CN103495037B - Traditional Chinese medicine for treating chronic gastritis and peptic ulcer disease caused by helicobacter pylori infection - Google Patents
Traditional Chinese medicine for treating chronic gastritis and peptic ulcer disease caused by helicobacter pylori infection Download PDFInfo
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Abstract
The invention relates to traditional Chinese medicine for treating chronic gastritis and a peptic ulcer disease caused by helicobacter pylori infection. The traditional Chinese medicine is composed of the following raw materials, by weight, 10-15 parts of mangnolia officinalis, 15-20 parts of astragalus, 25-30 parts of salvia miltiorrhiza, 25-30 parts of dandelion, 15-20 parts of oldenlandia diffusa, 10-25 parts of tangerine peels, 10-15 parts of white paeony roots, 10-15 parts of radix angelicae, 10-15 parts of rhizoma atractylodis, 15-20 parts of rhizoma bletillae and 25-30 parts of cuttle bones. The traditional Chinese medicine is reasonable in composition, obvious in treatment effect, good in improvement effect on gastric mucosa observed under an endoscope, obvious in improvement effect on stomach pathology change, high in eradication rate of stomach helicobacter pylori, free of obvious toxic and side effect and adverse reaction, good in treatment compliance and capable of effectively treating helicobacter pylori and stomach diseases related to the same.
Description
Technical field
The present invention relates to a kind of Chinese medicine formula, is a kind ofly treat the Chinese medicine that helicobacter pylori infections causes chronic gastritis and peptic ulcer disease specifically.
Background technology
From nineteen eighty-two Australia scholar's Barry Marshall and Luo Bin Warren found helicobacter pylori (Helicobacter pylori, be called for short Hp), and demonstrate this bacteriological infection stomach and can cause gastritis, gastric ulcer and duodenal ulcer, and with gastric cancer and primary malignant lymphoma in close relations since, domestic and international gastroenterologist is studied the eradication therapy of Hp with regard to starting.Inquire into and eradicate Hp therapeutic scheme, as curing the chronic gastritis relevant to Hp, the fundamental way of peptic ulcer disease.The first-line treatment scheme of current global eradication Hp mainly proton pump inhibitor adds clarithromycin and adds amoxicillin or proton pump inhibitor and add clarithromycin and add metronidazole.Along with going deep into of research, there has also been new discovery to the medicine and prescription eradicating Hp, clinical efficacy also increases.But also reflects some problems, distinct issues are that Hp constantly rises to clarithromycin and antibiotic drug resistance, make it fastbacteria pearl and are on the increase simultaneously, external study on large sample display, its drug resistance incidence rate is 3.0-19.3%; The side reaction of medicine increases, and especially under gastrointestinal pessimal stimulation and digestive tract power, degradation allows patient agonize; Consumption cost is higher, and the compliance of patient's drug administration is reduced; Curative effect is difficult to maintain; The eradication rate of Hp is difficult to further raising, these are all the difficult points that Hp research is eradicated in puzzlement, be series of problems urgently to be resolved hurrily, therefore, the method seeking effectively to solve clinical faced difficulties is very important with improving curative effect, reduce the medicine of side effect.
Modern Study on etiology shows, Hp is a kind of gram-negative bacteria of S-shaped or arc-shaped bend, below the mucous wall parasitizing gastric mucosa specifically, surface epithelial cell, except the gastric epithelial cell surface of mucosal epithelial surface and duodenum and esophagus, not yet find that there is this antibacterial parasitism at other positions at present.Visible, Hp can infect the epithelial cell in stomach specifically, and stomach is the specific host of Hp.Nanfang Hospital of No.1 Military Medical Univ. reports, Hp produces inflammation by a series of medium of release and to the effect of body immune system, gastric mucosal cell is bred increase, also easily cause the damage of DNA and increase to occur the danger of aneuploid simultaneously, further formation is multiple carcinogenic or cause consolidation material, and therefore thinking that Hp infects is chronic gastritis to the main startup factor of atrophic gastritis, intestinal epithelial metaplasia, atypical hyperplasia and stomach cancer development.All research shows that Hp infects and Hp toxin changes in the development of gastric cancer play Main Function to stomach lining inflammation, precancerosis.
It is a worldwide problem that Hp infects, and China belongs to high and infects country, and the infection rate of general population is at 50-80%.571 people of Henan IMS to a township have carried out gastroscope generaI investigation, and Hp infection rate male is 72%, and women is 63%, 15-20 year Younger group is 53.6%, and adult group is 76%, and normal gastric mucosa is 6.6%, and chronic gastritis is 93%.Beijing Medical University carries out gastroscopy biopsy to Mouping County, shandong Province the High Risk For Gastric Cancer area 347 routine asymptomatic patients, and Hp recall rate is 52.5%.The Hp infection rate age 20-29 year group be 45.7%, 30-39 years old group be 63%, increasing with the age and be stabilized in about 60%, was 78.9% at >=70 years old, was described early the age of China population Hp infection rate, infect contain green grass or young crops, in, old age.Infect the clinical manifestation of associated gastritis, Peptic Ulcers according to Hp, differential diagnosis in tcm surely belongs to the category of gastric abscess, noisy, syndrome of feeling fullness and distension in the upper abdomen.Make a general survey of Chinese medicine to set forth the Pathogenesis Theory of above-mentioned disease, mainly weakness of the spleen and stomach, mechanism of qi lose smooth, or irritability is violated inverse, gallbladder and lost and secrete clearly, or eating and drinking without temperance, cold temperature are not normal, or qi depression to blood stasis, stomach-Yin virtual loss etc., but still lack the understanding to diseases caused by exogenous pathogenic factor evil poison damage stomach mansion.
Chinese medicine has rich experience treating such as gastric abscess, painful abdominal mass, noisy disease, it is also different people, different views when determining Therapeutic Principle, or overweight taste, or duty in liver and gall, or pay attention to cold-evil, or control damp and hot, or distinguish that gas distinguishes blood, or pay attention to treatment, or emphasize diet etc., there is good clinical guidance.But along with medical science applied development and the further exploration to etiology and pathogenesis, the gastropathy that this bacteriological infection of Hp causes, more scholar more payes attention to formulating Therapeutic Principle for the cause of disease.The Chinese medicine of current clinical treatment chronic gastritis has a lot, and treatment also obtains certain curative effect.
Summary of the invention
Technical problem to be solved by this invention is to overcome above-mentioned the deficiencies in the prior art, and provide a kind of component reasonable, cost is low, instant effect, has no side effect, and is applicable to treat the Chinese medicine that helicobacter pylori infections causes chronic gastritis and peptic ulcer disease.
The technical scheme that above-mentioned technical problem to be solved by this invention adopts is: a kind ofly treat the Chinese medicine that helicobacter pylori infections causes chronic gastritis and peptic ulcer disease, it adopts Cortex Magnoliae Officinalis, the Radix Astragali, Radix Salviae Miltiorrhizae, Herba Taraxaci, Herba Hedyotidis Diffusae, Pericarpium Citri Reticulatae, the Radix Paeoniae Alba, the Radix Angelicae Dahuricae, the Rhizoma Atractylodis Macrocephalae, Pseudobulbus Bletillae (Rhizoma Bletillae), Os Sepiae is raw material, it is characterized in that its raw material composition and weight proportion are: Cortex Magnoliae Officinalis 10-15, Radix Astragali 15-20, Radix Salviae Miltiorrhizae 25-30, Herba Taraxaci 25-30, Herba Hedyotidis Diffusae 15-20, Pericarpium Citri Reticulatae 10-25, Radix Paeoniae Alba 10-15, Radix Angelicae Dahuricae 10-15, Rhizoma Atractylodis Macrocephalae 10-15, Pseudobulbus Bletillae (Rhizoma Bletillae) 15-20, Os Sepiae 25-30.
By the standard selected said medicine in proportion that " Chinese Pharmacopoeia " is promulgated for 2000, decontamination, sieve earth.Then by above-mentioned Herba Taraxaci 1/2 amount, Radix Salviae Miltiorrhizae 1/2 amount, Herba Hedyotidis Diffusae, Pericarpium Citri Reticulatae, Pseudobulbus Bletillae (Rhizoma Bletillae) extracting in water 2 times, merging filtrate leaves standstill, and removes sediment, and concentrated thick paste is for subsequent use; Herba Taraxaci 1/2 amount just remaining again, Radix Salviae Miltiorrhizae 1/2 amount, Cortex Magnoliae Officinalis, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, the Radix Angelicae Dahuricae, it is for subsequent use that cuttlefish bone meal is broken into coarse powder; Above-mentioned gained thick paste and gained coarse powder blender are stirred, drying and sterilizing, powder patent medicine falls apart, then row sterilization packaging.
Usage and dosage: every day three times, each 6g, half an hour, boiled water was taken after mixing it with water after meal.It within three weeks, is a course for the treatment of.2 to 3 courses for the treatment of of continuous use.
Therapeutic effect: 90 routine patients, after the course for the treatment of, helicobacter pylori clearance rate is 84.44%.Through tcm symptom comparitive study, treatment group tcm symptom treatment total effective rate is 95.56%, is obviously better than 82.22% of matched group, has significant difference (P < 0.01); Treatment group traditional Chinese medical science individual event symptom curative effect is obviously better than matched group, and except gastric abscess curative effect zero difference (P > 0.05), other symptom curative effects all have significant difference, (P < 0.01); Treatment group compares with matched group TCM symptom score, has significant difference (P < 0.05); Treatment group compares with matched group individual event symptom integral, has significant difference (P < 0.05); Treatment group scope curative effect is 84.44%, and matched group is 74.44%, two groups and compares and have significant difference, (P < 0.05); Two groups of pathology comparitive study treatment groups are obviously better than matched group, and except atrophy zero difference (P ﹥ 0.05), other all have significant difference (P ﹤ 0.01); Treatment group helicobacter pylori clearance rate is 84.44%, and matched group is 74.44%, two groups and compares and have significant difference, (P < 0.05).
The present invention adopts traditional pure Chinese medicine, and be dosage form with powder, boiled water is taken after mixing it with water, and effectively can treat helicobacter pylori infections and cause the disease such as chronic gastritis and peptic ulcer disease.The drug matching reasonable recipe selected, therapeutic effect is remarkable.Endoscopic Observation gastric mucosa improves effective, improves obviously to stomach pathological change, high to the eradication rate of helicobacter pylori, without obvious toxic and side effects and untoward reaction, and low price, curative compliance is good.Effectively can treat helicobacter pylori and treatment gastritis correlated to Helicobacter pylori.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described.
The present invention a kind ofly treats the Chinese medicine that helicobacter pylori infections causes chronic gastritis and peptic ulcer disease, it adopts Cortex Magnoliae Officinalis, the Radix Astragali, Radix Salviae Miltiorrhizae, Herba Taraxaci, Herba Hedyotidis Diffusae, Pericarpium Citri Reticulatae, the Radix Paeoniae Alba, the Radix Angelicae Dahuricae, the Rhizoma Atractylodis Macrocephalae, Pseudobulbus Bletillae (Rhizoma Bletillae), Os Sepiae to be raw material, it is characterized in that its raw material composition and weight proportion are: Cortex Magnoliae Officinalis 10-15, Radix Astragali 15-20, Radix Salviae Miltiorrhizae 25-30, Herba Taraxaci 25-30, Herba Hedyotidis Diffusae 15-20, Pericarpium Citri Reticulatae 10-25, Radix Paeoniae Alba 10-15, Radix Angelicae Dahuricae 10-15, Rhizoma Atractylodis Macrocephalae 10-15, Pseudobulbus Bletillae (Rhizoma Bletillae) 15-20, Os Sepiae 25-30.
By the standard selected said medicine in proportion that " Chinese Pharmacopoeia " is promulgated for 2000, decontamination, sieve earth.Then by above-mentioned Herba Taraxaci 1/2 amount, Radix Salviae Miltiorrhizae 1/2 amount, Herba Hedyotidis Diffusae, Pericarpium Citri Reticulatae, Pseudobulbus Bletillae (Rhizoma Bletillae) extracting in water 2 times, merging filtrate leaves standstill, and removes sediment, and concentrated thick paste is for subsequent use; Herba Taraxaci 1/2 amount just remaining again, Radix Salviae Miltiorrhizae 1/2 amount, Cortex Magnoliae Officinalis, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, the Radix Angelicae Dahuricae, it is for subsequent use that cuttlefish bone meal is broken into coarse powder; Above-mentioned gained thick paste and gained coarse powder blender are stirred, drying and sterilizing, powder patent medicine falls apart, then row sterilization packaging.
The raw material weight proportioning of the best of the present invention is: Cortex Magnoliae Officinalis 12, the Radix Astragali 15, Radix Salviae Miltiorrhizae 30, Herba Taraxaci 30, Herba Hedyotidis Diffusae 15, Pericarpium Citri Reticulatae 10, the Radix Paeoniae Alba 15, the Radix Angelicae Dahuricae 15, the Rhizoma Atractylodis Macrocephalae 15, Pseudobulbus Bletillae (Rhizoma Bletillae) 18, Os Sepiae 30.
The characteristic of disease that Hp infects is diseases caused by exogenous pathogenic factor epidemic disease poison, and sick position is at taste, close with liver and gall; Its pathomechanism is evil poison invasion, pents up in stomach, injures stomach film, and for a long time then and in liver spleen, blood stasis due to qi deficiency, stasis of blood heat-transformation of a specified duration, stagnant heat is obstructed, and stomach film loses supports, and film corruption becomes rotten, even cancerate.Chinese medicine is thought, taste are the exterior and the interior each other, and mutually for using, The spleen is in charge of sending up essential substances, transporting and transforming nutrients from foodstuff is precise and tiny is its merit, and the stomach being liable to sending digested food downward, digesting food of being received are its use, and taste lifting is suitable, and receiving is normal, to complete digesting and assimilating of diet.If taste lifting imbalance, receiving is neglected one's duty, then all diseases are by giving birth to.Liver and gall are also the exterior and the interior, refinforce each other, liver controlling conveyance and dispersion, auxiliary taste QI movement being in harmonious way; Gallbladder secretes clear juice, helps taste to receive digesting and absorbing the essence of foodstuff.If hepato-biliary function is not normal, then and taste and raw disease.As " Plain Questions jade very will be discussed greatly " mentions when touching upon gastric abscess: " the nether world sky of fainting, wind is excessive to be won, and the sick gastral cavilty of the people is taken care and aches ", illustrate that gastric abscess and wood gas win partially, liver stomach is become estranged relevant.If damp-heat accumulation had both hindered the lifting of taste, affect the catharsis of liver and gall, the visible belch acid regurgitation of its disease, epigastric upset, create adapt circumstance for exopathogen infects and grows again; Blood stasis due to qi deficiency then stomach mansion is lost and is supported, and the deficiency of vital energy then stomach is moved unable, visible gastral cavity is swollen lack of appetite, and blood stasis then stomach network is smooth, and stomach film loses supports, visible gastralgia; Cloudy impairment of body fluid loses then stomach and loses and make moist, and in addition damp and hotly causes harm, and stomach film hinders infections by giving birth to.Saying as " Su Wen ﹒ comments pyretography ": " gathering of heresy, its gas must be empty ", the aggressive factor that deficiency of qi and yin causes Hp strengthens, the defensive factor reduction of stomach film, causes evil poison invasion, pents up in stomach, crouch for a long time and do not go.Therefore Hp causes a disease and belongs to exopathogen by outer invasion, below the mucous wall parasitizing gastric mucosa specifically, surface epithelial cell.Its sick position is at stomach mansion, and target position is at stomach film; Make gastric mucosa injury by its detoxifying function, destroy the barrier action of gastric mucosa, make mucosa by aggressive factor and defensive factor unbalance, thus be inflamed reaction or ulcer, intestinalization is raw and cancerate.Its Track character has challenges, gradual, repeatability, still has the characteristic of pyretic toxicity.Gastric mucosa hyperemia impaired as seen under gastroscope, edema, ooze out and even mucosal pallor, coarse injustice, mucosal atrophy, meet damp-heat accumulation, QI and blood is impaired, blood stasis due to qi deficiency, and cloudy impairment of body fluid loses, and stomach film loses the pathological state of supporting.The present invention establishes the evil poison of removing summer-heat, and QI and blood regulating, repairs and hinder infections, cuts anti-Therapeutic Principle of cancerating.Removing summer-heat evil poison-Hp infects, place Fu Weifu, and non-removing summer-heat can not eliminating evil poison; The reparation of QI and blood regulating-stomach film, depends on moistening of QI and blood foster.If gas can not moisten, blood can not be supported, and defensive enginery certainly will be made to weaken, therefore answers QI and blood regulating to improve stomach mansion environment, improves the anti-evil ability in stomach mansion, reaches eliminating evil object; The invasive that infections-Hp infects is hindered in reparation, causes inflammation and the ulcer of gastric mucosa, by eliminating pathogenic factor for supporting vital QI, repairs further and hinders infections, effectively protect stomach film, thus eliminate symptom, reach eliminating evil more sick object; Cut anti-to cancerate-modern study proves: Hp infects the pathological change causing gastric mucosa, and gastric mucosa is occurred, and inflammatory, atrophy, intestinalization are raw, become before cancer, even canceration, so in elimination Hp treatment, the generation become before will tackling cancer in time, plays Truncation.The determination of this Therapeutic Principle, to eradicating Hp and treatment Gastritis, gastric ulcer significant.
Cortex Magnoliae Officinalis of the present invention has effect and the antiulcer effect of excited gastrointestinal motility, and has anti-inflammatory and antalgic, antineoplastic action; The Radix Astragali has scavenging activated oxygen and anti-lipid peroxidation, anti-inflammatory and antalgic and antitumaous effect; Radix Salviae Miltiorrhizae has anti-inflammatory effect, by significantly suppressing Agarose Microdroflet Assay, preventing the too much release such as lysosomal enzyme, oxidation metabolites, alleviating tissue injury, with the development that controls inflammation; And there is gastric acid inhibitory and anti-ulcer effect, mainly through suppressing stomach H+, K+-ATP enzymatic activity realizes; Herba Taraxaci can anti-inflammation, reduces endotoxic activity, gastric acid secretion inhibiting, alleviates gastric mucosa damage, the incidence rate of ulcer and ulcer index are obviously declined.Herba Hedyotidis Diffusae has enhancing immunity, improves leukocytic phagocytic function in human blood, strengthens the specific killing activity to tumor cell, and the phagocytic function to tumor cell, also has the protective effect to damage gastric mucosa and antioxidation in addition.Above-mentioned inrigorating qi and promoting blood circulation antidote can effectively prevent and reverse gastric mucosa atrophy, promotes gastric mucosal blood flow, increases gastrointestinal peristalsis, thus repairs gastric mucosa, and prevention gastric mucosa atrophy, blocks and reverse its precancerous lesion.
Radix Astragali invigorating the spleen and replenishing QI in formula, to help the transporting of spleen, being received of stomach; Rhizoma Atractylodis Macrocephalae invigorating the spleen to clear away damp pathogen, spleen is strong and be beneficial to removing dampness, wets except and helps spleen invigorating; Cortex Magnoliae Officinalis alleviating distention in middle-JIAO is except full, and Compendium of Material Medica draws Li Dong Yuan cloud: " Cortex Magnoliae Officinalis is bitter can the therapeutic method to keep the adverse QI flowing downwards, therefore lets out real full, and temperature can QI invigorating, thus can wet dissipation full ", Pericarpium Citri Reticulatae is regulated the flow of vital energy stomach invigorating, two medicines and the Rhizoma Atractylodis Macrocephalae, Radix Astragali phase 5, makes it QI invigorating and not stagnant gas, circulation of qi promoting and do not consume gas.Herba Taraxaci, Herba Hedyotidis Diffusae heat-clearing and toxic substances removing, with hot and suffocating in clearing stomach, separate stomach and to be possessed poison, " book on Chinese herbal medicine is newly organized " is said: Herba Taraxaci is for rushing down the medicine of stomach-fire, and its gas is very flat, and pathogenic fire purging does not damage soil, and fire moves back and gastric qi is spontaneous, and visible Herba Taraxaci has to relieve inflammation or internal heat and protects the effect of stomach.Radix Paeoniae Alba easing the affected liver to relieve pain, Radix Angelicae Dahuricae removing dampness pain relieving, the kind slow liver stomach of two medicines is anxious, and increases the machine fallen.Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling and pain of subsiding a swelling, Pseudobulbus Bletillae (Rhizoma Bletillae) astringing to arrest bleeding and detumescence and promoting granulation, two medicines one are lived and one to be held back, and nourishing the stomach film, hinders infections again, with Cortex Magnoliae Officinalis, the Radix Astragali mutually 5, then QI and blood conditioning, stomach mansion granulation promoting.Get Os Sepiae simply, be intended to relieving gastric hyperacidity to alleviate stomachache.Make a general survey of full side, Cortex Magnoliae Officinalis, the Radix Astragali, Radix Salviae Miltiorrhizae, Herba Taraxaci, Herba Hedyotidis Diffusae are monarch drug, with the evil poison of removing summer-heat, QI and blood regulating; Pericarpium Citri Reticulatae, the Radix Paeoniae Alba, the Radix Angelicae Dahuricae, the Rhizoma Atractylodis Macrocephalae are ministerial drug, with principal drug assistance strengthening vital QI to eliminate pathogenic factors, and easing the affected liver spleen invigorating, relieving spasm to stop pain; Pseudobulbus Bletillae (Rhizoma Bletillae), Os Sepiae are adjuvant drug, with the anti-promoting flow of QI and blood of property of restraining too, help reparation stomach film to hinder infections with the merit of granulation promoting antacid.To doctor trained in Western medicine eliminate Hp and treat relevant gastropathy also substantially identical with the treatment viewpoint of anti-inflammation, gastric acid inhibitory, protection gastric mucosa.
Usage and dosage: every day three times, each 6g, half an hour, boiled water was taken after mixing it with water after meal.It within three weeks, is a course for the treatment of.
Efficacy assessment standard: with reference to " Chinese digestive endoscopy magazine " " the endoscopic classification grade scale of chronic gastritis and tentative suggestion for the treatment of ".
Tcm symptom total effects is evaluated:
(1) effective: clinical symptom disappearance.
(2) effective: clinical symptoms obviously alleviates 3.
(3) invalid: clinical symptoms is not improved.
Tcm symptom efficacy evaluation:
Scope efficacy evaluation:
(1) effective: the positive sign of scope mucosa directly perceived disappears or alleviates more than II grade (containing II grade).
(2) effective: the positive sign of scope mucosa directly perceived alleviates I grade.
(3) invalid: scope mucosa sign directly perceived is without alleviating and increasing the weight of.
Pathology efficacy evaluation:
(1) effective: the atrophy of pathologic finding body of gland, intestinalization life and dysplasia disappear or alleviate more than II grade (containing II grade).
(2) effective: atrophy, intestinalization life and dysplasia alleviate I grade.
(3) invalid: atrophy, intestinalization life and dysplasia alleviate not as good as I grade or increase the weight of.
Helicobacter pylori eradication is evaluated:
With gastric mucosa tissue section microscopy, or the experiment of carbon 14 urea breath is feminine gender, be then assessed as helicobacter pylori infections and turn out cloudy.
Usage of the present invention and the course for the treatment of: every day three times, each 6g, half an hour, boiled water was taken after mixing it with water after meal.It within three weeks, is a course for the treatment of.2 to 3 courses for the treatment of of continuous use.
Therapeutic effect: 90 routine patients, after the course for the treatment of, helicobacter pylori clearance rate is 84.44%.Treatment group tcm symptom treatment total effective rate is 95.56%, is obviously better than 82.22% of matched group, has significant difference (P < 0.01); Treatment group traditional Chinese medical science individual event symptom curative effect is obviously better than matched group, and except gastric abscess curative effect zero difference (P > 0.05), other symptom curative effects all have significant difference, (P < 0.01); Treatment group compares with matched group TCM symptom score, has significant difference (P < 0.05); Treatment group compares with matched group individual event symptom integral, has significant difference (P < 0.05); Treatment group scope curative effect is 84.44%, and matched group is 74.44%, two groups and compares and have significant difference, (P < 0.05); Two groups of pathology comparitive study treatment groups are obviously better than matched group, and except atrophy zero difference (P ﹥ 0.05), other all have significant difference (P ﹤ 0.01); Treatment group helicobacter pylori clearance rate is 84.44%, and matched group is 74.44%, two groups and compares and have significant difference, (P < 0.05).
Embodiment 1: a kind ofly treat the Chinese medicine that helicobacter pylori infections causes chronic gastritis and peptic ulcer disease, takes raw material by following weight proportion: Cortex Magnoliae Officinalis 12, the Radix Astragali 15, Radix Salviae Miltiorrhizae 30, Herba Taraxaci 30, Herba Hedyotidis Diffusae 15, Pericarpium Citri Reticulatae 10, the Radix Paeoniae Alba 15, the Radix Angelicae Dahuricae 15, the Rhizoma Atractylodis Macrocephalae 15, Pseudobulbus Bletillae (Rhizoma Bletillae) 18, Os Sepiae 30.Decontamination, sieve earth.Then by above-mentioned Herba Taraxaci 1/2 amount, Radix Salviae Miltiorrhizae 1/2 amount, Herba Hedyotidis Diffusae, Pericarpium Citri Reticulatae, Pseudobulbus Bletillae (Rhizoma Bletillae) extracting in water 2 times, merging filtrate leaves standstill, and removes sediment, and concentrated thick paste is for subsequent use; Herba Taraxaci 1/2 amount just remaining again, Radix Salviae Miltiorrhizae 1/2 amount, Cortex Magnoliae Officinalis, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, the Radix Angelicae Dahuricae, it is for subsequent use that cuttlefish bone meal is broken into coarse powder; Above-mentioned gained thick paste and gained coarse powder blender are stirred, drying and sterilizing, powder patent medicine falls apart, then row sterilization packaging.
Method consumption: every day three times, each 6g, half an hour, boiled water was taken after mixing it with water after meal.It within three weeks, is a course for the treatment of.2 to 3 courses for the treatment of of continuous use.
Case one is permitted certain, man, 38 years old, and individual, people from Weihai City examines in October, 2011.
Suffer from gastric abscess more than 4 years, once in certain hospital's row gastroscopy, be diagnosed as chronic superficial gastritis, pathological diagnosis is that stomach lining inflammation part companion glandular epithelium intestinalization is raw, Helicobacter pylori.Give antibacterial and protection gastric mucosa Drug therapy first quarter moon, once with other drug treatment, the state of an illness is not felt any better, symptom when examining: gastric abscess (+++), feeling of fullness (++), poor appetite (++), belch (++), noisy (++) yet.Gastroscope finding: gastric mucosa is congested, rotten to the corn, there is little hemorrhagic focus, examine as chronic superficial gastritis.Pathological diagnosis: gastric antrum chronic inflammation, part glandular epithelium intestinalization is raw, and body of stomach subregion is moderate atypical hyperplasia, helicobacter pylori (+).Three large routines and Liver and kidney function check normal range.
Observation of curative effect: take medicine and namely feel gastric abscess for one week and obviously alleviate, after taking medicine, symptom disappears substantially.
Embodiment 2: a kind ofly treat the Chinese medicine that helicobacter pylori infections causes chronic gastritis and peptic ulcer disease, takes raw material by following weight proportion: Cortex Magnoliae Officinalis 10, the Radix Astragali 15, Radix Salviae Miltiorrhizae 30, Herba Taraxaci 25, Herba Hedyotidis Diffusae 20, Pericarpium Citri Reticulatae 25, the Radix Paeoniae Alba 10, the Radix Angelicae Dahuricae 10, the Rhizoma Atractylodis Macrocephalae 10, Pseudobulbus Bletillae (Rhizoma Bletillae) 15, Os Sepiae 25.Decontamination, sieve earth.Then by above-mentioned Herba Taraxaci 1/2 amount, Radix Salviae Miltiorrhizae 1/2 amount, Herba Hedyotidis Diffusae, Pericarpium Citri Reticulatae, Pseudobulbus Bletillae (Rhizoma Bletillae) extracting in water 2 times, merging filtrate leaves standstill, and removes sediment, and concentrated thick paste is for subsequent use; Herba Taraxaci 1/2 amount just remaining again, Radix Salviae Miltiorrhizae 1/2 amount, Cortex Magnoliae Officinalis, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, the Radix Angelicae Dahuricae, it is for subsequent use that cuttlefish bone meal is broken into coarse powder; Above-mentioned gained thick paste and gained coarse powder blender are stirred, drying and sterilizing, powder patent medicine falls apart, then row sterilization packaging.
Method consumption: every day three times, each 6g, half an hour, boiled water was taken after mixing it with water after meal.It within three weeks, is a course for the treatment of.2 to 3 courses for the treatment of of continuous use.
Case two flood so-and-so, man, 52 years old, peasant, people from Huancui District, Weihai City examined in May, 2011.
Suffer from gastric abscess more than 6 years, once in certain hospital's row gastroscopy, be diagnosed as chronic atrophic gastritis, pathological diagnosis is chronic atrophic gastritis, Helicobacter pylori.Be interrupted and take antibacterial and protection gastric mucosa Drug therapy, also once took Chinese medicine decoction treatment, Relapse rate shows effect, symptom when examining: gastric abscess (++), feeling of fullness (+++), poor appetite (+++), belch (+), noisy (++).Gastroscope finding: the coarse injustice of gastric mucosa mucosa has more lamellar erosion as seen, examines as chronic atrophic gastritis.Pathological diagnosis: chronic atrophic gastritis, part glandular epithelium intestinal hypertrophy, a little body of gland arrangement is tight, helicobacter pylori (+).Three large routines and Liver and kidney function check normal range.
Treatment: to the present embodiment medicine, three times on the one, take 21 days continuously, further consultation once weekly, avoids cold and uncooked food and pungently waits irritable food, and enjoin if any irritated and other untoward reaction, at once examine.Check after taking medicine January.
Observation of curative effect: take medicine and namely feel gastric abscess for one week and obviously alleviate, after taking medicine, symptom disappears substantially.
Embodiment 3:: a kind ofly treat the Chinese medicine that helicobacter pylori infections causes chronic gastritis and peptic ulcer disease, takes raw material by following weight proportion: Cortex Magnoliae Officinalis 12, the Radix Astragali 18, Radix Salviae Miltiorrhizae 27, Herba Taraxaci 28, Herba Hedyotidis Diffusae 19, Pericarpium Citri Reticulatae 15, the Radix Paeoniae Alba 14, the Radix Angelicae Dahuricae 14, the Rhizoma Atractylodis Macrocephalae 14, Pseudobulbus Bletillae (Rhizoma Bletillae) 18, Os Sepiae 26.Decontamination, sieve earth.Then by above-mentioned Herba Taraxaci 1/2 amount, Radix Salviae Miltiorrhizae 1/2 amount, Herba Hedyotidis Diffusae, Pericarpium Citri Reticulatae, Pseudobulbus Bletillae (Rhizoma Bletillae) extracting in water 2 times, merging filtrate leaves standstill, and removes sediment, and concentrated thick paste is for subsequent use; Herba Taraxaci 1/2 amount just remaining again, Radix Salviae Miltiorrhizae 1/2 amount, Cortex Magnoliae Officinalis, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, the Radix Angelicae Dahuricae, it is for subsequent use that cuttlefish bone meal is broken into coarse powder; Above-mentioned gained thick paste and gained coarse powder blender are stirred, drying and sterilizing, powder patent medicine falls apart, then row sterilization packaging.
Method consumption: every day three times, each 6g, half an hour, boiled water was taken after mixing it with water after meal.It within three weeks, is a course for the treatment of.2 to 3 courses for the treatment of of continuous use.
Case three Zou so-and-so, man, 49 years old, individual, the flourish urban human in Weihai City is examined in March, 2009.
Suffer from gastric abscess more than 7 years, once in certain hospital's row gastroscopy, be diagnosed as chronic atrophic gastritis, pathological diagnosis is that stomach lining inflammation part companion glandular epithelium intestinalization is raw, Helicobacter pylori.Be interrupted and take antibacterial and protection gastric mucosa Drug therapy, also once took Chinese medicine decoction treatment, Relapse rate shows effect, symptom when examining: gastric abscess (++), feeling of fullness (++), poor appetite (+++), belch (+), noisy (++).Gastroscope finding: the coarse injustice of gastric mucosa mucosa has more lamellar erosion as seen, is dispersed in petechia, examines as chronic atrophic gastritis.Pathological diagnosis: gastric antrum chronic inflammation, part glandular epithelium intestinalization is raw, helicobacter pylori (+).Three large routines and Liver and kidney function check normal range.
Treatment: to the present embodiment medicine, three times on the one, take 21 days continuously, further consultation once weekly, avoids cold and uncooked food and pungently waits irritable food, and enjoin if any irritated and other untoward reaction, at once examine.Check after taking medicine January.
Observation of curative effect: take medicine and namely feel gastric abscess for one week and obviously alleviate, after taking medicine, symptom disappears substantially.
Embodiment 4: a kind ofly treat the Chinese medicine that helicobacter pylori infections causes chronic gastritis and peptic ulcer disease, takes raw material by following weight proportion: Cortex Magnoliae Officinalis 14, the Radix Astragali 16, Radix Salviae Miltiorrhizae 26, Herba Taraxaci 25, Herba Hedyotidis Diffusae 18, Pericarpium Citri Reticulatae 22, the Radix Paeoniae Alba 12, the Radix Angelicae Dahuricae 12, the Rhizoma Atractylodis Macrocephalae 12, Pseudobulbus Bletillae (Rhizoma Bletillae) 15, Os Sepiae 28.Decontamination, sieve earth.Then by above-mentioned Herba Taraxaci 1/2 amount, Radix Salviae Miltiorrhizae 1/2 amount, Herba Hedyotidis Diffusae, Pericarpium Citri Reticulatae, Pseudobulbus Bletillae (Rhizoma Bletillae) extracting in water 2 times, merging filtrate leaves standstill, and removes sediment, and concentrated thick paste is for subsequent use; Herba Taraxaci 1/2 amount just remaining again, Radix Salviae Miltiorrhizae 1/2 amount, Cortex Magnoliae Officinalis, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, the Radix Angelicae Dahuricae, it is for subsequent use that cuttlefish bone meal is broken into coarse powder; Above-mentioned gained thick paste and gained coarse powder blender are stirred, drying and sterilizing, powder patent medicine falls apart, then row sterilization packaging.
Method consumption: every day three times, each 6g, half an hour, boiled water was taken after mixing it with water after meal.It within three weeks, is a course for the treatment of.2 to 3 courses for the treatment of of continuous use.After one course for the treatment of, helicobacter pylori clearance rate is 84.44%.Through tcm symptom comparitive study, treatment group tcm symptom treatment total effective rate is 95.56%.
Claims (2)
1. treat the Chinese medicine that helicobacter pylori infections causes chronic gastritis and peptic ulcer disease for one kind, it adopts Cortex Magnoliae Officinalis, the Radix Astragali, Radix Salviae Miltiorrhizae, Herba Taraxaci, Herba Hedyotidis Diffusae, Pericarpium Citri Reticulatae, the Radix Paeoniae Alba, the Radix Angelicae Dahuricae, the Rhizoma Atractylodis Macrocephalae, Pseudobulbus Bletillae (Rhizoma Bletillae), Os Sepiae to be raw material, it is characterized in that its raw material composition and weight proportion are: Cortex Magnoliae Officinalis 10-15, Radix Astragali 15-20, Radix Salviae Miltiorrhizae 25-30, Herba Taraxaci 25-30, Herba Hedyotidis Diffusae 15-20, Pericarpium Citri Reticulatae 10-25, Radix Paeoniae Alba 10-15, Radix Angelicae Dahuricae 10-15, Rhizoma Atractylodis Macrocephalae 10-15, Pseudobulbus Bletillae (Rhizoma Bletillae) 15-20, Os Sepiae 25-30.
2. treatment helicobacter pylori infections according to claim 1 causes the Chinese medicine of chronic gastritis and peptic ulcer disease, it is characterized in that raw material weight proportioning is: Cortex Magnoliae Officinalis 12, the Radix Astragali 15, Radix Salviae Miltiorrhizae 30, Herba Taraxaci 30, Herba Hedyotidis Diffusae 15, Pericarpium Citri Reticulatae 10, the Radix Paeoniae Alba 15, the Radix Angelicae Dahuricae 15, the Rhizoma Atractylodis Macrocephalae 15, Pseudobulbus Bletillae (Rhizoma Bletillae) 18, Os Sepiae 30.
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| CN1190005A (en) * | 1997-02-03 | 1998-08-12 | 裴树丰 | Compound Weisukang capsule for gastropathy and its preparation |
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