recent years, utilize the mode of the method raising NMR signal of laser light pump and spin-exchange technology polarization inert gas to obtain very big concern.The intensity of NMR signal (S) and nuclear polarizability (P
0) relevant, the thermal equilibrium polarization degree that proton nuclei is distributed and determined by Boltzmann in magnetic field, and the noble gas nuclear polarization that the method for process laser light pump and spin-exchange technology obtains, higher more than 10000 times than the thermally equilibrated polarizability of proton nuclei, and the proton density of pulmonary is compared low three magnitudes left and right with the density of tissue, the NMR signal of the non-equilibrium nuclear spin polarization noble gas that therefore, utilizes laser light pump and spin-exchange technology to produce can obtain the nuclear magnetic resonance of pulmonary as the mode of contrast agent.
At present, imaging major way at human lung's hyperpolarized noble gas is: in the noble gas of collecting polarization on the laser light pump polarizer being transferred to the sampler bag (Tedlar) of politef material, then tested human body sucks gas in bag in lung, holds one's breath and carry out imaging on magnetic resonance imager.Although this mode can obtain the image of pulmonary, can not guarantee that each human body can suck the hyperpolarized noble gas of equal volume, in the time of can not guaranteeing to sample, the volume of the interior gas of human lung equates at every turn.Therefore limited application and the quantitative analysis of hyperpolarized noble gas in human lung's imaging, particularly need repeatedly repeated sampling just can obtain the information of parameter, such as the quantitative analysis of the propagation measurement of pulmonary, pulmonary ventilation function (Fractional Ventilation) etc.
Pulmonary's imaging with respect to hyperpolarized noble gas at human body, pulmonary's imaging of animal can realize that repeatability sucks the hyperpolarized noble gas of equivalent, can obtain than once air-breathing higher-quality nuclear magnetic resonance, and need to repeatedly suck the parameters such as diffusion that gas could be measured.This is because animal is generally narcotism when the hyperpolarized noble gas imaging, by intubation procedure and respirator, controls the gas flow of the incoming call of animal and exhalation and holds one's breath and sample, and sucks the hyperpolarized noble gas of equivalent while realizing each sampling.But, for the hyperpolarized noble gas nuclear magnetic resonance of human body, for the consideration of human-body safety and comfort level, be generally to carry out autonomous respiration under waking state.Therefore, the more difficult control of gas volume that sucks at every turn and breathe out.
Current existing respirator or respiratory system, (1) for animal, after usually needing anesthesia, the gas pressure by monitoring pulmonary or by the Gas flow-limiting device by the mode of high pressure to gas, make its passive suction and breath; (2) the conventional respirator for human body, can realize that the quantitative gas of human body sucks, and still, is also generally that the mode by pressure makes the passive breathing of human body, but can not realizes the breath of equivalent.
In addition, in view of the particularity of hyperpolarized noble gas, during use, need the quantitative suction gas of human body on the one hand, need on the other hand to keep the polarizability of noble gas.
Summary of the invention
The objective of the invention is to be the problems referred to above that exist for prior art, human body hyperpolarized gas breathing equipment under a kind of non-narcotization is provided.This device comprises control station, I/O interface, four electromagnetic valves, four solid-state relays, two logical Pneumatic valves, threeway break-in Pneumatic valve, three gas flowmeters, two nitrogen cylinders, hyperpolarized gas sampler bags, seals organic glass case and oxygen cylinder.This apparatus structure is simple, it is convenient to control, can make human body can accurately suck under non-narcotization and the hyperpolarized gas of the constant volume of breathing out, guarantee that at every turn the gas volume in pulmonary is constant when sucking hyperpolarized gas, can repeatedly breathe and repeated sampling.
To achieve these goals, the present invention is by the following technical solutions:
Human body hyperpolarized gas breathing equipment under a kind of non-narcotization, this device comprises control station, I/O interface, four electromagnetic valves, four solid-state relays, two logical Pneumatic valves, threeway break-in Pneumatic valve, three gas flowmeters, two nitrogen cylinders, hyperpolarized gas sampler bags, seals organic glass case and oxygen cylinder, the gas outlet of the first electromagnetic valve is communicated with the air inlet of the first gas flowmeter by pipeline, the first gas flowmeter is connected to gas outlet's pipeline, the air inlet of the first electromagnetic valve is communicated with the interface A of threeway break-in Pneumatic valve and the gas outlet of the second electromagnetic valve respectively through three-way pipeline, the control end of the first electromagnetic valve is connected with the outfan of the first solid-state relay, the air inlet of the second electromagnetic valve is communicated with the gas outlet of the 3rd gas flowmeter by pipeline, the import of the 3rd gas flowmeter is communicated with oxygen cylinder by pipeline, the control end of the second electromagnetic valve is connected with the outfan of the second solid-state relay, the air inlet of the 3rd electromagnetic valve is connected with the first nitrogen cylinder by pipeline, gas outlet is communicated with the interface A of threeway break-in Pneumatic valve by pipeline, the control end of the 3rd electromagnetic valve is connected with the outfan of the 3rd solid-state relay, the air inlet of the 4th electromagnetic valve is communicated with the second nitrogen cylinder by pipeline, gas outlet is connected with the control gas interface of two logical Pneumatic valves, the control end of the 4th electromagnetic valve is connected with the outfan of the 4th solid-state relay, the hyperpolarized gas sampler bag is placed in the organic Yurisangja of sealing, the hyperpolarized gas sampler bag is communicated with the air inlet of two logical Pneumatic valves by pipeline, sealing organic Yurisangja is communicated with the air inlet of the second gas flowmeter by pipeline, the second gas flowmeter is connected to gas outlet's pipeline, the gas outlet of two logical Pneumatic valves is communicated with the interface B of threeway break-in Pneumatic valve by pipeline, threeway break-in Pneumatic valve is connected to corrugated hose, the input of I/O interface is connected with the outfan of control station, the outfan of I/O interface respectively with the first solid-state relay, the second solid-state relay, the 3rd solid-state relay and the 4th solid-state relay and the first gas flowmeter, the second gas flowmeter is connected with the input of the 3rd gas flowmeter.
In above-mentioned hyperpolarized gas sampler bag, hyperpolarized gas is housed.
Above-mentioned hyperpolarized gas is xenon, helium or Krypton.
Above-mentioned hyperpolarized gas sampler bag, two logical Pneumatic valves, threeway break-in Pneumatic valve and pipeline all adopt polytetrafluoroethylmaterial material.
Breath method by the present invention for human body hyperpolarized gas under non-narcotization, the method includes the steps of:
Hyperpolarized gas adopts the hyperpolarization xenon.
When apparatus of the present invention are started working, threeway break-in Pneumatic valve is communicated with the hyperpolarized gas pipeline, corrugated hose, two logical Pneumatic valves are opened, the human lung inhales and is stored in the hyperpolarization xenon in sampler bag, the minimizing that is stored in the hyperpolarization xenon in sampler bag can cause the stereomutation of sampler bag, because whole lucite box is airtight, one end of the second gas flowmeter and the lucite box of sealing are connected, one end passes through second gas outlet's pipeline to air, the two pressure is identical, therefore the change amount of the hyperpolarization xenon in the hyperpolarized gas sampler bag can accurately be measured by the second gas flowmeter, when the volume of crossing the second gas flowmeter when gas flow is 500ml, control and close two logical Pneumatic valves by control station, at this moment the hyperpolarization xenon be stored in sampler bag no longer flows out, the human lung can not continue to suck gas, enter the pattern of holding one's breath, now pulmonary gases constancy of volume, hyperpolarization xenon in the human lung is sampled.
After sampling finishes, the break-in of threeway break-in Pneumatic valve is communicated with corrugated hose and oxygen corrugated hose, the first electromagnetic valve is opened, human body is by the corrugated hose active expiration, when gas reaches 500ml through the volume of the first gas flowmeter, control and to close the first electromagnetic valve by control station, make the break-in of threeway break-in Pneumatic valve be communicated with hyperpolarized gas pipeline and corrugated hose simultaneously, human lung's end of exhaling.
After expiration finishes, the break-in of threeway break-in Pneumatic valve is communicated with oxygen corrugated hose and pipeline, open the second electromagnetic valve, the human lung initiatively sucks by corrugated hose, oxygen corrugated hose the oxygen provided by oxygen cylinder, when the oxygen volume through the 3rd gas flowmeter is 500ml, operating console cuts out the second electromagnetic valve, makes the break-in of threeway break-in Pneumatic valve be communicated with hyperpolarized gas pipeline and corrugated hose simultaneously, and the human lung enters the screen oxygen stage.
After screen oxygen finishes, threeway break-in Pneumatic valve break-in connecting pipe and oxygen corrugated hose, the first electromagnetic valve is opened, the human lung exhales by air tube, oxygen corrugated hose, when gas reaches 500ml through the volume of the first gas flowmeter, control and to close the first electromagnetic valve by control station, make the break-in of threeway break-in Pneumatic valve be communicated with hyperpolarized gas pipeline and corrugated hose simultaneously, human lung's end of exhaling.
The present invention compared with prior art, has the following advantages and effect:
1, human body can accurately suck the hyperpolarized gas of constant volume under non-narcotization, the gas of the equal volume of can breathing out, use existing respirator or respiratory system, human body can not be at the suction of precise volumes under waking state and the gas of exhalation equal volume;
2, human body accurate oxygen and identical gas volume of breathing out that sucks constant volume under non-narcotization, can guarantee that at every turn the gas volume in pulmonary is constant when sucking hyperpolarized gas.
3, respiratory system can realize that the A Single Intake by Inhalation hyperpolarized gas carries out imaging, and the hyperpolarized gas that also can realize repeatedly repeating sucking equivalent carries out by the air-breathing irrealizable diffusion tensor imaging of single.
4, quantitatively oxygen uptake and quantitative expiration can guarantee the participant of imaging simultaneously and guarantee blood oxygen level and physiological status in the situation that repeatedly inhale hyperpolarized gas.
The accompanying drawing explanation
Fig. 1 is human body hyperpolarized gas breathing equipment structural representation under a kind of non-narcotization.
In figure: the 1-control station; The 2-I/O interface; 3-the first solid-state relay; 4-the first gas flowmeter; 5-the first electromagnetic valve; The 6-oxygen cylinder; 7-the second solid-state relay; 8-the second electromagnetic valve; 9-the 3rd gas flowmeter; 10-the 3rd solid-state relay; 11-the 3rd electromagnetic valve; 12-the 4th solid-state relay; 13-the first nitrogen cylinder; 14-the 4th electromagnetic valve; 15-the second nitrogen cylinder; The logical Pneumatic valve of 16-two; 17-hyperpolarized gas sampler bag; The lucite box of 18-sealing; 19-the second gas flowmeter; 20-threeway break-in Pneumatic valve.
Fig. 2 is the breath method flow chart for human body hyperpolarized gas under non-narcotization by the present invention.
The specific embodiment
Below in conjunction with accompanying drawing, the present invention is further illustrated:
Human body hyperpolarized gas breathing equipment under a kind of non-narcotization, this device comprises control station 1,5,8,11,14, four solid- state relays 3,7,10,12 of 2, four electromagnetic valves of I/O interface, two logical Pneumatic valves 16,4,9,19, two nitrogen cylinders 13,15 of 20, three gas flowmeters of threeway break-in Pneumatic valve, hyperpolarized gas sampler bag 17, seal organic glass case 18 and oxygen cylinder 6, the gas outlet of the first electromagnetic valve 5 is communicated with the air inlet of the first gas flowmeter 4 by pipeline, the first gas flowmeter 4 is connected to gas outlet's pipeline, the air inlet of the first electromagnetic valve 5 is connected with the gas outlet of the second electromagnetic valve 8 with the interface A of threeway break-in Pneumatic valve 20 respectively through three-way pipeline, the control end of the first electromagnetic valve 5 is connected with the outfan of the first solid-state relay 3, the air inlet of the second electromagnetic valve 8 is connected with the gas outlet of the 3rd gas flowmeter 9 by pipeline, the air inlet of the 3rd gas flowmeter 9 is communicated with oxygen cylinder 6 by pipeline, the control end of the second electromagnetic valve 8 is connected with the outfan of the second solid-state relay 7, the air inlet of the 3rd electromagnetic valve 11 is connected with the first nitrogen cylinder 13 by pipeline, gas outlet is connected with the control gas interface of threeway break-in Pneumatic valve 20 by pipeline, the control end of the 3rd electromagnetic valve 11 is connected with the outfan of the 3rd solid-state relay 10, the air inlet of the 4th electromagnetic valve 14 is communicated with the second nitrogen cylinder 15 by pipeline, gas outlet is connected with the control gas interface of two logical Pneumatic valves 16, the control end of the 4th electromagnetic valve 14 is connected with the outfan of the 4th solid-state relay 12, hyperpolarized gas sampler bag 17 is placed in the organic Yurisangja 18 of sealing, hyperpolarized gas sampler bag 17 is communicated with two logical Pneumatic valves 16 by pipeline, sealing organic Yurisangja 18 is communicated with the air inlet of the second gas flowmeter 19 by pipeline, the second gas flowmeter 19 is connected to gas outlet's pipeline, the gas outlet of two logical Pneumatic valves 16 is connected with the interface B of threeway break-in Pneumatic valve 20 by pipeline, threeway break-in Pneumatic valve 20 is connected to corrugated hose, the input of I/O interface 2 is connected with the outfan of control station 1, the outfan of I/O interface 2 respectively with the first solid-state relay 3, the second solid-state relay 7, the 3rd solid-state relay 10 and the 4th solid-state relay 12 and the first gas flowmeter 4, the second gas flowmeter 19 is connected with the input of the 3rd gas flowmeter 9.
In above-mentioned hyperpolarized gas sampler bag 17, hyperpolarized gas is housed.
Above-mentioned hyperpolarized gas is xenon, helium or Krypton.
Above-mentioned hyperpolarized gas sampler bag 17, two logical Pneumatic valves 16, threeway break-in Pneumatic valve 20 and pipeline all adopt polytetrafluoroethylmaterial material.
Breath method by the present invention for human body hyperpolarized gas under non-narcotization, the method includes the steps of:
Step 1: control station 1 sends instruction to control I/O interface 2, be communicated with respectively the 4th solid-state relay 12 and the 3rd solid-state relay 10, the 4th electromagnetic valve 14 and the 3rd electromagnetic valve 11 are opened respectively, the high pressure nitrogen provided by the second nitrogen cylinder 15 and the first nitrogen cylinder 13 drives respectively two logical Pneumatic valves 16 to open and threeway break-in Pneumatic valve 20 is communicated with the pipeline between two logical Pneumatic valves 16 and human body, human body initiatively sucks the hyperpolarized xenon gas be stored in sampler bag 17 by pipeline, when control station 1 monitors volume that the second gas flowmeter 19 flows through and is 500ml, sending the 4th electromagnetic valve 14 that instruction controls by the 4th solid-state relay 12 closes two logical Pneumatic valves 16, human body enters the stage of holding one's breath and carries out the nuclear magnetic resonance sampling,
Step 2(exhalation process): control station 1 sends instruction to control I/O interface 2, be communicated with respectively first, the 3rd solid-state relay 3, 10, control first, the 3rd electromagnetic valve 5, 11 open respectively, the pipeline that the high pressure nitrogen provided by the first nitrogen cylinder 13 drives threeway break-in Pneumatic valve 20 to be communicated with between electromagnetic valve 5 and human body, the human lung is by corrugated hose active breath, when control station 1 monitors volume that the first gas flowmeter 4 flows through and is 500ml, send that instruction is controlled respectively the first electromagnetic valve 5 by the first solid-state relay 3 and the 3rd solid-state relay 10 and the 3rd electromagnetic valve 11 cuts out, threeway break-in Pneumatic valve 20 is communicated with the outlet of two logical Pneumatic valves 16 and the pipeline between human body, the human lung exhale finish to prepare next time air-breathing,
Step 3(oxygen uptake process): control station 1 sends instruction to control I/O interface 2, be communicated with respectively the second solid-state relay 7 and the 3rd solid-state relay 10, control the second electromagnetic valve 8 and the 3rd electromagnetic valve 11 is opened respectively, the pipeline that the high pressure nitrogen provided by the first nitrogen cylinder 13 drives threeway break-in Pneumatic valve 20 to be communicated with between electromagnetic valve 8 and human body, the oxygen provided by oxygen cylinder 6 initiatively is provided by corrugated hose the human lung, when control station 1 monitors gas volume that the 3rd gas flowmeter 9 flows through and is 500ml, send that instruction is controlled respectively the first electromagnetic valve 5 by the second solid-state relay 7 and the 3rd solid-state relay 10 and the 3rd electromagnetic valve 11 cuts out, threeway break-in Pneumatic valve 20 is communicated with hyperpolarized gas pipeline and corrugated hose, the air-breathing end of human lung prepares to exhale next time,
Step 4: repeating step 2 is exhaled, and then returns to step 1, is circulated until stop sampling.
Gas volume supposition set amount in above specific embodiment step is 500mL, in actual experiment, can need to adjust according to experiment.
Except hyperpolarized xenon (
131xe and
129xe) outside gas, hyperpolarized gas also comprises: hyperpolarization helium (
3he) gas, the hyperpolarization krypton (
87kr) gas etc.
The work process of hyperpolarized gas breathing equipment is divided into four steps, sucks the oxygen-breath of hyperpolarization gas hold one's breath-breath-suction specified rate that is:.The suction hyperpolarized gas refers to human body under the control of hyperpolarization gas respiratory system and initiatively sucks quantitative hyperpolarized gas and hold one's breath and sampled; After sampling finishes, human lung's gas of respiratory system given volume of initiatively breathing out under the control of respiratory system; Then in order to maintain the normal physiological status of human body, under the control of respiratory system, the human lung sucks the oxygen volume that respiratory system is set; Then under the control of respiratory system, human lung's respiratory system of breathing out is set the gas of volume, then enters next gas circulation.Can also experimental needs and the physiological status of human body select repeatedly respiratory oxygen, resorb the hyperpolarization xenon, also can select continuous several times to suck the hyperpolarization xenon, sample again, respiratory oxygen maintains normal physiological status again.
Claims (4)
1. human body hyperpolarized gas breathing equipment under a non-narcotization, it is characterized in that, this device comprises control station (1), I/O interface (2), four electromagnetic valves (5,8,11,14), four solid-state relays (3,7,10,12), two logical Pneumatic valves (16), threeway break-in Pneumatic valve (20), three gas flowmeters (4,9,19), two nitrogen cylinders (13,15), hyperpolarized gas sampler bag (17), seals organic glass case (18) and oxygen cylinder (6), the gas outlet of the first electromagnetic valve (5) is communicated with the air inlet of the first gas flowmeter (4) by pipeline, the first gas flowmeter (4) is connected to gas outlet's pipeline, the air inlet of the first electromagnetic valve (5) is communicated with the interface A of threeway break-in Pneumatic valve (20) and the gas outlet of the second electromagnetic valve (8) respectively through three-way pipeline, the control end of the first electromagnetic valve (5) is connected with the outfan of the first solid-state relay (3), the air inlet of the second electromagnetic valve (8) is communicated with the gas outlet of the 3rd gas flowmeter (9) by pipeline, the air inlet of the 3rd gas flowmeter (9) is communicated with oxygen cylinder (6) by pipeline, the control end of the second electromagnetic valve (8) is connected with the outfan of the second solid-state relay (7), the air inlet of the 3rd electromagnetic valve (11) is connected with the first nitrogen cylinder (13) by pipeline, gas outlet is controlled the gas interface by pipeline and threeway break-in Pneumatic valve (20) and is communicated with, the control end of the 3rd electromagnetic valve (11) is connected with the outfan of the 3rd solid-state relay (10), the air inlet of the 4th electromagnetic valve (14) is communicated with the second nitrogen cylinder (15) by pipeline, gas outlet is connected with the control gas interface of two logical Pneumatic valves (16), the control end of the 4th electromagnetic valve (14) is connected with the outfan of the 4th solid-state relay (12), hyperpolarized gas sampler bag (17) is placed in the organic Yurisangja of sealing (18), hyperpolarized gas sampler bag (17) is communicated with the air inlet of two logical Pneumatic valves (16) by pipeline, sealing organic Yurisangja (18) is communicated with the air inlet of the second gas flowmeter (19) by pipeline, the second gas flowmeter (19) is connected to gas outlet's pipeline, the outlet of two logical Pneumatic valves (16) is communicated with the interface B of threeway break-in Pneumatic valve (20) by pipeline, threeway break-in Pneumatic valve (20) is connected to corrugated hose, the input of I/O interface (2) is connected with the outfan of control station (1), the outfan of I/O interface (2) respectively with the first solid-state relay (3), the second solid-state relay (7), the 3rd solid-state relay (10) and the 4th solid-state relay (12) and the first gas flowmeter (4), the second gas flowmeter (19) is connected with the input of the 3rd gas flowmeter (9).
2. human body hyperpolarized gas breathing equipment under a kind of non-narcotization according to claim 1, is characterized in that: in described hyperpolarized gas sampler bag (17), hyperpolarized gas is housed.
3. human body hyperpolarized gas breathing equipment under a kind of non-narcotization according to claim 2, it is characterized in that: described hyperpolarized gas is xenon, helium or Krypton.
4. human body hyperpolarized gas breathing equipment under a kind of non-narcotization according to claim 1 is characterized in that: described hyperpolarized gas sampler bag (17), two logical Pneumatic valves (16), threeway break-in Pneumatic valve and pipeline all adopt polytetrafluoroethylmaterial material.
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| CN104224401A (en) * | 2014-09-30 | 2014-12-24 | 中国科学院武汉物理与数学研究所 | Animal autonomous respiration device used for hyperpolarization gas MRI |
| CN104287731A (en) * | 2014-09-30 | 2015-01-21 | 中国科学院武汉物理与数学研究所 | Animal expiration device for MRI (magnetic resonance imaging) of lung hyperpolarization gas |
| CN106249183A (en) * | 2016-09-24 | 2016-12-21 | 中国科学院武汉物理与数学研究所 | A kind of hyperpolarization xenon magnetic resonance method based on spectrum picture integration |
| CN108553731A (en) * | 2018-05-03 | 2018-09-21 | 浙江氙科医疗器械有限公司 | A kind of portable xenon oxygen gas mixture suction apparatus |
| CN108578868A (en) * | 2018-05-03 | 2018-09-28 | 浙江氙科医疗器械有限公司 | Pipeline structure in portable xenon oxygen gas mixture suction apparatus |
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| CN108553731A (en) * | 2018-05-03 | 2018-09-21 | 浙江氙科医疗器械有限公司 | A kind of portable xenon oxygen gas mixture suction apparatus |
| CN108578868A (en) * | 2018-05-03 | 2018-09-28 | 浙江氙科医疗器械有限公司 | Pipeline structure in portable xenon oxygen gas mixture suction apparatus |
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| Publication number | Publication date |
|---|---|
| CN103495251B (en) | 2016-01-20 |
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